DT-Web

DB00655 - Estrone


Identification
Name Estrone
Accession Number DB00655 (APRD00588)
Type small molecule
Description Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 270.3661
Groups approved
Monoisotopic Weight 270.161979948
Pharmacology
Indication For management of perimenopausal and postmenopausal symptoms.
Mechanism of action Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) release from the anterior pituitary.
Absorption 43%
Protein binding > 95%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include nausea and vomiting. Estrogen related side effects include nausea, breast tenderness, fluid retention and edema, headaches and/or migraines, chloasma and poor contact lens fit. Estrogen hormone deficiency is associated with breakthrough bleeding, hypomenorrhea, irritability, depression and menopausal symptoms. Withdrawal bleeds may occur in females.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Fosphenytoin The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estrone.
Griseofulvin The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, estrone.
Phenobarbital The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estrone.
Phenytoin The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estrone.
Prednisolone The estrogenic agent, estrone, may increase the effect of the corticosteroid, prednisolone.
Prednisone The estrogenic agent, estrone, may increase the effect of corticosteroid, prednisone.
Primidone The enzyme inducer, primidone, decreases the effect of the hormone agent, estrone.
Tipranavir Estropipate may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Tipranavir may decrease the serum concentration Estropipate. Monitor for estrogen deficiency during concomitant therapy.
Food Interactions Not Available

Targets


Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Margeat E, Bourdoncle A, Margueron R, Poujol N, Cavailles V, Royer C: Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta. J Mol Biol. 2003 Feb 7;326(1):77-92. - Pubmed
  • Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7663

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4278
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score 0.6444
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. - Pubmed
DTHybrid score 0.972
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2347
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4325
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6376
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3954
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.476
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1613

Transporters


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions inhibitor
References
  • Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed
DTHybrid score 0.2664
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inducer
References
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
  • Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. - Pubmed
DTHybrid score 0.6886
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. - Pubmed
DTHybrid score 0.3244
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Imai Y, Tsukahara S, Asada S, Sugimoto Y: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res. 2004 Jun 15;64(12):4346-52. - Pubmed
  • Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T: Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther. 2003 Jan;2(1):105-12. - Pubmed
  • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. Epub 2003 Apr 7. - Pubmed
  • Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed
  • Miwa M, Tsukahara S, Ishikawa E, Asada S, Imai Y, Sugimoto Y: Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants. Int J Cancer. 2003 Dec 10;107(5):757-63. - Pubmed
  • Imai Y, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res. 2002 Mar;93(3):231-5. - Pubmed
DTHybrid score 0.3868
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A: Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res. 2001 Sep;18(9):1262-9. - Pubmed
DTHybrid score 0.3363

Carriers


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions
References Not Available
DTHybrid score 0.2664
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6886
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.3244
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.3868
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions
References Not Available
DTHybrid score 0.3363

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.4774
4119 Cytochrome P450 2D6 CYP2D6 0.4575
4924 Cytochrome P450 2C8 CYP2C8 0.4373
6107 Cytochrome P450 3A7 CYP3A7 0.2963
6241 Nuclear receptor coactivator 2 NCOA2 0.2336
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2036
5718 Cytochrome P450 2A6 CYP2A6 0.1979
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1746
862 Multidrug resistance-associated protein 1 ABCC1 0.1681
20 Prostaglandin G/H synthase 1 PTGS1 0.1406
1729 Solute carrier family 22 member 6 SLC22A6 0.1328
776 Bile salt export pump ABCB11 0.1284
6142 Solute carrier family 22 member 8 SLC22A8 0.1233
6145 Solute carrier family 22 member 1 SLC22A1 0.1153
869 Estrogen receptor beta ESR2 0.1137
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1119
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1112
3811 Cytochrome P450 19A1 CYP19A1 0.1099
6106 Cytochrome P450 2C18 CYP2C18 0.1075
290 Prostaglandin G/H synthase 2 PTGS2 0.0908
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0859
614 Progesterone receptor PGR 0.0834
2164 Multidrug resistance-associated protein 4 ABCC4 0.083
492 Histamine H1 receptor HRH1 0.0801
6143 Solute carrier family 22 member 7 SLC22A7 0.079
6144 Solute carrier family 22 member 2 SLC22A2 0.0744
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0736
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.072
6141 Sodium/bile acid cotransporter SLC10A1 0.0711
1024 Solute carrier family 22 member 11 SLC22A11 0.0674
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0649
738 Monocarboxylate transporter 1 SLC16A1 0.0631
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0621
824 Sodium-dependent serotonin transporter SLC6A4 0.0619
556 Alpha-1A adrenergic receptor ADRA1A 0.0611
871 Glucocorticoid receptor NR3C1 0.0608
118 Organic cation/carnitine transporter 2 SLC22A5 0.059
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0585
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0579
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0577
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0577
502 5-hydroxytryptamine 2A receptor HTR2A 0.0557
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0556
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0555
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0534
831 D(2) dopamine receptor DRD2 0.0534
6148 Multidrug resistance-associated protein 7 ABCC10 0.053
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0526
817 DNA topoisomerase 2-alpha TOP2A 0.0524
320 5-hydroxytryptamine 1A receptor HTR1A 0.0513
756 Sex hormone-binding globulin SHBG 0.0511
318 Alpha-2A adrenergic receptor ADRA2A 0.0501
731 HIV-1 protease HIV-1 protease 0.0491
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.049
6147 Solute carrier family 22 member 3 SLC22A3 0.0488
3947 Xanthine dehydrogenase/oxidase XDH 0.0477
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0473
6031 Cytochrome P450 3A43 CYP3A43 0.047
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0451
146 Androgen receptor AR 0.0443
3923 Cholinesterase BCHE 0.044
6136 Multidrug resistance-associated protein 5 ABCC5 0.0437
33 Cystine/glutamate transporter SLC7A11 0.0435
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0434
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0413
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0408
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0408
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0403
833 Organic cation/carnitine transporter 1 SLC22A4 0.0401
844 Epidermal growth factor receptor EGFR 0.04
3941 Amine oxidase [flavin-containing] A MAOA 0.0391
6137 Multidrug resistance-associated protein 6 ABCC6 0.0388
341 5-hydroxytryptamine 3 receptor HTR3A 0.0384
23 D(1A) dopamine receptor DRD1 0.0384
847 Mu-type opioid receptor OPRM1 0.0382
260 Cytochrome P450 51 ERG11 0.0378
761 Cytochrome P450 51 ERG11 0.0378
3163 Cytochrome P450 51 cyp51 0.0378
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0377
891 Dihydropteroate synthase folP 0.0374
5359 Dihydropteroate synthase folP 0.0374
7175 Dihydropteroate synthase sulI 0.0374
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0372
6220 Aryl hydrocarbon receptor AHR 0.0371
632 Alpha-1B adrenergic receptor ADRA1B 0.0369
465 Calmodulin CALM1 0.0362
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0356
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0355
4604 Liver carboxylesterase 1 CES1 0.0352
590 5-hydroxytryptamine 2C receptor HTR2C 0.0343
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0338
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0337
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0331
373 Transthyretin TTR 0.0329
70 Type-1 angiotensin II receptor AGTR1 0.0325
885 5-hydroxytryptamine 1B receptor HTR1B 0.0325
36 Insulin receptor INSR 0.0325
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0323
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0323
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0322
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0317
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0317
504 Mast/stem cell growth factor receptor KIT 0.0314
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0312
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0305
713 Sodium-dependent dopamine transporter SLC6A3 0.0305
904 Glutathione S-transferase P GSTP1 0.0305
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0303
467 Delta-type opioid receptor OPRD1 0.0303
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0302
482 Glycine receptor subunit alpha-1 GLRA1 0.0301
1757 Myeloperoxidase MPO 0.03
193 Beta-1 adrenergic receptor ADRB1 0.03
122 P2Y purinoceptor 12 P2RY12 0.0298
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0294
696 Kappa-type opioid receptor OPRK1 0.0293
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0288
766 Beta-2 adrenergic receptor ADRB2 0.0288
380 Cytochrome P450 17A1 CYP17A1 0.0288
3932 Glutathione S-transferase A2 GSTA2 0.0285
725 5-hydroxytryptamine 1D receptor HTR1D 0.0283
6167 Organic solute transporter subunit beta OSTB 0.028
6166 Organic solute transporter subunit alpha OSTA 0.028
3587 Gastrotropin FABP6 0.0276
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0275
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0271
29 Tubulin beta-1 chain TUBB1 0.0269
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0267
85 Growth hormone receptor GHR 0.0266
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0264
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0264
6599 HTH-type transcriptional regulator ttgR ttgR 0.026
777 Tumor necrosis factor TNF 0.0258
789 Alpha-1D adrenergic receptor ADRA1D 0.0257
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0256
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0254
16 Adenosine A1 receptor ADORA1 0.0252
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0251
228 Beta platelet-derived growth factor receptor PDGFRB 0.025
4120 NADPH--cytochrome P450 reductase POR 0.025
6014 Cytochrome P450 2A13 CYP2A13 0.0248
638 D(3) dopamine receptor DRD3 0.0248
84 Nuclear receptor 0B1 NR0B1 0.0246
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0246
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0244
1353 DNA topoisomerase 1 TOP1 0.0242
3552 DNA topoisomerase 1 topA 0.0242
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.024
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0239
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0236
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0236
705 Glutamate receptor 1 GRIA1 0.0236
6182 Cytochrome P450 2J2 CYP2J2 0.0236
6085 Fatty acid-binding protein, intestinal FABP2 0.0234
737 Mineralocorticoid receptor NR3C2 0.0233
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0232
26 Vascular endothelial growth factor receptor 3 FLT4 0.0232
3939 Amine oxidase [flavin-containing] B MAOB 0.0225
1178 Adenosine A2a receptor ADORA2A 0.0224
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0224
407 Vascular endothelial growth factor receptor 2 KDR 0.0224
32 Vascular endothelial growth factor receptor 1 FLT1 0.0222
477 DNA topoisomerase 4 subunit A parC 0.0222
886 DNA topoisomerase 4 subunit A parC 0.0222
6226 DNA topoisomerase 4 subunit A parC 0.0222
629 Alpha-2B adrenergic receptor ADRA2B 0.0218
404 DNA gyrase subunit A gyrA 0.0218
6224 DNA gyrase subunit A gyrA 0.0218
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0216
275 Arachidonate 5-lipoxygenase ALOX5 0.0215
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0212
1010 Cytochrome P450 51A1 CYP51A1 0.0212
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0212
1852 Microtubule-associated protein 2 MAP2 0.0212
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0211
4311 tRNA TRDMT1 0.0211
4325 tRNA trmD 0.0211
4328 tRNA trmD 0.0211
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0207
273 Apoptosis regulator Bcl-2 BCL2 0.0206
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0205
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0205
469 Annexin A1 ANXA1 0.0203
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0203
758 Thyroid hormone receptor alpha THRA 0.0203
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0202
378 Alpha-2C adrenergic receptor ADRA2C 0.02
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.02
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0195
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0195
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0194
244 Angiotensin-converting enzyme ACE 0.0192
6146 High affinity copper uptake protein 1 SLC31A1 0.0192
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0192
811 Translocator protein TSPO 0.0192
537 ATP synthase delta chain, mitochondrial ATP5D 0.0191
908 Glutathione S-transferase theta-1 GSTT1 0.019
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0187
3426 Glutamine synthetase glnA 0.0186
3987 Glutamine synthetase GLUL 0.0186
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0185
6149 Solute carrier family 22 member 10 SLC22A10 0.0185
3810 Catechol O-methyltransferase COMT 0.0183
346 Thyroid hormone receptor beta-1 THRB 0.0181
613 Atrial natriuretic peptide receptor A NPR1 0.0179
1192 Sulfotransferase 1A1 SULT1A1 0.0177
4228 Keratin, type II cytoskeletal 7 KRT7 0.0177
232 Corticosteroid-binding globulin SERPINA6 0.0177
1517 Beta-3 adrenergic receptor ADRB3 0.0177
6020 Aldehyde oxidase AOX1 0.0177
594 Thyroxine-binding globulin SERPINA7 0.0176
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0176
4122 Histone deacetylase 2 HDAC2 0.0174
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0173
672 Prostaglandin F2-alpha receptor PTGFR 0.0171
4203 Histamine N-methyltransferase HNMT 0.0171
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0171
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0171
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
251 Alcohol dehydrogenase 1A ADH1A 0.0169
6163 Copper-transporting ATPase 2 ATP7B 0.0167
6165 Copper-transporting ATPase 1 ATP7A 0.0167
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0167
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0165
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0165
117 Sterol O-acyltransferase 1 SOAT1 0.0164
818 50S ribosomal protein L10 rplJ 0.0163
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0163
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0163
820 Glycine receptor subunit alpha-2 GLRA2 0.0163
284 DNA-directed RNA polymerase beta chain rpoB 0.0162
5773 DNA-directed RNA polymerase beta chain rpoB 0.0162
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0161
444 Alcohol dehydrogenase 1B ADH1B 0.0159
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0158
571 Melatonin receptor type 1A MTNR1A 0.0157
362 Melatonin receptor type 1B MTNR1B 0.0157
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0157
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0156
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0156
4148 Serine/threonine-protein kinase mTOR MTOR 0.0156
6228 Nuclear receptor coactivator 1 NCOA1 0.0155
992 Protein tyrosine kinase 2 beta PTK2B 0.0154
511 5-hydroxytryptamine 1F receptor HTR1F 0.0154
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0154
432 D(4) dopamine receptor DRD4 0.0153
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0151
6102 Arylamine N-acetyltransferase 2 NAT2 0.0148
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0148
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0148
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0148
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0148
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0147
780 Retinoic acid receptor RXR-gamma RXRG 0.0146
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0146
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0146
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0144
517 Alcohol dehydrogenase 1C ADH1C 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0144
183 Vascular endothelial growth factor A VEGFA 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
2539 Tubulin alpha-1 chain TUBA4A 0.0142
2449 Tubulin alpha-3 chain TUBA1A 0.0142
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0142
716 5-hydroxytryptamine 7 receptor HTR7 0.0142
896 Glutathione S-transferase Mu 1 GSTM1 0.0141
5923 Microtubule-associated protein tau MAPT 0.0141
5924 Microtubule-associated protein 4 MAP4 0.0141
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.014
1656 CYP2B protein CYP2B 0.014
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0139
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0139
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0138
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0137
952 Dipeptidyl peptidase 4 DPP4 0.0137
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0136
161 Tubulin beta chain TUBB 0.0135
312 Tubulin beta chain TUB2 0.0135
3809 Estrogen-related receptor gamma ESRRG 0.0134
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0134
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0133
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0132
436 5-hydroxytryptamine 2B receptor HTR2B 0.0132
88 Retinoic acid receptor RXR-beta RXRB 0.0132
124 Histamine H2 receptor HRH2 0.013
7 Nitric oxide synthase, inducible NOS2 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
814 Ryanodine receptor 1 RYR1 0.0128
921 Glutamate receptor 2 GRIA2 0.0126
1714 Mitogen-activated protein kinase 3 MAPK3 0.0126
569 Retinal dehydrogenase 2 ALDH1A2 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0123
823 Fibroblast growth factor receptor 2 FGFR2 0.0123
489 Monocarboxylate transporter 2 SLC16A7 0.0122
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0122
719 Retinoic acid receptor responder protein 1 RARRES1 0.0122
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0122
770 Retinoic acid-induced protein 3 GPRC5A 0.0121
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
94 5-hydroxytryptamine 4 receptor HTR4 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
4237 50S ribosomal protein L22 rplV 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
4192 DNA topoisomerase 2-beta TOP2B 0.0118
1629 Transcription factor AP-1 JUN 0.0116
768 FK506-binding protein 1A FKBP1A 0.0116
48 Pyridoxal kinase PDXK 0.0116
611 Retinal dehydrogenase 1 ALDH1A1 0.0116
295 Carbonic anhydrase 1 CA1 0.0115
4773 Deoxycytidine kinase DCK 0.0115
6151 Monocarboxylate transporter 10 SLC16A10 0.0114
5934 Cytochrome P450 26A1 CYP26A1 0.0114
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0112
936 Ephrin type-A receptor 2 EPHA2 0.0112
500 Monocarboxylate transporter 4 SLC16A3 0.0111
365 Dihydrofolate reductase DHFR 0.011
2381 Dihydrofolate reductase DFR1 0.011
2833 Dihydrofolate reductase Not Available 0.011
2931 Dihydrofolate reductase folA 0.011
3544 Dihydrofolate reductase folA 0.011
3682 Dihydrofolate reductase folA 0.011
6642 Dihydrofolate reductase folA 0.011
6756 Dihydrofolate reductase dfrA 0.011
6043 Putative G-protein coupled receptor 44 GPR44 0.011
427 Substance-P receptor TACR1 0.0109
4238 50S ribosomal protein L4 rplD 0.0109
5578 50S ribosomal protein L4 rplD 0.0109
6173 50S ribosomal protein L4 rplD 0.0109
6219 50S ribosomal protein L4 rplD 0.0109
3917 Methylenetetrahydrofolate reductase MTHFR 0.0108
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0108
1650 Heme carrier protein 1 SLC46A1 0.0107
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0107
2107 Microtubule-associated protein 1A MAP1A 0.0106
174 Sigma 1-type opioid receptor SIGMAR1 0.0106
5880 Thrombopoietin receptor MPL 0.0106
68 Cannabinoid receptor 1 CNR1 0.0106
5787 Angiopoietin-1 receptor TEK 0.0106
4116 Dihydropteroate synthetase Not Available 0.0106
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
239 Coagulation factor X F10 0.0105
162 Retinoic acid receptor gamma-1 RARG 0.0105
2211 Fatty acid-binding protein, heart FABP3 0.0105
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0104
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0104
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0104
1792 Tissue-type plasminogen activator PLAT 0.0104
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0104
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0104
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0104
3830 Calreticulin CALR 0.0104
563 Thyroid peroxidase TPO 0.0103
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0103
4210 Toll-like receptor 4 TLR4 0.0103
165 FL cytokine receptor FLT3 0.0102
24 Thymidylate synthase TMP1 0.0101
359 Thymidylate synthase TYMS 0.0101
2626 Thymidylate synthase thyA 0.0101
2729 Thymidylate synthase thyA 0.0101
5352 Thymidylate synthase THYA 0.0101
199 Monocarboxylate transporter 8 SLC16A2 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0101
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0101
1618 High affinity nerve growth factor receptor NTRK1 0.0101
1063 Signal transducer and activator of transcription 5B STAT5B 0.0101
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0101
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.01
474 Acetylcholinesterase ACHE 0.01
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0099
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0099
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0099
1256 5-hydroxytryptamine 6 receptor HTR6 0.0098
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0098
5650 NimA-related protein DR_0842 0.0098
527 Prostacyclin receptor PTGIR 0.0097
1291 cAMP response element-binding protein CREB1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0097
6035 Nuclear receptor ROR-beta RORB 0.0096
6034 Hydroxyindole O-methyltransferase ASMT 0.0096
6036 Eosinophil peroxidase EPX 0.0096
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0095
592 Carbonic anhydrase 4 CA4 0.0095
566 Serotransferrin TF 0.0094
3856 Fibroblast growth factor receptor 3 FGFR3 0.0094
1569 G1/S-specific cyclin-D1 CCND1 0.0094
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0094
381 Prolactin receptor PRLR 0.0093
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0092
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0091
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0091
6138 Multidrug resistance protein 3 ABCB4 0.0091
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.009
6044 Serum paraoxonase/lactonase 3 PON3 0.009
1630 Integrin beta-2 ITGB2 0.009
976 Platelet glycoprotein IX GP9 0.0089
2236 Casein kinase II subunit alpha CSNK2A1 0.0089
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0088
723 Cytosolic phospholipase A2 PLA2G4A 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0086
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0086
3937 Fatty-acid amide hydrolase FAAH 0.0085
54 Prothrombin F2 0.0085
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0085
153 Dopamine beta-hydroxylase DBH 0.0085
484 Tyrosine-protein kinase ABL2 ABL2 0.0084
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0084
1525 Heparin-binding growth factor 2 FGF2 0.0084
765 Indoleamine 2,3-dioxygenase IDO1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
528 5-hydroxytryptamine 1E receptor HTR1E 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
163 D(1B) dopamine receptor DRD5 0.0082
293 Gamma-glutamyl hydrolase GGH 0.0081
106 Cannabinoid receptor 2 CNR2 0.0081
357 Carbonic anhydrase 2 CA2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
459 Retinoic acid receptor RXR-alpha RXRA 0.0078
860 Nicotinamide N-methyltransferase NNMT 0.0078
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0078
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
699 Nicotinic acid receptor 1 GPR109A 0.0078
928 Nicotinic acid receptor 2 GPR109B 0.0078
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
2178 Metabotropic glutamate receptor 5 GRM5 0.0078
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0077
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0077
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0077
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0077
3957 Adenosine deaminase ADA 0.0076
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0076
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0076
558 Solute carrier family 12 member 1 SLC12A1 0.0076
751 Potassium channel subfamily K member 6 KCNK6 0.0075
268 Adenosine A2b receptor ADORA2B 0.0075
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0075
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0074
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0074
319 Opioid receptor, sigma 1 OPRS1 0.0074
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0073
6126 Carbonic anhydrase 7 CA7 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
1050 Bile salt sulfotransferase SULT2A1 0.0072
6432 Transporter snf 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0071
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0071
6168 Solute carrier family 22 member 16 SLC22A16 0.0071
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0071
3868 Calcineurin subunit B isoform 2 PPP3R2 0.007
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.007
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
2021 Thrombomodulin THBD 0.007
1760 Aminopeptidase N ANPEP 0.0069
6843 Aminopeptidase N pepN 0.0069
1275 Estrogen sulfotransferase SULT1E1 0.0069
49 Endothelin B receptor EDNRB 0.0069
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0069
172 Potassium channel subfamily K member 1 KCNK1 0.0068
2599 Tyrosine-protein kinase HCK HCK 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
6837 Serine/threonine-protein kinase 17B STK17B 0.0067
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0067
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0067
2112 Toll-like receptor 9 TLR9 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
2981 Phospholipase A2, membrane associated PLA2G2A 0.0065
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0065
856 Vitamin D3 receptor VDR 0.0065
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0064
1820 Beta-nerve growth factor NGF 0.0064
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0064
1992 Vitamin D-binding protein GC 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6033 High affinity interleukin-8 receptor A CXCR1 0.0063
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
2183 Fatty acid-binding protein, adipocyte FABP4 0.0063
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.006
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0059
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0058
3382 Glycolipid transfer protein GLTP 0.0058
4103 Proteasome subunit beta type 2 PSMB2 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0058
4102 Proteasome subunit beta type 5 PSMB5 0.0058
4101 Proteasome subunit beta type 1 PSMB1 0.0058
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0058
572 Integrin alpha-L ITGAL 0.0058
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0057
581 Cytochrome P450 2R1 CYP2R1 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0055
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0055
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0055
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0055
267 Plasminogen activator inhibitor 1 SERPINE1 0.0055
131 Synaptic vesicular amine transporter SLC18A2 0.0055
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0055
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0055
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0055
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0055
1374 Natriuretic peptides B NPPB 0.0054
1827 Gap junction alpha-1 protein GJA1 0.0054
1908 Vascular cell adhesion protein 1 VCAM1 0.0054
518 Peroxidase/catalase T katG 0.0054
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0054
1649 Small inducible cytokine A2 CCL2 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
5300 Antigen peptide transporter 1 TAP1 0.0051
164 Histamine H4 receptor HRH4 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
6221 Steroid hormone receptor ERR1 ESRRA 0.005
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
65 Matrix metalloproteinase-9 Not Available 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
2230 Catalase CAT 0.0049
3249 Catalase katA 0.0049
3625 Catalase katA 0.0049
4539 Catalase katA 0.0049
4941 Catalase katB 0.0049
5818 Folate receptor alpha FOLR1 0.0049
714 Glutathione reductase, mitochondrial GSR 0.0048
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0048
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0048
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
1864 RET proto-oncogene RET 0.0048
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0048
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0048
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
226 Gonadotropin-releasing hormone receptor GNRHR 0.0047
822 Aldose reductase AKR1B1 0.0047
291 Nitric-oxide synthase, endothelial NOS3 0.0047
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0047
6824 Tyrosine-protein kinase Lyn LYN 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
3014 Ribonuclease UK114 HRSP12 0.0046
634 Squalene monooxygenase SQLE 0.0046
7196 Squalene monooxygenase ERG1 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
208 DNA-directed RNA polymerase beta' chain rpoC 0.0046
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4217 Telomerase reverse transcriptase TERT 0.0046
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0045
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0043
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0043
6501 Fatty acid-binding protein, liver FABP1 0.0043
6174 50S ribosomal protein L32 rpmF 0.0043
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0042
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0042
760 Fibroblast growth factor 1 FGF1 0.0042
6103 Arylamine N-acetyltransferase 1 NAT1 0.0042
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0042
1648 Elastin ELN 0.0041
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0041
3601 Dihydropteroate synthase 1 folP1 0.0041
3807 Dihydropteroate synthase 1 folP1 0.0041
3808 Dihydropteroate synthase 2 folP2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6100 BDNF/NT-3 growth factors receptor NTRK2 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
4225 Uridine phosphorylase 1 UPP1 0.004
2958 Probable tautomerase ydcE pptA 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
473 L-lactate dehydrogenase A chain LDHA 0.0039
1541 Metalloproteinase mmp20 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2207 Rhodopsin RHO 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
6677 Myelin P2 protein PMP2 0.0038
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0038
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
2216 Fibroblast growth factor receptor 4 FGFR4 0.0037
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
2320 Thymidine kinase, cytosolic TK1 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
3404 Exotoxin A eta 0.0036
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0035
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0035
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0035
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0035
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0035
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0035
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0035
6218 Pannexin-1 PANX1 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
939 50S ribosomal protein L3 rplC 0.0035
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0034
1268 Neuropeptide S receptor NPSR1 0.0034
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0034
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0034
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
229 Retinoic acid receptor beta RARB 0.0034
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0034
730 Retinoic acid receptor alpha RARA 0.0033
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
76 Nitric-oxide synthase, brain NOS1 0.0033
5626 Nucleoside diphosphate kinase B NME2 0.0033
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0033
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0033
707 72 kDa type IV collagenase MMP2 0.0033
331 Retinol-binding protein I, cellular RBP1 0.0032
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1867 Major prion protein PRNP 0.0032
1196 Complement decay-accelerating factor CD55 0.0032
6459 Glycodelin PAEP 0.0032
6131 Carbonic anhydrase 14 CA14 0.0032
3086 Plasmepsin-2 Not Available 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
595 Fibrinogen alpha chain FGA 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
6073 Potassium channel subfamily K member 9 KCNK9 0.0031
6072 Potassium channel subfamily K member 3 KCNK3 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2391 Ferrochelatase hemH 0.0031
6502 Ferrochelatase DKFZp686P18130 0.0031
1591 Ferrochelatase, mitochondrial FECH 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
411 Glycine N-methyltransferase GNMT 0.003
2298 Cytochrome P450-cam camC 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
702 UMP-CMP kinase CMPK1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
6122 Carbonic anhydrase 3 CA3 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
6645 D-amino-acid oxidase DAO 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
6042 Prostaglandin reductase 2 PTGR2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2808 Chloramphenicol acetyltransferase 3 cat3 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
1039 Histone deacetylase 9 HDAC9 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
358 Cystathionine beta-synthase CBS 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0027
1123 Eosinophil cationic protein RNASE3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
2408 Tyrosine-protein kinase SYK SYK 0.0026
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
798 Osteocalcin BGLAP 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
2540 Choloylglycine hydrolase cbh 0.0024
3616 Fatty acid-binding protein, epidermal FABP5 0.0024
5431 Lipid binding protein Not Available 0.0024
5433 UPF0230 protein TM_1468 TM_1468 0.0024
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
6231 Pepsin A PGA3 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
3221 Cytochrome c4 cc4 0.0023
369 Coagulation factor VII F7 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
1313 Lactoylglutathione lyase GLO1 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
2091 Endoplasmin HSP90B1 0.0021
3007 Carbonic anhydrase 12 CA12 0.0021
4205 Carbonic anhydrase 9 CA9 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
627 11-cis retinol dehydrogenase RDH5 0.002
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
283 SEC14-like protein 2 SEC14L2 0.002
1970 Protein kinase C alpha type PRKCA 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
6500 Phospholipase A2 PLA2G1B 0.0019
4992 Cytochrome c peroxidase Not Available 0.0019
857 Malate dehydrogenase, mitochondrial MDH2 0.0019
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1243 Cathepsin D CTSD 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
3233 Bile acid receptor NR1H4 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
6316 ADP-ribosylation factor 1 ARF1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
694 Matrix protein 2 M 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
2802 Endoglucanase G celCCG 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
810 Heme oxygenase 1 HMOX1 0.0011
3391 Heme oxygenase 1 pbsA1 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4386 Hemoglobin-like protein HbN glbN 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0011
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0011
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0011
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0011
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0011
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0011
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0011
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0011
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0011
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0011
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0011
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0011
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0011
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0011
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0011
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0011
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0011
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0011
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0011
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0011
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0011
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0011
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0011
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0011
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0011
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0011
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
2149 Angiogenin ANG 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
3583 6-phosphogluconolactonase pgl 0.001
328 Sorbitol dehydrogenase SORD 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
597 Dihydropteridine reductase QDPR 0.001
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0009
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0009
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0009
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
626 Cysteine dioxygenase type 1 CDO1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0009
12 Alcohol dehydrogenase class 3 ADH5 0.0009
77 L-lactate dehydrogenase B chain LDHB 0.0009
4954 Soluble cytochrome b558 Not Available 0.0009
4943 Cytochrome c6 petJ 0.0009
4916 Cyanoglobin glbN 0.0009
4925 Cytochrome c-type protein SHP shp 0.0009
4947 Bacterial hemoglobin vhb 0.0009
4994 Hemoglobin-like protein HbO glbO 0.0009
4915 Cytochrome c-550 psbV 0.0009
4959 Cytochrome c-550 psbV 0.0009
5216 Cytochrome c-550 psbV 0.0009
4934 Cytochrome c-551 nirM 0.0009
5218 Cytochrome c-551 nirM 0.0009
4984 Neuroglobin NGB 0.0009
4975 Cytochrome c-556 RPA3973 0.0009
5000 HemO hemO 0.0009
4981 Iron-starvation protein PigA pigA 0.0009
4905 Cytochrome c2 Not Available 0.0009
4939 Cytochrome c2 cycA 0.0009
4964 Cytochrome c2 cycA 0.0009
4979 Cytochrome c2 cycA 0.0009
6673 Cytochrome c2 cycA 0.0009
4942 Diheme cytochrome c napB napB 0.0009
4910 Cytoglobin CYGB 0.0009
4936 Cytochrome c2 iso-2 Not Available 0.0009
4998 Hemoglobin-like protein yjbI yjbI 0.0009
4935 Cytochrome c-554 cycA1 0.0009
4909 CooA protein cooA 0.0009
4907 Cytochrome c-L moxG 0.0009
6865 Cytochrome c-L moxG 0.0009
4961 Hemophore HasA hasA 0.0009
4971 Nonaheme cytochrome c hmcA 0.0009
4904 Cytochrome c family protein GSU1996 0.0009
4976 Apocytochrome f petA 0.0009
6407 Apocytochrome f petA 0.0009
4931 Cytochrome P450 167A1 CYP167A1 0.0009
4903 Methyl-accepting chemotaxis protein Tar4 0.0009
4937 Cytochrome oxidase subunit II rcoxA 0.0009
4764 Cytochrome P450 165C4 CYP165C4 0.0009
4972 P450cin cinA 0.0009
4960 Putative cytochrome P450-family protein SCO7417 0.0009
4989 Cytochrome c551 peroxidase ccp 0.0009
5222 Cytochrome c551 peroxidase ccpA 0.0009
4999 Cytochrome P450 165B3 CYP165B3 0.0009
4926 Heme-based aerotactic transducer hemAT hemAT 0.0009
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0009
4922 Cytochrome c, putative SO_4144 0.0009
4993 Hydroxylamine oxidoreductase hao1 0.0009
4952 Catalase/peroxidase katA 0.0009
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0009
3093 Catalase HPII katE 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
1507 Cytochrome c CYCS 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
5579 Carboxypeptidase B CPB1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
279 Tyrosinase TYR 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
654 Flavin reductase BLVRB 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
125 DNA polymerase beta POLB 0.0007
4920 Peroxidase/catalase katG 0.0007
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
5682 Ribonuclease pancreatic RNASE1 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
3291 Cytochrome c-552 cycA 0.0006
4927 Cytochrome c-552 nrfA 0.0006
4938 Cytochrome c-552 cycA 0.0006
4953 Cytochrome c-552 nrfA 0.0006
5217 Cytochrome c-552 cycM 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0006
2701 Nitric oxide synthase oxygenase nos 0.0006
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
5961 Insulin INS 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
693 Hemoglobin subunit beta HBB 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
6524 Protein tonB tonB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
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