DT-Web

DB01041 - Thalidomide


Identification
Name Thalidomide
Accession Number DB01041 (APRD01251)
Type small molecule
Description A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 258.2295
Groups approved
Monoisotopic Weight 258.064056818
Pharmacology
Indication For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
Mechanism of action In patients with erythema nodosum leprosum (ENL) the mechanism of action is not fully understood. Available data from in vitro studies and preliminary clinical trials suggest that the immunologic effects of this compound can vary substantially under different conditions, but may be related to suppression of excessive tumor necrosis factor-alpha (TNF-a) production and down-modulation of selected cell surface adhesion molecules involved in leukocyte migration. For example, administration of thalidomide has been reported to decrease circulating levels of TNF-a in patients with ENL, however, it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. As a cancer treatment, the drug may act as a VEGF inhibitor.
Absorption The absolute bioavailability has not yet been characterized in human subjects due to its poor aqueous solubility. In studies of both healthy volunteers and subjects with Hansen’s disease, the mean time to peak plasma concentrations (Tmax) ranged from 2.9 to 5.7 hours indicating that thalidomide is slowly absorbed from the gastrointestinal tract.
Protein binding 55% and 66% for the (+)R and (−)S enantiomers, respectively.
Biotransformation Thalidomide itself does not appear to be hepatically metabolized to any large extent, but appears to undergo non-enzymatic hydrolysis in plasma to multiple metabolites. Thalidomide may be metabolized hepatically by enzymes of the cytochrome P450 enzyme system. The end product of metabolism, phthalic acid, is excreted as a glycine conjugate.
Route of elimination Thalidomide itself has less than 0.7% of the dose excreted in the urine as unchanged drug.
Toxicity The R-configuration and the S-configuration are more toxic individually than the racemic mixture. The LD50 could not be established in mice for racemic thalidomide, whereas LD50 values for the R and S configurations are reported to be 0.4 to 0.7 g/kg and 0.5 to 1.5 g/kg, respectively.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abatacept Thalidomide may increase the adverse effects of Abatacept. Increased risk of serious infection. Concomitant therapy should be avoided.
Amikacin Thalidomide increases the renal toxicity of the aminoglycoside
Anakinra Thalidomide may increase the adverse effects of Anakinra. Increased risk of serious infection. Concomitant therapy should be avoided.
Dexamethasone Increased risk of dermatologic adverse effects and venous thromboembolic events (VTE). Consider VTE prophylaxis during concomitant therapy and monitor for adverse dematologic effects.
Gentamicin Thalidomide increases the renal toxicity of the aminoglycoside
Natalizumab Thalidomide may increase the adverse effects of Natalizumab. Concurrent administration should be avoided due to increased risk of infection.
Netilmicin Thalidomide increases the renal toxicity of the aminoglycoside
Rilonacept Thalidomide may increase the adverse effects of Rilonacept. Increased risk of serious infection. Concomitant therapy should be avoided.
Tobramycin Thalidomide increases the renal toxicity of the aminoglycoside
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Triprolidine The CNS depressants, Triprolidine and Thalidomide, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions Not Available

Targets


Protein cereblon
Name Protein cereblon
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Zhu YX, Kortuem KM, Stewart AK: Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7. doi: 10.3109/10428194.2012.728597. Epub 2012 Sep 28. - Pubmed
DTHybrid score Not Available
Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action yes
Actions inhibitor
References
  • Richardson P, Hideshima T, Anderson K: Thalidomide in multiple myeloma. Biomed Pharmacother. 2002 May;56(3):115-28. - Pubmed
  • Fu LM, Fu-Liu CS: Thalidomide and tuberculosis. Int J Tuberc Lung Dis. 2002 Jul;6(7):569-72. - Pubmed
  • Enomoto N, Takei Y, Hirose M, Ikejima K, Miwa H, Kitamura T, Sato N: Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production. Gastroenterology. 2002 Jul;123(1):291-300. - Pubmed
  • Rajkumar SV: Thalidomide in the treatment of multiple myeloma. Expert Rev Anticancer Ther. 2001 Jun;1(1):20-8. - Pubmed
  • Vescovo G, Ravara B, Angelini A, Sandri M, Carraro U, Ceconi C, Dalla Libera L: Effect of thalidomide on the skeletal muscle in experimental heart failure. Eur J Heart Fail. 2002 Aug;4(4):455-60. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7822
Nuclear factor NF-kappa-B p105 subunit
Name Nuclear factor NF-kappa-B p105 subunit
Gene Name NFKB1
Pharmacological action yes
Actions antagonist
References
  • Yasui K, Kobayashi N, Yamazaki T, Agematsu K: Thalidomide as an immunotherapeutic agent: the effects on neutrophil-mediated inflammation. Curr Pharm Des. 2005;11(3):395-401. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3613
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Stephens TD, Bunde CJ, Fillmore BJ: Mechanism of action in thalidomide teratogenesis. Biochem Pharmacol. 2000 Jun 15;59(12):1489-99. - Pubmed
  • Shoji A, Kuwahara M, Ozaki H, Sawai H: Modified DNA aptamer that binds the (R)-isomer of a thalidomide derivative with high enantioselectivity. J Am Chem Soc. 2007 Feb 7;129(5):1456-64. - Pubmed
  • Stephens TD, Fillmore BJ: Hypothesis: thalidomide embryopathy-proposed mechanism of action. Teratology. 2000 Mar;61(3):189-95. - Pubmed
DTHybrid score Not Available
Fibroblast growth factor receptor 2
Name Fibroblast growth factor receptor 2
Gene Name FGFR2
Pharmacological action yes
Actions antagonist
References
  • Eichholz A, Merchant S, Gaya AM: Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther. 2010 Jun 24;3:69-82. - Pubmed
DTHybrid score 0.6364
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action unknown
Actions antagonist
References
  • Horrobin DF: A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels. Med Hypotheses. 2003 May;60(5):615-23. - Pubmed
  • Hada M, Mizutari K: [A case report of metastatic pancreatic cancer that responded remarkably to the combination of thalidomide, celecoxib and irinotecan] Gan To Kagaku Ryoho. 2004 Sep;31(9):1407-10. - Pubmed
  • Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI: Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell Immunol. 2004 Aug;230(2):81-8. - Pubmed
  • Wiedmann MW, Caca K: Molecularly targeted therapy for gastrointestinal cancer. Curr Cancer Drug Targets. 2005 May;5(3):171-93. - Pubmed
  • Du GJ, Lin HH, Xu QT, Wang MW: Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. Vascul Pharmacol. 2005 Aug;43(2):112-9. - Pubmed
DTHybrid score 0.6084

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4646
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3336
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3566
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5827
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.7235
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.6084
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3323
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5353

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.5068
4119 Cytochrome P450 2D6 CYP2D6 0.3007
4924 Cytochrome P450 2C8 CYP2C8 0.2797
1588 Multidrug resistance protein 1 ABCB1 0.2409
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.2045
6107 Cytochrome P450 3A7 CYP3A7 0.1752
6030 Cytochrome P450 2B6 CYP2B6 0.1725
5718 Cytochrome P450 2A6 CYP2A6 0.1255
587 Serum albumin ALB 0.1248
1729 Solute carrier family 22 member 6 SLC22A6 0.1014
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0968
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0918
2232 Interleukin-5 IL5 0.0915
1593 Mucin-2 MUC2 0.0912
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0883
2216 Fibroblast growth factor receptor 4 FGFR4 0.0765
3856 Fibroblast growth factor receptor 3 FGFR3 0.0725
7 Nitric oxide synthase, inducible NOS2 0.0717
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0712
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0706
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.0676
1123 Eosinophil cationic protein RNASE3 0.0672
6106 Cytochrome P450 2C18 CYP2C18 0.0634
1898 Cytochrome P450 1B1 CYP1B1 0.0622
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0614
3852 Neuropilin-1 NRP1 0.0589
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.054
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0517
275 Arachidonate 5-lipoxygenase ALOX5 0.0513
492 Histamine H1 receptor HRH1 0.0485
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0474
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0472
6142 Solute carrier family 22 member 8 SLC22A8 0.0458
1757 Myeloperoxidase MPO 0.0448
862 Multidrug resistance-associated protein 1 ABCC1 0.0443
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0439
3811 Cytochrome P450 19A1 CYP19A1 0.0439
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0433
2164 Multidrug resistance-associated protein 4 ABCC4 0.0416
824 Sodium-dependent serotonin transporter SLC6A4 0.0402
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0397
6145 Solute carrier family 22 member 1 SLC22A1 0.0395
776 Bile salt export pump ABCB11 0.0392
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0369
6144 Solute carrier family 22 member 2 SLC22A2 0.0368
766 Beta-2 adrenergic receptor ADRB2 0.0357
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0344
1820 Beta-nerve growth factor NGF 0.0337
193 Beta-1 adrenergic receptor ADRB1 0.0336
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0334
502 5-hydroxytryptamine 2A receptor HTR2A 0.0334
831 D(2) dopamine receptor DRD2 0.0323
6143 Solute carrier family 22 member 7 SLC22A7 0.0322
3090 Chitosanase csn 0.0317
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0316
468 Cytochrome P450 4A11 CYP4A11 0.0316
556 Alpha-1A adrenergic receptor ADRA1A 0.0304
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0304
1024 Solute carrier family 22 member 11 SLC22A11 0.03
260 Cytochrome P450 51 ERG11 0.0298
761 Cytochrome P450 51 ERG11 0.0298
3163 Cytochrome P450 51 cyp51 0.0298
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0294
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0293
504 Mast/stem cell growth factor receptor KIT 0.0292
318 Alpha-2A adrenergic receptor ADRA2A 0.0284
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0283
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0278
1517 Beta-3 adrenergic receptor ADRB3 0.0278
1253 Interferon gamma IFNG 0.0276
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0276
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0274
341 5-hydroxytryptamine 3 receptor HTR3A 0.0273
3941 Amine oxidase [flavin-containing] A MAOA 0.0273
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0271
5787 Angiopoietin-1 receptor TEK 0.0269
6220 Aryl hydrocarbon receptor AHR 0.0268
407 Vascular endothelial growth factor receptor 2 KDR 0.0267
136 Estrogen receptor ESR1 0.0267
817 DNA topoisomerase 2-alpha TOP2A 0.0263
36 Insulin receptor INSR 0.0258
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0258
6031 Cytochrome P450 3A43 CYP3A43 0.0254
617 Muscarinic acetylcholine receptor M2 CHRM2 0.025
320 5-hydroxytryptamine 1A receptor HTR1A 0.0249
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0249
23 D(1A) dopamine receptor DRD1 0.0243
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0243
590 5-hydroxytryptamine 2C receptor HTR2C 0.0243
118 Organic cation/carnitine transporter 2 SLC22A5 0.0243
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0241
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.024
3923 Cholinesterase BCHE 0.0238
373 Transthyretin TTR 0.0237
2782 Complement C1s subcomponent C1S 0.0235
2112 Toll-like receptor 9 TLR9 0.0233
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0225
146 Androgen receptor AR 0.0223
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0223
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.022
3932 Glutathione S-transferase A2 GSTA2 0.0219
3814 Complement C1r subcomponent C1R 0.0218
632 Alpha-1B adrenergic receptor ADRA1B 0.0218
3815 Complement C1q subcomponent subunit A C1QA 0.0217
3816 Complement C1q subcomponent subunit B C1QB 0.0217
3817 Complement C1q subcomponent subunit C C1QC 0.0217
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0216
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0215
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0215
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0215
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0215
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0214
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0213
713 Sodium-dependent dopamine transporter SLC6A3 0.021
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0207
65 Matrix metalloproteinase-9 Not Available 0.0207
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0206
6147 Solute carrier family 22 member 3 SLC22A3 0.0206
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0205
465 Calmodulin CALM1 0.0202
3939 Amine oxidase [flavin-containing] B MAOB 0.0202
885 5-hydroxytryptamine 1B receptor HTR1B 0.0202
6014 Cytochrome P450 2A13 CYP2A13 0.02
3312 Fatty acid-binding protein, brain FABP7 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0197
6102 Arylamine N-acetyltransferase 2 NAT2 0.0196
731 HIV-1 protease HIV-1 protease 0.0194
1789 Lymphotoxin-alpha LTA 0.0193
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0193
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0192
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0188
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0187
1159 Interleukin-6 IL6 0.0185
26 Vascular endothelial growth factor receptor 3 FLT4 0.0185
871 Glucocorticoid receptor NR3C1 0.0185
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0184
228 Beta platelet-derived growth factor receptor PDGFRB 0.0183
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0179
32 Vascular endothelial growth factor receptor 1 FLT1 0.0179
122 P2Y purinoceptor 12 P2RY12 0.0178
16 Adenosine A1 receptor ADORA1 0.0177
3947 Xanthine dehydrogenase/oxidase XDH 0.0176
638 D(3) dopamine receptor DRD3 0.0174
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0172
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0171
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.017
6148 Multidrug resistance-associated protein 7 ABCC10 0.0168
477 DNA topoisomerase 4 subunit A parC 0.0168
886 DNA topoisomerase 4 subunit A parC 0.0168
6226 DNA topoisomerase 4 subunit A parC 0.0168
847 Mu-type opioid receptor OPRM1 0.0166
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0166
404 DNA gyrase subunit A gyrA 0.0165
6224 DNA gyrase subunit A gyrA 0.0165
5798 Mitogen-activated protein kinase 11 MAPK11 0.0164
891 Dihydropteroate synthase folP 0.0163
5359 Dihydropteroate synthase folP 0.0163
7175 Dihydropteroate synthase sulI 0.0163
833 Organic cation/carnitine transporter 1 SLC22A4 0.0163
1618 High affinity nerve growth factor receptor NTRK1 0.0162
613 Atrial natriuretic peptide receptor A NPR1 0.0161
165 FL cytokine receptor FLT3 0.0161
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.016
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0159
70 Type-1 angiotensin II receptor AGTR1 0.0158
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0157
789 Alpha-1D adrenergic receptor ADRA1D 0.0157
811 Translocator protein TSPO 0.0157
725 5-hydroxytryptamine 1D receptor HTR1D 0.0157
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0156
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0155
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0154
6824 Tyrosine-protein kinase Lyn LYN 0.0153
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0153
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0152
936 Ephrin type-A receptor 2 EPHA2 0.0149
6137 Multidrug resistance-associated protein 6 ABCC6 0.0149
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0146
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0145
6182 Cytochrome P450 2J2 CYP2J2 0.0144
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0143
1178 Adenosine A2a receptor ADORA2A 0.0142
629 Alpha-2B adrenergic receptor ADRA2B 0.0141
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0139
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0137
1010 Cytochrome P450 51A1 CYP51A1 0.0137
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0137
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0134
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0133
723 Cytosolic phospholipase A2 PLA2G4A 0.0132
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0132
467 Delta-type opioid receptor OPRD1 0.0132
703 NADPH azoreductase azr 0.0132
696 Kappa-type opioid receptor OPRK1 0.0131
80 Peroxisome proliferator-activated receptor alpha PPARA 0.013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.013
33 Cystine/glutamate transporter SLC7A11 0.0129
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0129
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0129
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
378 Alpha-2C adrenergic receptor ADRA2C 0.0129
738 Monocarboxylate transporter 1 SLC16A1 0.0128
844 Epidermal growth factor receptor EGFR 0.0128
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0126
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0126
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0125
571 Melatonin receptor type 1A MTNR1A 0.0124
737 Mineralocorticoid receptor NR3C2 0.0124
362 Melatonin receptor type 1B MTNR1B 0.0124
850 Vasopressin V1b receptor AVPR1B 0.0122
614 Progesterone receptor PGR 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
4604 Liver carboxylesterase 1 CES1 0.0121
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.012
6141 Sodium/bile acid cotransporter SLC10A1 0.012
482 Glycine receptor subunit alpha-1 GLRA1 0.012
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0119
6043 Putative G-protein coupled receptor 44 GPR44 0.0118
1656 CYP2B protein CYP2B 0.0116
48 Pyridoxal kinase PDXK 0.0116
1507 Cytochrome c CYCS 0.0116
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0116
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0116
1648 Elastin ELN 0.0114
432 D(4) dopamine receptor DRD4 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
6136 Multidrug resistance-associated protein 5 ABCC5 0.0112
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0111
705 Glutamate receptor 1 GRIA1 0.0111
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0111
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.011
94 5-hydroxytryptamine 4 receptor HTR4 0.0108
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0107
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0107
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
427 Substance-P receptor TACR1 0.0105
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0103
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0103
130 Prostacyclin synthase PTGIS 0.0102
1714 Mitogen-activated protein kinase 3 MAPK3 0.0102
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0102
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0101
4122 Histone deacetylase 2 HDAC2 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.01
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.01
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.01
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.01
3823 Cytokine receptor common gamma chain IL2RG 0.01
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
1439 Lactotransferrin LTF 0.0098
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0097
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
6085 Fatty acid-binding protein, intestinal FABP2 0.0096
4116 Dihydropteroate synthetase Not Available 0.0095
1192 Sulfotransferase 1A1 SULT1A1 0.0095
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
124 Histamine H2 receptor HRH2 0.0093
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0093
6146 High affinity copper uptake protein 1 SLC31A1 0.0093
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0091
3601 Dihydropteroate synthase 1 folP1 0.0091
3807 Dihydropteroate synthase 1 folP1 0.0091
3808 Dihydropteroate synthase 2 folP2 0.0091
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
295 Carbonic anhydrase 1 CA1 0.009
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
921 Glutamate receptor 2 GRIA2 0.0089
756 Sex hormone-binding globulin SHBG 0.0088
716 5-hydroxytryptamine 7 receptor HTR7 0.0088
183 Vascular endothelial growth factor A VEGFA 0.0088
1275 Estrogen sulfotransferase SULT1E1 0.0088
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0088
724 Interleukin-2 receptor alpha chain IL2RA 0.0087
717 Interleukin-2 receptor subunit beta IL2RB 0.0087
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0086
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
592 Carbonic anhydrase 4 CA4 0.0086
558 Solute carrier family 12 member 1 SLC12A1 0.0086
2449 Tubulin alpha-3 chain TUBA1A 0.0086
232 Corticosteroid-binding globulin SERPINA6 0.0086
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0085
3810 Catechol O-methyltransferase COMT 0.0085
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0085
904 Glutathione S-transferase P GSTP1 0.0084
908 Glutathione S-transferase theta-1 GSTT1 0.0083
2236 Casein kinase II subunit alpha CSNK2A1 0.0083
273 Apoptosis regulator Bcl-2 BCL2 0.0082
153 Dopamine beta-hydroxylase DBH 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0081
820 Glycine receptor subunit alpha-2 GLRA2 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0079
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0079
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0079
380 Cytochrome P450 17A1 CYP17A1 0.0078
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0078
869 Estrogen receptor beta ESR2 0.0077
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0077
4311 tRNA TRDMT1 0.0077
4325 tRNA trmD 0.0077
4328 tRNA trmD 0.0077
251 Alcohol dehydrogenase 1A ADH1A 0.0076
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
106 Cannabinoid receptor 2 CNR2 0.0075
537 ATP synthase delta chain, mitochondrial ATP5D 0.0075
444 Alcohol dehydrogenase 1B ADH1B 0.0074
6126 Carbonic anhydrase 7 CA7 0.0074
634 Squalene monooxygenase SQLE 0.0074
7196 Squalene monooxygenase ERG1 0.0074
459 Retinoic acid receptor RXR-alpha RXRA 0.0073
1650 Heme carrier protein 1 SLC46A1 0.0073
528 5-hydroxytryptamine 1E receptor HTR1E 0.0072
4192 DNA topoisomerase 2-beta TOP2B 0.0072
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0071
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0071
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0071
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0071
4203 Histamine N-methyltransferase HNMT 0.007
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.007
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.007
68 Cannabinoid receptor 1 CNR1 0.007
49 Endothelin B receptor EDNRB 0.007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0069
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0068
1256 5-hydroxytryptamine 6 receptor HTR6 0.0067
6033 High affinity interleukin-8 receptor A CXCR1 0.0067
365 Dihydrofolate reductase DHFR 0.0066
2381 Dihydrofolate reductase DFR1 0.0066
2833 Dihydrofolate reductase Not Available 0.0066
2931 Dihydrofolate reductase folA 0.0066
3544 Dihydrofolate reductase folA 0.0066
3682 Dihydrofolate reductase folA 0.0066
6642 Dihydrofolate reductase folA 0.0066
6756 Dihydrofolate reductase dfrA 0.0066
54 Prothrombin F2 0.0066
239 Coagulation factor X F10 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
828 Phenylalanine-4-hydroxylase PAH 0.0066
3109 Phenylalanine-4-hydroxylase phhA 0.0066
511 5-hydroxytryptamine 1F receptor HTR1F 0.0066
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
1629 Transcription factor AP-1 JUN 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
357 Carbonic anhydrase 2 CA2 0.0064
976 Platelet glycoprotein IX GP9 0.0064
4228 Keratin, type II cytoskeletal 7 KRT7 0.0063
133 Dihydropterate synthase sulI 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
518 Peroxidase/catalase T katG 0.0062
6149 Solute carrier family 22 member 10 SLC22A10 0.0062
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
163 D(1B) dopamine receptor DRD5 0.006
489 Monocarboxylate transporter 2 SLC16A7 0.006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.006
818 50S ribosomal protein L10 rplJ 0.006
1374 Natriuretic peptides B NPPB 0.0059
1827 Gap junction alpha-1 protein GJA1 0.0059
1908 Vascular cell adhesion protein 1 VCAM1 0.0059
822 Aldose reductase AKR1B1 0.0058
517 Alcohol dehydrogenase 1C ADH1C 0.0058
84 Nuclear receptor 0B1 NR0B1 0.0057
6500 Phospholipase A2 PLA2G1B 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6020 Aldehyde oxidase AOX1 0.0056
4120 NADPH--cytochrome P450 reductase POR 0.0056
4103 Proteasome subunit beta type 2 PSMB2 0.0055
4102 Proteasome subunit beta type 5 PSMB5 0.0055
4101 Proteasome subunit beta type 1 PSMB1 0.0055
1050 Bile salt sulfotransferase SULT2A1 0.0055
676 Tyrosine 3-monooxygenase TH 0.0054
29 Tubulin beta-1 chain TUBB1 0.0054
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0053
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
291 Nitric-oxide synthase, endothelial NOS3 0.0053
563 Thyroid peroxidase TPO 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
814 Ryanodine receptor 1 RYR1 0.0052
161 Tubulin beta chain TUBB 0.0051
312 Tubulin beta chain TUB2 0.0051
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.005
2230 Catalase CAT 0.005
3249 Catalase katA 0.005
3625 Catalase katA 0.005
4539 Catalase katA 0.005
4941 Catalase katB 0.005
1053 BC269730_2 FADS1 0.0049
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
6044 Serum paraoxonase/lactonase 3 PON3 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0047
780 Retinoic acid receptor RXR-gamma RXRG 0.0047
2539 Tubulin alpha-1 chain TUBA4A 0.0047
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0047
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0047
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0047
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0046
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0046
5300 Antigen peptide transporter 1 TAP1 0.0046
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
3426 Glutamine synthetase glnA 0.0046
3987 Glutamine synthetase GLUL 0.0046
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0045
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0045
6131 Carbonic anhydrase 14 CA14 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0045
3937 Fatty-acid amide hydrolase FAAH 0.0045
390 Adenosine A3 receptor ADORA3 0.0044
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0044
6163 Copper-transporting ATPase 2 ATP7B 0.0044
6165 Copper-transporting ATPase 1 ATP7A 0.0044
5934 Cytochrome P450 26A1 CYP26A1 0.0044
3830 Calreticulin CALR 0.0043
3957 Adenosine deaminase ADA 0.0043
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0043
6432 Transporter snf 0.0043
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
88 Retinoic acid receptor RXR-beta RXRB 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
3809 Estrogen-related receptor gamma ESRRG 0.0042
469 Annexin A1 ANXA1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2021 Thrombomodulin THBD 0.0041
6103 Arylamine N-acetyltransferase 1 NAT1 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
6036 Eosinophil peroxidase EPX 0.0041
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0041
6174 50S ribosomal protein L32 rpmF 0.004
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1196 Complement decay-accelerating factor CD55 0.0039
284 DNA-directed RNA polymerase beta chain rpoB 0.0039
5773 DNA-directed RNA polymerase beta chain rpoB 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0037
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0037
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
268 Adenosine A2b receptor ADORA2B 0.0037
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
569 Retinal dehydrogenase 2 ALDH1A2 0.0037
581 Cytochrome P450 2R1 CYP2R1 0.0037
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0036
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0036
1864 RET proto-oncogene RET 0.0036
3913 Glutamic acid decarboxylase GAD65 0.0036
896 Glutathione S-transferase Mu 1 GSTM1 0.0036
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0035
611 Retinal dehydrogenase 1 ALDH1A1 0.0034
174 Sigma 1-type opioid receptor SIGMAR1 0.0034
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
1992 Vitamin D-binding protein GC 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0034
1063 Signal transducer and activator of transcription 5B STAT5B 0.0034
2808 Chloramphenicol acetyltransferase 3 cat3 0.0034
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0033
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
1039 Histone deacetylase 9 HDAC9 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
24 Thymidylate synthase TMP1 0.0031
359 Thymidylate synthase TYMS 0.0031
2626 Thymidylate synthase thyA 0.0031
2729 Thymidylate synthase thyA 0.0031
5352 Thymidylate synthase THYA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2417 Chloramphenicol acetyltransferase cat 0.0031
3278 Chloramphenicol acetyltransferase cat 0.0031
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.0031
2810 Dr hemagglutinin structural subunit draA 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.003
3904 Alanine aminotransferase 2 GPT2 0.003
735 Alanine aminotransferase 1 GPT 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0029
164 Histamine H4 receptor HRH4 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0029
770 Retinoic acid-induced protein 3 GPRC5A 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0029
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0029
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0029
1792 Tissue-type plasminogen activator PLAT 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0028
358 Cystathionine beta-synthase CBS 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0028
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
484 Tyrosine-protein kinase ABL2 ABL2 0.0027
474 Acetylcholinesterase ACHE 0.0027
3404 Exotoxin A eta 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
4238 50S ribosomal protein L4 rplD 0.0027
5578 50S ribosomal protein L4 rplD 0.0027
6173 50S ribosomal protein L4 rplD 0.0027
6219 50S ribosomal protein L4 rplD 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0026
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0026
2207 Rhodopsin RHO 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
952 Dipeptidyl peptidase 4 DPP4 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
1630 Integrin beta-2 ITGB2 0.0026
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0025
856 Vitamin D3 receptor VDR 0.0025
85 Growth hormone receptor GHR 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
798 Osteocalcin BGLAP 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6122 Carbonic anhydrase 3 CA3 0.0025
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0025
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0025
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0025
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0025
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0025
1541 Metalloproteinase mmp20 0.0025
4237 50S ribosomal protein L22 rplV 0.0025
2298 Cytochrome P450-cam camC 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6070 Nischarin NISCH 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
1313 Lactoylglutathione lyase GLO1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0023
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0023
1770 Phospholipase C PLCL1 0.0023
2841 Phospholipase C plc 0.0023
3007 Carbonic anhydrase 12 CA12 0.0023
4205 Carbonic anhydrase 9 CA9 0.0023
369 Coagulation factor VII F7 0.0023
5924 Microtubule-associated protein 4 MAP4 0.0023
5923 Microtubule-associated protein tau MAPT 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
3086 Plasmepsin-2 Not Available 0.0023
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
997 Protein kinase C beta type PRKCB 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1970 Protein kinase C alpha type PRKCA 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
1243 Cathepsin D CTSD 0.0019
572 Integrin alpha-L ITGAL 0.0019
3221 Cytochrome c4 cc4 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
4773 Deoxycytidine kinase DCK 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
1360 Sphingomyelin phosphodiesterase SMPD1 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
1830 5'-nucleotidase NT5E 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
4785 Ig gamma-1 chain C region IGHG1 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
4217 Telomerase reverse transcriptase TERT 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0014
1268 Neuropeptide S receptor NPSR1 0.0014
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0014
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0014
1525 Heparin-binding growth factor 2 FGF2 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
2320 Thymidine kinase, cytosolic TK1 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
4692 A/G-specific adenine glycosylase mutY 0.0011
6218 Pannexin-1 PANX1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
4943 Cytochrome c6 petJ 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
4984 Neuroglobin NGB 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4947 Bacterial hemoglobin vhb 0.001
4994 Hemoglobin-like protein HbO glbO 0.001
4916 Cyanoglobin glbN 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4942 Diheme cytochrome c napB napB 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4975 Cytochrome c-556 RPA3973 0.001
4961 Hemophore HasA hasA 0.001
4936 Cytochrome c2 iso-2 Not Available 0.001
4910 Cytoglobin CYGB 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
5000 HemO hemO 0.001
4981 Iron-starvation protein PigA pigA 0.001
4904 Cytochrome c family protein GSU1996 0.001
4907 Cytochrome c-L moxG 0.001
6865 Cytochrome c-L moxG 0.001
4909 CooA protein cooA 0.001
4976 Apocytochrome f petA 0.001
6407 Apocytochrome f petA 0.001
4971 Nonaheme cytochrome c hmcA 0.001
4764 Cytochrome P450 165C4 CYP165C4 0.001
4989 Cytochrome c551 peroxidase ccp 0.001
5222 Cytochrome c551 peroxidase ccpA 0.001
4937 Cytochrome oxidase subunit II rcoxA 0.001
4926 Heme-based aerotactic transducer hemAT hemAT 0.001
4935 Cytochrome c-554 cycA1 0.001
4999 Cytochrome P450 165B3 CYP165B3 0.001
4960 Putative cytochrome P450-family protein SCO7417 0.001
4931 Cytochrome P450 167A1 CYP167A1 0.001
4972 P450cin cinA 0.001
4993 Hydroxylamine oxidoreductase hao1 0.001
4922 Cytochrome c, putative SO_4144 0.001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.001
4952 Catalase/peroxidase katA 0.001
4903 Methyl-accepting chemotaxis protein Tar4 0.001
3093 Catalase HPII katE 0.001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
345 Plasma retinol-binding protein RBP4 0.001
2802 Endoglucanase G celCCG 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1341 Histamine H3 receptor HRH3 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
1184 Interferon beta IFNB1 0.0008
6459 Glycodelin PAEP 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
4920 Peroxidase/catalase katG 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4990 PpcA ppcA 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
1353 DNA topoisomerase 1 TOP1 0.0007
3552 DNA topoisomerase 1 topA 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
693 Hemoglobin subunit beta HBB 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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