DT-Web: DB00071

Identification
Name	Insulin, porcine
Accession Number	DB00071 (BIOD00031, BTD00031)
Type	biotech
Description	Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Hypoglycemic Agents
Molecular Weight	5795.6000
Groups	approved
Monoisotopic Weight	Not Available
Pharmacology
Indication	For the treatment of type I and II diabetes mellitus.
Mechanism of action	Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism.
Absorption	Not Available
Protein binding	Not Available
Biotransformation	Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.
Route of elimination	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Insulin receptor
Name	Insulin receptor
Gene Name	INSR
Pharmacological action	yes
Actions	binder
References	Chen LM, Yang XW, Tang JG: Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem (Tokyo). 2002 Jun;131(6):855-9. - Pubmed Desbuquois B, Chauvet G, Kouach M, Authier F: Cell itinerary and metabolic fate of proinsulin in rat liver: in vivo and in vitro studies. Endocrinology. 2003 Dec;144(12):5308-21. Epub 2003 Sep 11. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.7629
Insulin-like growth factor 1 receptor
Name	Insulin-like growth factor 1 receptor
Gene Name	IGF1R
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Fottner C, Engelhardt D, Weber MM: Regulation of steroidogenesis by insulin-like growth factors (IGFs) in adult human adrenocortical cells: IGF-I and, more potently, IGF-II preferentially enhance androgen biosynthesis through interaction with the IGF-I receptor and IGF-binding proteins. J Endocrinol. 1998 Sep;158(3):409-17. - Pubmed Zhang Q, Berggren PO, Hansson A, Tally M: Insulin-like growth factor-I-induced DNA synthesis in insulin-secreting cell line RINm5F is associated with phosphorylation of the insulin-like growth factor-I receptor and the insulin receptor substrate-2. J Endocrinol. 1998 Mar;156(3):573-81. - Pubmed Sowers JR, Jacobs DB, Simpson L, al-Homsi B, Grunberger G, Sokol R: Erythrocyte insulin and insulin-like growth factor-I receptor tyrosine kinase activity in hypertension in pregnancy. Metabolism. 1995 Oct;44(10):1308-13. - Pubmed
DTHybrid score	1.7567
Insulin-degrading enzyme
Name	Insulin-degrading enzyme
Gene Name	IDE
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Harada S, Smith RM, Smith JA, Jarett L: Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway. Endocrinology. 1993 Jun;132(6):2293-8. - Pubmed Hsu MC, Bai JP: Investigation into the presence of insulin-degrading enzyme in cultured type II alveolar cells and the effects of enzyme inhibitors on pulmonary bioavailability of insulin in rats. J Pharm Pharmacol. 1998 May;50(5):507-14. - Pubmed MARIGO S, PANELLI G: [Insulinase and its inhibition by hypoglycemic sulfonamides; data on insulin sensitivity during tolbutamide therapy.] Arch Sci Med (Torino). 1958 Jun;105(6):587-609. - Pubmed
DTHybrid score	1.509
HLA class II histocompatibility antigen, DQ(6) alpha chain
Name	HLA class II histocompatibility antigen, DQ(6) alpha chain
Gene Name	HLA-DQA2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Pugliese A, Bugawan T, Moromisato R, Awdeh ZL, Alper CA, Jackson RA, Erlich HA, Eisenbarth GS: Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes. J Clin Invest. 1994 Jun;93(6):2447-52. - Pubmed Hermann R, Soltesz G: [Pathogenesis and types of neonatal diabetes] Orv Hetil. 2000 Aug 20;141(34):1855-8. - Pubmed Donner H, Rau H, Braun J, Herwig J, Usadel KH, Badenhoop K: Highly polymorphic promoter regions of HLA DQA1 and DQB1 genes do not help to further define disease susceptibility in insulin-dependent diabetes mellitus. Tissue Antigens. 1997 Dec;50(6):642-5. - Pubmed
DTHybrid score	0.786
HLA class II histocompatibility antigen, DQ beta 1 chain
Name	HLA class II histocompatibility antigen, DQ beta 1 chain
Gene Name	HLA-DQB1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Mahran MZ, Ross DG, Sadeghi-Nejad A, Rabson AR: Use of the polymerase chain reaction mismatch technique to identify the HLA-DQw8 allele in patients with insulin-dependent diabetes mellitus. Am J Clin Pathol. 1992 Jan;97(1):29-33. - Pubmed Levy-Marchal C, Tichet J, Fajardy I, Gu XF, Dubois F, Czernichow P: Islet cell antibodies in normal French schoolchildren. Diabetologia. 1992 Jun;35(6):577-82. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Retinoblastoma-associated protein
Name	Retinoblastoma-associated protein
Gene Name	RB1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Biener Y, Zick Y: Basic polycations activate the insulin receptor kinase and a tightly associated serine kinase. Eur J Biochem. 1990 Nov 26;194(1):243-50. - Pubmed
DTHybrid score	1.2897
Cathepsin D
Name	Cathepsin D
Gene Name	CTSD
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Authier F, Metioui M, Fabrega S, Kouach M, Briand G: Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D. J Biol Chem. 2002 Mar 15;277(11):9437-46. Epub 2002 Jan 4. - Pubmed Ogino S, Cohen ML, Abdul-Karim FW: Atypical teratoid/rhabdoid tumor of the CNS: cytopathology and immunohistochemistry of insulin-like growth factor-II, insulin-like growth factor receptor type 1, cathepsin D, and Ki-67. Mod Pathol. 1999 Apr;12(4):379-85. - Pubmed Nunn SE, Peehl DM, Cohen P: Acid-activated insulin-like growth factor binding protein protease activity of cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma. J Cell Physiol. 1997 May;171(2):196-204. - Pubmed
DTHybrid score	1.9223
Carboxypeptidase E
Name	Carboxypeptidase E
Gene Name	CPE
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Polastri L, Galbiati F, Folli F, Davalli AM: Effects of carboxypeptidase E overexpression on insulin mRNA levels, regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA. Cell Transplant. 2002;11(8):803-11. - Pubmed Guest PC, Pipeleers D, Rossier J, Rhodes CJ, Hutton JC: Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. Biochem J. 1989 Dec 1;264(2):503-8. - Pubmed Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF: Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem. 1998 Feb 6;273(6):3431-7. - Pubmed
DTHybrid score	1.2901
Neuroendocrine convertase 2
Name	Neuroendocrine convertase 2
Gene Name	PCSK2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Zertal-Zidani S, Bounacer A, Scharfmann R: Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans. Diabetologia. 2007 Mar;50(3):585-95. Epub 2007 Jan 13. - Pubmed Utsunomiya N, Ohagi S, Sanke T, Tatsuta H, Hanabusa T, Nanjo K: Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. Diabetologia. 1998 Jun;41(6):701-5. - Pubmed Ohagi S, Sakaguchi H, Sanke T, Tatsuta H, Hanabusa T, Nanjo K: Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM. Diabetes. 1996 Jul;45(7):897-901. - Pubmed
DTHybrid score	1.2905
Neuroendocrine convertase 1
Name	Neuroendocrine convertase 1
Gene Name	PCSK1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Marriott D, Gillece-Castro B, Gorman CM: Prohormone convertase-1 will process prorelaxin, a member of the insulin family of hormones. Mol Endocrinol. 1992 Sep;6(9):1441-50. - Pubmed Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF: Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10299-304. Epub 2002 Jul 22. - Pubmed Kuwahata M, Tomoe Y, Harada N, Amano S, Segawa H, Tatsumi S, Ito M, Oka T, Miyamoto K: Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure. Biochim Biophys Acta. 2007 Jan;1772(1):60-5. Epub 2006 Oct 4. - Pubmed
DTHybrid score	1.2904
Protein NOV homolog
Name	Protein NOV homolog
Gene Name	NOV
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Burren CP, Wilson EM, Hwa V, Oh Y, Rosenfeld RG: Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily. J Clin Endocrinol Metab. 1999 Mar;84(3):1096-103. - Pubmed Lafont J, Laurent M, Thibout H, Lallemand F, Le Bouc Y, Atfi A, Martinerie C: The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner. J Biol Chem. 2002 Oct 25;277(43):41220-9. Epub 2002 Jul 30. - Pubmed Martinerie C, Chevalier G, Rauscher FJ 3rd, Perbal B: Regulation of nov by WT1: a potential role for nov in nephrogenesis. Oncogene. 1996 Apr 4;12(7):1479-92. - Pubmed
DTHybrid score	1.2902
Low-density lipoprotein receptor-related protein 2
Name	Low-density lipoprotein receptor-related protein 2
Gene Name	LRP2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, Farquhar MG: Megalin is an endocytic receptor for insulin. J Am Soc Nephrol. 1998 Oct;9(10):1759-66. - Pubmed Christensen EI, Birn H: Hormone, growth factor, and vitamin handling by proximal tubule cells. Curr Opin Nephrol Hypertens. 1997 Jan;6(1):20-7. - Pubmed Fuster DG, Bobulescu IA, Zhang J, Wade J, Moe OW: Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin. Am J Physiol Renal Physiol. 2007 Feb;292(2):F577-85. Epub 2006 Oct 3. - Pubmed
DTHybrid score	1.3242
Insulin-like growth factor-binding protein 7
Name	Insulin-like growth factor-binding protein 7
Gene Name	IGFBP7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lopez-Bermejo A, Buckway CK, Devi GR, Hwa V, Plymate SR, Oh Y, Rosenfeld RG: Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. Endocrinology. 2000 Nov;141(11):4072-80. - Pubmed Radulescu RT: One for all and all for one: RB defends the cell while IDE, PTEN and IGFBP-7 antagonize insulin and IGFs to protect RB. Med Hypotheses. 2007;69(5):1018-20. Epub 2007 May 1. - Pubmed Degeorges A, Wang F, Frierson HF Jr, Seth A, Chung LW, Sikes RA: Human prostate cancer expresses the low affinity insulin-like growth factor binding protein IGFBP-rP1. Cancer Res. 1999 Jun 15;59(12):2787-90. - Pubmed
DTHybrid score	1.2906
Synaptotagmin-like protein 4
Name	Synaptotagmin-like protein 4
Gene Name	SYTL4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T: Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol. 2005 Oct 10;171(1):99-109. - Pubmed Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R: MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem. 2006 Sep 15;281(37):26932-42. Epub 2006 Jul 10. - Pubmed Torii S, Takeuchi T, Nagamatsu S, Izumi T: Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J Biol Chem. 2004 May 21;279(21):22532-8. Epub 2004 Mar 17. - Pubmed
DTHybrid score	1.2899

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.8889

Id	Partner name	Gene Name	Score
1128	Alpha-2-macroglobulin	A2M	0.2835
1350	Insulin-like growth factor-binding protein 3	IGFBP3	0.1358
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.1165
6231	Pepsin A	PGA3	0.1088
308	30S ribosomal protein S12	rpsL	0.1066
6704	30S ribosomal protein S12	rpsL	0.1066
1372	Insulin receptor substrate 1	IRS1	0.0833
6501	Fatty acid-binding protein, liver	FABP1	0.0816
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.0808
1729	Solute carrier family 22 member 6	SLC22A6	0.0737
4512	Cytochrome P450 3A4	CYP3A4	0.064
3834	Nidogen-1	NID1	0.0561
4119	Cytochrome P450 2D6	CYP2D6	0.0492
3833	Plasma serine protease inhibitor	SERPINA5	0.0489
1349	Plasminogen activator inhibitor 2	SERPINB2	0.0489
1176	Mitogen-activated protein kinase 1	MAPK1	0.0487
4757	Cytochrome P450 2C9	CYP2C9	0.0467
3011	Suppressor of tumorigenicity protein 14	ST14	0.0463
6016	Cytochrome P450 2C19	CYP2C19	0.0429
587	Serum albumin	ALB	0.0424
791	Urokinase plasminogen activator surface receptor	PLAUR	0.0407
6024	Cytochrome P450 1A1	CYP1A1	0.038
267	Plasminogen activator inhibitor 1	SERPINE1	0.0375
1792	Tissue-type plasminogen activator	PLAT	0.0359
234	Plasminogen	PLG	0.0343
1588	Multidrug resistance protein 1	ABCB1	0.0302
6013	Cytochrome P450 2E1	CYP2E1	0.03
6030	Cytochrome P450 2B6	CYP2B6	0.027
4924	Cytochrome P450 2C8	CYP2C8	0.0262
1074	Urokinase-type plasminogen activator	PLAU	0.0252
4118	Cytochrome P450 3A5	CYP3A5	0.0244
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0205
5312	Kinesin-like protein KIF1A	KIF1A	0.0205
2615	Chemotaxis protein cheA	cheA	0.0194
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0179
6107	Cytochrome P450 3A7	CYP3A7	0.0177
5718	Cytochrome P450 2A6	CYP2A6	0.0176
2621	Thermoresistant gluconokinase	gntK	0.0168
5466	Putative sugar kinase	STM4066	0.0167
4517	Probable butyrate kinase 2	buk2	0.0167
2878	Probable serine/threonine-protein kinase pknB	pknB	0.0167
20	Prostaglandin G/H synthase 1	PTGS1	0.0162
3669	Ribokinase	rbsK	0.0146
2717	Folylpolyglutamate synthase	fgs	0.0139
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0139
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0135
48	Pyridoxal kinase	PDXK	0.0131
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
318	Alpha-2A adrenergic receptor	ADRA2A	0.0116
492	Histamine H1 receptor	HRH1	0.0108
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0107
3941	Amine oxidase [flavin-containing] A	MAOA	0.0102
831	D(2) dopamine receptor	DRD2	0.01
817	DNA topoisomerase 2-alpha	TOP2A	0.0096
4878	Glycoprotein hormones alpha chain	CGA	0.0093
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0093
4877	Beta-mannanase	man	0.0093
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0093
4880	Membrane cofactor protein	CD46	0.0093
4850	Beta-2-glycoprotein 1	APOH	0.0093
1072	Granzyme B	GZMB	0.0093
4889	Ig epsilon chain C region	IGHE	0.0093
4852	Reticulon-4 receptor	RTN4R	0.0093
757	Fusion glycoprotein F0	F	0.0093
4875	Fusion glycoprotein F0	F	0.0093
442	Envelope glycoprotein	gp41	0.0093
4859	Envelope glycoprotein	env	0.0093
4189	Alpha-galactosidase A	GLA	0.0093
4869	Major capsid protein	A430L	0.0093
4856	CD209 antigen	CD209	0.0093
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0093
1354	Beta-glucuronidase	GUSB	0.0093
4721	Beta-1,4-mannanase	manA	0.0093
4845	ADAM 33	ADAM33	0.0093
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0093
3352	Structural polyprotein	Not Available	0.0093
3628	Structural polyprotein	Not Available	0.0093
4892	Structural polyprotein	Not Available	0.0093
290	Prostaglandin G/H synthase 2	PTGS2	0.009
556	Alpha-1A adrenergic receptor	ADRA1A	0.009
885	5-hydroxytryptamine 1B receptor	HTR1B	0.009
23	D(1A) dopamine receptor	DRD1	0.0089
1898	Cytochrome P450 1B1	CYP1B1	0.0088
3811	Cytochrome P450 19A1	CYP19A1	0.0086
6145	Solute carrier family 22 member 1	SLC22A1	0.0084
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
824	Sodium-dependent serotonin transporter	SLC6A4	0.0082
1184	Interferon beta	IFNB1	0.0081
6858	Inactive carboxylesterase 4	CES1P1	0.0081
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0081
793	T-cell surface antigen CD2	CD2	0.0081
4861	Interleukin-6 receptor alpha chain	IL6R	0.0081
1379	Interleukin-12 subunit beta	IL12B	0.0081
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0081
4890	Hemagglutinin	HA	0.0081
6566	Hemagglutinin	Not Available	0.0081
3837	Cytokine receptor common beta chain	CSF2RB	0.0081
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0081
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0081
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0079
3923	Cholinesterase	BCHE	0.0079
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0077
6106	Cytochrome P450 2C18	CYP2C18	0.0076
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0076
3444	Cyanovirin-N	Not Available	0.0075
1859	Prostatic acid phosphatase	ACPP	0.0075
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0075
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0075
3140	Hemagglutinin-neuraminidase	HN	0.0075
3609	Hemagglutinin-neuraminidase	HN	0.0075
2297	Genome polyprotein	Not Available	0.0075
2322	Genome polyprotein	Not Available	0.0075
2694	Genome polyprotein	Not Available	0.0075
2719	Genome polyprotein	Not Available	0.0075
2860	Genome polyprotein	Not Available	0.0075
2928	Genome polyprotein	Not Available	0.0075
3160	Genome polyprotein	Not Available	0.0075
3260	Genome polyprotein	Not Available	0.0075
4783	Genome polyprotein	Not Available	0.0075
5726	Genome polyprotein	Not Available	0.0075
5779	Genome polyprotein	Not Available	0.0075
5867	Genome polyprotein	Not Available	0.0075
6253	Genome polyprotein	Not Available	0.0075
6301	Genome polyprotein	Not Available	0.0075
6380	Genome polyprotein	Not Available	0.0075
6381	Genome polyprotein	Not Available	0.0075
6437	Genome polyprotein	Not Available	0.0075
6520	Genome polyprotein	Not Available	0.0075
6521	Genome polyprotein	Not Available	0.0075
6652	Genome polyprotein	Not Available	0.0075
6734	Genome polyprotein	Not Available	0.0075
6735	Genome polyprotein	Not Available	0.0075
6736	Genome polyprotein	Not Available	0.0075
6737	Genome polyprotein	Not Available	0.0075
6738	Genome polyprotein	Not Available	0.0075
6739	Genome polyprotein	Not Available	0.0075
6744	Genome polyprotein	Not Available	0.0075
6748	Genome polyprotein	Not Available	0.0075
6894	Genome polyprotein	Not Available	0.0075
6898	Genome polyprotein	Not Available	0.0075
554	Low-density lipoprotein receptor	LDLR	0.0073
4666	Fucose-binding lectin PA-IIL	lecB	0.0071
2372	Bifunctional tail protein	9	0.0071
4787	Envelope glycoprotein gp160	env	0.0071
4820	Envelope glycoprotein gp160	env	0.0071
5727	Envelope glycoprotein gp160	env	0.0071
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.007
118	Organic cation/carnitine transporter 2	SLC22A5	0.007
852	Heparin cofactor 2	SERPIND1	0.007
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0069
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0068
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0068
3939	Amine oxidase [flavin-containing] B	MAOB	0.0067
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0066
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0066
16	Adenosine A1 receptor	ADORA1	0.0066
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0065
64	Neuraminidase	NA	0.0065
641	Neuraminidase	NA	0.0065
2676	Neuraminidase	NA	0.0065
3026	Neuraminidase	NA	0.0065
3519	Neuraminidase	NA	0.0065
6007	Neuraminidase	NA	0.0065
6144	Solute carrier family 22 member 2	SLC22A2	0.0064
3794	Osmolarity sensor protein envZ	envZ	0.0064
5644	Sensor protein phoQ	phoQ	0.0064
5641	Rod shape-determining protein MreB	TM_0588	0.0064
4178	DNA repair protein RAD51 homolog 1	RAD51	0.0064
5645	DNA topoisomerase 4 subunit B	parE	0.0064
6227	DNA topoisomerase 4 subunit B	parE	0.0064
5649	Potassium-transporting ATPase B chain	kdpB	0.0064
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0064
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0064
5643	General secretion pathway protein E	epsE	0.0064
5642	Chaperone clpB	clpB	0.0064
193	Beta-1 adrenergic receptor	ADRB1	0.0063
1439	Lactotransferrin	LTF	0.0063
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0063
595	Fibrinogen alpha chain	FGA	0.0063
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
632	Alpha-1B adrenergic receptor	ADRA1B	0.0062
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0061
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
2430	Chondroitinase B	cslB	0.006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.006
6307	Ig gamma-2 chain C region	IGHG2	0.0059
2581	Chondroitinase AC	cslA	0.0059
6847	Lactase-phlorizin hydrolase	LCT	0.0058
6500	Phospholipase A2	PLA2G1B	0.0057
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0056
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0056
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0056
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0056
5302	TrwB	trwB	0.0056
2282	Protein recA	recA	0.0056
2315	Protein recA	recA	0.0056
2332	Protein recA	recA	0.0056
5263	Protein recA	recA	0.0056
2397	Dihydroxyacetone kinase	dhaK	0.0056
4751	Mitogen-activated protein kinase 12	MAPK12	0.0056
5646	Galactokinase	GALK1	0.0056
2852	DNA mismatch repair protein mutL	mutL	0.0056
740	Argininosuccinate synthase	ASS1	0.0056
865	Argininosuccinate synthase	ASS1	0.0056
2680	Argininosuccinate synthase	argG	0.0056
3194	Argininosuccinate synthase	argG	0.0056
5265	FtsH	ftsH	0.0056
862	Multidrug resistance-associated protein 1	ABCC1	0.0055
936	Ephrin type-A receptor 2	EPHA2	0.0055
4604	Liver carboxylesterase 1	CES1	0.0055
309	Antithrombin-III	SERPINC1	0.0054
2207	Rhodopsin	RHO	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
638	D(3) dopamine receptor	DRD3	0.0052
3814	Complement C1r subcomponent	C1R	0.0052
571	Melatonin receptor type 1A	MTNR1A	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0052
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0051
3231	Death-associated protein kinase 1	DAPK1	0.0051
789	Alpha-1D adrenergic receptor	ADRA1D	0.0051
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
887	DNA gyrase subunit B	gyrB	0.0049
4150	DNA gyrase subunit B	gyrB	0.0049
6225	DNA gyrase subunit B	gyrB	0.0049
136	Estrogen receptor	ESR1	0.0049
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0049
4785	Ig gamma-1 chain C region	IGHG1	0.0049
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0048
2371	Pantothenate kinase	coaA	0.0048
825	Arsenical pump-driving ATPase	ASNA1	0.0048
3435	Arsenical pump-driving ATPase	arsA	0.0048
2892	Acetylglutamate kinase	argB	0.0048
3550	Acetylglutamate kinase	argB	0.0048
1881	Hexokinase-1	HK1	0.0048
76	Nitric-oxide synthase, brain	NOS1	0.0048
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0047
766	Beta-2 adrenergic receptor	ADRB2	0.0047
2727	S-adenosylmethionine synthetase	metK	0.0046
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0045
465	Calmodulin	CALM1	0.0045
6220	Aryl hydrocarbon receptor	AHR	0.0045
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0044
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0044
777	Tumor necrosis factor	TNF	0.0044
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0043
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0042
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0042
2236	Casein kinase II subunit alpha	CSNK2A1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
952	Dipeptidyl peptidase 4	DPP4	0.0042
207	Glutathione synthetase	GSS	0.0042
5269	Glutathione synthetase	gshB	0.0042
6143	Solute carrier family 22 member 7	SLC22A7	0.0041
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0041
2251	Thymidylate kinase	tmk	0.0041
2254	Thymidylate kinase	DTYMK	0.0041
3522	Thymidylate kinase	tmk	0.0041
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.004
103	Muscarinic acetylcholine receptor M1	CHRM1	0.004
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.004
432	D(4) dopamine receptor	DRD4	0.004
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.004
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
833	Organic cation/carnitine transporter 1	SLC22A4	0.0039
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
3822	Actin, alpha skeletal muscle	ACTA1	0.0038
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0037
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0037
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0037
1836	Mitogen-activated protein kinase 10	MAPK10	0.0036
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0035
273	Apoptosis regulator Bcl-2	BCL2	0.0034
1757	Myeloperoxidase	MPO	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
712	Tubulin alpha chain	TUB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
6014	Cytochrome P450 2A13	CYP2A13	0.0034
3947	Xanthine dehydrogenase/oxidase	XDH	0.0034
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
468	Cytochrome P450 4A11	CYP4A11	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
6147	Solute carrier family 22 member 3	SLC22A3	0.0032
6142	Solute carrier family 22 member 8	SLC22A8	0.0032
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0031
2164	Multidrug resistance-associated protein 4	ABCC4	0.0031
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0031
818	50S ribosomal protein L10	rplJ	0.003
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0029
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0029
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0028
776	Bile salt export pump	ABCB11	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0028
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0027
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0025
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
6070	Nischarin	NISCH	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
3957	Adenosine deaminase	ADA	0.0023
6148	Multidrug resistance-associated protein 7	ABCC10	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0023
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0023
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
731	HIV-1 protease	HIV-1 protease	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0021
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0021
260	Cytochrome P450 51	ERG11	0.0021
761	Cytochrome P450 51	ERG11	0.0021
3163	Cytochrome P450 51	cyp51	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
869	Estrogen receptor beta	ESR2	0.0021
871	Glucocorticoid receptor	NR3C1	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
6020	Aldehyde oxidase	AOX1	0.002
1820	Beta-nerve growth factor	NGF	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.002
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.002
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0019
716	5-hydroxytryptamine 7 receptor	HTR7	0.0019
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
124	Histamine H2 receptor	HRH2	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0019
122	P2Y purinoceptor 12	P2RY12	0.0018
33	Cystine/glutamate transporter	SLC7A11	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
504	Mast/stem cell growth factor receptor	KIT	0.0018
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1648	Elastin	ELN	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0017
1656	CYP2B protein	CYP2B	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
373	Transthyretin	TTR	0.0016
474	Acetylcholinesterase	ACHE	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
427	Substance-P receptor	TACR1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
921	Glutamate receptor 2	GRIA2	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0015
70	Type-1 angiotensin II receptor	AGTR1	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
6432	Transporter	snf	0.0015
6102	Arylamine N-acetyltransferase 2	NAT2	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
904	Glutathione S-transferase P	GSTP1	0.0014
2449	Tubulin alpha-3 chain	TUBA1A	0.0014
847	Mu-type opioid receptor	OPRM1	0.0014
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
543	Penicillin-binding protein 1B	mrcB	0.0013
6186	Penicillin-binding protein 1B	ponB	0.0013
6822	Penicillin-binding protein 1b	pbp1b	0.0013
6844	Penicillin-binding protein 1b	pbp1b	0.0013
380	Cytochrome P450 17A1	CYP17A1	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
645	Penicillin-binding protein 1A	mrcA	0.0013
5805	Penicillin-binding protein 1A	ponA	0.0013
6185	Penicillin-binding protein 1A	mrcA	0.0013
6799	Penicillin-binding protein 1A	pbpA	0.0013
159	Penicillin-binding protein 2B	penA	0.0013
6121	Penicillin-binding protein 2B	penA	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
1024	Solute carrier family 22 member 11	SLC22A11	0.0013
6146	High affinity copper uptake protein 1	SLC31A1	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0012
518	Peroxidase/catalase T	katG	0.0012
1629	Transcription factor AP-1	JUN	0.0012
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
828	Phenylalanine-4-hydroxylase	PAH	0.0011
3109	Phenylalanine-4-hydroxylase	phhA	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6043	Putative G-protein coupled receptor 44	GPR44	0.0011
563	Thyroid peroxidase	TPO	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
467	Delta-type opioid receptor	OPRD1	0.0011
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
6136	Multidrug resistance-associated protein 5	ABCC5	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
1192	Sulfotransferase 1A1	SULT1A1	0.001
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.001
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.001
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
6137	Multidrug resistance-associated protein 6	ABCC6	0.0009
6182	Cytochrome P450 2J2	CYP2J2	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
365	Dihydrofolate reductase	DHFR	0.0009
2381	Dihydrofolate reductase	DFR1	0.0009
2833	Dihydrofolate reductase	Not Available	0.0009
2931	Dihydrofolate reductase	folA	0.0009
3544	Dihydrofolate reductase	folA	0.0009
3682	Dihydrofolate reductase	folA	0.0009
6642	Dihydrofolate reductase	folA	0.0009
6756	Dihydrofolate reductase	dfrA	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0009
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
3830	Calreticulin	CALR	0.0008
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0008
146	Androgen receptor	AR	0.0008
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0008
1618	High affinity nerve growth factor receptor	NTRK1	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
811	Translocator protein	TSPO	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
976	Platelet glycoprotein IX	GP9	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
3810	Catechol O-methyltransferase	COMT	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
822	Aldose reductase	AKR1B1	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
6141	Sodium/bile acid cotransporter	SLC10A1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0006
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
183	Vascular endothelial growth factor A	VEGFA	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1864	RET proto-oncogene	RET	0.0006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0006
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0006
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
153	Dopamine beta-hydroxylase	DBH	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
751	Potassium channel subfamily K member 6	KCNK6	0.0005
1039	Histone deacetylase 9	HDAC9	0.0005
4120	NADPH--cytochrome P450 reductase	POR	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0005
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
896	Glutathione S-transferase Mu 1	GSTM1	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
172	Potassium channel subfamily K member 1	KCNK1	0.0005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0005
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
6149	Solute carrier family 22 member 10	SLC22A10	0.0004
165	FL cytokine receptor	FLT3	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
24	Thymidylate synthase	TMP1	0.0004
359	Thymidylate synthase	TYMS	0.0004
2626	Thymidylate synthase	thyA	0.0004
2729	Thymidylate synthase	thyA	0.0004
5352	Thymidylate synthase	THYA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0004
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0004
737	Mineralocorticoid receptor	NR3C2	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0004
295	Carbonic anhydrase 1	CA1	0.0004
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0004
614	Progesterone receptor	PGR	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
6085	Fatty acid-binding protein, intestinal	FABP2	0.0003
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0003
164	Histamine H4 receptor	HRH4	0.0003
54	Prothrombin	F2	0.0003
738	Monocarboxylate transporter 1	SLC16A1	0.0003
7	Nitric oxide synthase, inducible	NOS2	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0002
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00071 - Insulin, porcine

Targets

Enzymes

Predictions