DT-Web: DB01079

Identification
Name	Tegaserod
Accession Number	DB01079 (APRD00096)
Type	small molecule
Description	Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating and constipation associated with irritable bowel syndrome. On March 30, 2007, the U.S. Food and Drug Administration requested that Novartis withdraw Zelnorm from shelves. The FDA alleges a relationship between prescriptions of the drug and increased risks of heart attack or stroke. [Wikipedia]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Gastrointestinal Agents Serotonin Agonists
Molecular Weight	301.3867
Groups	withdrawn
Monoisotopic Weight	301.190260383
Pharmacology
Indication	Provides relief from the symptoms of irritable bowel syndrome including chronic idiopathic constipation.
Mechanism of action	Tegaserod is a 5-HT₄ receptor partial agonist that binds with high affinity at human 5-HT₄ receptors, whereas it has no appreciable affinity for 5-HT₃ or dopamine receptors. It has moderate affinity for 5-HT₁ receptors. Tegaserod, by acting as an agonist at neuronal 5-HT₄ receptors, triggers the release of further neurotransmitters such as calcitonin gene-related peptide from sensory neurons. The activation of 5-HT₄ receptors in the gastrointestinal tract stimulates the peristaltic reflex and intestinal secretion, as well as inhibits visceral sensitivity.
Absorption	Rapidly absorbed after oral administration, with an absolute bioavailability of approximately 10%.
Protein binding	98%
Biotransformation	Tegaserod is metabolized mainly via two pathways. The first is a presystemic acid catalyzed hydrolysis in the stomach followed by oxidation and conjugation which produces the main metabolite of tegaserod, 5-methoxyindole-3-carboxylic acid glucuronide. The main metabolite has negligible affinity for 5-HT₄ receptors in vitro. The second metabolic pathway of tegaserod is direct glucuronidation which leads to generation of three isomeric N-glucuronides.
Route of elimination	Approximately two-thirds of the orally administered dose of tegaserod is excreted unchanged in the feces, with the remaining one-third excreted in the urine, primarily as the main metabolite.
Toxicity	Oral LD₅₀ in rat is 2000 mg/kg.
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Take before a meal, to increase absorption, take 30 minutes before a meal.

5-hydroxytryptamine 4 receptor
Name	5-hydroxytryptamine 4 receptor
Gene Name	HTR4
Pharmacological action	unknown
Actions	antagonist,partial agonist
References	Camilleri M: Review article: tegaserod. Aliment Pharmacol Ther. 2001 Mar;15(3):277-89. - Pubmed Kamm MA: Review article: the complexity of drug development for irritable bowel syndrome. Aliment Pharmacol Ther. 2002 Mar;16(3):343-51. - Pubmed Corsetti M, Tack J: Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome. Expert Opin Pharmacother. 2002 Aug;3(8):1211-8. - Pubmed Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP: The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. Epub 2004 Oct 4. - Pubmed Cole P, Rabasseda X: Tegaserod: a serotonin 5-HT4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome. Drugs Today (Barc). 2004 Dec;40(12):1013-30. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.2717
5-hydroxytryptamine 2B receptor
Name	5-hydroxytryptamine 2B receptor
Gene Name	HTR2B
Pharmacological action	unknown
Actions	antagonist
References	Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP: The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. Epub 2004 Oct 4. - Pubmed McCullough JL, Armstrong SR, Hegde SS, Beattie DT: The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat. Pharmacol Res. 2006 Apr;53(4):353-8. Epub 2006 Feb 21. - Pubmed Greenwood-Van Meerveld B, Campbell-Dittmeyer K, Johnson AC, Hicks GA: 5-HT2B receptors do not modulate sensitivity to colonic distension in rats with acute colorectal hypersensitivity. Neurogastroenterol Motil. 2006 May;18(5):343-5. - Pubmed
DTHybrid score	0.2675
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	unknown
Actions	antagonist
References	Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP: The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. Epub 2004 Oct 4. - Pubmed
DTHybrid score	0.3303
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	unknown
Actions	antagonist
References	Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP: The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. Epub 2004 Oct 4. - Pubmed
DTHybrid score	0.4244

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4793
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3287
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4804
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.614
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3159

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Actions	substrate,inhibitor
References	Ismair MG, Kullak-Ublick GA, Blakely RD, Fried M, Vavricka SR: Tegaserod inhibits the serotonin transporter SERT. Digestion. 2007;75(2-3):90-5. Epub 2007 May 18. - Pubmed
DTHybrid score	0.3613

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.4663
6016	Cytochrome P450 2C19	CYP2C19	0.308
1588	Multidrug resistance protein 1	ABCB1	0.2264
831	D(2) dopamine receptor	DRD2	0.2237
320	5-hydroxytryptamine 1A receptor	HTR1A	0.217
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.2107
6030	Cytochrome P450 2B6	CYP2B6	0.1802
4118	Cytochrome P450 3A5	CYP3A5	0.1726
23	D(1A) dopamine receptor	DRD1	0.1596
318	Alpha-2A adrenergic receptor	ADRA2A	0.1477
6107	Cytochrome P450 3A7	CYP3A7	0.1404
492	Histamine H1 receptor	HRH1	0.1328
556	Alpha-1A adrenergic receptor	ADRA1A	0.1242
713	Sodium-dependent dopamine transporter	SLC6A3	0.1239
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1231
5718	Cytochrome P450 2A6	CYP2A6	0.1212
6024	Cytochrome P450 1A1	CYP1A1	0.1178
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1107
638	D(3) dopamine receptor	DRD3	0.1074
629	Alpha-2B adrenergic receptor	ADRA2B	0.0965
725	5-hydroxytryptamine 1D receptor	HTR1D	0.096
378	Alpha-2C adrenergic receptor	ADRA2C	0.0952
432	D(4) dopamine receptor	DRD4	0.093
20	Prostaglandin G/H synthase 1	PTGS1	0.0877
587	Serum albumin	ALB	0.0875
632	Alpha-1B adrenergic receptor	ADRA1B	0.0798
716	5-hydroxytryptamine 7 receptor	HTR7	0.0782
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0743
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0738
163	D(1B) dopamine receptor	DRD5	0.0711
3941	Amine oxidase [flavin-containing] A	MAOA	0.0711
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0701
274	Muscarinic acetylcholine receptor M5	CHRM5	0.063
1181	Alpha-1-acid glycoprotein 1	ORM1	0.062
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0614
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0593
6106	Cytochrome P450 2C18	CYP2C18	0.0548
789	Alpha-1D adrenergic receptor	ADRA1D	0.0538
6145	Solute carrier family 22 member 1	SLC22A1	0.0514
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0493
3939	Amine oxidase [flavin-containing] B	MAOB	0.0471
290	Prostaglandin G/H synthase 2	PTGS2	0.0469
131	Synaptic vesicular amine transporter	SLC18A2	0.0467
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.041
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0408
847	Mu-type opioid receptor	OPRM1	0.0404
380	Cytochrome P450 17A1	CYP17A1	0.0397
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0396
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0392
766	Beta-2 adrenergic receptor	ADRB2	0.0388
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0384
6144	Solute carrier family 22 member 2	SLC22A2	0.0375
193	Beta-1 adrenergic receptor	ADRB1	0.0367
1729	Solute carrier family 22 member 6	SLC22A6	0.0359
1898	Cytochrome P450 1B1	CYP1B1	0.0358
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0353
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0349
3811	Cytochrome P450 19A1	CYP19A1	0.0332
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.033
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0328
862	Multidrug resistance-associated protein 1	ABCC1	0.0327
696	Kappa-type opioid receptor	OPRK1	0.0315
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0311
118	Organic cation/carnitine transporter 2	SLC22A5	0.0286
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0284
467	Delta-type opioid receptor	OPRD1	0.0267
36	Insulin receptor	INSR	0.0258
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0257
465	Calmodulin	CALM1	0.0237
776	Bile salt export pump	ABCB11	0.0237
474	Acetylcholinesterase	ACHE	0.0235
2164	Multidrug resistance-associated protein 4	ABCC4	0.0234
6432	Transporter	snf	0.0232
174	Sigma 1-type opioid receptor	SIGMAR1	0.0218
136	Estrogen receptor	ESR1	0.0214
6147	Solute carrier family 22 member 3	SLC22A3	0.0211
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0209
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0207
124	Histamine H2 receptor	HRH2	0.0203
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0201
833	Organic cation/carnitine transporter 1	SLC22A4	0.02
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0196
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0195
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0192
1656	CYP2B protein	CYP2B	0.019
3923	Cholinesterase	BCHE	0.0184
817	DNA topoisomerase 2-alpha	TOP2A	0.0184
891	Dihydropteroate synthase	folP	0.0183
5359	Dihydropteroate synthase	folP	0.0183
7175	Dihydropteroate synthase	sulI	0.0183
571	Melatonin receptor type 1A	MTNR1A	0.0181
362	Melatonin receptor type 1B	MTNR1B	0.0181
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.018
260	Cytochrome P450 51	ERG11	0.0179
761	Cytochrome P450 51	ERG11	0.0179
3163	Cytochrome P450 51	cyp51	0.0179
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0178
6142	Solute carrier family 22 member 8	SLC22A8	0.0175
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0175
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0174
468	Cytochrome P450 4A11	CYP4A11	0.017
16	Adenosine A1 receptor	ADORA1	0.0168
6143	Solute carrier family 22 member 7	SLC22A7	0.0168
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0167
6031	Cytochrome P450 3A43	CYP3A43	0.0164
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0162
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0161
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0161
731	HIV-1 protease	HIV-1 protease	0.0158
6182	Cytochrome P450 2J2	CYP2J2	0.0157
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0156
904	Glutathione S-transferase P	GSTP1	0.0152
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0149
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0149
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0147
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0144
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0142
1178	Adenosine A2a receptor	ADORA2A	0.0142
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.014
122	P2Y purinoceptor 12	P2RY12	0.0139
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0136
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0136
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0135
6102	Arylamine N-acetyltransferase 2	NAT2	0.0134
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0131
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0131
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0128
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
777	Tumor necrosis factor	TNF	0.0127
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0126
70	Type-1 angiotensin II receptor	AGTR1	0.0126
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0124
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0124
4116	Dihydropteroate synthetase	Not Available	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0119
1024	Solute carrier family 22 member 11	SLC22A11	0.0118
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0116
6220	Aryl hydrocarbon receptor	AHR	0.0112
1757	Myeloperoxidase	MPO	0.0112
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0112
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0111
921	Glutamate receptor 2	GRIA2	0.011
365	Dihydrofolate reductase	DHFR	0.011
2381	Dihydrofolate reductase	DFR1	0.011
2833	Dihydrofolate reductase	Not Available	0.011
2931	Dihydrofolate reductase	folA	0.011
3544	Dihydrofolate reductase	folA	0.011
3682	Dihydrofolate reductase	folA	0.011
6642	Dihydrofolate reductase	folA	0.011
6756	Dihydrofolate reductase	dfrA	0.011
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0109
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0109
482	Glycine receptor subunit alpha-1	GLRA1	0.0109
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0108
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0108
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0108
811	Translocator protein	TSPO	0.0107
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0106
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0106
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.01
1010	Cytochrome P450 51A1	CYP51A1	0.0099
4122	Histone deacetylase 2	HDAC2	0.0098
146	Androgen receptor	AR	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0097
871	Glucocorticoid receptor	NR3C1	0.0095
6148	Multidrug resistance-associated protein 7	ABCC10	0.0094
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0093
6014	Cytochrome P450 2A13	CYP2A13	0.0093
4604	Liver carboxylesterase 1	CES1	0.0093
504	Mast/stem cell growth factor receptor	KIT	0.0092
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0092
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0092
6136	Multidrug resistance-associated protein 5	ABCC5	0.0092
3810	Catechol O-methyltransferase	COMT	0.0092
6141	Sodium/bile acid cotransporter	SLC10A1	0.0091
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0089
613	Atrial natriuretic peptide receptor A	NPR1	0.0089
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0088
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0088
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0088
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0088
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0086
3947	Xanthine dehydrogenase/oxidase	XDH	0.0085
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0084
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0083
869	Estrogen receptor beta	ESR2	0.0083
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0079
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0077
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0076
844	Epidermal growth factor receptor	EGFR	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0075
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0074
705	Glutamate receptor 1	GRIA1	0.0074
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0074
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0072
295	Carbonic anhydrase 1	CA1	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0071
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.007
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.007
373	Transthyretin	TTR	0.007
518	Peroxidase/catalase T	katG	0.007
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0069
6137	Multidrug resistance-associated protein 6	ABCC6	0.0069
319	Opioid receptor, sigma 1	OPRS1	0.0069
407	Vascular endothelial growth factor receptor 2	KDR	0.0069
1517	Beta-3 adrenergic receptor	ADRB3	0.0068
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0068
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0066
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0066
275	Arachidonate 5-lipoxygenase	ALOX5	0.0065
1636	Trace amine-associated receptor 1	TAAR1	0.0064
1618	High affinity nerve growth factor receptor	NTRK1	0.0064
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0064
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0064
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0064
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0064
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0063
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0063
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0063
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0063
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0063
173	Toll-like receptor 7	TLR7	0.0063
133	Dihydropterate synthase	sulI	0.0063
565	Extracellular calcium-sensing receptor	CASR	0.0062
1275	Estrogen sulfotransferase	SULT1E1	0.0061
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0061
592	Carbonic anhydrase 4	CA4	0.0061
2112	Toll-like receptor 9	TLR9	0.0061
4203	Histamine N-methyltransferase	HNMT	0.006
228	Beta platelet-derived growth factor receptor	PDGFRB	0.006
1541	Metalloproteinase	mmp20	0.006
26	Vascular endothelial growth factor receptor 3	FLT4	0.0059
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0058
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0058
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0058
153	Dopamine beta-hydroxylase	DBH	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0058
6126	Carbonic anhydrase 7	CA7	0.0058
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0058
161	Tubulin beta chain	TUBB	0.0057
312	Tubulin beta chain	TUB2	0.0057
427	Substance-P receptor	TACR1	0.0057
1192	Sulfotransferase 1A1	SULT1A1	0.0057
6085	Fatty acid-binding protein, intestinal	FABP2	0.0057
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0057
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0056
32	Vascular endothelial growth factor receptor 1	FLT1	0.0056
164	Histamine H4 receptor	HRH4	0.0056
4120	NADPH--cytochrome P450 reductase	POR	0.0056
29	Tubulin beta-1 chain	TUBB1	0.0056
823	Fibroblast growth factor receptor 2	FGFR2	0.0055
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0055
1050	Bile salt sulfotransferase	SULT2A1	0.0055
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0055
444	Alcohol dehydrogenase 1B	ADH1B	0.0055
273	Apoptosis regulator Bcl-2	BCL2	0.0055
88	Retinoic acid receptor RXR-beta	RXRB	0.0054
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0054
1648	Elastin	ELN	0.0054
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0054
251	Alcohol dehydrogenase 1A	ADH1A	0.0054
1629	Transcription factor AP-1	JUN	0.0053
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0053
24	Thymidylate synthase	TMP1	0.0053
359	Thymidylate synthase	TYMS	0.0053
2626	Thymidylate synthase	thyA	0.0053
2729	Thymidylate synthase	thyA	0.0053
5352	Thymidylate synthase	THYA	0.0053
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0052
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0051
634	Squalene monooxygenase	SQLE	0.0051
7196	Squalene monooxygenase	ERG1	0.0051
738	Monocarboxylate transporter 1	SLC16A1	0.0051
6766	O-GlcNAcase BT_4395	BT_4395	0.0049
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0049
563	Thyroid peroxidase	TPO	0.0049
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0049
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0049
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0049
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0048
614	Progesterone receptor	PGR	0.0048
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0048
952	Dipeptidyl peptidase 4	DPP4	0.0048
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0047
6146	High affinity copper uptake protein 1	SLC31A1	0.0047
6044	Serum paraoxonase/lactonase 3	PON3	0.0047
4311	tRNA	TRDMT1	0.0046
4325	tRNA	trmD	0.0046
4328	tRNA	trmD	0.0046
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0046
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0046
2230	Catalase	CAT	0.0045
3249	Catalase	katA	0.0045
3625	Catalase	katA	0.0045
4539	Catalase	katA	0.0045
4941	Catalase	katB	0.0045
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0045
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0045
357	Carbonic anhydrase 2	CA2	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
183	Vascular endothelial growth factor A	VEGFA	0.0045
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0044
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0044
390	Adenosine A3 receptor	ADORA3	0.0044
976	Platelet glycoprotein IX	GP9	0.0044
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0044
49	Endothelin B receptor	EDNRB	0.0044
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0044
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0044
756	Sex hormone-binding globulin	SHBG	0.0043
3426	Glutamine synthetase	glnA	0.0043
3987	Glutamine synthetase	GLUL	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
3957	Adenosine deaminase	ADA	0.0043
737	Mineralocorticoid receptor	NR3C2	0.0042
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
6020	Aldehyde oxidase	AOX1	0.0041
517	Alcohol dehydrogenase 1C	ADH1C	0.0041
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0041
814	Ryanodine receptor 1	RYR1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0041
3932	Glutathione S-transferase A2	GSTA2	0.004
3404	Exotoxin A	eta	0.004
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.004
3937	Fatty-acid amide hydrolase	FAAH	0.0039
3823	Cytokine receptor common gamma chain	IL2RG	0.0039
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0039
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0039
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0039
162	Retinoic acid receptor gamma-1	RARG	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
3809	Estrogen-related receptor gamma	ESRRG	0.0038
3856	Fibroblast growth factor receptor 3	FGFR3	0.0037
908	Glutathione S-transferase theta-1	GSTT1	0.0037
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0037
130	Prostacyclin synthase	PTGIS	0.0037
268	Adenosine A2b receptor	ADORA2B	0.0036
780	Retinoic acid receptor RXR-gamma	RXRG	0.0036
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0036
3086	Plasmepsin-2	Not Available	0.0036
4228	Keratin, type II cytoskeletal 7	KRT7	0.0036
3808	Dihydropteroate synthase 2	folP2	0.0036
3601	Dihydropteroate synthase 1	folP1	0.0036
3807	Dihydropteroate synthase 1	folP1	0.0036
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0036
473	L-lactate dehydrogenase A chain	LDHA	0.0035
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0034
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0034
54	Prothrombin	F2	0.0034
724	Interleukin-2 receptor alpha chain	IL2RA	0.0034
717	Interleukin-2 receptor subunit beta	IL2RB	0.0034
284	DNA-directed RNA polymerase beta chain	rpoB	0.0034
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0034
2178	Metabotropic glutamate receptor 5	GRM5	0.0034
712	Tubulin alpha chain	TUB1	0.0034
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0034
1374	Natriuretic peptides B	NPPB	0.0034
1827	Gap junction alpha-1 protein	GJA1	0.0033
1908	Vascular cell adhesion protein 1	VCAM1	0.0033
6506	Stathmin-4	STMN4	0.0033
229	Retinoic acid receptor beta	RARB	0.0033
84	Nuclear receptor 0B1	NR0B1	0.0033
730	Retinoic acid receptor alpha	RARA	0.0032
2290	ADP-ribosyl cyclase 2	BST1	0.0032
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0032
239	Coagulation factor X	F10	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0031
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0031
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
65	Matrix metalloproteinase-9	Not Available	0.0031
3639	Thymidine phosphorylase	deoA	0.003
3936	Thymidine phosphorylase	TYMP	0.003
818	50S ribosomal protein L10	rplJ	0.003
4103	Proteasome subunit beta type 2	PSMB2	0.003
4102	Proteasome subunit beta type 5	PSMB5	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
4101	Proteasome subunit beta type 1	PSMB1	0.003
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
6103	Arylamine N-acetyltransferase 1	NAT1	0.003
469	Annexin A1	ANXA1	0.003
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0029
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0029
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0029
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0029
165	FL cytokine receptor	FLT3	0.0029
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0029
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0029
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0028
751	Potassium channel subfamily K member 6	KCNK6	0.0028
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0028
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0028
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0028
7	Nitric oxide synthase, inducible	NOS2	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0027
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0027
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0027
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0027
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0027
4192	DNA topoisomerase 2-beta	TOP2B	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
172	Potassium channel subfamily K member 1	KCNK1	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
3913	Glutamic acid decarboxylase	GAD65	0.0026
6174	50S ribosomal protein L32	rpmF	0.0025
1196	Complement decay-accelerating factor	CD55	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0025
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0025
1992	Vitamin D-binding protein	GC	0.0025
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
5300	Antigen peptide transporter 1	TAP1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6070	Nischarin	NISCH	0.0024
33	Cystine/glutamate transporter	SLC7A11	0.0024
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
4226	Uridine phosphorylase 2	UPP2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
820	Glycine receptor subunit alpha-2	GLRA2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1630	Integrin beta-2	ITGB2	0.0023
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0023
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
2808	Chloramphenicol acetyltransferase 3	cat3	0.0022
2298	Cytochrome P450-cam	camC	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
735	Alanine aminotransferase 1	GPT	0.0021
3904	Alanine aminotransferase 2	GPT2	0.0021
4225	Uridine phosphorylase 1	UPP1	0.0021
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0021
1262	Corticotropin-lipotropin	POMC	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.0021
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
5787	Angiopoietin-1 receptor	TEK	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.002
5934	Cytochrome P450 26A1	CYP26A1	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
2417	Chloramphenicol acetyltransferase	cat	0.002
3278	Chloramphenicol acetyltransferase	cat	0.002
6048	Troponin C, skeletal muscle	TNNC2	0.002
2810	Dr hemagglutinin structural subunit	draA	0.002
1820	Beta-nerve growth factor	NGF	0.002
2207	Rhodopsin	RHO	0.002
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.002
2449	Tubulin alpha-3 chain	TUBA1A	0.0019
6163	Copper-transporting ATPase 2	ATP7B	0.0019
6165	Copper-transporting ATPase 1	ATP7A	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
723	Cytosolic phospholipase A2	PLA2G4A	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0019
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
856	Vitamin D3 receptor	VDR	0.0018
543	Penicillin-binding protein 1B	mrcB	0.0018
6186	Penicillin-binding protein 1B	ponB	0.0018
6822	Penicillin-binding protein 1b	pbp1b	0.0018
6844	Penicillin-binding protein 1b	pbp1b	0.0018
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0018
1268	Neuropeptide S receptor	NPSR1	0.0018
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0018
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
645	Penicillin-binding protein 1A	mrcA	0.0018
5805	Penicillin-binding protein 1A	ponA	0.0018
6185	Penicillin-binding protein 1A	mrcA	0.0018
6799	Penicillin-binding protein 1A	pbpA	0.0018
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0018
159	Penicillin-binding protein 2B	penA	0.0018
6121	Penicillin-binding protein 2B	penA	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
6459	Glycodelin	PAEP	0.0018
1341	Histamine H3 receptor	HRH3	0.0018
572	Integrin alpha-L	ITGAL	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0017
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
828	Phenylalanine-4-hydroxylase	PAH	0.0017
3109	Phenylalanine-4-hydroxylase	phhA	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
6073	Potassium channel subfamily K member 9	KCNK9	0.0016
6072	Potassium channel subfamily K member 3	KCNK3	0.0016
1830	5'-nucleotidase	NT5E	0.0016
760	Fibroblast growth factor 1	FGF1	0.0016
1243	Cathepsin D	CTSD	0.0016
4217	Telomerase reverse transcriptase	TERT	0.0016
936	Ephrin type-A receptor 2	EPHA2	0.0016
896	Glutathione S-transferase Mu 1	GSTM1	0.0016
3830	Calreticulin	CALR	0.0016
1039	Histone deacetylase 9	HDAC9	0.0016
3221	Cytochrome c4	cc4	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0015
758	Thyroid hormone receptor alpha	THRA	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
1864	RET proto-oncogene	RET	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0015
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0015
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
2236	Casein kinase II subunit alpha	CSNK2A1	0.0015
6043	Putative G-protein coupled receptor 44	GPR44	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
291	Nitric-oxide synthase, endothelial	NOS3	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4773	Deoxycytidine kinase	DCK	0.0014
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0014
2539	Tubulin alpha-1 chain	TUBA4A	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
798	Osteocalcin	BGLAP	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
2232	Interleukin-5	IL5	0.0014
1291	cAMP response element-binding protein	CREB1	0.0014
1593	Mucin-2	MUC2	0.0014
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
2021	Thrombomodulin	THBD	0.0013
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
4210	Toll-like receptor 4	TLR4	0.0013
489	Monocarboxylate transporter 2	SLC16A7	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
5798	Mitogen-activated protein kinase 11	MAPK11	0.0013
5923	Microtubule-associated protein tau	MAPT	0.0013
5924	Microtubule-associated protein 4	MAP4	0.0013
2320	Thymidine kinase, cytosolic	TK1	0.0012
267	Plasminogen activator inhibitor 1	SERPINE1	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
232	Corticosteroid-binding globulin	SERPINA6	0.0012
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0012
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
1852	Microtubule-associated protein 2	MAP2	0.0012
6824	Tyrosine-protein kinase Lyn	LYN	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6218	Pannexin-1	PANX1	0.0011
6221	Steroid hormone receptor ERR1	ESRRA	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
106	Cannabinoid receptor 2	CNR2	0.0011
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
4237	50S ribosomal protein L22	rplV	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
68	Cannabinoid receptor 1	CNR1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
6131	Carbonic anhydrase 14	CA14	0.001
283	SEC14-like protein 2	SEC14L2	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
6151	Monocarboxylate transporter 10	SLC16A10	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
997	Protein kinase C beta type	PRKCB	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6122	Carbonic anhydrase 3	CA3	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
4948	Cytochrome c-553	Not Available	0.0009
4923	Cytochrome c3	DvMF_2499	0.0009
4945	Cytochrome c3	Not Available	0.0009
4949	Cytochrome c3	DVU_3171	0.0009
4968	Cytochrome c3	cytc3	0.0009
4997	Cytochrome c3	SO_2727	0.0009
5219	Cytochrome c3	cyd	0.0009
4902	Nine-heme cytochrome c	Ddes_2038	0.0009
3189	High-molecular-weight cytochrome c	hmcA	0.0009
6677	Myelin P2 protein	PMP2	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
3007	Carbonic anhydrase 12	CA12	0.0009
4205	Carbonic anhydrase 9	CA9	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
244	Angiotensin-converting enzyme	ACE	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0007
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0007
2802	Endoglucanase G	celCCG	0.0007
822	Aldose reductase	AKR1B1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
1507	Cytochrome c	CYCS	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4916	Cyanoglobin	glbN	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4943	Cytochrome c6	petJ	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
5000	HemO	hemO	0.0004
4984	Neuroglobin	NGB	0.0004
4909	CooA protein	cooA	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
4961	Hemophore HasA	hasA	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4910	Cytoglobin	CYGB	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4972	P450cin	cinA	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
4952	Catalase/peroxidase	katA	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
4920	Peroxidase/catalase	katG	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01079 - Tegaserod

Targets

Enzymes

Transporters

Predictions