DT-Web

DB00398 - Sorafenib


Identification
Name Sorafenib
Accession Number DB00398 (APRD01304, DB07438)
Type small molecule
Description Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 464.825
Groups approved
Monoisotopic Weight 464.08630272
Pharmacology
Indication Sorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.
Mechanism of action Sorafenib interacts with multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß). Several of these kinases are thought to be involved in angiogenesis, thus sorafenib reduces blood flow to the tumor. Sorafenib is unique in targeting the Raf/Mek/Erk pathway. By inhibiting these kinases, genetic transcription involving cell proliferation and angiogenesis is inhibited.
Absorption The mean relative bioavailability is 38-49% for the tablet form, when compared to an oral solution. Sorafenib reached peak plasma levels in 3 hours following oral administration. With a high-fat meal, bioavailability is reduced by 29% compared to administration in the fasted state.
Protein binding 99.5% bound to plasma proteins.
Biotransformation Sorafenib is metabolized primarily in the liver, undergoing oxidative metabolism, mediated by CYP3A4, as well as glucuronidation mediated by UGT1A9. Sorafenib accounts for approximately 70-85% of the circulating analytes in plasma at steady- state. Eight metabolites of sorafenib have been identified, of which five have been detected in plasma. The main circulating metabolite of sorafenib in plasma, the pyridine N-oxide, shows in vitro potency similar to that of sorafenib. This metabolite comprises approximately 9-16% of circulating analytes at steady-state.
Route of elimination Following oral administration of a 100 mg dose of a solution formulation of sorafenib, 96% of the dose was recovered within 14 days, with 77% of the dose excreted in feces, and 19% of the dose excreted in urine as glucuronidated metabolites.
Toxicity The highest dose of sorafenib studied clinically is 800 mg twice daily. The adverse reactions observed at this dose were primarily diarrhea and dermatologic events. No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Carboplatin Sorafenib may enhance the adverse/toxic effect of carboplatin. Concurrent use of sorafenib with carboplatin and placlitaxel in patients with squamous cell lung cancer is contraindicated. The use of this combination in other settings is not specifically contraindicated, but any such use should be approached with added caution.
Etravirine Sorafebib, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Tretinoin The strong CYP2C8 inhibitor, Sorafenib, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Sorafenib is initiated, discontinued to dose changed.
Food Interactions Not Available

Targets


B-Raf proto-oncogene serine/threonine-protein kinase
Name B-Raf proto-oncogene serine/threonine-protein kinase
Gene Name BRAF
Pharmacological action yes
Actions inhibitor
References
  • Flaherty KT: Chemotherapy and targeted therapy combinations in advanced melanoma. Clin Cancer Res. 2006 Apr 1;12(7 Pt 2):2366s-2370s. - Pubmed
  • Haluska FG, Ibrahim N: Therapeutic targets in melanoma: map kinase pathway. Curr Oncol Rep. 2006 Sep;8(5):400-5. - Pubmed
  • Kim S, Yazici YD, Calzada G, Wang ZY, Younes MN, Jasser SA, El-Naggar AK, Myers JN: Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice. Mol Cancer Ther. 2007 Jun;6(6):1785-92. - Pubmed
  • Eisen T, Ahmad T, Flaherty KT, Gore M, Kaye S, Marais R, Gibbens I, Hackett S, James M, Schuchter LM, Nathanson KL, Xia C, Simantov R, Schwartz B, Poulin-Costello M, O'Dwyer PJ, Ratain MJ: Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer. 2006 Sep 4;95(5):581-6. Epub 2006 Aug 1. - Pubmed
  • Lu X, Tang X, Guo W, Ren T, Zhao H: Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. J Surg Oncol. 2010 Sep 1. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1239
RAF proto-oncogene serine/threonine-protein kinase
Name RAF proto-oncogene serine/threonine-protein kinase
Gene Name RAF1
Pharmacological action yes
Actions inhibitor
References
  • Adnane L, Trail PA, Taylor I, Wilhelm SM: Sorafenib (BAY 43-9006, Nexavar((R))), a Dual-Action Inhibitor That Targets RAF/MEK/ERK Pathway in Tumor Cells and Tyrosine Kinases VEGFR/PDGFR in Tumor Vasculature. Methods Enzymol. 2005;407:597-612. - Pubmed
  • Gollob JA, Wilhelm S, Carter C, Kelley SL: Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 2006 Aug;33(4):392-406. - Pubmed
  • Huether A, Hopfner M, Baradari V, Schuppan D, Scherubl H: Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma. Biochem Pharmacol. 2007 May 1;73(9):1308-17. Epub 2007 Jan 5. - Pubmed
  • Cascone T, Gridelli C, Ciardiello F: Combined targeted therapies in non-small cell lung cancer: a winner strategy? Curr Opin Oncol. 2007 Mar;19(2):98-102. - Pubmed
  • Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, Nicolella D, Comunale D, De Vita A, Rossi A: Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist. 2007 Feb;12(2):191-200. - Pubmed
  • Lu X, Tang X, Guo W, Ren T, Zhao H: Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. J Surg Oncol. 2010 Sep 1. - Pubmed
DTHybrid score 0.3403
Vascular endothelial growth factor receptor 3
Name Vascular endothelial growth factor receptor 3
Gene Name FLT4
Pharmacological action yes
Actions antagonist
References
  • Lathia C, Lettieri J, Cihon F, Gallentine M, Radtke M, Sundaresan P: Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics. Cancer Chemother Pharmacol. 2006 May;57(5):685-92. Epub 2005 Aug 25. - Pubmed
  • Adnane L, Trail PA, Taylor I, Wilhelm SM: Sorafenib (BAY 43-9006, Nexavar((R))), a Dual-Action Inhibitor That Targets RAF/MEK/ERK Pathway in Tumor Cells and Tyrosine Kinases VEGFR/PDGFR in Tumor Vasculature. Methods Enzymol. 2005;407:597-612. - Pubmed
  • Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, Nicolella D, Comunale D, De Vita A, Rossi A: Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist. 2007 Feb;12(2):191-200. - Pubmed
  • Strumberg D: Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc). 2005 Dec;41(12):773-84. - Pubmed
  • Reddy GK, Bukowski RM: Sorafenib: recent update on activity as a single agent and in combination with interferon-alpha2 in patients with advanced-stage renal cell carcinoma. Clin Genitourin Cancer. 2006 Mar;4(4):246-8. - Pubmed
DTHybrid score 0.488
Vascular endothelial growth factor receptor 2
Name Vascular endothelial growth factor receptor 2
Gene Name KDR
Pharmacological action yes
Actions antagonist
References
  • Schoffski P, Dumez H, Clement P, Hoeben A, Prenen H, Wolter P, Joniau S, Roskams T, Van Poppel H: Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review. Ann Oncol. 2006 Aug;17(8):1185-96. Epub 2006 Jan 17. - Pubmed
  • Veronese ML, Mosenkis A, Flaherty KT, Gallagher M, Stevenson JP, Townsend RR, O'Dwyer PJ: Mechanisms of hypertension associated with BAY 43-9006. J Clin Oncol. 2006 Mar 20;24(9):1363-9. Epub 2006 Jan 30. - Pubmed
  • Rini BI: Sorafenib. Expert Opin Pharmacother. 2006 Mar;7(4):453-61. - Pubmed
  • Adnane L, Trail PA, Taylor I, Wilhelm SM: Sorafenib (BAY 43-9006, Nexavar((R))), a Dual-Action Inhibitor That Targets RAF/MEK/ERK Pathway in Tumor Cells and Tyrosine Kinases VEGFR/PDGFR in Tumor Vasculature. Methods Enzymol. 2005;407:597-612. - Pubmed
  • Lacouture ME, Desai A, Soltani K, Petronic-Rosic V, Laumann AE, Ratain MJ, Stadler WM: Inflammation of actinic keratoses subsequent to therapy with sorafenib, a multitargeted tyrosine-kinase inhibitor. Clin Exp Dermatol. 2006 Nov;31(6):783-5. Epub 2006 Jul 4. - Pubmed
DTHybrid score 1.6865
FL cytokine receptor
Name FL cytokine receptor
Gene Name FLT3
Pharmacological action yes
Actions antagonist
References
  • Auclair D, Miller D, Yatsula V, Pickett W, Carter C, Chang Y, Zhang X, Wilkie D, Burd A, Shi H, Rocks S, Gedrich R, Abriola L, Vasavada H, Lynch M, Dumas J, Trail PA, Wilhelm SM: Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia. 2007 Mar;21(3):439-45. Epub 2007 Jan 4. - Pubmed
  • Lierman E, Lahortiga I, Van Miegroet H, Mentens N, Marynen P, Cools J: The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. Haematologica. 2007 Jan;92(1):27-34. - Pubmed
DTHybrid score 0.3068
Beta platelet-derived growth factor receptor
Name Beta platelet-derived growth factor receptor
Gene Name PDGFRB
Pharmacological action yes
Actions antagonist
References
  • Gollob JA: Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. Clin Genitourin Cancer. 2005 Dec;4(3):167-74. - Pubmed
  • Guida T, Anaganti S, Provitera L, Gedrich R, Sullivan E, Wilhelm SM, Santoro M, Carlomagno F: Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. - Pubmed
  • Unnithan J, Rini BI: The role of targeted therapy in metastatic renal cell carcinoma. ScientificWorldJournal. 2007 Mar 2;7:800-7. - Pubmed
DTHybrid score 0.4802
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action yes
Actions antagonist
References
  • Guida T, Anaganti S, Provitera L, Gedrich R, Sullivan E, Wilhelm SM, Santoro M, Carlomagno F: Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. - Pubmed
  • Koch CA, Gimm O, Vortmeyer AO, Al-Ali HK, Lamesch P, Ott R, Kluge R, Bierbach U, Tannapfel A: Does the expression of c-kit (CD117) in neuroendocrine tumors represent a target for therapy? Ann N Y Acad Sci. 2006 Aug;1073:517-26. - Pubmed
  • Lierman E, Lahortiga I, Van Miegroet H, Mentens N, Marynen P, Cools J: The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. Haematologica. 2007 Jan;92(1):27-34. - Pubmed
  • Cascone T, Gridelli C, Ciardiello F: Combined targeted therapies in non-small cell lung cancer: a winner strategy? Curr Opin Oncol. 2007 Mar;19(2):98-102. - Pubmed
  • Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006 Dec 15;66(24):11851-8. - Pubmed
DTHybrid score 0.5144
Basic fibroblast growth factor receptor 1
Name Basic fibroblast growth factor receptor 1
Gene Name FGFR1
Pharmacological action yes
Actions inhibitor
References
  • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. - Pubmed
  • Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, Santoro M: BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34. - Pubmed
  • Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov. 2006 Oct;5(10):835-44. - Pubmed
DTHybrid score 1.1346
Proto-oncogene tyrosine-protein kinase receptor ret
Name Proto-oncogene tyrosine-protein kinase receptor ret
Gene Name RET
Pharmacological action yes
Actions inhibitor
References
  • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. - Pubmed
  • Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, Santoro M: BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34. - Pubmed
  • Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov. 2006 Oct;5(10):835-44. - Pubmed
DTHybrid score 0.8404
Vascular endothelial growth factor receptor 1
Name Vascular endothelial growth factor receptor 1
Gene Name FLT1
Pharmacological action yes
Actions inhibitor
References
  • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. - Pubmed
  • Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, Santoro M: BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34. - Pubmed
  • Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov. 2006 Oct;5(10):835-44. - Pubmed
DTHybrid score 0.7683

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.877
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.7304
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.5377
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Gomo C, Coriat R, Faivre L, Mir O, Ropert S, Billemont B, Dauphin A, Tod M, Goldwasser F, Blanchet B: Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2010 Aug 13. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 1.269
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.5418
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.7217
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.7357
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.7455
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ: Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Feb 25. - Pubmed
DTHybrid score 0.7936
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate,inhibitor
References
  • Gomo C, Coriat R, Faivre L, Mir O, Ropert S, Billemont B, Dauphin A, Tod M, Goldwasser F, Blanchet B: Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2010 Aug 13. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Keating GM, Santoro A: Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs. 2009;69(2):223-40. doi: 10.2165/00003495-200969020-00006. - Pubmed
  • FDA label -
DTHybrid score 0.4188
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • FDA label -
DTHybrid score 0.4648

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
  • Lagas JS, van Waterschoot RA, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH: Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26. Epub 2010 Jan 26. - Pubmed
DTHybrid score 0.6191
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
DTHybrid score 0.3251
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
  • Lagas JS, van Waterschoot RA, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH: Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26. Epub 2010 Jan 26. - Pubmed
DTHybrid score 0.9229
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
DTHybrid score 0.4214
RalA-binding protein 1
Name RalA-binding protein 1
Gene Name Not Available
Actions substrate
References
  • Singhal SS, Sehrawat A, Sahu M, Singhal P, Vatsyayan R, Rao Lelsani PC, Yadav S, Awasthi S: Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38. doi: 10.1002/ijc.24767. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
950 Alpha platelet-derived growth factor receptor PDGFRA 0.406
823 Fibroblast growth factor receptor 2 FGFR2 0.3071
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.2882
6013 Cytochrome P450 2E1 CYP2E1 0.2554
587 Serum albumin ALB 0.2352
6024 Cytochrome P450 1A1 CYP1A1 0.2268
20 Prostaglandin G/H synthase 1 PTGS1 0.2117
2599 Tyrosine-protein kinase HCK HCK 0.2089
3856 Fibroblast growth factor receptor 3 FGFR3 0.1946
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.1847
5718 Cytochrome P450 2A6 CYP2A6 0.184
862 Multidrug resistance-associated protein 1 ABCC1 0.1807
5787 Angiopoietin-1 receptor TEK 0.1705
1729 Solute carrier family 22 member 6 SLC22A6 0.1622
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1564
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1463
5798 Mitogen-activated protein kinase 11 MAPK11 0.1436
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1422
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1357
776 Bile salt export pump ABCB11 0.1308
936 Ephrin type-A receptor 2 EPHA2 0.1283
290 Prostaglandin G/H synthase 2 PTGS2 0.1273
2216 Fibroblast growth factor receptor 4 FGFR4 0.1252
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.1236
6142 Solute carrier family 22 member 8 SLC22A8 0.1219
1618 High affinity nerve growth factor receptor NTRK1 0.119
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1157
6106 Cytochrome P450 2C18 CYP2C18 0.1156
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1124
492 Histamine H1 receptor HRH1 0.1043
1898 Cytochrome P450 1B1 CYP1B1 0.1034
6145 Solute carrier family 22 member 1 SLC22A1 0.101
824 Sodium-dependent serotonin transporter SLC6A4 0.0987
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0908
6144 Solute carrier family 22 member 2 SLC22A2 0.0905
1128 Alpha-2-macroglobulin A2M 0.0851
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0824
847 Mu-type opioid receptor OPRM1 0.0799
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0797
3811 Cytochrome P450 19A1 CYP19A1 0.0773
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0768
502 5-hydroxytryptamine 2A receptor HTR2A 0.0749
831 D(2) dopamine receptor DRD2 0.0748
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0709
1144 Hepatocyte growth factor receptor MET 0.0709
6143 Solute carrier family 22 member 7 SLC22A7 0.0706
556 Alpha-1A adrenergic receptor ADRA1A 0.0698
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0686
6824 Tyrosine-protein kinase Lyn LYN 0.0677
467 Delta-type opioid receptor OPRD1 0.0666
6136 Multidrug resistance-associated protein 5 ABCC5 0.0658
696 Kappa-type opioid receptor OPRK1 0.064
118 Organic cation/carnitine transporter 2 SLC22A5 0.0638
136 Estrogen receptor ESR1 0.0612
6148 Multidrug resistance-associated protein 7 ABCC10 0.0603
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0601
766 Beta-2 adrenergic receptor ADRB2 0.0584
817 DNA topoisomerase 2-alpha TOP2A 0.0583
760 Fibroblast growth factor 1 FGF1 0.0572
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0567
731 HIV-1 protease HIV-1 protease 0.0564
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0559
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0559
4604 Liver carboxylesterase 1 CES1 0.0543
6147 Solute carrier family 22 member 3 SLC22A3 0.0539
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.0537
1024 Solute carrier family 22 member 11 SLC22A11 0.0532
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0531
713 Sodium-dependent dopamine transporter SLC6A3 0.053
320 5-hydroxytryptamine 1A receptor HTR1A 0.0529
6031 Cytochrome P450 3A43 CYP3A43 0.0526
318 Alpha-2A adrenergic receptor ADRA2A 0.0522
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0501
6137 Multidrug resistance-associated protein 6 ABCC6 0.05
871 Glucocorticoid receptor NR3C1 0.0497
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0487
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0479
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0474
3810 Catechol O-methyltransferase COMT 0.0474
23 D(1A) dopamine receptor DRD1 0.047
6141 Sodium/bile acid cotransporter SLC10A1 0.0469
3852 Neuropilin-1 NRP1 0.0468
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0467
590 5-hydroxytryptamine 2C receptor HTR2C 0.0467
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0462
632 Alpha-1B adrenergic receptor ADRA1B 0.045
193 Beta-1 adrenergic receptor ADRB1 0.0445
341 5-hydroxytryptamine 3 receptor HTR3A 0.0442
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.044
468 Cytochrome P450 4A11 CYP4A11 0.0435
260 Cytochrome P450 51 ERG11 0.0432
761 Cytochrome P450 51 ERG11 0.0432
3163 Cytochrome P450 51 cyp51 0.0432
617 Muscarinic acetylcholine receptor M2 CHRM2 0.043
3941 Amine oxidase [flavin-containing] A MAOA 0.0429
70 Type-1 angiotensin II receptor AGTR1 0.0422
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0413
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0409
844 Epidermal growth factor receptor EGFR 0.0404
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0402
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0399
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0397
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0393
146 Androgen receptor AR 0.0393
638 D(3) dopamine receptor DRD3 0.0388
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0385
465 Calmodulin CALM1 0.038
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0375
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0372
6182 Cytochrome P450 2J2 CYP2J2 0.0367
3923 Cholinesterase BCHE 0.0366
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0362
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0356
6102 Arylamine N-acetyltransferase 2 NAT2 0.0355
885 5-hydroxytryptamine 1B receptor HTR1B 0.035
477 DNA topoisomerase 4 subunit A parC 0.035
886 DNA topoisomerase 4 subunit A parC 0.035
6226 DNA topoisomerase 4 subunit A parC 0.035
833 Organic cation/carnitine transporter 1 SLC22A4 0.0349
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0348
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0348
404 DNA gyrase subunit A gyrA 0.0344
6224 DNA gyrase subunit A gyrA 0.0344
738 Monocarboxylate transporter 1 SLC16A1 0.0341
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0329
614 Progesterone receptor PGR 0.0327
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0327
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0323
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0315
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0311
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0308
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0308
3939 Amine oxidase [flavin-containing] B MAOB 0.0307
122 P2Y purinoceptor 12 P2RY12 0.0306
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0305
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0299
6220 Aryl hydrocarbon receptor AHR 0.0299
1063 Signal transducer and activator of transcription 5B STAT5B 0.0299
1353 DNA topoisomerase 1 TOP1 0.0297
3552 DNA topoisomerase 1 topA 0.0297
4120 NADPH--cytochrome P450 reductase POR 0.0296
789 Alpha-1D adrenergic receptor ADRA1D 0.0296
725 5-hydroxytryptamine 1D receptor HTR1D 0.0295
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0288
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0286
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0286
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0284
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0279
275 Arachidonate 5-lipoxygenase ALOX5 0.0278
1757 Myeloperoxidase MPO 0.0278
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0276
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0276
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0275
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0272
629 Alpha-2B adrenergic receptor ADRA2B 0.027
6026 Alcohol dehydrogenase 6 ADH6 0.0266
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0263
24 Thymidylate synthase TMP1 0.0262
359 Thymidylate synthase TYMS 0.0262
2626 Thymidylate synthase thyA 0.0262
2729 Thymidylate synthase thyA 0.0262
5352 Thymidylate synthase THYA 0.0262
891 Dihydropteroate synthase folP 0.0261
5359 Dihydropteroate synthase folP 0.0261
7175 Dihydropteroate synthase sulI 0.0261
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.026
36 Insulin receptor INSR 0.0258
756 Sex hormone-binding globulin SHBG 0.0257
484 Tyrosine-protein kinase ABL2 ABL2 0.0255
1864 RET proto-oncogene RET 0.0253
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0252
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0252
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0251
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0248
6085 Fatty acid-binding protein, intestinal FABP2 0.0247
737 Mineralocorticoid receptor NR3C2 0.0245
811 Translocator protein TSPO 0.0244
29 Tubulin beta-1 chain TUBB1 0.0242
378 Alpha-2C adrenergic receptor ADRA2C 0.0241
869 Estrogen receptor beta ESR2 0.0238
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0231
273 Apoptosis regulator Bcl-2 BCL2 0.0229
3947 Xanthine dehydrogenase/oxidase XDH 0.0227
432 D(4) dopamine receptor DRD4 0.0226
161 Tubulin beta chain TUBB 0.0223
312 Tubulin beta chain TUB2 0.0223
380 Cytochrome P450 17A1 CYP17A1 0.0221
5626 Nucleoside diphosphate kinase B NME2 0.022
777 Tumor necrosis factor TNF 0.0219
33 Cystine/glutamate transporter SLC7A11 0.0211
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0206
117 Sterol O-acyltransferase 1 SOAT1 0.0205
1192 Sulfotransferase 1A1 SULT1A1 0.0204
124 Histamine H2 receptor HRH2 0.0203
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0202
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.02
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0199
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0198
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0198
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0198
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0198
818 50S ribosomal protein L10 rplJ 0.0198
6020 Aldehyde oxidase AOX1 0.0196
319 Opioid receptor, sigma 1 OPRS1 0.0195
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0194
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0192
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
436 5-hydroxytryptamine 2B receptor HTR2B 0.0189
952 Dipeptidyl peptidase 4 DPP4 0.0189
5294 Nucleoside diphosphate kinase A NME1 0.0189
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0189
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0189
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0188
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0188
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0187
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0187
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0186
908 Glutathione S-transferase theta-1 GSTT1 0.0185
904 Glutathione S-transferase P GSTP1 0.0183
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
4773 Deoxycytidine kinase DCK 0.0183
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0183
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0183
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0182
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0182
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0182
94 5-hydroxytryptamine 4 receptor HTR4 0.018
1010 Cytochrome P450 51A1 CYP51A1 0.0179
716 5-hydroxytryptamine 7 receptor HTR7 0.0179
5880 Thrombopoietin receptor MPL 0.0178
1656 CYP2B protein CYP2B 0.0177
2539 Tubulin alpha-1 chain TUBA4A 0.0176
373 Transthyretin TTR 0.0172
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0172
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0172
427 Substance-P receptor TACR1 0.017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0169
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0169
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0169
232 Corticosteroid-binding globulin SERPINA6 0.0166
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0165
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0164
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0157
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0153
474 Acetylcholinesterase ACHE 0.0153
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0153
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0153
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0152
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0152
1650 Heme carrier protein 1 SLC46A1 0.0151
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.015
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.015
365 Dihydrofolate reductase DHFR 0.015
2381 Dihydrofolate reductase DFR1 0.015
2833 Dihydrofolate reductase Not Available 0.015
2931 Dihydrofolate reductase folA 0.015
3544 Dihydrofolate reductase folA 0.015
3682 Dihydrofolate reductase folA 0.015
6642 Dihydrofolate reductase folA 0.015
6756 Dihydrofolate reductase dfrA 0.015
1852 Microtubule-associated protein 2 MAP2 0.0149
6014 Cytochrome P450 2A13 CYP2A13 0.0148
723 Cytosolic phospholipase A2 PLA2G4A 0.0148
1050 Bile salt sulfotransferase SULT2A1 0.0145
4122 Histone deacetylase 2 HDAC2 0.0144
6146 High affinity copper uptake protein 1 SLC31A1 0.0143
174 Sigma 1-type opioid receptor SIGMAR1 0.0143
3809 Estrogen-related receptor gamma ESRRG 0.0143
163 D(1B) dopamine receptor DRD5 0.0142
131 Synaptic vesicular amine transporter SLC18A2 0.0139
3917 Methylenetetrahydrofolate reductase MTHFR 0.0139
1178 Adenosine A2a receptor ADORA2A 0.0138
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0136
1630 Integrin beta-2 ITGB2 0.0135
1648 Elastin ELN 0.0135
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0135
5923 Microtubule-associated protein tau MAPT 0.0134
5924 Microtubule-associated protein 4 MAP4 0.0134
16 Adenosine A1 receptor ADORA1 0.0134
469 Annexin A1 ANXA1 0.0133
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0133
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0133
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0132
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0131
489 Monocarboxylate transporter 2 SLC16A7 0.0131
2808 Chloramphenicol acetyltransferase 3 cat3 0.013
54 Prothrombin F2 0.0129
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
6044 Serum paraoxonase/lactonase 3 PON3 0.0127
1256 5-hydroxytryptamine 6 receptor HTR6 0.0127
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0126
2981 Phospholipase A2, membrane associated PLA2G2A 0.0126
4192 DNA topoisomerase 2-beta TOP2B 0.0125
705 Glutamate receptor 1 GRIA1 0.0125
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0124
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0124
1629 Transcription factor AP-1 JUN 0.0123
6043 Putative G-protein coupled receptor 44 GPR44 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0122
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0122
992 Protein tyrosine kinase 2 beta PTK2B 0.0121
6599 HTH-type transcriptional regulator ttgR ttgR 0.0121
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
6167 Organic solute transporter subunit beta OSTB 0.0118
6166 Organic solute transporter subunit alpha OSTA 0.0118
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0116
1275 Estrogen sulfotransferase SULT1E1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0115
5300 Antigen peptide transporter 1 TAP1 0.0114
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0114
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0114
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0114
921 Glutamate receptor 2 GRIA2 0.0113
6103 Arylamine N-acetyltransferase 1 NAT1 0.0113
2021 Thrombomodulin THBD 0.0113
482 Glycine receptor subunit alpha-1 GLRA1 0.0113
6149 Solute carrier family 22 member 10 SLC22A10 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
295 Carbonic anhydrase 1 CA1 0.0111
284 DNA-directed RNA polymerase beta chain rpoB 0.0111
5773 DNA-directed RNA polymerase beta chain rpoB 0.0111
1760 Aminopeptidase N ANPEP 0.011
6843 Aminopeptidase N pepN 0.011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.011
528 5-hydroxytryptamine 1E receptor HTR1E 0.011
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
84 Nuclear receptor 0B1 NR0B1 0.0109
896 Glutathione S-transferase Mu 1 GSTM1 0.0109
6163 Copper-transporting ATPase 2 ATP7B 0.0108
6165 Copper-transporting ATPase 1 ATP7A 0.0108
239 Coagulation factor X F10 0.0108
2443 Azurin azu 0.0108
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0107
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0107
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0106
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
4237 50S ribosomal protein L22 rplV 0.0106
267 Plasminogen activator inhibitor 1 SERPINE1 0.0105
293 Gamma-glutamyl hydrolase GGH 0.0105
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0103
511 5-hydroxytryptamine 1F receptor HTR1F 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0101
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.01
768 FK506-binding protein 1A FKBP1A 0.01
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
4116 Dihydropteroate synthetase Not Available 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
6221 Steroid hormone receptor ERR1 ESRRA 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
183 Vascular endothelial growth factor A VEGFA 0.0097
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0096
4203 Histamine N-methyltransferase HNMT 0.0096
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0096
459 Retinoic acid receptor RXR-alpha RXRA 0.0096
49 Endothelin B receptor EDNRB 0.0096
3932 Glutathione S-transferase A2 GSTA2 0.0095
4238 50S ribosomal protein L4 rplD 0.0094
5578 50S ribosomal protein L4 rplD 0.0094
6173 50S ribosomal protein L4 rplD 0.0094
6219 50S ribosomal protein L4 rplD 0.0094
3957 Adenosine deaminase ADA 0.0094
68 Cannabinoid receptor 1 CNR1 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0093
2449 Tubulin alpha-3 chain TUBA1A 0.0093
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0092
572 Integrin alpha-L ITGAL 0.0092
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0091
578 Endothelin-1 receptor EDNRA 0.009
814 Ryanodine receptor 1 RYR1 0.009
6042 Prostaglandin reductase 2 PTGR2 0.0089
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0089
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0089
1517 Beta-3 adrenergic receptor ADRB3 0.0089
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0089
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0088
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0088
702 UMP-CMP kinase CMPK1 0.0087
357 Carbonic anhydrase 2 CA2 0.0086
3937 Fatty-acid amide hydrolase FAAH 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
7 Nitric oxide synthase, inducible NOS2 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
4217 Telomerase reverse transcriptase TERT 0.0084
6500 Phospholipase A2 PLA2G1B 0.0083
1313 Lactoylglutathione lyase GLO1 0.0082
6432 Transporter snf 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0081
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0081
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
1196 Complement decay-accelerating factor CD55 0.008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0079
780 Retinoic acid receptor RXR-gamma RXRG 0.0079
4311 tRNA TRDMT1 0.0079
4325 tRNA trmD 0.0079
4328 tRNA trmD 0.0079
173 Toll-like receptor 7 TLR7 0.0079
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0078
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0078
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0078
1792 Tissue-type plasminogen activator PLAT 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
718 Folate receptor gamma FOLR3 0.0075
299 Folate receptor beta FOLR2 0.0075
804 Mitochondrial folate transporter/carrier SLC25A32 0.0075
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
558 Solute carrier family 12 member 1 SLC12A1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1541 Metalloproteinase mmp20 0.0074
6033 High affinity interleukin-8 receptor A CXCR1 0.0074
976 Platelet glycoprotein IX GP9 0.0074
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
4226 Uridine phosphorylase 2 UPP2 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
518 Peroxidase/catalase T katG 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.007
3587 Gastrotropin FABP6 0.007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0068
162 Retinoic acid receptor gamma-1 RARG 0.0068
6171 Solute carrier family 28 member 3 SLC28A3 0.0068
3086 Plasmepsin-2 Not Available 0.0068
106 Cannabinoid receptor 2 CNR2 0.0068
563 Thyroid peroxidase TPO 0.0067
1483 Membrane copper amine oxidase AOC3 0.0067
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
1039 Histone deacetylase 9 HDAC9 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
4225 Uridine phosphorylase 1 UPP1 0.0066
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0066
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
3639 Thymidine phosphorylase deoA 0.0065
3936 Thymidine phosphorylase TYMP 0.0065
2320 Thymidine kinase, cytosolic TK1 0.0065
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0063
5482 Sialidase-2 NEU2 0.0062
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0062
3270 Elongation factor G fusA 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
413 Amidophosphoribosyltransferase PPAT 0.0062
2515 Amidophosphoribosyltransferase purF 0.0062
3714 Amidophosphoribosyltransferase purF 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6126 Carbonic anhydrase 7 CA7 0.006
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
2232 Interleukin-5 IL5 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
1593 Mucin-2 MUC2 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
6218 Pannexin-1 PANX1 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0058
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0058
5934 Cytochrome P450 26A1 CYP26A1 0.0057
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
751 Potassium channel subfamily K member 6 KCNK6 0.0056
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0055
714 Glutathione reductase, mitochondrial GSR 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
6837 Serine/threonine-protein kinase 17B STK17B 0.0054
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0054
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
4760 Mll3241 protein mll3241 0.0052
1992 Vitamin D-binding protein GC 0.0052
712 Tubulin alpha chain TUB1 0.0052
172 Potassium channel subfamily K member 1 KCNK1 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0049
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
4692 A/G-specific adenine glycosylase mutY 0.0047
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
527 Prostacyclin receptor PTGIR 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
5818 Folate receptor alpha FOLR1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6212 Tubulin gamma-1 chain TUBG1 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0043
291 Nitric-oxide synthase, endothelial NOS3 0.0043
569 Retinal dehydrogenase 2 ALDH1A2 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0041
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0041
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0041
164 Histamine H4 receptor HRH4 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
730 Retinoic acid receptor alpha RARA 0.004
611 Retinal dehydrogenase 1 ALDH1A1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0039
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0039
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0039
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0037
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0037
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0037
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0036
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0036
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0036
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0036
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0036
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
2091 Endoplasmin HSP90B1 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
645 Penicillin-binding protein 1A mrcA 0.0035
5805 Penicillin-binding protein 1A ponA 0.0035
6185 Penicillin-binding protein 1A mrcA 0.0035
6799 Penicillin-binding protein 1A pbpA 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0034
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
340 Apoptotic protease-activating factor 1 APAF1 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0032
2391 Ferrochelatase hemH 0.0032
6502 Ferrochelatase DKFZp686P18130 0.0032
1591 Ferrochelatase, mitochondrial FECH 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
207 Glutathione synthetase GSS 0.0029
5269 Glutathione synthetase gshB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
1360 Sphingomyelin phosphodiesterase SMPD1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
76 Nitric-oxide synthase, brain NOS1 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0028
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0028
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0028
6493 Cytochrome c oxidase subunit 6C COX6C 0.0028
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0028
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0028
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0028
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0028
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0028
6559 Cytochrome c oxidase subunit 2 ctaC 0.0028
6669 Cytochrome c oxidase subunit 2 ctaC 0.0028
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0028
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0028
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0028
6558 Cytochrome c oxidase subunit 1 ctaD 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4041 Microsomal glutathione S-transferase 2 MGST2 0.0027
2207 Rhodopsin RHO 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
6859 Protein S100-A4 S100A4 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6501 Fatty acid-binding protein, liver FABP1 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1341 Histamine H3 receptor HRH3 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
3404 Exotoxin A eta 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
298 Renin REN 0.0021
4031 Glutathione S-transferase A1 GSTA1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
4034 Glutaredoxin-1 GLRX 0.002
4043 Glutaredoxin-2, mitochondrial GLRX2 0.002
910 Epididymal secretory glutathione peroxidase GPX5 0.002
903 Glutathione S-transferase A5 GSTA5 0.002
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.002
4037 Hypothetical protein GPX1 0.002
4297 Hypothetical protein SP_1951 0.002
4521 Hypothetical protein BC_2969 0.002
4540 Hypothetical protein TM_1070 0.002
4555 Hypothetical protein MT1739 0.002
4569 Hypothetical protein mshD 0.002
4578 Hypothetical protein PA3270 0.002
4747 Hypothetical protein PA3967 0.002
5177 Hypothetical protein TM_0096 0.002
5194 Hypothetical protein PA1204 0.002
5240 Hypothetical protein Rv2991 0.002
5370 Hypothetical protein TM_1158 0.002
5710 Hypothetical protein Tb927.5.1360 0.002
1928 Leukotriene C4 synthase LTC4S 0.002
4029 Microsomal glutathione S-transferase 3 MGST3 0.002
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.002
4032 Microsomal glutathione S-transferase 1 MGST1 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
4036 Glutathione peroxidase 6 GPX6 0.002
911 Glutathione peroxidase 3 GPX3 0.002
4040 Glutathione peroxidase 7 GPX7 0.002
907 Glutathione peroxidase 2 GPX2 0.002
906 Glutathione peroxidase 1 GPX1 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
4035 Glutathione S-transferase Mu 5 GSTM5 0.002
900 Glutathione S-transferase A4 GSTA4 0.002
5431 Lipid binding protein Not Available 0.002
4042 Glutathione transferase omega-2 GSTO2 0.002
4038 Glutathione peroxidase 4 GPX4 0.002
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.002
4033 S-formylglutathione hydrolase ESD 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
2922 Glycerol kinase glpK 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
3319 Hydroxyacylglutathione hydrolase HAGH 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
898 Glutathione S-transferase A3 GSTA3 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
897 Glutathione S-transferase kappa 1 GSTK1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
909 Maleylacetoacetate isomerase GSTZ1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
899 Glutathione S-transferase Mu 3 GSTM3 0.0017
905 Glutathione transferase omega-1 GSTO1 0.0017
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
3669 Ribokinase rbsK 0.0017
1881 Hexokinase-1 HK1 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
788 Creatine kinase M-type CKM 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2165 Glutathione S-transferase Mu 2 GSTM2 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0015
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
901 Glutathione S-transferase Mu 4 GSTM4 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
48 Pyridoxal kinase PDXK 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
2251 Thymidylate kinase tmk 0.0014
2254 Thymidylate kinase DTYMK 0.0014
3522 Thymidylate kinase tmk 0.0014
3221 Cytochrome c4 cc4 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
5682 Ribonuclease pancreatic RNASE1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
2298 Cytochrome P450-cam camC 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
798 Osteocalcin BGLAP 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
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