DT-Web: DB00694

Identification

Name

Daunorubicin

Accession Number

DB00694 (APRD00521)

Type

small molecule

Description

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

527.5199

Groups

approved

Monoisotopic Weight

527.179146153

Pharmacology

Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Mechanism of action

Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Absorption

Not Available

Protein binding

97% binding-albumin

Biotransformation

Hepatic

Route of elimination

Twenty-five percent of an administered dose of daunorubicin hydrochloride is eliminated in an active form by urinary excretion and an estimated 40% by biliary excretion.

Toxicity

LD₅₀=20 mg/kg (mice, IV); LD₅₀=13 mg/kg (rat, IV)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Trastuzumab	Trastuzumab may increase the cardiotoxicity of Daunorubicin. Signs and symptoms of cardiac dysfunction should be monitored for frequently. Increased risk of heart failure. Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Food Interactions

Not Available

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	intercalation
References	Aubel-Sadron G, Londos-Gagliardi D: Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie. 1984 May;66(5):333-52. - Pubmed Zunino F, Capranico G: DNA topoisomerase II as the primary target of anti-tumor anthracyclines. Anticancer Drug Des. 1990 Nov;5(4):307-17. - Pubmed
DTHybrid score	Not Available
DNA topoisomerase 2-alpha
Name	DNA topoisomerase 2-alpha
Gene Name	TOP2A
Pharmacological action	yes
Actions	inhibitor
References	Aubel-Sadron G, Londos-Gagliardi D: Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie. 1984 May;66(5):333-52. - Pubmed Zunino F, Capranico G: DNA topoisomerase II as the primary target of anti-tumor anthracyclines. Anticancer Drug Des. 1990 Nov;5(4):307-17. - Pubmed
DTHybrid score	0.6048
DNA topoisomerase 2-beta
Name	DNA topoisomerase 2-beta
Gene Name	TOP2B
Pharmacological action	yes
Actions	inhibitor
References	Aubel-Sadron G, Londos-Gagliardi D: Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie. 1984 May;66(5):333-52. - Pubmed Zunino F, Capranico G: DNA topoisomerase II as the primary target of anti-tumor anthracyclines. Anticancer Drug Des. 1990 Nov;5(4):307-17. - Pubmed
DTHybrid score	0.4459

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8162
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inducer
References	- Wang T, Chen FY, Han JY, Shao NX, Ou-Yuang RR: [Study of CYP3A5 in drug resistance mechanisms in acute leukemia]. Zhonghua Xue Ye Xue Za Zhi. 2003 Jun;24(6):286-9. - Pubmed
DTHybrid score	0.4722
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5684
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3717
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.294
Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	substrate
References	- Yee SB, Pritsos CA: Comparison of oxygen radical generation from the reductive activation of doxorubicin, streptonigrin, and menadione by xanthine oxidase and xanthine dehydrogenase. Arch Biochem Biophys. 1997 Nov 15;347(2):235-41. - Pubmed Yee SB, Pritsos CA: Reductive activation of doxorubicin by xanthine dehydrogenase from EMT6 mouse mammary carcinoma tumors. Chem Biol Interact. 1997 May 2;104(2-3):87-101. - Pubmed
DTHybrid score	0.4898
NADPH--cytochrome P450 reductase
Name	NADPH--cytochrome P450 reductase
Gene Name	POR
Actions	substrate
References	- Bachur NR, Gordon SL, Gee MV, Kon H: NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci U S A. 1979 Feb;76(2):954-7. - Pubmed Di Re J, Lee C, Riddick DS: Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin. Can J Physiol Pharmacol. 1999 Aug;77(8):589-97. - Pubmed
DTHybrid score	0.2809

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Zhou G, Kuo MT: Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin. J Biol Chem. 1998 Jun 19;273(25):15387-94. - Pubmed Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. - Pubmed Tang F, Ouyang H, Yang JZ, Borchardt RT: Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers. J Pharm Sci. 2004 May;93(5):1185-94. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed Takara K, Sakaeda T, Kakumoto M, Tanigawara Y, Kobayashi H, Okumura K, Ohnishi N, Yokoyama T: Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport. Oncol Res. 2009;17(11-12):527-33. - Pubmed Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P: Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules. 2010 Feb 9;15(2):857-70. - Pubmed Perez-Victoria JM, Chiquero MJ, Conseil G, Dayan G, Di Pietro A, Barron D, Castanys S, Gamarro F: Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin. Biochemistry. 1999 Feb 9;38(6):1736-43. - Pubmed Pallis M, Turzanski J, Harrison G, Wheatley K, Langabeer S, Burnett AK, Russell NH: Use of standardized flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br J Haematol. 1999 Feb;104(2):307-12. - Pubmed Chiodini B, Bassan R, Barbui T: Cellular uptake and antiproliferative effects of therapeutic concentrations of idarubicin or daunorubicin and their alcohol metabolites, with or without cyclosporin A, in MDR1+ human leukemic cells. Leuk Lymphoma. 1999 May;33(5-6):485-97. - Pubmed Romsicki Y, Sharom FJ: The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry. 1999 May 25;38(21):6887-96. - Pubmed Hiessbock R, Wolf C, Richter E, Hitzler M, Chiba P, Kratzel M, Ecker G: Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines. J Med Chem. 1999 Jun 3;42(11):1921-6. - Pubmed
DTHybrid score	0.7282
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Loe DW, Almquist KC, Cole SP, Deeley RG: ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem. 1996 Apr 19;271(16):9683-9. - Pubmed Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T: Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem Biophys Res Commun. 1998 Jun 29;247(3):859-63. - Pubmed Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd: Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. Mol Cancer Ther. 2003 Mar;2(3):307-16. - Pubmed Nunoya K, Grant CE, Zhang D, Cole SP, Deeley RG: Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. - Pubmed Versantvoort CH, Broxterman HJ, Lankelma J, Feller N, Pinedo HM: Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells. Biochem Pharmacol. 1994 Sep 15;48(6):1129-36. - Pubmed Yazaki K, Yamanaka N, Masuno T, Konagai S, Shitan N, Kaneko S, Ueda K, Sato F: Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation. Plant Mol Biol. 2006 Jun;61(3):491-503. - Pubmed Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. - Pubmed Nabekura T, Yamaki T, Hiroi T, Ueno K, Kitagawa S: Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. Pharmacol Res. 2010 Mar;61(3):259-63. Epub 2009 Nov 26. - Pubmed Renes J, de Vries EG, Nienhuis EF, Jansen PL, Muller M: ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br J Pharmacol. 1999 Feb;126(3):681-8. - Pubmed Hooijberg JH, Pinedo HM, Vrasdonk C, Priebe W, Lankelma J, Broxterman HJ: The effect of glutathione on the ATPase activity of MRP1 in its natural membranes. FEBS Lett. 2000 Mar 3;469(1):47-51. - Pubmed Marbeuf-Gueye C, Salerno M, Quidu P, Garnier-Suillerot A: Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P. Eur J Pharmacol. 2000 Mar 17;391(3):207-16. - Pubmed Evers R, Kool M, Smith AJ, van Deemter L, de Haas M, Borst P: Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport. Br J Cancer. 2000 Aug;83(3):366-74. - Pubmed Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed
DTHybrid score	0.4246
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inhibitor
References	Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed
DTHybrid score	0.4291
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate
References	Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA: A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb;47(2):181-6. - Pubmed
DTHybrid score	0.2644
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions	substrate
References	Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. - Pubmed
DTHybrid score	0.2402
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.2879
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate
References	Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score	0.2217
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW: Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. Epub 2003 Mar 28. - Pubmed Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates S, Varadi A, Sarkadi B: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. - Pubmed Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S, Pumplin DW, Fang HB, Ross DD: Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Mol Pharmacol. 2003 Dec;64(6):1452-62. - Pubmed
DTHybrid score	0.4826

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.3666
4757	Cytochrome P450 2C9	CYP2C9	0.3556
6016	Cytochrome P450 2C19	CYP2C19	0.3139
4924	Cytochrome P450 2C8	CYP2C8	0.2892
6107	Cytochrome P450 3A7	CYP3A7	0.2834
6030	Cytochrome P450 2B6	CYP2B6	0.2112
6013	Cytochrome P450 2E1	CYP2E1	0.1952
477	DNA topoisomerase 4 subunit A	parC	0.1809
886	DNA topoisomerase 4 subunit A	parC	0.1809
6226	DNA topoisomerase 4 subunit A	parC	0.1809
6875	Type-2 restriction enzyme EcoRV	ecoRVR	0.1797
404	DNA gyrase subunit A	gyrA	0.1778
6224	DNA gyrase subunit A	gyrA	0.1778
6145	Solute carrier family 22 member 1	SLC22A1	0.1666
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1572
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1494
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.142
118	Organic cation/carnitine transporter 2	SLC22A5	0.123
1729	Solute carrier family 22 member 6	SLC22A6	0.1227
587	Serum albumin	ALB	0.1217
6142	Solute carrier family 22 member 8	SLC22A8	0.1126
5718	Cytochrome P450 2A6	CYP2A6	0.1112
2164	Multidrug resistance-associated protein 4	ABCC4	0.105
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0942
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0906
6147	Solute carrier family 22 member 3	SLC22A3	0.0873
6143	Solute carrier family 22 member 7	SLC22A7	0.0825
6141	Sodium/bile acid cotransporter	SLC10A1	0.0823
20	Prostaglandin G/H synthase 1	PTGS1	0.0819
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0815
290	Prostaglandin G/H synthase 2	PTGS2	0.0754
833	Organic cation/carnitine transporter 1	SLC22A4	0.0709
136	Estrogen receptor	ESR1	0.0689
3811	Cytochrome P450 19A1	CYP19A1	0.0677
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0654
908	Glutathione S-transferase theta-1	GSTT1	0.061
556	Alpha-1A adrenergic receptor	ADRA1A	0.0608
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0582
6106	Cytochrome P450 2C18	CYP2C18	0.0576
6136	Multidrug resistance-associated protein 5	ABCC5	0.0563
161	Tubulin beta chain	TUBB	0.0558
312	Tubulin beta chain	TUB2	0.0558
1024	Solute carrier family 22 member 11	SLC22A11	0.055
468	Cytochrome P450 4A11	CYP4A11	0.0549
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.053
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0522
904	Glutathione S-transferase P	GSTP1	0.0509
492	Histamine H1 receptor	HRH1	0.0495
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0491
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0491
318	Alpha-2A adrenergic receptor	ADRA2A	0.0489
871	Glucocorticoid receptor	NR3C1	0.047
6020	Aldehyde oxidase	AOX1	0.0465
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0457
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0447
831	D(2) dopamine receptor	DRD2	0.0444
1353	DNA topoisomerase 1	TOP1	0.044
3552	DNA topoisomerase 1	topA	0.044
3923	Cholinesterase	BCHE	0.0431
193	Beta-1 adrenergic receptor	ADRB1	0.0431
824	Sodium-dependent serotonin transporter	SLC6A4	0.0429
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0426
766	Beta-2 adrenergic receptor	ADRB2	0.0423
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0416
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0415
731	HIV-1 protease	HIV-1 protease	0.0413
29	Tubulin beta-1 chain	TUBB1	0.0404
4079	Lipoic acid synthetase, mitochondrial	LIAS	0.0397
45	Lipoyltransferase 1, mitochondrial	LIPT1	0.0397
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0396
2539	Tubulin alpha-1 chain	TUBA4A	0.0386
176	30S ribosomal protein S10	rpsJ	0.0385
6175	30S ribosomal protein S10	rpsJ	0.0385
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.0384
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0384
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0384
4773	Deoxycytidine kinase	DCK	0.0383
273	Apoptosis regulator Bcl-2	BCL2	0.037
844	Epidermal growth factor receptor	EGFR	0.0367
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0366
5923	Microtubule-associated protein tau	MAPT	0.0365
5924	Microtubule-associated protein 4	MAP4	0.0365
896	Glutathione S-transferase Mu 1	GSTM1	0.0365
847	Mu-type opioid receptor	OPRM1	0.0363
1852	Microtubule-associated protein 2	MAP2	0.0362
146	Androgen receptor	AR	0.0361
1757	Myeloperoxidase	MPO	0.0354
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0352
723	Cytosolic phospholipase A2	PLA2G4A	0.0352
6168	Solute carrier family 22 member 16	SLC22A16	0.0345
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0342
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.034
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0338
7	Nitric oxide synthase, inducible	NOS2	0.0336
713	Sodium-dependent dopamine transporter	SLC6A3	0.0333
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0329
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0329
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0329
4604	Liver carboxylesterase 1	CES1	0.0328
1629	Transcription factor AP-1	JUN	0.0327
6146	High affinity copper uptake protein 1	SLC31A1	0.0325
2449	Tubulin alpha-3 chain	TUBA1A	0.0323
738	Monocarboxylate transporter 1	SLC16A1	0.032
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0314
6163	Copper-transporting ATPase 2	ATP7B	0.0313
6165	Copper-transporting ATPase 1	ATP7A	0.0313
632	Alpha-1B adrenergic receptor	ADRA1B	0.0312
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0311
131	Synaptic vesicular amine transporter	SLC18A2	0.031
614	Progesterone receptor	PGR	0.0308
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0307
33	Cystine/glutamate transporter	SLC7A11	0.0306
4180	DNA-(apurinic or apyrimidinic site) lyase	APEX1	0.0305
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0303
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0302
504	Mast/stem cell growth factor receptor	KIT	0.03
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.03
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.03
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.03
6031	Cytochrome P450 3A43	CYP3A43	0.0299
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0296
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0295
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0289
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0289
869	Estrogen receptor beta	ESR2	0.0286
23	D(1A) dopamine receptor	DRD1	0.0284
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0283
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0272
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0272
6210	Tubulin delta chain	TUBD1	0.0272
6212	Tubulin gamma-1 chain	TUBG1	0.0272
6211	Tubulin epsilon chain	TUBE1	0.0272
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0269
6220	Aryl hydrocarbon receptor	AHR	0.0268
465	Calmodulin	CALM1	0.0267
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0265
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0265
70	Type-1 angiotensin II receptor	AGTR1	0.0263
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0261
6085	Fatty acid-binding protein, intestinal	FABP2	0.026
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0259
36	Insulin receptor	INSR	0.0258
3611	Cytidine deaminase	cdd	0.0258
3707	Cytidine deaminase	cdd	0.0258
4211	Cytidine deaminase	CDA	0.0258
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0255
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0253
629	Alpha-2B adrenergic receptor	ADRA2B	0.0252
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0251
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.025
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0249
3941	Amine oxidase [flavin-containing] A	MAOA	0.0249
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0248
378	Alpha-2C adrenergic receptor	ADRA2C	0.0247
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0245
380	Cytochrome P450 17A1	CYP17A1	0.0245
789	Alpha-1D adrenergic receptor	ADRA1D	0.0243
5626	Nucleoside diphosphate kinase B	NME2	0.0242
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0241
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.024
76	Nitric-oxide synthase, brain	NOS1	0.0239
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0238
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0237
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0235
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.023
777	Tumor necrosis factor	TNF	0.0227
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0226
260	Cytochrome P450 51	ERG11	0.0226
761	Cytochrome P450 51	ERG11	0.0226
3163	Cytochrome P450 51	cyp51	0.0226
638	D(3) dopamine receptor	DRD3	0.0222
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0222
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0221
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0219
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0213
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0213
124	Histamine H2 receptor	HRH2	0.0212
24	Thymidylate synthase	TMP1	0.0212
359	Thymidylate synthase	TYMS	0.0212
2626	Thymidylate synthase	thyA	0.0212
2729	Thymidylate synthase	thyA	0.0212
5352	Thymidylate synthase	THYA	0.0212
4203	Histamine N-methyltransferase	HNMT	0.0212
737	Mineralocorticoid receptor	NR3C2	0.0211
373	Transthyretin	TTR	0.0211
756	Sex hormone-binding globulin	SHBG	0.021
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.021
6171	Solute carrier family 28 member 3	SLC28A3	0.0209
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0203
683	Potassium transporter	GK0582	0.0203
992	Protein tyrosine kinase 2 beta	PTK2B	0.0202
3932	Glutathione S-transferase A2	GSTA2	0.02
6182	Cytochrome P450 2J2	CYP2J2	0.02
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0199
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0197
5294	Nucleoside diphosphate kinase A	NME1	0.0194
6167	Organic solute transporter subunit beta	OSTB	0.0193
6166	Organic solute transporter subunit alpha	OSTA	0.0193
2808	Chloramphenicol acetyltransferase 3	cat3	0.0193
702	UMP-CMP kinase	CMPK1	0.0191
407	Vascular endothelial growth factor receptor 2	KDR	0.019
6014	Cytochrome P450 2A13	CYP2A13	0.0189
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0189
3939	Amine oxidase [flavin-containing] B	MAOB	0.0188
1830	5'-nucleotidase	NT5E	0.0187
1656	CYP2B protein	CYP2B	0.0186
467	Delta-type opioid receptor	OPRD1	0.0184
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0184
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0183
26	Vascular endothelial growth factor receptor 3	FLT4	0.0183
3270	Elongation factor G	fusA	0.0181
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0178
4228	Keratin, type II cytoskeletal 7	KRT7	0.0177
327	Glutathione reductase	gor	0.0176
5110	Glutathione reductase	GR2	0.0176
32	Vascular endothelial growth factor receptor 1	FLT1	0.0175
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0172
1405	Thiopurine S-methyltransferase	TPMT	0.0172
16	Adenosine A1 receptor	ADORA1	0.0172
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0171
291	Nitric-oxide synthase, endothelial	NOS3	0.017
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0169
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0168
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0168
461	Glycine receptor subunit alpha-3	GLRA3	0.0167
1178	Adenosine A2a receptor	ADORA2A	0.0166
63	Malate dehydrogenase	mdh	0.0165
2329	Malate dehydrogenase	mdh	0.0165
3445	Malate dehydrogenase	mdh	0.0165
4420	Malate dehydrogenase	mdh	0.0165
4438	Malate dehydrogenase	mdh	0.0165
3823	Cytokine receptor common gamma chain	IL2RG	0.0163
125	DNA polymerase beta	POLB	0.0162
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0162
696	Kappa-type opioid receptor	OPRK1	0.0162
1517	Beta-3 adrenergic receptor	ADRB3	0.0161
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.016
1192	Sulfotransferase 1A1	SULT1A1	0.016
936	Ephrin type-A receptor 2	EPHA2	0.0159
13	Aminomethyltransferase, mitochondrial	AMT	0.0159
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
117	Sterol O-acyltransferase 1	SOAT1	0.0158
958	Insulin-like growth factor 1 receptor	IGF1R	0.0157
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0157
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0157
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0156
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0156
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0153
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0153
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0151
432	D(4) dopamine receptor	DRD4	0.015
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0149
952	Dipeptidyl peptidase 4	DPP4	0.0149
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
6149	Solute carrier family 22 member 10	SLC22A10	0.0148
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0146
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0146
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0146
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0146
6043	Putative G-protein coupled receptor 44	GPR44	0.0144
165	FL cytokine receptor	FLT3	0.0144
1010	Cytochrome P450 51A1	CYP51A1	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0144
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0142
724	Interleukin-2 receptor alpha chain	IL2RA	0.0142
717	Interleukin-2 receptor subunit beta	IL2RB	0.0142
1650	Heme carrier protein 1	SLC46A1	0.0142
3587	Gastrotropin	FABP6	0.0141
49	Endothelin B receptor	EDNRB	0.0139
275	Arachidonate 5-lipoxygenase	ALOX5	0.0139
474	Acetylcholinesterase	ACHE	0.0138
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0138
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0138
232	Corticosteroid-binding globulin	SERPINA6	0.0137
5787	Angiopoietin-1 receptor	TEK	0.0137
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0137
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0136
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0136
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0135
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0133
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0132
818	50S ribosomal protein L10	rplJ	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
183	Vascular endothelial growth factor A	VEGFA	0.0131
578	Endothelin-1 receptor	EDNRA	0.0131
1714	Mitogen-activated protein kinase 3	MAPK3	0.013
3307	Acriflavine resistance protein B	acrB	0.013
322	Vasopressin V2 receptor	AVPR2	0.0128
469	Annexin A1	ANXA1	0.0126
2236	Casein kinase II subunit alpha	CSNK2A1	0.0124
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
122	P2Y purinoceptor 12	P2RY12	0.0122
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0122
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
4237	50S ribosomal protein L22	rplV	0.0121
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0121
1569	G1/S-specific cyclin-D1	CCND1	0.0121
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0121
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.012
4031	Glutathione S-transferase A1	GSTA1	0.012
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0119
6218	Pannexin-1	PANX1	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
6859	Protein S100-A4	S100A4	0.0117
239	Coagulation factor X	F10	0.0117
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0116
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0116
48	Pyridoxal kinase	PDXK	0.0116
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0115
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0115
489	Monocarboxylate transporter 2	SLC16A7	0.0114
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0114
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
4122	Histone deacetylase 2	HDAC2	0.0112
4238	50S ribosomal protein L4	rplD	0.0111
5578	50S ribosomal protein L4	rplD	0.0111
6173	50S ribosomal protein L4	rplD	0.0111
6219	50S ribosomal protein L4	rplD	0.0111
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0111
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0111
571	Melatonin receptor type 1A	MTNR1A	0.0111
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0111
362	Melatonin receptor type 1B	MTNR1B	0.011
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.011
84	Nuclear receptor 0B1	NR0B1	0.011
823	Fibroblast growth factor receptor 2	FGFR2	0.011
814	Ryanodine receptor 1	RYR1	0.0109
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
2443	Azurin	azu	0.0108
484	Tyrosine-protein kinase ABL2	ABL2	0.0107
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0107
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0106
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0104
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0104
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0103
716	5-hydroxytryptamine 7 receptor	HTR7	0.0103
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0103
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0101
1770	Phospholipase C	PLCL1	0.0101
2841	Phospholipase C	plc	0.0101
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0101
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0101
1176	Mitogen-activated protein kinase 1	MAPK1	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
3856	Fibroblast growth factor receptor 3	FGFR3	0.0099
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0099
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0099
6228	Nuclear receptor coactivator 1	NCOA1	0.0098
603	DNA polymerase alpha catalytic subunit	POLA1	0.0098
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0098
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0098
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0097
284	DNA-directed RNA polymerase beta chain	rpoB	0.0097
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0097
6241	Nuclear receptor coactivator 2	NCOA2	0.0097
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0097
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0096
3809	Estrogen-related receptor gamma	ESRRG	0.0096
68	Cannabinoid receptor 1	CNR1	0.0096
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0096
163	D(1B) dopamine receptor	DRD5	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0094
293	Gamma-glutamyl hydrolase	GGH	0.0094
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0094
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
365	Dihydrofolate reductase	DHFR	0.0093
2381	Dihydrofolate reductase	DFR1	0.0093
2833	Dihydrofolate reductase	Not Available	0.0093
2931	Dihydrofolate reductase	folA	0.0093
3544	Dihydrofolate reductase	folA	0.0093
3682	Dihydrofolate reductase	folA	0.0093
6642	Dihydrofolate reductase	folA	0.0093
6756	Dihydrofolate reductase	dfrA	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0092
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0092
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0091
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0091
5934	Cytochrome P450 26A1	CYP26A1	0.0091
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0089
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0089
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0089
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0089
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0088
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0088
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0088
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0087
6010	Thiamine transporter 1	SLC19A2	0.0086
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0086
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0086
1374	Natriuretic peptides B	NPPB	0.0086
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0086
1827	Gap junction alpha-1 protein	GJA1	0.0086
1908	Vascular cell adhesion protein 1	VCAM1	0.0086
6042	Prostaglandin reductase 2	PTGR2	0.0085
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0085
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0083
811	Translocator protein	TSPO	0.0083
5818	Folate receptor alpha	FOLR1	0.0083
850	Vasopressin V1b receptor	AVPR1B	0.0081
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0081
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0081
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0081
6138	Multidrug resistance protein 3	ABCB4	0.008
1050	Bile salt sulfotransferase	SULT2A1	0.0079
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0079
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0079
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0079
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0079
2282	Protein recA	recA	0.0079
2315	Protein recA	recA	0.0079
2332	Protein recA	recA	0.0079
5263	Protein recA	recA	0.0079
5265	FtsH	ftsH	0.0079
5646	Galactokinase	GALK1	0.0079
5302	TrwB	trwB	0.0079
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0078
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0078
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0078
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0078
5645	DNA topoisomerase 4 subunit B	parE	0.0078
6227	DNA topoisomerase 4 subunit B	parE	0.0078
3794	Osmolarity sensor protein envZ	envZ	0.0078
5649	Potassium-transporting ATPase B chain	kdpB	0.0078
5643	General secretion pathway protein E	epsE	0.0078
5641	Rod shape-determining protein MreB	TM_0588	0.0078
4178	DNA repair protein RAD51 homolog 1	RAD51	0.0078
5642	Chaperone clpB	clpB	0.0078
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0078
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0078
5644	Sensor protein phoQ	phoQ	0.0078
449	Ornithine decarboxylase	ODC1	0.0078
714	Glutathione reductase, mitochondrial	GSR	0.0078
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0077
175	Thiamin pyrophosphokinase 1	TPK1	0.0077
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0076
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0076
1313	Lactoylglutathione lyase	GLO1	0.0076
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0076
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0076
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
400	Coagulation factor IX	F9	0.0075
5461	Coagulation factor IX	F9	0.0075
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0074
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0074
3810	Catechol O-methyltransferase	COMT	0.0074
751	Potassium channel subfamily K member 6	KCNK6	0.0074
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
54	Prothrombin	F2	0.0074
705	Glutamate receptor 1	GRIA1	0.0073
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0073
6824	Tyrosine-protein kinase Lyn	LYN	0.0073
2852	DNA mismatch repair protein mutL	mutL	0.0073
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0072
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0072
2216	Fibroblast growth factor receptor 4	FGFR4	0.0072
1618	High affinity nerve growth factor receptor	NTRK1	0.0072
6070	Nischarin	NISCH	0.0071
3830	Calreticulin	CALR	0.0071
921	Glutamate receptor 2	GRIA2	0.0071
976	Platelet glycoprotein IX	GP9	0.0071
2599	Tyrosine-protein kinase HCK	HCK	0.0071
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.007
6837	Serine/threonine-protein kinase 17B	STK17B	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
106	Cannabinoid receptor 2	CNR2	0.007
890	Niemann-Pick C1-like protein 1	NPC1L1	0.007
5312	Kinesin-like protein KIF1A	KIF1A	0.0069
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0069
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0068
604	Vitamin K-dependent protein Z	PROZ	0.0068
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0068
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
172	Potassium channel subfamily K member 1	KCNK1	0.0068
4751	Mitogen-activated protein kinase 12	MAPK12	0.0068
2397	Dihydroxyacetone kinase	dhaK	0.0068
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0067
768	FK506-binding protein 1A	FKBP1A	0.0067
4311	tRNA	TRDMT1	0.0066
4325	tRNA	trmD	0.0066
4328	tRNA	trmD	0.0066
6034	Hydroxyindole O-methyltransferase	ASMT	0.0066
6035	Nuclear receptor ROR-beta	RORB	0.0066
6036	Eosinophil peroxidase	EPX	0.0066
164	Histamine H4 receptor	HRH4	0.0066
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0066
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0066
2112	Toll-like receptor 9	TLR9	0.0065
3957	Adenosine deaminase	ADA	0.0065
207	Glutathione synthetase	GSS	0.0065
5269	Glutathione synthetase	gshB	0.0065
1881	Hexokinase-1	HK1	0.0064
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0064
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0064
2615	Chemotaxis protein cheA	cheA	0.0064
2371	Pantothenate kinase	coaA	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
2892	Acetylglutamate kinase	argB	0.0064
3550	Acetylglutamate kinase	argB	0.0064
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3231	Death-associated protein kinase 1	DAPK1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1760	Aminopeptidase N	ANPEP	0.0063
6843	Aminopeptidase N	pepN	0.0063
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0063
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0063
422	Vitamin K-dependent protein C	PROC	0.0063
1245	Vitamin K-dependent protein S	PROS1	0.0063
427	Substance-P receptor	TACR1	0.0062
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0062
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0062
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0062
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0062
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0061
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0061
6044	Serum paraoxonase/lactonase 3	PON3	0.0061
2727	S-adenosylmethionine synthetase	metK	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.006
820	Glycine receptor subunit alpha-2	GLRA2	0.0059
887	DNA gyrase subunit B	gyrB	0.0059
4150	DNA gyrase subunit B	gyrB	0.0059
6225	DNA gyrase subunit B	gyrB	0.0059
694	Matrix protein 2	M	0.0059
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0058
268	Adenosine A2b receptor	ADORA2B	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0058
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0057
5073	Ferredoxin--NADP reductase	petH	0.0057
5076	Ferredoxin--NADP reductase	fpr	0.0057
5119	Ferredoxin--NADP reductase	petH	0.0057
5121	Ferredoxin--NADP reductase	fpr	0.0057
6432	Transporter	snf	0.0057
765	Indoleamine 2,3-dioxygenase	IDO1	0.0057
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0057
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0056
6102	Arylamine N-acetyltransferase 2	NAT2	0.0056
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0056
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0055
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0055
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0055
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0055
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0055
94	5-hydroxytryptamine 4 receptor	HTR4	0.0054
295	Carbonic anhydrase 1	CA1	0.0054
551	Carnitine O-acetyltransferase	CRAT	0.0054
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0054
153	Dopamine beta-hydroxylase	DBH	0.0054
6111	DNA polymerase epsilon subunit 4	POLE4	0.0053
6112	DNA polymerase epsilon subunit 3	POLE3	0.0053
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0053
6110	DNA polymerase epsilon subunit 2	POLE2	0.0053
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
565	Extracellular calcium-sensing receptor	CASR	0.0052
1864	RET proto-oncogene	RET	0.0052
712	Tubulin alpha chain	TUB1	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
2251	Thymidylate kinase	tmk	0.0052
2254	Thymidylate kinase	DTYMK	0.0052
3522	Thymidylate kinase	tmk	0.0052
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0052
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0052
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0052
4217	Telomerase reverse transcriptase	TERT	0.0051
828	Phenylalanine-4-hydroxylase	PAH	0.0051
3109	Phenylalanine-4-hydroxylase	phhA	0.0051
798	Osteocalcin	BGLAP	0.0051
4103	Proteasome subunit beta type 2	PSMB2	0.0051
4102	Proteasome subunit beta type 5	PSMB5	0.0051
4101	Proteasome subunit beta type 1	PSMB1	0.0051
5300	Antigen peptide transporter 1	TAP1	0.0051
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.005
444	Alcohol dehydrogenase 1B	ADH1B	0.005
267	Plasminogen activator inhibitor 1	SERPINE1	0.005
517	Alcohol dehydrogenase 1C	ADH1C	0.005
2391	Ferrochelatase	hemH	0.0049
6502	Ferrochelatase	DKFZp686P18130	0.0049
1591	Ferrochelatase, mitochondrial	FECH	0.0049
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0049
856	Vitamin D3 receptor	VDR	0.0049
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0048
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0048
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0048
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0048
654	Flavin reductase	BLVRB	0.0048
3822	Actin, alpha skeletal muscle	ACTA1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0047
369	Coagulation factor VII	F7	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0046
780	Retinoic acid receptor RXR-gamma	RXRG	0.0046
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0046
173	Toll-like receptor 7	TLR7	0.0046
2232	Interleukin-5	IL5	0.0045
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0045
1593	Mucin-2	MUC2	0.0045
6221	Steroid hormone receptor ERR1	ESRRA	0.0045
3937	Fatty-acid amide hydrolase	FAAH	0.0045
1836	Mitogen-activated protein kinase 10	MAPK10	0.0045
357	Carbonic anhydrase 2	CA2	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0044
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0044
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0043
2472	Voltage-gated potassium channel	kcsA	0.0043
6366	Voltage-gated potassium channel	kcsA	0.0043
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0042
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0042
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0042
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0042
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0042
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0042
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0042
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0042
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0042
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0042
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0042
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0042
6559	Cytochrome c oxidase subunit 2	ctaC	0.0042
6669	Cytochrome c oxidase subunit 2	ctaC	0.0042
822	Aldose reductase	AKR1B1	0.0042
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0042
6558	Cytochrome c oxidase subunit 1	ctaD	0.0042
88	Retinoic acid receptor RXR-beta	RXRB	0.0042
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0042
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0041
1630	Integrin beta-2	ITGB2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.004
592	Carbonic anhydrase 4	CA4	0.004
2320	Thymidine kinase, cytosolic	TK1	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
564	Cellular retinoic acid-binding protein 1	CRABP1	0.004
569	Retinal dehydrogenase 2	ALDH1A2	0.004
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.004
2268	Cholesterol oxidase	choB	0.004
2822	Cholesterol oxidase	choA	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0039
319	Opioid receptor, sigma 1	OPRS1	0.0039
2540	Choloylglycine hydrolase	cbh	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
1341	Histamine H3 receptor	HRH3	0.0038
611	Retinal dehydrogenase 1	ALDH1A1	0.0037
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0037
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0037
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0037
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
527	Prostacyclin receptor	PTGIR	0.0036
4486	Phenol 2-hydroxylase component B	pheA2	0.0036
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0036
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0036
5117	Dihydrolipoyl dehydrogenase	lpd	0.0036
4439	Ferredoxin reductase	bphA4	0.0036
6501	Fatty acid-binding protein, liver	FABP1	0.0036
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0036
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0036
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0036
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
4503	NADPH-flavin oxidoreductase	frp	0.0035
340	Apoptotic protease-activating factor 1	APAF1	0.0035
482	Glycine receptor subunit alpha-1	GLRA1	0.0035
5189	Trimethylamine dehydrogenase	tmd	0.0035
4836	Ferredoxin-dependent glutamate synthase 2	gltS	0.0035
672	Prostaglandin F2-alpha receptor	PTGFR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
5126	Arginase	rocF	0.0035
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0035
5122	Mersacidin decarboxylase	mrsD	0.0035
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0035
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0035
526	Thioredoxin reductase	trxB	0.0035
3767	Thioredoxin reductase	trxB	0.0035
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0035
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0035
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0035
5083	Cryptochrome DASH	cry	0.0035
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0035
5115	FkbI	fkbI	0.0035
3133	UDP-galactopyranose mutase	glf	0.0035
5099	UDP-galactopyranose mutase	glf	0.0035
5095	Putidaredoxin reductase	camA	0.0035
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0035
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0035
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0035
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0035
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0035
5081	L-aspartate oxidase	nadB	0.0035
1410	Oxidoreductase	HSD17B6	0.0035
4725	Oxidoreductase	Not Available	0.0035
5124	Oxidoreductase	Not Available	0.0035
5111	Phenylacetone monooxygenase	pamO	0.0035
5109	Outer membrane protein p64k or PM-6	m-6	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1483	Membrane copper amine oxidase	AOC3	0.0035
5201	FMN-binding protein	DvMF_2023	0.0034
5178	Protein nrdI	nrdI	0.0034
3293	Flavodoxin	Not Available	0.0034
4614	Flavodoxin	DVU_2680	0.0034
5172	Flavodoxin	isiB	0.0034
5173	Flavodoxin	isiB	0.0034
5182	Flavodoxin	fldA	0.0034
5198	Flavodoxin-1	fldA	0.0034
5170	Epidermin decarboxylase	epiD	0.0034
5179	Probable aromatic acid decarboxylase	pad1	0.0034
5175	Hypothetical protein SMU.260	SMU_260	0.0034
5202	Nitroreductase family protein	BC_1844	0.0034
5197	Trp repressor binding protein WrbA, putative	DR_A0214	0.0034
2586	Isopentenyl-diphosphate Delta-isomerase	idi	0.0034
5187	Isopentenyl-diphosphate delta-isomerase	fni	0.0034
5199	Isopentenyl-diphosphate delta-isomerase	fni	0.0034
5131	PhzG	phzG	0.0034
5181	Hypothetical protein yhdA	azr	0.0034
5190	Rubredoxin-oxygen oxidoreductase	roo	0.0034
5200	NADH dehydrogenase	nox	0.0034
5191	Morphinone reductase	morB	0.0034
5193	Phenazine biosynthesis protein phzG	phzG	0.0034
4405	Nitric oxide reductase	fprA	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0033
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0033
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0033
6174	50S ribosomal protein L32	rpmF	0.0032
162	Retinoic acid receptor gamma-1	RARG	0.0032
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0032
3102	Flavohemoprotein	hmp	0.0032
4969	Flavohemoprotein	hmp	0.0032
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4440	NADH peroxidase	npr	0.0031
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
666	NADP-dependent malic enzyme	ME1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0031
277	Purine nucleoside phosphorylase	PNP	0.0031
2870	Purine nucleoside phosphorylase	punA	0.0031
2945	Purine nucleoside phosphorylase	punA	0.0031
4659	Purine nucleoside phosphorylase	TM_1596	0.0031
4825	Purine nucleoside phosphorylase	TTHA1435	0.0031
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0031
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0031
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0031
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0031
5332	MtdA bifunctional protein	mtdA	0.0031
5322	Oxidoreductase ydhF	ydhF	0.0031
4403	Protein iolS	iolS	0.0031
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0031
5330	General stress protein 69	yhdN	0.0031
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0031
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0031
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
572	Integrin alpha-L	ITGAL	0.0031
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
5072	N,N-dimethylglycine oxidase	dmg	0.003
6500	Phospholipase A2	PLA2G1B	0.003
408	Riboflavin kinase	RFK	0.003
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.003
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.003
2300	Lysozyme	E	0.003
3633	Lysozyme	R	0.003
5597	Lysozyme	17	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
3594	Deoxyribodipyrimidine photo-lyase	phr	0.003
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.003
5080	Deoxyribodipyrimidine photo-lyase	phr	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.003
2526	NADPH-ferredoxin reductase fprA	fprA	0.003
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.003
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.003
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.003
2470	Pyruvate oxidase	pox5	0.003
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
251	Alcohol dehydrogenase 1A	ADH1A	0.003
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.003
4407	FMN-dependent NADH-azoreductase	azoR	0.003
5169	FMN-dependent NADH-azoreductase	azoR	0.003
5176	YtnJ	moxC	0.003
3680	Dihydroorotate dehydrogenase A	pyrDA	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
5206	Phosphopantothenoylcysteine decarboxylase	PPCDC	0.0029
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0029
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0029
3507	Chorismate synthase	aroC	0.0029
5171	Chorismate synthase	aroC	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
292	Activin receptor type-1	ACVR1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1525	Heparin-binding growth factor 2	FGF2	0.0028
849	Activated CDC42 kinase 1	TNK2	0.0028
126	D-lactate dehydrogenase	dld	0.0028
3545	D-lactate dehydrogenase	Not Available	0.0028
4510	D-lactate dehydrogenase	ldhA	0.0028
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0028
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0028
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0028
2893	Glycine oxidase	thiO	0.0028
634	Squalene monooxygenase	SQLE	0.0027
7196	Squalene monooxygenase	ERG1	0.0027
6608	Serine/threonine-protein kinase Sgk1	SGK1	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
624	Guanidinoacetate N-methyltransferase	GAMT	0.0027
4582	Putative pteridine reductase 2	ptr2	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
2775	Dihydroorotate dehydrogenase	pyrD	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0027
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0027
2286	Isocitrate dehydrogenase [NADP]	icd	0.0027
2302	Isocitrate dehydrogenase [NADP]	icd	0.0027
2771	Isocitrate dehydrogenase [NADP]	icd	0.0027
5328	Prostaglandin F synthase	Tb11.02.2310	0.0027
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0027
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
3446	NADP-dependent alcohol dehydrogenase	adh	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2636	Shikimate dehydrogenase	aroE	0.0027
3515	Shikimate dehydrogenase	aroE	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0027
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0027
989	L-xylulose reductase	DCXR	0.0027
770	Retinoic acid-induced protein 3	GPRC5A	0.0027
719	Retinoic acid receptor responder protein 1	RARRES1	0.0027
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0027
2567	Thymidylate synthase thyX	thyX	0.0026
2823	Trypanothione reductase	TPR	0.0026
1648	Elastin	ELN	0.0026
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
5180	L(+)-mandelate dehydrogenase	mdlB	0.0026
2769	P-hydroxybenzoate hydroxylase	pobA	0.0026
2809	P-hydroxybenzoate hydroxylase	pobA	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
760	Fibroblast growth factor 1	FGF1	0.0025
2021	Thrombomodulin	THBD	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4531	Putative ketoacyl reductase	actIII	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6297	Prostaglandin reductase 1	PTGR1	0.0025
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.0025
2159	Quinone oxidoreductase	CRYZ	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
3062	Aspartate-semialdehyde dehydrogenase	asd	0.0025
1275	Estrogen sulfotransferase	SULT1E1	0.0025
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0024
4226	Uridine phosphorylase 2	UPP2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0024
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0024
2380	Monomeric sarcosine oxidase	soxA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1124	Sepiapterin reductase	SPR	0.0024
2675	Pteridine reductase 1	PTR1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4284	Pentaerythritol tetranitrate reductase	onr	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
6645	D-amino-acid oxidase	DAO	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
6268	Hydroxyacid oxidase 1	HAO1	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
6126	Carbonic anhydrase 7	CA7	0.0023
4225	Uridine phosphorylase 1	UPP1	0.0022
1992	Vitamin D-binding protein	GC	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
5798	Mitogen-activated protein kinase 11	MAPK11	0.0022
6131	Carbonic anhydrase 14	CA14	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
1196	Complement decay-accelerating factor	CD55	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0021
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0021
413	Amidophosphoribosyltransferase	PPAT	0.0021
2515	Amidophosphoribosyltransferase	purF	0.0021
3714	Amidophosphoribosyltransferase	purF	0.0021
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.002
6122	Carbonic anhydrase 3	CA3	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0019
3926	Choline transporter-like protein 2	SLC44A2	0.0019
3925	Choline transporter-like protein 4	SLC44A4	0.0019
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0019
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0019
3927	Choline transporter-like protein 3	SLC44A3	0.0019
1686	Choline transporter-like protein 1	SLC44A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
861	Choline kinase alpha	CHKA	0.0019
769	High-affinity choline transporter 1	SLC5A7	0.0019
700	Choline dehydrogenase, mitochondrial	CHDH	0.0019
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0019
576	Choline O-acetyltransferase	CHAT	0.0019
3922	Phospholipase D2	PLD2	0.0019
3924	Phospholipase D1	PLD1	0.0019
5682	Ribonuclease pancreatic	RNASE1	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
1074	Urokinase-type plasminogen activator	PLAU	0.0019
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0019
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0019
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0019
174	Sigma 1-type opioid receptor	SIGMAR1	0.0019
518	Peroxidase/catalase T	katG	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
1792	Tissue-type plasminogen activator	PLAT	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
3639	Thymidine phosphorylase	deoA	0.0017
3936	Thymidine phosphorylase	TYMP	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
563	Thyroid peroxidase	TPO	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
627	11-cis retinol dehydrogenase	RDH5	0.0016
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0016
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
1243	Cathepsin D	CTSD	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
898	Glutathione S-transferase A3	GSTA3	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
6755	Poliovirus receptor	PVR	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0015
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
899	Glutathione S-transferase Mu 3	GSTM3	0.0015
905	Glutathione transferase omega-1	GSTO1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
1039	Histone deacetylase 9	HDAC9	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
3904	Alanine aminotransferase 2	GPT2	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
3007	Carbonic anhydrase 12	CA12	0.0013
4205	Carbonic anhydrase 9	CA9	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
473	L-lactate dehydrogenase A chain	LDHA	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0012
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1295	Fatty acid synthase	FASN	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
345	Plasma retinol-binding protein	RBP4	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
816	Biliverdin reductase A	BLVRA	0.0007
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0007
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0007
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0006
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0006
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0006
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0006
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0006
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0006
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0006
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0006
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0006
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0006
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0006
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0006
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0006
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0006
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0006
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0006
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0006
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0006
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0006
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0006
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0006
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0006
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0006
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0006
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0006
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0006
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0006
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0006
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0006
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0006
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0006
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0006
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0006
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0006
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0006
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0006
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0006
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0006
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0006
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0006
729	GDP-L-fucose synthetase	TSTA3	0.0006
3463	GDP-L-fucose synthetase	fcl	0.0006
167	L-lactate dehydrogenase C chain	LDHC	0.0006
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0006
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0006
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0006
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0006
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0006
206	3-keto-steroid reductase	HSD17B7	0.0006
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0006
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0006
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0006
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0006
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0006
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0006
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0006
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0006
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0006
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0006
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0006
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0006
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0006
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0006
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0006
34	7-dehydrocholesterol reductase	DHCR7	0.0006
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0006
711	UDP-glucose 6-dehydrogenase	UGDH	0.0006
3672	UDP-glucose 6-dehydrogenase	hasB	0.0006
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0006
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0006
107	C-4 methylsterol oxidase	SC4MOL	0.0006
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0006
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0006
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0006
643	Peroxisomal bifunctional enzyme	EHHADH	0.0006
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0006
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0006
328	Sorbitol dehydrogenase	SORD	0.0006
396	Alcohol dehydrogenase 4	ADH4	0.0006
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0006
597	Dihydropteridine reductase	QDPR	0.0006
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0006
857	Malate dehydrogenase, mitochondrial	MDH2	0.0005
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0005
77	L-lactate dehydrogenase B chain	LDHB	0.0005
12	Alcohol dehydrogenase class 3	ADH5	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6026	Alcohol dehydrogenase 6	ADH6	0.0005
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0005
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0005
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0005
626	Cysteine dioxygenase type 1	CDO1	0.0005
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0005
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0005
3221	Cytochrome c4	cc4	0.0005
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0005
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0005
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0005
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0005
810	Heme oxygenase 1	HMOX1	0.0005
3391	Heme oxygenase 1	pbsA1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
279	Tyrosinase	TYR	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00694 - Daunorubicin

Targets

Enzymes

Transporters

Predictions