DT-Web

DB00568 - Cinnarizine


Identification
Name Cinnarizine
Accession Number DB00568 (APRD00332)
Type small molecule
Description Cinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 368.5139
Groups approved
Monoisotopic Weight 368.225248906
Pharmacology
Indication For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Mechanism of action Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Paton DM, Webster DR: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. - Pubmed
DTHybrid score 0.6156
Voltage-dependent L-type calcium channel subunit alpha-1C
Name Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.5232
Voltage-dependent L-type calcium channel subunit alpha-1D
Name Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name CACNA1D
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.4537
Voltage-dependent L-type calcium channel subunit alpha-1F
Name Voltage-dependent L-type calcium channel subunit alpha-1F
Gene Name CACNA1F
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.2841
Voltage-dependent L-type calcium channel subunit alpha-1S
Name Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name CACNA1S
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.4671
Voltage-dependent T-type calcium channel subunit alpha-1G
Name Voltage-dependent T-type calcium channel subunit alpha-1G
Gene Name CACNA1G
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.3686
Voltage-dependent T-type calcium channel subunit alpha-1H
Name Voltage-dependent T-type calcium channel subunit alpha-1H
Gene Name CACNA1H
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.3412
Voltage-dependent T-type calcium channel subunit alpha-1I
Name Voltage-dependent T-type calcium channel subunit alpha-1I
Gene Name CACNA1I
Pharmacological action yes
Actions inhibitor
References
  • Singh BN: The mechanism of action of calcium antagonists relative to their clinical applications. Br J Clin Pharmacol. 1986;21 Suppl 2:109S-121S. - Pubmed
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
DTHybrid score 0.2794
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action no
Actions other/unknown
References
  • Hirose G: Drug induced parkinsonism: A review. J Neurol. 2006 Aug;253 Suppl 3:iii22-iii24. - doi:10.1007/s00415-006-3004-8
  • Brucke T, Wober C, Podreka I, Wober-Bingol C, Asenbaum S, Aull S, Wenger S, Ilieva D, Harasko-van der Meer C, Wessely P, et al.: D2 receptor blockade by flunarizine and cinnarizine explains extrapyramidal side effects. A SPECT study. J Cereb Blood Flow Metab. 1995 May;15(3):513-8. - Pubmed
  • Kuzuhara S: [Drug-induced parkinsonism] Nippon Rinsho. 1997 Jan;55(1):112-7. - Pubmed
DTHybrid score 0.3085

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6782
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5723
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6245
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4129
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4175
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3788

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.6239
6016 Cytochrome P450 2C19 CYP2C19 0.3916
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.3428
1588 Multidrug resistance protein 1 ABCB1 0.318
4924 Cytochrome P450 2C8 CYP2C8 0.3057
4118 Cytochrome P450 3A5 CYP3A5 0.2945
6013 Cytochrome P450 2E1 CYP2E1 0.2839
6107 Cytochrome P450 3A7 CYP3A7 0.2364
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.2331
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.1694
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.1473
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.1473
502 5-hydroxytryptamine 2A receptor HTR2A 0.141
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.1357
465 Calmodulin CALM1 0.1244
556 Alpha-1A adrenergic receptor ADRA1A 0.1169
23 D(1A) dopamine receptor DRD1 0.1151
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0968
318 Alpha-2A adrenergic receptor ADRA2A 0.0868
587 Serum albumin ALB 0.086
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0851
20 Prostaglandin G/H synthase 1 PTGS1 0.0834
824 Sodium-dependent serotonin transporter SLC6A4 0.0826
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0797
590 5-hydroxytryptamine 2C receptor HTR2C 0.079
6106 Cytochrome P450 2C18 CYP2C18 0.0779
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0765
632 Alpha-1B adrenergic receptor ADRA1B 0.0732
638 D(3) dopamine receptor DRD3 0.0718
320 5-hydroxytryptamine 1A receptor HTR1A 0.0708
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0675
6145 Solute carrier family 22 member 1 SLC22A1 0.0668
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0657
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0634
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0625
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0609
629 Alpha-2B adrenergic receptor ADRA2B 0.0597
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0585
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0584
432 D(4) dopamine receptor DRD4 0.0572
378 Alpha-2C adrenergic receptor ADRA2C 0.0571
6220 Aryl hydrocarbon receptor AHR 0.056
713 Sodium-dependent dopamine transporter SLC6A3 0.055
1898 Cytochrome P450 1B1 CYP1B1 0.0544
193 Beta-1 adrenergic receptor ADRB1 0.0542
118 Organic cation/carnitine transporter 2 SLC22A5 0.0542
737 Mineralocorticoid receptor NR3C2 0.0539
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0538
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0535
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0532
450 Muscarinic acetylcholine receptor M4 CHRM4 0.052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0518
789 Alpha-1D adrenergic receptor ADRA1D 0.0516
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0502
3923 Cholinesterase BCHE 0.0496
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0491
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0482
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0479
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0471
862 Multidrug resistance-associated protein 1 ABCC1 0.0454
6048 Troponin C, skeletal muscle TNNC2 0.0441
776 Bile salt export pump ABCB11 0.0432
6144 Solute carrier family 22 member 2 SLC22A2 0.0431
3941 Amine oxidase [flavin-containing] A MAOA 0.0421
3811 Cytochrome P450 19A1 CYP19A1 0.042
766 Beta-2 adrenergic receptor ADRB2 0.041
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0408
1729 Solute carrier family 22 member 6 SLC22A6 0.0407
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0401
163 D(1B) dopamine receptor DRD5 0.0399
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0396
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0392
290 Prostaglandin G/H synthase 2 PTGS2 0.0387
833 Organic cation/carnitine transporter 1 SLC22A4 0.0386
885 5-hydroxytryptamine 1B receptor HTR1B 0.0381
341 5-hydroxytryptamine 3 receptor HTR3A 0.0375
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0374
725 5-hydroxytryptamine 1D receptor HTR1D 0.0367
3939 Amine oxidase [flavin-containing] B MAOB 0.0359
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0357
6031 Cytochrome P450 3A43 CYP3A43 0.0356
716 5-hydroxytryptamine 7 receptor HTR7 0.0344
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0337
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0323
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.032
468 Cytochrome P450 4A11 CYP4A11 0.0315
436 5-hydroxytryptamine 2B receptor HTR2B 0.0314
2164 Multidrug resistance-associated protein 4 ABCC4 0.0314
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0307
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0295
136 Estrogen receptor ESR1 0.0292
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0286
295 Carbonic anhydrase 1 CA1 0.0286
233 Potassium channel subfamily K member 2 KCNK2 0.0273
6147 Solute carrier family 22 member 3 SLC22A3 0.0269
6014 Cytochrome P450 2A13 CYP2A13 0.0267
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0263
36 Insulin receptor INSR 0.0258
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.025
6148 Multidrug resistance-associated protein 7 ABCC10 0.0248
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0242
847 Mu-type opioid receptor OPRM1 0.0216
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0215
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0215
1108 Calpastatin CAST 0.0211
1089 Cartilage oligomeric matrix protein COMP 0.0211
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.021
6133 Sodium channel subunit beta-2 SCN2B 0.0207
6135 Sodium channel subunit beta-4 SCN4B 0.0207
6127 Carbonic anhydrase-related protein CA8 0.0207
6129 Carbonic anhydrase-related protein 11 CA11 0.0207
6134 Sodium channel subunit beta-3 SCN3B 0.0207
6132 Sodium channel subunit beta-1 SCN1B 0.0207
6128 Carbonic anhydrase-related protein 10 CA10 0.0207
1256 5-hydroxytryptamine 6 receptor HTR6 0.0207
817 DNA topoisomerase 2-alpha TOP2A 0.02
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0195
696 Kappa-type opioid receptor OPRK1 0.0195
1341 Histamine H3 receptor HRH3 0.0193
891 Dihydropteroate synthase folP 0.0192
5359 Dihydropteroate synthase folP 0.0192
7175 Dihydropteroate synthase sulI 0.0192
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0191
6142 Solute carrier family 22 member 8 SLC22A8 0.019
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0187
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0185
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0184
6131 Carbonic anhydrase 14 CA14 0.0184
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0183
6130 Carbonic anhydrase 13 CA13 0.0182
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0182
6126 Carbonic anhydrase 7 CA7 0.018
122 P2Y purinoceptor 12 P2RY12 0.0179
731 HIV-1 protease HIV-1 protease 0.0177
467 Delta-type opioid receptor OPRD1 0.0177
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0173
6020 Aldehyde oxidase AOX1 0.0172
6122 Carbonic anhydrase 3 CA3 0.0172
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0171
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0171
1656 CYP2B protein CYP2B 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0165
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
131 Synaptic vesicular amine transporter SLC18A2 0.0163
6143 Solute carrier family 22 member 7 SLC22A7 0.0162
404 DNA gyrase subunit A gyrA 0.0161
6224 DNA gyrase subunit A gyrA 0.0161
592 Carbonic anhydrase 4 CA4 0.0159
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0158
2132 Protein S100-B S100B 0.0157
1275 Estrogen sulfotransferase SULT1E1 0.0157
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0156
3007 Carbonic anhydrase 12 CA12 0.0155
4205 Carbonic anhydrase 9 CA9 0.0155
94 5-hydroxytryptamine 4 receptor HTR4 0.0153
260 Cytochrome P450 51 ERG11 0.0153
761 Cytochrome P450 51 ERG11 0.0153
3163 Cytochrome P450 51 cyp51 0.0153
482 Glycine receptor subunit alpha-1 GLRA1 0.015
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0149
777 Tumor necrosis factor TNF 0.0149
124 Histamine H2 receptor HRH2 0.0146
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0146
528 5-hydroxytryptamine 1E receptor HTR1E 0.0144
6182 Cytochrome P450 2J2 CYP2J2 0.0144
174 Sigma 1-type opioid receptor SIGMAR1 0.0144
380 Cytochrome P450 17A1 CYP17A1 0.0139
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0138
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0136
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0136
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0132
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0132
751 Potassium channel subfamily K member 6 KCNK6 0.0131
871 Glucocorticoid receptor NR3C1 0.0131
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.013
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0128
6102 Arylamine N-acetyltransferase 2 NAT2 0.0126
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0125
3947 Xanthine dehydrogenase/oxidase XDH 0.0122
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0122
921 Glutamate receptor 2 GRIA2 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0121
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0121
1757 Myeloperoxidase MPO 0.012
172 Potassium channel subfamily K member 1 KCNK1 0.012
357 Carbonic anhydrase 2 CA2 0.012
6136 Multidrug resistance-associated protein 5 ABCC5 0.0116
48 Pyridoxal kinase PDXK 0.0116
1010 Cytochrome P450 51A1 CYP51A1 0.0114
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0114
537 ATP synthase delta chain, mitochondrial ATP5D 0.0113
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0112
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0111
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0111
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.011
146 Androgen receptor AR 0.011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0108
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0108
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0108
16 Adenosine A1 receptor ADORA1 0.0108
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0108
1517 Beta-3 adrenergic receptor ADRB3 0.0106
613 Atrial natriuretic peptide receptor A NPR1 0.0105
844 Epidermal growth factor receptor EGFR 0.0104
3932 Glutathione S-transferase A2 GSTA2 0.0104
1178 Adenosine A2a receptor ADORA2A 0.0104
734 D1 dopamine receptor-interacting protein calcyon CALY 0.01
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.01
504 Mast/stem cell growth factor receptor KIT 0.0099
869 Estrogen receptor beta ESR2 0.0098
474 Acetylcholinesterase ACHE 0.0098
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
427 Substance-P receptor TACR1 0.0097
705 Glutamate receptor 1 GRIA1 0.0096
4120 NADPH--cytochrome P450 reductase POR 0.0095
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
4203 Histamine N-methyltransferase HNMT 0.0093
1024 Solute carrier family 22 member 11 SLC22A11 0.0093
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
571 Melatonin receptor type 1A MTNR1A 0.0092
362 Melatonin receptor type 1B MTNR1B 0.0092
2449 Tubulin alpha-3 chain TUBA1A 0.0092
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0089
70 Type-1 angiotensin II receptor AGTR1 0.0089
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0088
4604 Liver carboxylesterase 1 CES1 0.0087
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0086
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0086
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0085
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0084
251 Alcohol dehydrogenase 1A ADH1A 0.0084
3810 Catechol O-methyltransferase COMT 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0083
275 Arachidonate 5-lipoxygenase ALOX5 0.0082
1192 Sulfotransferase 1A1 SULT1A1 0.0082
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0082
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0081
4228 Keratin, type II cytoskeletal 7 KRT7 0.0079
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0079
164 Histamine H4 receptor HRH4 0.0079
563 Thyroid peroxidase TPO 0.0078
84 Nuclear receptor 0B1 NR0B1 0.0078
6137 Multidrug resistance-associated protein 6 ABCC6 0.0077
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0076
373 Transthyretin TTR 0.0076
444 Alcohol dehydrogenase 1B ADH1B 0.0075
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0075
923 Glutamate receptor 3 GRIA3 0.0074
2112 Toll-like receptor 9 TLR9 0.0073
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0073
820 Glycine receptor subunit alpha-2 GLRA2 0.0073
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0072
811 Translocator protein TSPO 0.0072
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0071
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0071
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.007
4238 50S ribosomal protein L4 rplD 0.007
5578 50S ribosomal protein L4 rplD 0.007
6173 50S ribosomal protein L4 rplD 0.007
6219 50S ribosomal protein L4 rplD 0.007
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
2230 Catalase CAT 0.0069
3249 Catalase katA 0.0069
3625 Catalase katA 0.0069
4539 Catalase katA 0.0069
4941 Catalase katB 0.0069
106 Cannabinoid receptor 2 CNR2 0.0068
228 Beta platelet-derived growth factor receptor PDGFRB 0.0068
511 5-hydroxytryptamine 1F receptor HTR1F 0.0068
1636 Trace amine-associated receptor 1 TAAR1 0.0067
518 Peroxidase/catalase T katG 0.0066
6432 Transporter snf 0.0066
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0066
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0065
517 Alcohol dehydrogenase 1C ADH1C 0.0065
4237 50S ribosomal protein L22 rplV 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0065
68 Cannabinoid receptor 1 CNR1 0.0064
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0064
1820 Beta-nerve growth factor NGF 0.0064
33 Cystine/glutamate transporter SLC7A11 0.0063
4122 Histone deacetylase 2 HDAC2 0.0063
6146 High affinity copper uptake protein 1 SLC31A1 0.0063
756 Sex hormone-binding globulin SHBG 0.0063
173 Toll-like receptor 7 TLR7 0.0063
133 Dihydropterate synthase sulI 0.0063
818 50S ribosomal protein L10 rplJ 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0061
780 Retinoic acid receptor RXR-gamma RXRG 0.0061
6141 Sodium/bile acid cotransporter SLC10A1 0.0061
365 Dihydrofolate reductase DHFR 0.006
2381 Dihydrofolate reductase DFR1 0.006
2833 Dihydrofolate reductase Not Available 0.006
2931 Dihydrofolate reductase folA 0.006
3544 Dihydrofolate reductase folA 0.006
3682 Dihydrofolate reductase folA 0.006
6642 Dihydrofolate reductase folA 0.006
6756 Dihydrofolate reductase dfrA 0.006
407 Vascular endothelial growth factor receptor 2 KDR 0.006
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0059
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0059
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
1629 Transcription factor AP-1 JUN 0.0057
5934 Cytochrome P450 26A1 CYP26A1 0.0057
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0057
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0057
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0057
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0056
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0056
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0056
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0056
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
823 Fibroblast growth factor receptor 2 FGFR2 0.0055
88 Retinoic acid receptor RXR-beta RXRB 0.0055
6859 Protein S100-A4 S100A4 0.0055
26 Vascular endothelial growth factor receptor 3 FLT4 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0054
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
569 Retinal dehydrogenase 2 ALDH1A2 0.0053
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
32 Vascular endothelial growth factor receptor 1 FLT1 0.0052
1714 Mitogen-activated protein kinase 3 MAPK3 0.0052
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0051
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
611 Retinal dehydrogenase 1 ALDH1A1 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.005
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.005
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0049
581 Cytochrome P450 2R1 CYP2R1 0.0049
7 Nitric oxide synthase, inducible NOS2 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
1050 Bile salt sulfotransferase SULT2A1 0.0049
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0048
719 Retinoic acid receptor responder protein 1 RARRES1 0.0048
770 Retinoic acid-induced protein 3 GPRC5A 0.0048
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0048
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0048
1618 High affinity nerve growth factor receptor NTRK1 0.0048
183 Vascular endothelial growth factor A VEGFA 0.0048
3917 Methylenetetrahydrofolate reductase MTHFR 0.0047
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0046
161 Tubulin beta chain TUBB 0.0046
312 Tubulin beta chain TUB2 0.0046
1992 Vitamin D-binding protein GC 0.0046
738 Monocarboxylate transporter 1 SLC16A1 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0046
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0045
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0045
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0045
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0045
232 Corticosteroid-binding globulin SERPINA6 0.0044
400 Coagulation factor IX F9 0.0044
5461 Coagulation factor IX F9 0.0044
614 Progesterone receptor PGR 0.0044
153 Dopamine beta-hydroxylase DBH 0.0044
49 Endothelin B receptor EDNRB 0.0044
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0043
54 Prothrombin F2 0.0043
3937 Fatty-acid amide hydrolase FAAH 0.0043
1048 Protein S100-A13 S100A13 0.0043
2226 Protein S100-A12 S100A12 0.0043
273 Apoptosis regulator Bcl-2 BCL2 0.0043
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0043
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
24 Thymidylate synthase TMP1 0.0042
359 Thymidylate synthase TYMS 0.0042
2626 Thymidylate synthase thyA 0.0042
2729 Thymidylate synthase thyA 0.0042
5352 Thymidylate synthase THYA 0.0042
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0042
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0041
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
6174 50S ribosomal protein L32 rpmF 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0041
604 Vitamin K-dependent protein Z PROZ 0.0041
634 Squalene monooxygenase SQLE 0.004
7196 Squalene monooxygenase ERG1 0.004
3957 Adenosine deaminase ADA 0.0039
6043 Putative G-protein coupled receptor 44 GPR44 0.0039
284 DNA-directed RNA polymerase beta chain rpoB 0.0039
5773 DNA-directed RNA polymerase beta chain rpoB 0.0039
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
162 Retinoic acid receptor gamma-1 RARG 0.0039
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0039
6044 Serum paraoxonase/lactonase 3 PON3 0.0039
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
976 Platelet glycoprotein IX GP9 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
1374 Natriuretic peptides B NPPB 0.0038
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0037
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0037
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0037
422 Vitamin K-dependent protein C PROC 0.0037
1245 Vitamin K-dependent protein S PROS1 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0037
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
130 Prostacyclin synthase PTGIS 0.0037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0036
904 Glutathione S-transferase P GSTP1 0.0036
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
814 Ryanodine receptor 1 RYR1 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
2236 Casein kinase II subunit alpha CSNK2A1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
856 Vitamin D3 receptor VDR 0.0034
3830 Calreticulin CALR 0.0034
712 Tubulin alpha chain TUB1 0.0034
239 Coagulation factor X F10 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0033
469 Annexin A1 ANXA1 0.0033
6506 Stathmin-4 STMN4 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2298 Cytochrome P450-cam camC 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0033
1648 Elastin ELN 0.0032
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0032
908 Glutathione S-transferase theta-1 GSTT1 0.0032
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0032
1268 Neuropeptide S receptor NPSR1 0.0032
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0032
6034 Hydroxyindole O-methyltransferase ASMT 0.0032
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0032
6035 Nuclear receptor ROR-beta RORB 0.0032
6036 Eosinophil peroxidase EPX 0.0032
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
2981 Phospholipase A2, membrane associated PLA2G2A 0.0032
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
268 Adenosine A2b receptor ADORA2B 0.0031
936 Ephrin type-A receptor 2 EPHA2 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
1039 Histone deacetylase 9 HDAC9 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
4225 Uridine phosphorylase 1 UPP1 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
798 Osteocalcin BGLAP 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.003
6163 Copper-transporting ATPase 2 ATP7B 0.003
6165 Copper-transporting ATPase 1 ATP7A 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
6073 Potassium channel subfamily K member 9 KCNK9 0.0029
6072 Potassium channel subfamily K member 3 KCNK3 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0028
208 DNA-directed RNA polymerase beta' chain rpoC 0.0028
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0028
765 Indoleamine 2,3-dioxygenase IDO1 0.0028
319 Opioid receptor, sigma 1 OPRS1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0028
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0028
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
369 Coagulation factor VII F7 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0026
1630 Integrin beta-2 ITGB2 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
29 Tubulin beta-1 chain TUBB1 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
1262 Corticotropin-lipotropin POMC 0.0026
5880 Thrombopoietin receptor MPL 0.0025
1541 Metalloproteinase mmp20 0.0025
6221 Steroid hormone receptor ERR1 ESRRA 0.0025
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0024
896 Glutathione S-transferase Mu 1 GSTM1 0.0024
165 FL cytokine receptor FLT3 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6070 Nischarin NISCH 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
4192 DNA topoisomerase 2-beta TOP2B 0.0023
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
822 Aldose reductase AKR1B1 0.0023
2207 Rhodopsin RHO 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
2320 Thymidine kinase, cytosolic TK1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
1830 5'-nucleotidase NT5E 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
1243 Cathepsin D CTSD 0.0016
6149 Solute carrier family 22 member 10 SLC22A10 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
2853 14 kDa fatty acid-binding protein Not Available 0.0015
1864 RET proto-oncogene RET 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
4773 Deoxycytidine kinase DCK 0.0014
3086 Plasmepsin-2 Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
3404 Exotoxin A eta 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
997 Protein kinase C beta type PRKCB 0.0012
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
6168 Solute carrier family 22 member 16 SLC22A16 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
572 Integrin alpha-L ITGAL 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
345 Plasma retinol-binding protein RBP4 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.001
1353 DNA topoisomerase 1 TOP1 0.001
3552 DNA topoisomerase 1 topA 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0008
3221 Cytochrome c4 cc4 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
1507 Cytochrome c CYCS 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4984 Neuroglobin NGB 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4943 Cytochrome c6 petJ 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4910 Cytoglobin CYGB 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
5000 HemO hemO 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4909 CooA protein cooA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4961 Hemophore HasA hasA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4972 P450cin cinA 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3093 Catalase HPII katE 0.0005
4952 Catalase/peroxidase katA 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6218 Pannexin-1 PANX1 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
489 Monocarboxylate transporter 2 SLC16A7 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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