DT-Web

DB01094 - Hesperetin


Identification
Name Hesperetin
Accession Number DB01094 (APRD00117)
Type small molecule
Description Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 302.2788
Groups approved
Monoisotopic Weight 302.07903818
Pharmacology
Indication For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again.
Mechanism of action Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sterol O-acyltransferase 1
Name Sterol O-acyltransferase 1
Gene Name SOAT1
Pharmacological action yes
Actions inhibitor
References
  • Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. - Pubmed
  • Chung MY, Rho MC, Ko JS, Ryu SY, Jeune KH, Kim K, Lee HS, Kim YK: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60. - Pubmed
DTHybrid score 0.4557
Sterol O-acyltransferase 2
Name Sterol O-acyltransferase 2
Gene Name SOAT2
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Microsomal triglyceride transfer protein large subunit
Name Microsomal triglyceride transfer protein large subunit
Gene Name MTTP
Pharmacological action yes
Actions antagonist
References
  • Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. - Pubmed
DTHybrid score 0.6534

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Breinholt VM, Offord EA, Brouwer C, Nielsen SE, Brosen K, Friedberg T: In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol. 2002 May;40(5):609-16. - Pubmed
DTHybrid score 0.3384

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Zhang S, Yang X, Morris ME: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 2004 May;65(5):1208-16. - Pubmed
  • Imai Y, Tsukahara S, Asada S, Sugimoto Y: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res. 2004 Jun 15;64(12):4346-52. - Pubmed
DTHybrid score 0.3213

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1792
1588 Multidrug resistance protein 1 ABCB1 0.1768
4757 Cytochrome P450 2C9 CYP2C9 0.0739
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0711
6016 Cytochrome P450 2C19 CYP2C19 0.0672
4119 Cytochrome P450 2D6 CYP2D6 0.0653
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0542
1760 Aminopeptidase N ANPEP 0.0538
6843 Aminopeptidase N pepN 0.0538
6024 Cytochrome P450 1A1 CYP1A1 0.0532
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0524
4924 Cytochrome P450 2C8 CYP2C8 0.0498
4118 Cytochrome P450 3A5 CYP3A5 0.0478
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0426
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0422
6013 Cytochrome P450 2E1 CYP2E1 0.0385
6030 Cytochrome P450 2B6 CYP2B6 0.0383
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0352
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0342
862 Multidrug resistance-associated protein 1 ABCC1 0.0326
6107 Cytochrome P450 3A7 CYP3A7 0.0299
587 Serum albumin ALB 0.0269
36 Insulin receptor INSR 0.0258
5718 Cytochrome P450 2A6 CYP2A6 0.0233
1898 Cytochrome P450 1B1 CYP1B1 0.0228
817 DNA topoisomerase 2-alpha TOP2A 0.0184
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0183
20 Prostaglandin G/H synthase 1 PTGS1 0.0179
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0166
1729 Solute carrier family 22 member 6 SLC22A6 0.0165
6145 Solute carrier family 22 member 1 SLC22A1 0.0159
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0153
776 Bile salt export pump ABCB11 0.0149
844 Epidermal growth factor receptor EGFR 0.0147
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0135
6144 Solute carrier family 22 member 2 SLC22A2 0.0133
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0131
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.013
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
3941 Amine oxidase [flavin-containing] A MAOA 0.0126
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0124
3811 Cytochrome P450 19A1 CYP19A1 0.0123
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0116
318 Alpha-2A adrenergic receptor ADRA2A 0.0116
504 Mast/stem cell growth factor receptor KIT 0.0116
2164 Multidrug resistance-associated protein 4 ABCC4 0.0116
290 Prostaglandin G/H synthase 2 PTGS2 0.0116
6148 Multidrug resistance-associated protein 7 ABCC10 0.0115
6106 Cytochrome P450 2C18 CYP2C18 0.0114
6137 Multidrug resistance-associated protein 6 ABCC6 0.0112
492 Histamine H1 receptor HRH1 0.0108
885 5-hydroxytryptamine 1B receptor HTR1B 0.0107
502 5-hydroxytryptamine 2A receptor HTR2A 0.0107
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
33 Cystine/glutamate transporter SLC7A11 0.0102
118 Organic cation/carnitine transporter 2 SLC22A5 0.0102
824 Sodium-dependent serotonin transporter SLC6A4 0.01
831 D(2) dopamine receptor DRD2 0.01
556 Alpha-1A adrenergic receptor ADRA1A 0.01
136 Estrogen receptor ESR1 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6147 Solute carrier family 22 member 3 SLC22A3 0.0096
992 Protein tyrosine kinase 2 beta PTK2B 0.0095
725 5-hydroxytryptamine 1D receptor HTR1D 0.0095
6143 Solute carrier family 22 member 7 SLC22A7 0.0092
228 Beta platelet-derived growth factor receptor PDGFRB 0.009
23 D(1A) dopamine receptor DRD1 0.0089
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0088
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0086
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0085
6220 Aryl hydrocarbon receptor AHR 0.0084
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0083
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
320 5-hydroxytryptamine 1A receptor HTR1A 0.0079
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
468 Cytochrome P450 4A11 CYP4A11 0.0075
26 Vascular endothelial growth factor receptor 3 FLT4 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0074
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0074
632 Alpha-1B adrenergic receptor ADRA1B 0.0073
32 Vascular endothelial growth factor receptor 1 FLT1 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
3947 Xanthine dehydrogenase/oxidase XDH 0.007
1024 Solute carrier family 22 member 11 SLC22A11 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
407 Vascular endothelial growth factor receptor 2 KDR 0.0068
3939 Amine oxidase [flavin-containing] B MAOB 0.0067
713 Sodium-dependent dopamine transporter SLC6A3 0.0067
16 Adenosine A1 receptor ADORA1 0.0066
1757 Myeloperoxidase MPO 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0065
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0065
789 Alpha-1D adrenergic receptor ADRA1D 0.0063
193 Beta-1 adrenergic receptor ADRB1 0.0063
4120 NADPH--cytochrome P450 reductase POR 0.0063
869 Estrogen receptor beta ESR2 0.0062
629 Alpha-2B adrenergic receptor ADRA2B 0.0062
511 5-hydroxytryptamine 1F receptor HTR1F 0.0062
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0062
273 Apoptosis regulator Bcl-2 BCL2 0.0061
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.0059
3923 Cholinesterase BCHE 0.0058
731 HIV-1 protease HIV-1 protease 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0056
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0056
904 Glutathione S-transferase P GSTP1 0.0054
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0053
638 D(3) dopamine receptor DRD3 0.0052
6146 High affinity copper uptake protein 1 SLC31A1 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
1650 Heme carrier protein 1 SLC46A1 0.005
378 Alpha-2C adrenergic receptor ADRA2C 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
833 Organic cation/carnitine transporter 1 SLC22A4 0.0049
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0048
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0047
6165 Copper-transporting ATPase 1 ATP7A 0.0047
70 Type-1 angiotensin II receptor AGTR1 0.0047
766 Beta-2 adrenergic receptor ADRB2 0.0047
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0046
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0045
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0045
465 Calmodulin CALM1 0.0045
2539 Tubulin alpha-1 chain TUBA4A 0.0045
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0044
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0044
165 FL cytokine receptor FLT3 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
777 Tumor necrosis factor TNF 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
373 Transthyretin TTR 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
3856 Fibroblast growth factor receptor 3 FGFR3 0.0041
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
432 D(4) dopamine receptor DRD4 0.004
896 Glutathione S-transferase Mu 1 GSTM1 0.0039
871 Glucocorticoid receptor NR3C1 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0038
4604 Liver carboxylesterase 1 CES1 0.0038
6136 Multidrug resistance-associated protein 5 ABCC5 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0037
5998 Toll-like receptor 8 TLR8 0.0035
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
275 Arachidonate 5-lipoxygenase ALOX5 0.0034
712 Tubulin alpha chain TUB1 0.0034
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
823 Fibroblast growth factor receptor 2 FGFR2 0.0032
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
936 Ephrin type-A receptor 2 EPHA2 0.0032
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0032
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0031
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0031
293 Gamma-glutamyl hydrolase GGH 0.0031
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0031
6182 Cytochrome P450 2J2 CYP2J2 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
818 50S ribosomal protein L10 rplJ 0.003
183 Vascular endothelial growth factor A VEGFA 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
173 Toll-like receptor 7 TLR7 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
6031 Cytochrome P450 3A43 CYP3A43 0.003
469 Annexin A1 ANXA1 0.003
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
3810 Catechol O-methyltransferase COMT 0.0029
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
163 D(1B) dopamine receptor DRD5 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0028
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0027
5626 Nucleoside diphosphate kinase B NME2 0.0027
239 Coagulation factor X F10 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0026
6020 Aldehyde oxidase AOX1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0024
6228 Nuclear receptor coactivator 1 NCOA1 0.0024
6241 Nuclear receptor coactivator 2 NCOA2 0.0024
6070 Nischarin NISCH 0.0024
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
847 Mu-type opioid receptor OPRM1 0.0023
3957 Adenosine deaminase ADA 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
4225 Uridine phosphorylase 1 UPP1 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0022
696 Kappa-type opioid receptor OPRK1 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
380 Cytochrome P450 17A1 CYP17A1 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0021
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0021
413 Amidophosphoribosyltransferase PPAT 0.0021
2515 Amidophosphoribosyltransferase purF 0.0021
3714 Amidophosphoribosyltransferase purF 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
467 Delta-type opioid receptor OPRD1 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
484 Tyrosine-protein kinase ABL2 ABL2 0.002
24 Thymidylate synthase TMP1 0.002
359 Thymidylate synthase TYMS 0.002
2626 Thymidylate synthase thyA 0.002
2729 Thymidylate synthase thyA 0.002
5352 Thymidylate synthase THYA 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1192 Sulfotransferase 1A1 SULT1A1 0.002
1820 Beta-nerve growth factor NGF 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
124 Histamine H2 receptor HRH2 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
1864 RET proto-oncogene RET 0.0018
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
122 P2Y purinoceptor 12 P2RY12 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
760 Fibroblast growth factor 1 FGF1 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
3639 Thymidine phosphorylase deoA 0.0017
3936 Thymidine phosphorylase TYMP 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
1656 CYP2B protein CYP2B 0.0017
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
161 Tubulin beta chain TUBB 0.0016
312 Tubulin beta chain TUB2 0.0016
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1243 Cathepsin D CTSD 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
474 Acetylcholinesterase ACHE 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
7 Nitric oxide synthase, inducible NOS2 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
702 UMP-CMP kinase CMPK1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
6432 Transporter snf 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
146 Androgen receptor AR 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
518 Peroxidase/catalase T katG 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
563 Thyroid peroxidase TPO 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
6085 Fatty acid-binding protein, intestinal FABP2 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
3587 Gastrotropin FABP6 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
4237 50S ribosomal protein L22 rplV 0.001
5818 Folate receptor alpha FOLR1 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
614 Progesterone receptor PGR 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0002
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