DT-Web

DB01131 - Proguanil


Identification
Name Proguanil
Accession Number DB01131 (APRD00188)
Type small molecule
Description Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 253.731
Groups approved
Monoisotopic Weight 253.109423244
Pharmacology
Indication For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Mechanism of action Proguanil inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
Absorption Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.
Protein binding Approximately 75%
Biotransformation Variably metabolized in the liver by cytochrome P450 isoenzymes to the active triazine metabolite, cycloguanil. This variable metabolism of proguanil may have profound clinical importance in poor metabolizers such as the Asian and African populations at risk for malaria infection. Prophylaxis with proguanil may not be effective in these persons because they may not achieve adequate therapeutic levels of the active compound, cycloguanil, even after multiple doses.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Plasmodium
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Proguanil may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Lumefantrine Proguanil may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Food Interactions
  • Take with food.

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DHFR
Pharmacological action yes
Actions inhibitor
References
  • Kaneko A, Bergqvist Y, Takechi M, Kalkoa M, Kaneko O, Kobayakawa T, Ishizaki T, Bjorkman A: Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil. J Infect Dis. 1999 Apr;179(4):974-9. - Pubmed
  • Vasconcelos KF, Plowe CV, Fontes CJ, Kyle D, Wirth DF, Pereira da Silva LH, Zalis MG: Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. Mem Inst Oswaldo Cruz. 2000 Sep-Oct;95(5):721-8. - Pubmed
  • Tahar R, de Pecoulas PE, Basco LK, Chiadmi M, Mazabraud A: Kinetic properties of dihydrofolate reductase from wild-type and mutant Plasmodium vivax expressed in Escherichia coli. Mol Biochem Parasitol. 2001 Apr 6;113(2):241-9. - Pubmed
  • Durand R, Jafari S, Bouchaud O, Ralaimazava P, Keundjian A, Le Bras J: Plasmodium falciparum: pfcrt and DHFR mutations are associated with failure of chloroquine plus proguanil prophylaxis in travelers. J Infect Dis. 2001 Dec 15;184(12):1633-4. - Pubmed
  • Le Bras J, Durand R: The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum. Fundam Clin Pharmacol. 2003 Apr;17(2):147-53. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1405
Bifunctional dihydrofolate reductase-thymidylate synthase
Name Bifunctional dihydrofolate reductase-thymidylate synthase
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4797

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Lu AH, Shu Y, Huang SL, Wang W, Ou-Yang DS, Zhou HH: In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. Acta Pharmacol Sin. 2000 Aug;21(8):747-52. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4276
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5193
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4478
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5117
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3218
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6091

Predictions


Id Partner name Gene Name Score
2381 Dihydrofolate reductase DFR1 1.1405
2833 Dihydrofolate reductase Not Available 1.1405
2931 Dihydrofolate reductase folA 1.1405
3544 Dihydrofolate reductase folA 1.1405
3682 Dihydrofolate reductase folA 1.1405
6642 Dihydrofolate reductase folA 1.1405
6756 Dihydrofolate reductase dfrA 1.1405
4924 Cytochrome P450 2C8 CYP2C8 0.267
1588 Multidrug resistance protein 1 ABCB1 0.2034
4116 Dihydropteroate synthetase Not Available 0.1888
4118 Cytochrome P450 3A5 CYP3A5 0.1777
6030 Cytochrome P450 2B6 CYP2B6 0.171
6107 Cytochrome P450 3A7 CYP3A7 0.1294
6024 Cytochrome P450 1A1 CYP1A1 0.126
5718 Cytochrome P450 2A6 CYP2A6 0.1125
6236 Trimethoprim-sensitive dihydrofolate reductase dfrB 0.0961
20 Prostaglandin G/H synthase 1 PTGS1 0.0893
587 Serum albumin ALB 0.0824
492 Histamine H1 receptor HRH1 0.0758
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0694
824 Sodium-dependent serotonin transporter SLC6A4 0.0645
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0536
6106 Cytochrome P450 2C18 CYP2C18 0.0531
502 5-hydroxytryptamine 2A receptor HTR2A 0.0523
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0505
831 D(2) dopamine receptor DRD2 0.0502
556 Alpha-1A adrenergic receptor ADRA1A 0.0493
290 Prostaglandin G/H synthase 2 PTGS2 0.0486
3811 Cytochrome P450 19A1 CYP19A1 0.0468
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0447
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0443
1729 Solute carrier family 22 member 6 SLC22A6 0.0439
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0425
103 Muscarinic acetylcholine receptor M1 CHRM1 0.042
1124 Sepiapterin reductase SPR 0.0413
6145 Solute carrier family 22 member 1 SLC22A1 0.0409
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0401
862 Multidrug resistance-associated protein 1 ABCC1 0.0395
318 Alpha-2A adrenergic receptor ADRA2A 0.0387
24 Thymidylate synthase TMP1 0.038
359 Thymidylate synthase TYMS 0.038
2626 Thymidylate synthase thyA 0.038
2729 Thymidylate synthase thyA 0.038
5352 Thymidylate synthase THYA 0.038
1898 Cytochrome P450 1B1 CYP1B1 0.0377
766 Beta-2 adrenergic receptor ADRB2 0.0375
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0374
713 Sodium-dependent dopamine transporter SLC6A3 0.0363
23 D(1A) dopamine receptor DRD1 0.0361
1650 Heme carrier protein 1 SLC46A1 0.0359
590 5-hydroxytryptamine 2C receptor HTR2C 0.0352
6144 Solute carrier family 22 member 2 SLC22A2 0.0352
320 5-hydroxytryptamine 1A receptor HTR1A 0.0348
3941 Amine oxidase [flavin-containing] A MAOA 0.0339
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0335
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0331
193 Beta-1 adrenergic receptor ADRB1 0.0324
260 Cytochrome P450 51 ERG11 0.0317
761 Cytochrome P450 51 ERG11 0.0317
3163 Cytochrome P450 51 cyp51 0.0317
341 5-hydroxytryptamine 3 receptor HTR3A 0.0316
632 Alpha-1B adrenergic receptor ADRA1B 0.0315
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0315
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0304
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0301
118 Organic cation/carnitine transporter 2 SLC22A5 0.0293
731 HIV-1 protease HIV-1 protease 0.0291
136 Estrogen receptor ESR1 0.0284
274 Muscarinic acetylcholine receptor M5 CHRM5 0.027
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.027
847 Mu-type opioid receptor OPRM1 0.0269
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0269
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0263
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0263
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0262
36 Insulin receptor INSR 0.0258
3939 Amine oxidase [flavin-containing] B MAOB 0.0255
776 Bile salt export pump ABCB11 0.0254
885 5-hydroxytryptamine 1B receptor HTR1B 0.0254
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0245
817 DNA topoisomerase 2-alpha TOP2A 0.0244
2164 Multidrug resistance-associated protein 4 ABCC4 0.0235
465 Calmodulin CALM1 0.0234
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0231
638 D(3) dopamine receptor DRD3 0.023
6142 Solute carrier family 22 member 8 SLC22A8 0.0227
871 Glucocorticoid receptor NR3C1 0.0222
467 Delta-type opioid receptor OPRD1 0.0221
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0216
789 Alpha-1D adrenergic receptor ADRA1D 0.0215
468 Cytochrome P450 4A11 CYP4A11 0.0214
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0214
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0211
696 Kappa-type opioid receptor OPRK1 0.0208
6143 Solute carrier family 22 member 7 SLC22A7 0.0206
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0204
725 5-hydroxytryptamine 1D receptor HTR1D 0.0203
629 Alpha-2B adrenergic receptor ADRA2B 0.0202
6031 Cytochrome P450 3A43 CYP3A43 0.0202
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0194
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0191
833 Organic cation/carnitine transporter 1 SLC22A4 0.0189
122 P2Y purinoceptor 12 P2RY12 0.0189
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0187
6147 Solute carrier family 22 member 3 SLC22A3 0.0186
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0186
891 Dihydropteroate synthase folP 0.0182
5359 Dihydropteroate synthase folP 0.0182
7175 Dihydropteroate synthase sulI 0.0182
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.018
378 Alpha-2C adrenergic receptor ADRA2C 0.0176
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0175
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0175
432 D(4) dopamine receptor DRD4 0.0175
3923 Cholinesterase BCHE 0.0174
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0169
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0168
16 Adenosine A1 receptor ADORA1 0.0167
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0165
777 Tumor necrosis factor TNF 0.0162
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0161
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0153
436 5-hydroxytryptamine 2B receptor HTR2B 0.0152
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0149
6220 Aryl hydrocarbon receptor AHR 0.0148
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0141
1178 Adenosine A2a receptor ADORA2A 0.014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.014
146 Androgen receptor AR 0.0136
70 Type-1 angiotensin II receptor AGTR1 0.0133
1024 Solute carrier family 22 member 11 SLC22A11 0.0133
6182 Cytochrome P450 2J2 CYP2J2 0.0133
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0131
6102 Arylamine N-acetyltransferase 2 NAT2 0.013
94 5-hydroxytryptamine 4 receptor HTR4 0.0129
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0128
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0127
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0127
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0127
482 Glycine receptor subunit alpha-1 GLRA1 0.0127
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0126
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0124
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0124
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0124
124 Histamine H2 receptor HRH2 0.0123
6014 Cytochrome P450 2A13 CYP2A13 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
6148 Multidrug resistance-associated protein 7 ABCC10 0.0122
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0122
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0121
1757 Myeloperoxidase MPO 0.0121
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0121
811 Translocator protein TSPO 0.012
163 D(1B) dopamine receptor DRD5 0.0118
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0117
592 Carbonic anhydrase 4 CA4 0.0116
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0115
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0115
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0115
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0115
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0115
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0114
474 Acetylcholinesterase ACHE 0.0113
716 5-hydroxytryptamine 7 receptor HTR7 0.0113
4604 Liver carboxylesterase 1 CES1 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
3947 Xanthine dehydrogenase/oxidase XDH 0.0113
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0111
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0111
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0111
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0111
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0111
1010 Cytochrome P450 51A1 CYP51A1 0.011
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.011
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0109
613 Atrial natriuretic peptide receptor A NPR1 0.0106
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
295 Carbonic anhydrase 1 CA1 0.0105
4773 Deoxycytidine kinase DCK 0.0104
380 Cytochrome P450 17A1 CYP17A1 0.0104
614 Progesterone receptor PGR 0.0104
4122 Histone deacetylase 2 HDAC2 0.0103
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0103
818 50S ribosomal protein L10 rplJ 0.0102
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0101
161 Tubulin beta chain TUBB 0.01
312 Tubulin beta chain TUB2 0.01
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.01
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0099
705 Glutamate receptor 1 GRIA1 0.0098
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
49 Endothelin B receptor EDNRB 0.0096
6136 Multidrug resistance-associated protein 5 ABCC5 0.0096
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0094
3810 Catechol O-methyltransferase COMT 0.0094
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0093
504 Mast/stem cell growth factor receptor KIT 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0092
6137 Multidrug resistance-associated protein 6 ABCC6 0.0092
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0092
537 ATP synthase delta chain, mitochondrial ATP5D 0.0092
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0091
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0091
1656 CYP2B protein CYP2B 0.0091
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0091
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0091
407 Vascular endothelial growth factor receptor 2 KDR 0.009
578 Endothelin-1 receptor EDNRA 0.009
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.009
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.009
373 Transthyretin TTR 0.009
844 Epidermal growth factor receptor EGFR 0.009
357 Carbonic anhydrase 2 CA2 0.0087
1256 5-hydroxytryptamine 6 receptor HTR6 0.0087
869 Estrogen receptor beta ESR2 0.0084
6126 Carbonic anhydrase 7 CA7 0.0084
921 Glutamate receptor 2 GRIA2 0.0084
6020 Aldehyde oxidase AOX1 0.0081
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0081
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
6141 Sodium/bile acid cotransporter SLC10A1 0.008
4120 NADPH--cytochrome P450 reductase POR 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
26 Vascular endothelial growth factor receptor 3 FLT4 0.0079
444 Alcohol dehydrogenase 1B ADH1B 0.0079
173 Toll-like receptor 7 TLR7 0.0079
183 Vascular endothelial growth factor A VEGFA 0.0077
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0076
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0076
32 Vascular endothelial growth factor receptor 1 FLT1 0.0076
427 Substance-P receptor TACR1 0.0074
756 Sex hormone-binding globulin SHBG 0.0074
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
518 Peroxidase/catalase T katG 0.0073
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0072
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0072
228 Beta platelet-derived growth factor receptor PDGFRB 0.0072
790 DNA polymerase subunit alpha B POLA2 0.0071
528 5-hydroxytryptamine 1E receptor HTR1E 0.0069
251 Alcohol dehydrogenase 1A ADH1A 0.0069
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0069
563 Thyroid peroxidase TPO 0.0068
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0067
952 Dipeptidyl peptidase 4 DPP4 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0065
275 Arachidonate 5-lipoxygenase ALOX5 0.0065
814 Ryanodine receptor 1 RYR1 0.0065
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0065
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0064
823 Fibroblast growth factor receptor 2 FGFR2 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
6432 Transporter snf 0.0063
738 Monocarboxylate transporter 1 SLC16A1 0.0063
133 Dihydropterate synthase sulI 0.0063
284 DNA-directed RNA polymerase beta chain rpoB 0.0062
5773 DNA-directed RNA polymerase beta chain rpoB 0.0062
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0062
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0061
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.006
131 Synaptic vesicular amine transporter SLC18A2 0.0059
904 Glutathione S-transferase P GSTP1 0.0059
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0057
1275 Estrogen sulfotransferase SULT1E1 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0055
1517 Beta-3 adrenergic receptor ADRB3 0.0055
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0055
6506 Stathmin-4 STMN4 0.0055
634 Squalene monooxygenase SQLE 0.0055
7196 Squalene monooxygenase ERG1 0.0055
1192 Sulfotransferase 1A1 SULT1A1 0.0054
517 Alcohol dehydrogenase 1C ADH1C 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0054
273 Apoptosis regulator Bcl-2 BCL2 0.0053
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0053
1629 Transcription factor AP-1 JUN 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
856 Vitamin D3 receptor VDR 0.0053
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0052
1618 High affinity nerve growth factor receptor NTRK1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
4311 tRNA TRDMT1 0.0051
4325 tRNA trmD 0.0051
4328 tRNA trmD 0.0051
1050 Bile salt sulfotransferase SULT2A1 0.005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
6146 High affinity copper uptake protein 1 SLC31A1 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
3917 Methylenetetrahydrofolate reductase MTHFR 0.0049
6044 Serum paraoxonase/lactonase 3 PON3 0.0049
3404 Exotoxin A eta 0.0049
174 Sigma 1-type opioid receptor SIGMAR1 0.0049
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0049
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0048
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
473 L-lactate dehydrogenase A chain LDHA 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
976 Platelet glycoprotein IX GP9 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
1483 Membrane copper amine oxidase AOC3 0.0046
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
714 Glutathione reductase, mitochondrial GSR 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3937 Fatty-acid amide hydrolase FAAH 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
54 Prothrombin F2 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
2230 Catalase CAT 0.0044
3249 Catalase katA 0.0044
3625 Catalase katA 0.0044
4539 Catalase katA 0.0044
4941 Catalase katB 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
6085 Fatty acid-binding protein, intestinal FABP2 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0042
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0042
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0042
239 Coagulation factor X F10 0.0042
1648 Elastin ELN 0.0041
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0041
2159 Quinone oxidoreductase CRYZ 0.004
164 Histamine H4 receptor HRH4 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
293 Gamma-glutamyl hydrolase GGH 0.004
3957 Adenosine deaminase ADA 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0039
581 Cytochrome P450 2R1 CYP2R1 0.0039
1541 Metalloproteinase mmp20 0.0039
3808 Dihydropteroate synthase 2 folP2 0.0039
3601 Dihydropteroate synthase 1 folP1 0.0039
3807 Dihydropteroate synthase 1 folP1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
88 Retinoic acid receptor RXR-beta RXRB 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0038
85 Growth hormone receptor GHR 0.0038
1374 Natriuretic peptides B NPPB 0.0038
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0036
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0036
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0036
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
7 Nitric oxide synthase, inducible NOS2 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
908 Glutathione S-transferase theta-1 GSTT1 0.0034
33 Cystine/glutamate transporter SLC7A11 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0033
4103 Proteasome subunit beta type 2 PSMB2 0.0033
4102 Proteasome subunit beta type 5 PSMB5 0.0033
4101 Proteasome subunit beta type 1 PSMB1 0.0033
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0032
268 Adenosine A2b receptor ADORA2B 0.0032
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
165 FL cytokine receptor FLT3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
6174 50S ribosomal protein L32 rpmF 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1196 Complement decay-accelerating factor CD55 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0028
2298 Cytochrome P450-cam camC 0.0028
1200 AMBP protein AMBP 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1992 Vitamin D-binding protein GC 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
5818 Folate receptor alpha FOLR1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1630 Integrin beta-2 ITGB2 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
469 Annexin A1 ANXA1 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
3830 Calreticulin CALR 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
358 Cystathionine beta-synthase CBS 0.0024
5787 Angiopoietin-1 receptor TEK 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
3086 Plasmepsin-2 Not Available 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0022
5934 Cytochrome P450 26A1 CYP26A1 0.0022
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
822 Aldose reductase AKR1B1 0.002
572 Integrin alpha-L ITGAL 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
666 NADP-dependent malic enzyme ME1 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0018
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0018
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0018
5332 MtdA bifunctional protein mtdA 0.0018
4403 Protein iolS iolS 0.0018
5322 Oxidoreductase ydhF ydhF 0.0018
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0018
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0018
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0018
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0018
5330 General stress protein 69 yhdN 0.0018
3778 NAD(P) transhydrogenase subunit beta pntB 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
1039 Histone deacetylase 9 HDAC9 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
4582 Putative pteridine reductase 2 ptr2 0.0016
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0016
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0016
5073 Ferredoxin--NADP reductase petH 0.0016
5076 Ferredoxin--NADP reductase fpr 0.0016
5119 Ferredoxin--NADP reductase petH 0.0016
5121 Ferredoxin--NADP reductase fpr 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
989 L-xylulose reductase DCXR 0.0016
3446 NADP-dependent alcohol dehydrogenase adh 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
2636 Shikimate dehydrogenase aroE 0.0016
3515 Shikimate dehydrogenase aroE 0.0016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0016
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0016
2286 Isocitrate dehydrogenase [NADP] icd 0.0016
2302 Isocitrate dehydrogenase [NADP] icd 0.0016
2771 Isocitrate dehydrogenase [NADP] icd 0.0016
654 Flavin reductase BLVRB 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
3221 Cytochrome c4 cc4 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0015
6297 Prostaglandin reductase 1 PTGR1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
4531 Putative ketoacyl reductase actIII 0.0015
3062 Aspartate-semialdehyde dehydrogenase asd 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
2207 Rhodopsin RHO 0.0014
267 Plasminogen activator inhibitor 1 SERPINE1 0.0014
162 Retinoic acid receptor gamma-1 RARG 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
2675 Pteridine reductase 1 PTR1 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6859 Protein S100-A4 S100A4 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6218 Pannexin-1 PANX1 0.0013
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1295 Fatty acid synthase FASN 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
816 Biliverdin reductase A BLVRA 0.0006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0006
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0006
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0005
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0005
328 Sorbitol dehydrogenase SORD 0.0005
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0005
597 Dihydropteridine reductase QDPR 0.0005
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0005
396 Alcohol dehydrogenase 4 ADH4 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
1507 Cytochrome c CYCS 0.0005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0005
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0005
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0005
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0005
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0005
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0005
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0005
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0005
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0005
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0005
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0005
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0005
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0005
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0005
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0005
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0005
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0005
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0005
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0005
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0005
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0005
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0005
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0005
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0005
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0005
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0005
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0005
107 C-4 methylsterol oxidase SC4MOL 0.0005
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0005
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0005
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0005
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0005
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0005
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0005
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0005
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0005
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0005
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0005
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0005
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0005
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0005
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0005
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0005
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0005
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0005
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0005
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0005
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0005
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0005
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0005
3726 D-3-phosphoglycerate dehydrogenase serA 0.0005
4291 D-3-phosphoglycerate dehydrogenase serA 0.0005
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0005
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0005
729 GDP-L-fucose synthetase TSTA3 0.0005
3463 GDP-L-fucose synthetase fcl 0.0005
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0005
167 L-lactate dehydrogenase C chain LDHC 0.0005
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0005
206 3-keto-steroid reductase HSD17B7 0.0005
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0005
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0005
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0005
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0005
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0005
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0005
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0005
643 Peroxisomal bifunctional enzyme EHHADH 0.0005
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0005
34 7-dehydrocholesterol reductase DHCR7 0.0005
711 UDP-glucose 6-dehydrogenase UGDH 0.0005
3672 UDP-glucose 6-dehydrogenase hasB 0.0005
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0005
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0005
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0005
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0004
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0004
626 Cysteine dioxygenase type 1 CDO1 0.0004
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0004
627 11-cis retinol dehydrogenase RDH5 0.0004
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
279 Tyrosinase TYR 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
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