DT-Web

DB00523 - Alitretinoin


Identification
Name Alitretinoin
Accession Number DB00523 (APRD00017)
Type small molecule
Description An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 300.4351
Groups approved
Monoisotopic Weight 300.20893014
Pharmacology
Indication For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
Mechanism of action Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Retinoic acid receptor alpha
Name Retinoic acid receptor alpha
Gene Name RARA
Pharmacological action yes
Actions agonist
References
  • Baumann L, Vujevich J, Halem M, Martin LK, Kerdel F, Lazarus M, Pacheco H, Black L, Bryde J: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging. Cutis. 2005 Jul;76(1):69-73. - Pubmed
  • Milliano MT, Luxon BA: Rat hepatic stellate cells become retinoid unresponsive during activation. Hepatol Res. 2005 Nov;33(3):225-33. Epub 2005 Oct 25. - Pubmed
  • Rasooly R, Schuster GU, Gregg JP, Xiao JH, Chandraratna RA, Stephensen CB: Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. J Immunol. 2005 Dec 15;175(12):7916-29. - Pubmed
  • Schrage K, Koopmans G, Joosten EA, Mey J: Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury. Eur J Neurosci. 2006 Jan;23(2):285-95. - Pubmed
  • Ritter M, Kattmann D, Teichler S, Hartmann O, Samuelsson MK, Burchert A, Bach JP, Kim TD, Berwanger B, Thiede C, Jager R, Ehninger G, Schafer H, Ueki N, Hayman MJ, Eilers M, Neubauer A: Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia. 2006 Mar;20(3):437-43. - Pubmed
  • Cheng C, Michaels J, Scheinfeld N: Alitretinoin: a comprehensive review. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1339
Retinoic acid receptor RXR-alpha
Name Retinoic acid receptor RXR-alpha
Gene Name RXRA
Pharmacological action yes
Actions agonist
References
  • Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, Wotton D: TGIF inhibits retinoid signaling. Mol Cell Biol. 2006 Feb;26(3):990-1001. - Pubmed
  • Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P: Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev. 2006 Jun 1;20(11):1525-38. - Pubmed
  • Zhelyaznik N, Mey J: Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. Neuroscience. 2006 Sep 15;141(4):1761-74. Epub 2006 Jun 19. - Pubmed
  • Fukasawa H, Kagechika H, Shudo K: [Retinoid therapy for autoimmune diseases] Nihon Rinsho Meneki Gakkai Kaishi. 2006 Jun;29(3):114-26. - Pubmed
  • Mizuguchi Y, Wada A, Nakagawa K, Ito M, Okano T: Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60. Biol Pharm Bull. 2006 Sep;29(9):1803-9. - Pubmed
  • Cheng C, Michaels J, Scheinfeld N: Alitretinoin: a comprehensive review. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43. - Pubmed
  • Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. - Pubmed
DTHybrid score 0.8797
Retinoic acid receptor beta
Name Retinoic acid receptor beta
Gene Name RARB
Pharmacological action yes
Actions agonist
References
  • Mizuiri H, Yoshida K, Toge T, Oue N, Aung PP, Noguchi T, Yasui W: DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. Cancer Sci. 2005 Sep;96(9):571-7. - Pubmed
  • Milliano MT, Luxon BA: Rat hepatic stellate cells become retinoid unresponsive during activation. Hepatol Res. 2005 Nov;33(3):225-33. Epub 2005 Oct 25. - Pubmed
  • Liu Z, Zhang L, Ding F, Li J, Guo M, Li W, Wang Y, Yu Z, Zhan Q, Wu M, Liu Z: 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells. Cancer Lett. 2005 Dec 18;230(2):271-83. - Pubmed
  • Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D: A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression. Differentiation. 2005 Oct;73(8):385-96. - Pubmed
  • Husson M, Enderlin V, Delacourte A, Ghenimi N, Alfos S, Pallet V, Higueret P: Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiol Dis. 2006 Jul;23(1):1-10. Epub 2006 Mar 10. - Pubmed
  • Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. - Pubmed
DTHybrid score 1.1364
Retinoic acid receptor RXR-beta
Name Retinoic acid receptor RXR-beta
Gene Name RXRB
Pharmacological action yes
Actions agonist
References
  • Brtko J: Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention. Cent Eur J Public Health. 2007 Mar;15(1):3-6. - Pubmed
  • Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H: International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006 Dec;58(4):760-72. - Pubmed
  • Bergheim I, Wolfgarten E, Bollschweiler E, Holscher AH, Bode CH, Parlesak A: Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus. J Carcinog. 2005 Nov 8;4:20. - Pubmed
  • Schrage K, Koopmans G, Joosten EA, Mey J: Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury. Eur J Neurosci. 2006 Jan;23(2):285-95. - Pubmed
  • Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H: Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact. 2005 Sep 10;156(1):25-39. - Pubmed
  • Cheng C, Michaels J, Scheinfeld N: Alitretinoin: a comprehensive review. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43. - Pubmed
  • Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. - Pubmed
DTHybrid score 1.0362
Retinoic acid receptor gamma-1
Name Retinoic acid receptor gamma-1
Gene Name RARG
Pharmacological action yes
Actions agonist
References
  • Dzhagalov I, Chambon P, He YW: Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma. J Immunol. 2007 Feb 15;178(4):2113-21. - Pubmed
  • Parrella E, Gianni M, Fratelli M, Barzago MM, Raska I Jr, Diomede L, Kurosaki M, Pisano C, Carminati P, Merlini L, Dallavalle S, Tavecchio M, Rochette-Egly C, Terao M, Garattini E: Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways. Mol Pharmacol. 2006 Sep;70(3):909-24. Epub 2006 Jun 20. - Pubmed
  • Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P: Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. Epub 2006 Jul 31. - Pubmed
  • Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.531
Retinoic acid receptor RXR-gamma
Name Retinoic acid receptor RXR-gamma
Gene Name RXRG
Pharmacological action yes
Actions agonist
References
  • Adamczewski Z, Makarewicz J, Mikosinski S, Knapska-Kucharska M, Gunerska-Szadkowska A, Oszukowska L, Karwowska A, Lewinski A: [Application of 13-cis-retinoic acid in patients with 131I scintigraphically-negative metastases of differentiated thyroid carcinoma] Endokrynol Pol. 2006 Jul-Aug;57(4):403-6. - Pubmed
  • Brtko J: Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention. Cent Eur J Public Health. 2007 Mar;15(1):3-6. - Pubmed
  • Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H: International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006 Dec;58(4):760-72. - Pubmed
  • He JC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, Klotman PE: Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol. 2007 Jan;18(1):93-102. Epub 2006 Dec 20. - Pubmed
  • Day RM, Lee YH, Park AM, Suzuki YJ: Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol. 2006 Jun;34(6):695-703. Epub 2006 Feb 2. - Pubmed
  • Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. - Pubmed
DTHybrid score 0.7398

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2944

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Schuetz EG, Yasuda K, Arimori K, Schuetz JD: Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. Arch Biochem Biophys. 1998 Feb 15;350(2):340-7. - Pubmed
DTHybrid score 0.2901

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.2901

Predictions


Id Partner name Gene Name Score
5934 Cytochrome P450 26A1 CYP26A1 0.2546
6283 Oxysterols receptor LXR-alpha NR1H3 0.2212
4512 Cytochrome P450 3A4 CYP3A4 0.1867
6241 Nuclear receptor coactivator 2 NCOA2 0.1759
4757 Cytochrome P450 2C9 CYP2C9 0.1367
4924 Cytochrome P450 2C8 CYP2C8 0.1307
331 Retinol-binding protein I, cellular RBP1 0.1294
3811 Cytochrome P450 19A1 CYP19A1 0.0982
587 Serum albumin ALB 0.0865
4119 Cytochrome P450 2D6 CYP2D6 0.0858
4118 Cytochrome P450 3A5 CYP3A5 0.0822
6024 Cytochrome P450 1A1 CYP1A1 0.0781
770 Retinoic acid-induced protein 3 GPRC5A 0.0757
719 Retinoic acid receptor responder protein 1 RARRES1 0.0757
6016 Cytochrome P450 2C19 CYP2C19 0.0711
6030 Cytochrome P450 2B6 CYP2B6 0.0688
6107 Cytochrome P450 3A7 CYP3A7 0.0644
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0614
84 Nuclear receptor 0B1 NR0B1 0.0595
569 Retinal dehydrogenase 2 ALDH1A2 0.0569
611 Retinal dehydrogenase 1 ALDH1A1 0.0535
5718 Cytochrome P450 2A6 CYP2A6 0.0528
6228 Nuclear receptor coactivator 1 NCOA1 0.0455
6106 Cytochrome P450 2C18 CYP2C18 0.0442
468 Cytochrome P450 4A11 CYP4A11 0.0439
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0432
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0419
6013 Cytochrome P450 2E1 CYP2E1 0.0419
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0333
36 Insulin receptor INSR 0.0258
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0255
20 Prostaglandin G/H synthase 1 PTGS1 0.025
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0229
1729 Solute carrier family 22 member 6 SLC22A6 0.0221
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0215
862 Multidrug resistance-associated protein 1 ABCC1 0.0212
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0211
290 Prostaglandin G/H synthase 2 PTGS2 0.0205
556 Alpha-1A adrenergic receptor ADRA1A 0.0197
6145 Solute carrier family 22 member 1 SLC22A1 0.019
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0189
492 Histamine H1 receptor HRH1 0.0189
831 D(2) dopamine receptor DRD2 0.0188
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0185
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0179
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0179
824 Sodium-dependent serotonin transporter SLC6A4 0.0173
502 5-hydroxytryptamine 2A receptor HTR2A 0.0172
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
318 Alpha-2A adrenergic receptor ADRA2A 0.0162
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0161
817 DNA topoisomerase 2-alpha TOP2A 0.0161
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0158
193 Beta-1 adrenergic receptor ADRB1 0.0156
1898 Cytochrome P450 1B1 CYP1B1 0.0155
6144 Solute carrier family 22 member 2 SLC22A2 0.0151
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0141
23 D(1A) dopamine receptor DRD1 0.0137
3941 Amine oxidase [flavin-containing] A MAOA 0.0136
3923 Cholinesterase BCHE 0.013
885 5-hydroxytryptamine 1B receptor HTR1B 0.0128
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0125
118 Organic cation/carnitine transporter 2 SLC22A5 0.0125
136 Estrogen receptor ESR1 0.0121
632 Alpha-1B adrenergic receptor ADRA1B 0.012
776 Bile salt export pump ABCB11 0.012
871 Glucocorticoid receptor NR3C1 0.0119
766 Beta-2 adrenergic receptor ADRB2 0.0117
725 5-hydroxytryptamine 1D receptor HTR1D 0.0115
320 5-hydroxytryptamine 1A receptor HTR1A 0.0113
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0112
590 5-hydroxytryptamine 2C receptor HTR2C 0.0109
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0105
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0105
789 Alpha-1D adrenergic receptor ADRA1D 0.0101
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.01
6143 Solute carrier family 22 member 7 SLC22A7 0.01
3939 Amine oxidase [flavin-containing] B MAOB 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0094
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0092
6142 Solute carrier family 22 member 8 SLC22A8 0.0092
465 Calmodulin CALM1 0.0091
629 Alpha-2B adrenergic receptor ADRA2B 0.0091
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0089
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0087
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0087
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
638 D(3) dopamine receptor DRD3 0.0083
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0078
2164 Multidrug resistance-associated protein 4 ABCC4 0.0076
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0075
713 Sodium-dependent dopamine transporter SLC6A3 0.0074
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0073
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0073
6147 Solute carrier family 22 member 3 SLC22A3 0.0072
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0072
731 HIV-1 protease HIV-1 protease 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
777 Tumor necrosis factor TNF 0.0071
16 Adenosine A1 receptor ADORA1 0.0071
833 Organic cation/carnitine transporter 1 SLC22A4 0.0071
378 Alpha-2C adrenergic receptor ADRA2C 0.0071
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
1178 Adenosine A2a receptor ADORA2A 0.0067
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0065
341 5-hydroxytryptamine 3 receptor HTR3A 0.0065
1192 Sulfotransferase 1A1 SULT1A1 0.0065
6148 Multidrug resistance-associated protein 7 ABCC10 0.0065
260 Cytochrome P450 51 ERG11 0.0064
761 Cytochrome P450 51 ERG11 0.0064
3163 Cytochrome P450 51 cyp51 0.0064
4604 Liver carboxylesterase 1 CES1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
124 Histamine H2 receptor HRH2 0.0063
844 Epidermal growth factor receptor EGFR 0.0063
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0063
869 Estrogen receptor beta ESR2 0.0063
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0062
6182 Cytochrome P450 2J2 CYP2J2 0.0062
847 Mu-type opioid receptor OPRM1 0.0061
818 50S ribosomal protein L10 rplJ 0.0057
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0057
474 Acetylcholinesterase ACHE 0.0055
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0055
122 P2Y purinoceptor 12 P2RY12 0.0054
504 Mast/stem cell growth factor receptor KIT 0.0054
467 Delta-type opioid receptor OPRD1 0.0054
6137 Multidrug resistance-associated protein 6 ABCC6 0.0054
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0054
3947 Xanthine dehydrogenase/oxidase XDH 0.0052
696 Kappa-type opioid receptor OPRK1 0.0052
511 5-hydroxytryptamine 1F receptor HTR1F 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
432 D(4) dopamine receptor DRD4 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
6220 Aryl hydrocarbon receptor AHR 0.0049
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0049
2449 Tubulin alpha-3 chain TUBA1A 0.0049
4120 NADPH--cytochrome P450 reductase POR 0.0048
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0048
273 Apoptosis regulator Bcl-2 BCL2 0.0048
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0047
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
2499 Tubulin beta-2C chain TUBB2C 0.0046
228 Beta platelet-derived growth factor receptor PDGFRB 0.0046
614 Progesterone receptor PGR 0.0044
1024 Solute carrier family 22 member 11 SLC22A11 0.0044
70 Type-1 angiotensin II receptor AGTR1 0.0043
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
380 Cytochrome P450 17A1 CYP17A1 0.0042
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0041
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
4238 50S ribosomal protein L4 rplD 0.004
5578 50S ribosomal protein L4 rplD 0.004
6173 50S ribosomal protein L4 rplD 0.004
6219 50S ribosomal protein L4 rplD 0.004
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.004
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.004
1517 Beta-3 adrenergic receptor ADRB3 0.0039
6136 Multidrug resistance-associated protein 5 ABCC5 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
373 Transthyretin TTR 0.0039
117 Sterol O-acyltransferase 1 SOAT1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
4122 Histone deacetylase 2 HDAC2 0.0038
4237 50S ribosomal protein L22 rplV 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
1757 Myeloperoxidase MPO 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
1656 CYP2B protein CYP2B 0.0037
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
163 D(1B) dopamine receptor DRD5 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0034
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
146 Androgen receptor AR 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
3957 Adenosine deaminase ADA 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
737 Mineralocorticoid receptor NR3C2 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
4103 Proteasome subunit beta type 2 PSMB2 0.0031
4102 Proteasome subunit beta type 5 PSMB5 0.0031
4101 Proteasome subunit beta type 1 PSMB1 0.0031
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.003
173 Toll-like receptor 7 TLR7 0.003
6031 Cytochrome P450 3A43 CYP3A43 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.003
239 Coagulation factor X F10 0.0029
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0029
1010 Cytochrome P450 51A1 CYP51A1 0.0029
683 Potassium transporter GK0582 0.0029
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
904 Glutathione S-transferase P GSTP1 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
6432 Transporter snf 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0026
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0026
427 Substance-P receptor TACR1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0026
1629 Transcription factor AP-1 JUN 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
6859 Protein S100-A4 S100A4 0.0025
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
738 Monocarboxylate transporter 1 SLC16A1 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
24 Thymidylate synthase TMP1 0.0025
359 Thymidylate synthase TYMS 0.0025
2626 Thymidylate synthase thyA 0.0025
2729 Thymidylate synthase thyA 0.0025
5352 Thymidylate synthase THYA 0.0025
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0024
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0024
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6070 Nischarin NISCH 0.0024
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
6020 Aldehyde oxidase AOX1 0.0022
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
365 Dihydrofolate reductase DHFR 0.0022
2381 Dihydrofolate reductase DFR1 0.0022
2833 Dihydrofolate reductase Not Available 0.0022
2931 Dihydrofolate reductase folA 0.0022
3544 Dihydrofolate reductase folA 0.0022
3682 Dihydrofolate reductase folA 0.0022
6642 Dihydrofolate reductase folA 0.0022
6756 Dihydrofolate reductase dfrA 0.0022
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0021
528 5-hydroxytryptamine 1E receptor HTR1E 0.0021
33 Cystine/glutamate transporter SLC7A11 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6167 Organic solute transporter subunit beta OSTB 0.0021
6166 Organic solute transporter subunit alpha OSTA 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
1820 Beta-nerve growth factor NGF 0.002
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
275 Arachidonate 5-lipoxygenase ALOX5 0.0019
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
165 FL cytokine receptor FLT3 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0019
1618 High affinity nerve growth factor receptor NTRK1 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
6102 Arylamine N-acetyltransferase 2 NAT2 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
823 Fibroblast growth factor receptor 2 FGFR2 0.0018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0018
908 Glutathione S-transferase theta-1 GSTT1 0.0018
1714 Mitogen-activated protein kinase 3 MAPK3 0.0018
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0018
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0018
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0018
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0018
811 Translocator protein TSPO 0.0018
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0018
921 Glutamate receptor 2 GRIA2 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1648 Elastin ELN 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0016
1830 5'-nucleotidase NT5E 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0016
6146 High affinity copper uptake protein 1 SLC31A1 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
1243 Cathepsin D CTSD 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0015
3810 Catechol O-methyltransferase COMT 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
976 Platelet glycoprotein IX GP9 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
1374 Natriuretic peptides B NPPB 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0014
814 Ryanodine receptor 1 RYR1 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
518 Peroxidase/catalase T katG 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
54 Prothrombin F2 0.0011
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
563 Thyroid peroxidase TPO 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
183 Vascular endothelial growth factor A VEGFA 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
1864 RET proto-oncogene RET 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
760 Fibroblast growth factor 1 FGF1 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
7 Nitric oxide synthase, inducible NOS2 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.0009
6165 Copper-transporting ATPase 1 ATP7A 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
1360 Sphingomyelin phosphodiesterase SMPD1 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
2981 Phospholipase A2, membrane associated PLA2G2A 0.0009
172 Potassium channel subfamily K member 1 KCNK1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
3830 Calreticulin CALR 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
822 Aldose reductase AKR1B1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
295 Carbonic anhydrase 1 CA1 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
164 Histamine H4 receptor HRH4 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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