DT-Web: DB01028

Identification

Name

Methoxyflurane

Accession Number

DB01028 (APRD00744)

Type

small molecule

Description

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Anesthetics, Inhalation

Molecular Weight

164.966

Groups

approved

Monoisotopic Weight

163.960726574

Pharmacology

Indication

For use in the induction and maintenance of general anesthesia

Mechanism of action

Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Hepatic.

Route of elimination

Not Available

Toxicity

LD₅₀=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Demeclocycline	The tetracycline, demeclocycline, may increase the renal toxicity of methoxyflurane.
Minocycline	The tetracycline, minocycline, may increase the renal toxicity of methoxyflurane.
Phenobarbital	The barbiturate, phenobarbital, increases the renal toxicity of methoxyflurane.
Primidone	The barbiturate, primidone, increases the renal toxicity of methoxyflurane.
Tetracycline	Tetracycline may increase the renal toxicity of methoxyflurane.

Food Interactions

Not Available

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Moody EJ, Suzdak PD, Paul SM, Skolnick P: Modulation of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J Neurochem. 1988 Nov;51(5):1386-93. - Pubmed Moody EJ, Skolnick P: The imidazobenzodiazepine Ro 15-4513 antagonizes methoxyflurane anesthesia. Life Sci. 1988;43(16):1269-76. - Pubmed Krasowski MD, Harrison NL: The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol. 2000 Feb;129(4):731-43. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5358
Glutamate receptor 1
Name	Glutamate receptor 1
Gene Name	GRIA1
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Martin DC, Plagenhoef M, Abraham J, Dennison RL, Aronstam RS: Volatile anesthetics and glutamate activation of N-methyl-D-aspartate receptors. Biochem Pharmacol. 1995 Mar 15;49(6):809-17. - Pubmed
DTHybrid score	0.6465
Glycine receptor subunit alpha-1
Name	Glycine receptor subunit alpha-1
Gene Name	GLRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Krasowski MD, Harrison NL: The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol. 2000 Feb;129(4):731-43. - Pubmed
DTHybrid score	0.61
Calcium-transporting ATPase type 2C member 1
Name	Calcium-transporting ATPase type 2C member 1
Gene Name	ATP2C1
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lopez MM, Kosk-Kosicka D: How do volatile anesthetics inhibit Ca(2+)-ATPases? J Biol Chem. 1995 Nov 24;270(47):28239-45. - Pubmed
DTHybrid score	0.6437
Potassium voltage-gated channel subfamily A member 1
Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Pharmacological action	yes
Actions	inducer
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Elliott JR, Elliott AA, Harper AA, Winpenny JP: Effects of general anaesthetics on neuronal sodium and potassium channels. Gen Pharmacol. 1992 Nov;23(6):1005-11. - Pubmed
DTHybrid score	0.5704
ATP synthase delta chain, mitochondrial
Name	ATP synthase delta chain, mitochondrial
Gene Name	ATP5D
Pharmacological action	unknown
Actions	unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6106
NADH-ubiquinone oxidoreductase chain 1
Name	NADH-ubiquinone oxidoreductase chain 1
Gene Name	MT-ND1
Pharmacological action	unknown
Actions	unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.5518

Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5586
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5019
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4464
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4948
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5315
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5512
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7466

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.3401
587	Serum albumin	ALB	0.2997
4924	Cytochrome P450 2C8	CYP2C8	0.2579
1588	Multidrug resistance protein 1	ABCB1	0.2262
4118	Cytochrome P450 3A5	CYP3A5	0.2254
6024	Cytochrome P450 1A1	CYP1A1	0.1645
6107	Cytochrome P450 3A7	CYP3A7	0.1488
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.1292
465	Calmodulin	CALM1	0.117
20	Prostaglandin G/H synthase 1	PTGS1	0.0979
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0979
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0967
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0935
492	Histamine H1 receptor	HRH1	0.0841
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0738
824	Sodium-dependent serotonin transporter	SLC6A4	0.0709
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0706
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0697
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0696
6106	Cytochrome P450 2C18	CYP2C18	0.0666
3811	Cytochrome P450 19A1	CYP19A1	0.0633
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0599
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0596
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.059
556	Alpha-1A adrenergic receptor	ADRA1A	0.057
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0556
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0552
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0536
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0534
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0534
831	D(2) dopamine receptor	DRD2	0.053
820	Glycine receptor subunit alpha-2	GLRA2	0.0525
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0515
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0509
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0507
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0507
1268	Neuropeptide S receptor	NPSR1	0.0507
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0485
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0479
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0476
318	Alpha-2A adrenergic receptor	ADRA2A	0.0475
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0465
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0465
290	Prostaglandin G/H synthase 2	PTGS2	0.0462
1108	Calpastatin	CAST	0.0448
1089	Cartilage oligomeric matrix protein	COMP	0.0448
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0446
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0445
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0438
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0433
921	Glutamate receptor 2	GRIA2	0.0429
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0425
1898	Cytochrome P450 1B1	CYP1B1	0.0422
862	Multidrug resistance-associated protein 1	ABCC1	0.0417
1729	Solute carrier family 22 member 6	SLC22A6	0.0416
713	Sodium-dependent dopamine transporter	SLC6A3	0.0411
6145	Solute carrier family 22 member 1	SLC22A1	0.041
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0408
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0408
6073	Potassium channel subfamily K member 9	KCNK9	0.0397
6072	Potassium channel subfamily K member 3	KCNK3	0.0397
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0396
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0395
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0395
468	Cytochrome P450 4A11	CYP4A11	0.0394
766	Beta-2 adrenergic receptor	ADRB2	0.0392
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0386
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0382
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.038
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.038
23	D(1A) dopamine receptor	DRD1	0.038
461	Glycine receptor subunit alpha-3	GLRA3	0.0379
6144	Solute carrier family 22 member 2	SLC22A2	0.0373
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0364
118	Organic cation/carnitine transporter 2	SLC22A5	0.0362
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0361
320	5-hydroxytryptamine 1A receptor	HTR1A	0.036
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0356
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0355
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0355
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0355
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0351
136	Estrogen receptor	ESR1	0.0351
5469	Head decoration protein	shp	0.035
3941	Amine oxidase [flavin-containing] A	MAOA	0.035
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0345
62	Glycine receptor subunit beta	GLRB	0.0341
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0334
811	Translocator protein	TSPO	0.033
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0315
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0313
847	Mu-type opioid receptor	OPRM1	0.0309
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0309
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0305
776	Bile salt export pump	ABCB11	0.0304
260	Cytochrome P450 51	ERG11	0.0301
761	Cytochrome P450 51	ERG11	0.0301
3163	Cytochrome P450 51	cyp51	0.0301
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0301
193	Beta-1 adrenergic receptor	ADRB1	0.0297
632	Alpha-1B adrenergic receptor	ADRA1B	0.0295
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0295
6048	Troponin C, skeletal muscle	TNNC2	0.0291
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.029
2132	Protein S100-B	S100B	0.0282
467	Delta-type opioid receptor	OPRD1	0.0275
731	HIV-1 protease	HIV-1 protease	0.0273
3939	Amine oxidase [flavin-containing] B	MAOB	0.0272
2207	Rhodopsin	RHO	0.027
696	Kappa-type opioid receptor	OPRK1	0.0263
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0262
36	Insulin receptor	INSR	0.0258
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0251
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.025
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0248
871	Glucocorticoid receptor	NR3C1	0.0247
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0246
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0244
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0242
6147	Solute carrier family 22 member 3	SLC22A3	0.0239
817	DNA topoisomerase 2-alpha	TOP2A	0.0238
2164	Multidrug resistance-associated protein 4	ABCC4	0.0234
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0234
789	Alpha-1D adrenergic receptor	ADRA1D	0.023
891	Dihydropteroate synthase	folP	0.023
5359	Dihydropteroate synthase	folP	0.023
7175	Dihydropteroate synthase	sulI	0.023
6014	Cytochrome P450 2A13	CYP2A13	0.0226
251	Alcohol dehydrogenase 1A	ADH1A	0.0226
6031	Cytochrome P450 3A43	CYP3A43	0.0226
638	D(3) dopamine receptor	DRD3	0.0224
629	Alpha-2B adrenergic receptor	ADRA2B	0.0224
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0217
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0217
122	P2Y purinoceptor 12	P2RY12	0.021
2981	Phospholipase A2, membrane associated	PLA2G2A	0.021
6151	Monocarboxylate transporter 10	SLC16A10	0.0209
6142	Solute carrier family 22 member 8	SLC22A8	0.0208
444	Alcohol dehydrogenase 1B	ADH1B	0.0207
833	Organic cation/carnitine transporter 1	SLC22A4	0.0206
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0205
3923	Cholinesterase	BCHE	0.0204
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0201
6143	Solute carrier family 22 member 7	SLC22A7	0.0198
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.019
6102	Arylamine N-acetyltransferase 2	NAT2	0.0187
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0186
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0186
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0177
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0174
517	Alcohol dehydrogenase 1C	ADH1C	0.0173
378	Alpha-2C adrenergic receptor	ADRA2C	0.0171
16	Adenosine A1 receptor	ADORA1	0.0167
477	DNA topoisomerase 4 subunit A	parC	0.0165
886	DNA topoisomerase 4 subunit A	parC	0.0165
6226	DNA topoisomerase 4 subunit A	parC	0.0165
432	D(4) dopamine receptor	DRD4	0.0164
404	DNA gyrase subunit A	gyrA	0.0163
6224	DNA gyrase subunit A	gyrA	0.0163
6220	Aryl hydrocarbon receptor	AHR	0.0161
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0157
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0156
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0155
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0155
94	5-hydroxytryptamine 4 receptor	HTR4	0.0152
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0151
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0147
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0142
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0141
1178	Adenosine A2a receptor	ADORA2A	0.014
3947	Xanthine dehydrogenase/oxidase	XDH	0.0137
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0135
777	Tumor necrosis factor	TNF	0.0135
6020	Aldehyde oxidase	AOX1	0.0135
716	5-hydroxytryptamine 7 receptor	HTR7	0.0134
4604	Liver carboxylesterase 1	CES1	0.0132
6136	Multidrug resistance-associated protein 5	ABCC5	0.0131
1010	Cytochrome P450 51A1	CYP51A1	0.0131
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0127
232	Corticosteroid-binding globulin	SERPINA6	0.0125
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0124
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0124
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0124
869	Estrogen receptor beta	ESR2	0.0123
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0123
592	Carbonic anhydrase 4	CA4	0.0123
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0123
818	50S ribosomal protein L10	rplJ	0.0121
1757	Myeloperoxidase	MPO	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0118
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0118
146	Androgen receptor	AR	0.0118
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0117
380	Cytochrome P450 17A1	CYP17A1	0.0117
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0115
1024	Solute carrier family 22 member 11	SLC22A11	0.0114
6182	Cytochrome P450 2J2	CYP2J2	0.0114
474	Acetylcholinesterase	ACHE	0.0113
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0113
3426	Glutamine synthetase	glnA	0.0113
3987	Glutamine synthetase	GLUL	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
2230	Catalase	CAT	0.0112
3249	Catalase	katA	0.0112
3625	Catalase	katA	0.0112
4539	Catalase	katA	0.0112
4941	Catalase	katB	0.0112
70	Type-1 angiotensin II receptor	AGTR1	0.0112
174	Sigma 1-type opioid receptor	SIGMAR1	0.0111
295	Carbonic anhydrase 1	CA1	0.011
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.011
504	Mast/stem cell growth factor receptor	KIT	0.011
131	Synaptic vesicular amine transporter	SLC18A2	0.0109
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0109
163	D(1B) dopamine receptor	DRD5	0.0108
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0108
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0107
1656	CYP2B protein	CYP2B	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0105
3810	Catechol O-methyltransferase	COMT	0.0105
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0104
563	Thyroid peroxidase	TPO	0.0103
4120	NADPH--cytochrome P450 reductase	POR	0.0103
1618	High affinity nerve growth factor receptor	NTRK1	0.0102
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
6148	Multidrug resistance-associated protein 7	ABCC10	0.0101
4237	50S ribosomal protein L22	rplV	0.01
614	Progesterone receptor	PGR	0.0099
4122	Histone deacetylase 2	HDAC2	0.0098
124	Histamine H2 receptor	HRH2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
275	Arachidonate 5-lipoxygenase	ALOX5	0.0096
3932	Glutathione S-transferase A2	GSTA2	0.0095
6137	Multidrug resistance-associated protein 6	ABCC6	0.0095
161	Tubulin beta chain	TUBB	0.0094
312	Tubulin beta chain	TUB2	0.0094
365	Dihydrofolate reductase	DHFR	0.0094
2381	Dihydrofolate reductase	DFR1	0.0094
2833	Dihydrofolate reductase	Not Available	0.0094
2931	Dihydrofolate reductase	folA	0.0094
3544	Dihydrofolate reductase	folA	0.0094
3682	Dihydrofolate reductase	folA	0.0094
6642	Dihydrofolate reductase	folA	0.0094
6756	Dihydrofolate reductase	dfrA	0.0094
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0093
844	Epidermal growth factor receptor	EGFR	0.0093
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0093
518	Peroxidase/catalase T	katG	0.0093
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0092
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0092
172	Potassium channel subfamily K member 1	KCNK1	0.0092
357	Carbonic anhydrase 2	CA2	0.0091
571	Melatonin receptor type 1A	MTNR1A	0.009
362	Melatonin receptor type 1B	MTNR1B	0.009
4238	50S ribosomal protein L4	rplD	0.0088
5578	50S ribosomal protein L4	rplD	0.0088
6173	50S ribosomal protein L4	rplD	0.0088
6219	50S ribosomal protein L4	rplD	0.0088
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0088
373	Transthyretin	TTR	0.0087
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0086
407	Vascular endothelial growth factor receptor 2	KDR	0.0085
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0084
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0083
1192	Sulfotransferase 1A1	SULT1A1	0.0083
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0083
29	Tubulin beta-1 chain	TUBB1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
3937	Fatty-acid amide hydrolase	FAAH	0.008
756	Sex hormone-binding globulin	SHBG	0.0079
173	Toll-like receptor 7	TLR7	0.0079
427	Substance-P receptor	TACR1	0.0077
6141	Sodium/bile acid cotransporter	SLC10A1	0.0077
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0077
68	Cannabinoid receptor 1	CNR1	0.0075
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0075
284	DNA-directed RNA polymerase beta chain	rpoB	0.0075
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0075
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0072
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0072
26	Vascular endothelial growth factor receptor 3	FLT4	0.0072
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0072
1275	Estrogen sulfotransferase	SULT1E1	0.0071
738	Monocarboxylate transporter 1	SLC16A1	0.0071
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
6126	Carbonic anhydrase 7	CA7	0.007
49	Endothelin B receptor	EDNRB	0.0069
32	Vascular endothelial growth factor receptor 1	FLT1	0.0069
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0069
84	Nuclear receptor 0B1	NR0B1	0.0068
952	Dipeptidyl peptidase 4	DPP4	0.0068
6432	Transporter	snf	0.0068
1636	Trace amine-associated receptor 1	TAAR1	0.0067
153	Dopamine beta-hydroxylase	DBH	0.0067
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0066
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0065
814	Ryanodine receptor 1	RYR1	0.0065
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0063
1050	Bile salt sulfotransferase	SULT2A1	0.0063
6138	Multidrug resistance protein 3	ABCB4	0.0063
780	Retinoic acid receptor RXR-gamma	RXRG	0.0063
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0063
133	Dihydropterate synthase	sulI	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.006
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.006
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.006
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.006
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.006
2298	Cytochrome P450-cam	camC	0.006
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0059
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0058
904	Glutathione S-transferase P	GSTP1	0.0058
411	Glycine N-methyltransferase	GNMT	0.0058
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0058
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0058
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0057
7	Nitric oxide synthase, inducible	NOS2	0.0057
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0057
856	Vitamin D3 receptor	VDR	0.0056
3175	Glutamate--cysteine ligase	gshA	0.0056
3809	Estrogen-related receptor gamma	ESRRG	0.0056
823	Fibroblast growth factor receptor 2	FGFR2	0.0056
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0055
6506	Stathmin-4	STMN4	0.0055
473	L-lactate dehydrogenase A chain	LDHA	0.0054
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0054
183	Vascular endothelial growth factor A	VEGFA	0.0054
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0053
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0053
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0053
1629	Transcription factor AP-1	JUN	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
54	Prothrombin	F2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0051
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
714	Glutathione reductase, mitochondrial	GSR	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
6589	Delta-hemolysin	hld	0.0051
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0051
6586	Protein S100-G	S100G	0.0051
6591	ATP synthase C chain	atpH	0.0051
6587	Rubredoxin	rub	0.0051
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0051
6588	Methionyl-tRNA formyltransferase	fmt	0.005
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.005
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.005
6593	Immunoglobulin G-binding protein G	spg	0.005
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.005
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.005
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.005
33	Cystine/glutamate transporter	SLC7A11	0.005
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.005
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.005
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.005
6766	O-GlcNAcase BT_4395	BT_4395	0.0049
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
737	Mineralocorticoid receptor	NR3C2	0.0049
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0049
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0049
6085	Fatty acid-binding protein, intestinal	FABP2	0.0049
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0049
4056	N-arachidonyl glycine receptor	GPR18	0.0049
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0049
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0049
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0049
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0049
4057	Glycine N-acyltransferase	GLYAT	0.0049
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0049
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0049
1466	Glycyl-tRNA synthetase	GARS	0.0049
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0049
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0049
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0049
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0049
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0049
24	Thymidylate synthase	TMP1	0.0049
359	Thymidylate synthase	TYMS	0.0049
2626	Thymidylate synthase	thyA	0.0049
2729	Thymidylate synthase	thyA	0.0049
5352	Thymidylate synthase	THYA	0.0049
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0049
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0049
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0049
273	Apoptosis regulator Bcl-2	BCL2	0.0049
3404	Exotoxin A	eta	0.0049
6146	High affinity copper uptake protein 1	SLC31A1	0.0049
1517	Beta-3 adrenergic receptor	ADRB3	0.0048
106	Cannabinoid receptor 2	CNR2	0.0048
6174	50S ribosomal protein L32	rpmF	0.0048
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0046
319	Opioid receptor, sigma 1	OPRS1	0.0046
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0046
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0046
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
581	Cytochrome P450 2R1	CYP2R1	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
164	Histamine H4 receptor	HRH4	0.0045
6043	Putative G-protein coupled receptor 44	GPR44	0.0044
569	Retinal dehydrogenase 2	ALDH1A2	0.0044
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0044
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0044
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0044
6279	Beta-2-microglobulin	B2M	0.0044
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0044
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0044
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0044
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0044
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0044
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0044
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0044
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0044
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0044
6559	Cytochrome c oxidase subunit 2	ctaC	0.0044
6669	Cytochrome c oxidase subunit 2	ctaC	0.0044
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0044
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0044
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0044
6558	Cytochrome c oxidase subunit 1	ctaD	0.0044
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0044
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0044
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0044
239	Coagulation factor X	F10	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0043
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0043
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0043
634	Squalene monooxygenase	SQLE	0.0043
7196	Squalene monooxygenase	ERG1	0.0043
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0043
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0043
6044	Serum paraoxonase/lactonase 3	PON3	0.0042
3904	Alanine aminotransferase 2	GPT2	0.0042
735	Alanine aminotransferase 1	GPT	0.0042
611	Retinal dehydrogenase 1	ALDH1A1	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0041
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0041
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0041
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0041
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
908	Glutathione S-transferase theta-1	GSTT1	0.0041
400	Coagulation factor IX	F9	0.004
5461	Coagulation factor IX	F9	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.004
309	Antithrombin-III	SERPINC1	0.004
3957	Adenosine deaminase	ADA	0.004
564	Cellular retinoic acid-binding protein 1	CRABP1	0.004
1541	Metalloproteinase	mmp20	0.0039
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0039
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0039
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
922	Glutamate receptor 4	GRIA4	0.0039
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0038
5934	Cytochrome P450 26A1	CYP26A1	0.0038
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0038
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
976	Platelet glycoprotein IX	GP9	0.0038
469	Annexin A1	ANXA1	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
1374	Natriuretic peptides B	NPPB	0.0038
3639	Thymidine phosphorylase	deoA	0.0037
3936	Thymidine phosphorylase	TYMP	0.0037
1827	Gap junction alpha-1 protein	GJA1	0.0037
1908	Vascular cell adhesion protein 1	VCAM1	0.0037
3884	SHMT2 protein	SHMT2	0.0037
3901	SHMT2 protein	SHMT2	0.0037
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0037
3879	Serine hydroxymethyltransferase 2	Not Available	0.0037
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0037
4311	tRNA	TRDMT1	0.0037
4325	tRNA	trmD	0.0037
4328	tRNA	trmD	0.0037
719	Retinoic acid receptor responder protein 1	RARRES1	0.0037
770	Retinoic acid-induced protein 3	GPRC5A	0.0037
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0037
604	Vitamin K-dependent protein Z	PROZ	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0037
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0037
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0036
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0036
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0036
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0036
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0036
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0036
4027	Glutamate receptor delta-1 subunit	GRID1	0.0036
4018	Glutamate receptor delta-2 subunit	GRID2	0.0036
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0036
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0036
664	Glutamate decarboxylase 2	GAD2	0.0036
3890	Glutamate decarboxylase 2	GAD2	0.0036
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0036
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0036
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0036
1912	Excitatory amino acid transporter 1	SLC1A3	0.0036
4016	Excitatory amino acid transporter 5	SLC1A7	0.0036
4019	Excitatory amino acid transporter 4	SLC1A6	0.0036
1047	Excitatory amino acid transporter 2	SLC1A2	0.0036
927	Metabotropic glutamate receptor 8	GRM8	0.0036
925	Metabotropic glutamate receptor 4	GRM4	0.0036
926	Metabotropic glutamate receptor 7	GRM7	0.0036
4020	Glutamyl aminopeptidase	ENPEP	0.0036
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0036
4026	Aspartyl aminopeptidase	DNPEP	0.0036
4017	5-oxoprolinase	OPLAH	0.0036
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0034
383	Glycine amidinotransferase, mitochondrial	GATM	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
1245	Vitamin K-dependent protein S	PROS1	0.0034
422	Vitamin K-dependent protein C	PROC	0.0034
291	Nitric-oxide synthase, endothelial	NOS3	0.0034
4226	Uridine phosphorylase 2	UPP2	0.0033
6352	Reaction center protein H chain	puhA	0.0033
6456	Reaction center protein H chain	puhA	0.0033
6682	Reaction center protein H chain	puhA	0.0033
6353	Reaction center protein L chain	pufL	0.0033
6454	Reaction center protein L chain	pufL	0.0033
6683	Reaction center protein L chain	pufL	0.0033
6354	Reaction center protein M chain	pufM	0.0033
6455	Reaction center protein M chain	pufM	0.0033
6684	Reaction center protein M chain	pufM	0.0033
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0033
1039	Histone deacetylase 9	HDAC9	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
751	Potassium channel subfamily K member 6	KCNK6	0.0033
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0033
165	FL cytokine receptor	FLT3	0.0033
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0033
1992	Vitamin D-binding protein	GC	0.0033
349	Serine--pyruvate aminotransferase	AGXT	0.0033
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0032
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0032
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0032
162	Retinoic acid receptor gamma-1	RARG	0.0032
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0032
268	Adenosine A2b receptor	ADORA2B	0.0032
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0032
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
65	Matrix metalloproteinase-9	Not Available	0.0031
4225	Uridine phosphorylase 1	UPP1	0.0031
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.003
5	Glutaminase liver isoform, mitochondrial	GLS2	0.003
917	Glutaminase kidney isoform, mitochondrial	GLS	0.003
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.003
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.003
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.003
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.003
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.003
5261	Phosphoribosylformylglycinamidine synthase	purL	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1630	Integrin beta-2	ITGB2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.003
665	Phosphoserine aminotransferase	PSAT1	0.003
4652	Phosphoserine aminotransferase	serC	0.003
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.003
420	Glutamate decarboxylase 1	GAD1	0.003
3900	Glutamate decarboxylase 1	GAD1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4217	Telomerase reverse transcriptase	TERT	0.003
923	Glutamate receptor 3	GRIA3	0.003
896	Glutathione S-transferase Mu 1	GSTM1	0.0029
3027	Streptavidin	Not Available	0.0029
625	Glutamate carboxypeptidase 2	FOLH1	0.0029
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0029
3808	Dihydropteroate synthase 2	folP2	0.0029
3601	Dihydropteroate synthase 1	folP1	0.0029
3807	Dihydropteroate synthase 1	folP1	0.0029
413	Amidophosphoribosyltransferase	PPAT	0.0029
2515	Amidophosphoribosyltransferase	purF	0.0029
3714	Amidophosphoribosyltransferase	purF	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1253	Interferon gamma	IFNG	0.0028
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
1671	Excitatory amino acid transporter 3	SLC1A1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
798	Osteocalcin	BGLAP	0.0028
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0027
3877	Growth-inhibiting protein 18	GIG18	0.0027
916	Metabotropic glutamate receptor 1	GRM1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3856	Fibroblast growth factor receptor 3	FGFR3	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6163	Copper-transporting ATPase 2	ATP7B	0.0027
6165	Copper-transporting ATPase 1	ATP7A	0.0027
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0027
5682	Ribonuclease pancreatic	RNASE1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0026
763	Tyrosine aminotransferase	TAT	0.0026
5493	Tyrosine aminotransferase	Not Available	0.0026
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0026
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0026
358	Cystathionine beta-synthase	CBS	0.0026
4192	DNA topoisomerase 2-beta	TOP2B	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0025
369	Coagulation factor VII	F7	0.0025
4103	Proteasome subunit beta type 2	PSMB2	0.0025
4102	Proteasome subunit beta type 5	PSMB5	0.0025
4101	Proteasome subunit beta type 1	PSMB1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0025
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0025
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0025
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0025
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0025
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0025
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
936	Ephrin type-A receptor 2	EPHA2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
2320	Thymidine kinase, cytosolic	TK1	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
5798	Mitogen-activated protein kinase 11	MAPK11	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1864	RET proto-oncogene	RET	0.0018
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0018
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0018
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0018
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
267	Plasminogen activator inhibitor 1	SERPINE1	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
3221	Cytochrome c4	cc4	0.0017
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
6221	Steroid hormone receptor ERR1	ESRRA	0.0016
1243	Cathepsin D	CTSD	0.0016
3830	Calreticulin	CALR	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
558	Solute carrier family 12 member 1	SLC12A1	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
822	Aldose reductase	AKR1B1	0.0014
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0014
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
6859	Protein S100-A4	S100A4	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0013
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0013
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0013
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0013
597	Dihydropteridine reductase	QDPR	0.0013
328	Sorbitol dehydrogenase	SORD	0.0013
396	Alcohol dehydrogenase 4	ADH4	0.0013
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0013
572	Integrin alpha-L	ITGAL	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0013
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0012
666	NADP-dependent malic enzyme	ME1	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
857	Malate dehydrogenase, mitochondrial	MDH2	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
77	L-lactate dehydrogenase B chain	LDHB	0.0012
12	Alcohol dehydrogenase class 3	ADH5	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1295	Fatty acid synthase	FASN	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
810	Heme oxygenase 1	HMOX1	0.0012
3391	Heme oxygenase 1	pbsA1	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0012
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0012
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0011
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0011
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
13	Aminomethyltransferase, mitochondrial	AMT	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
76	Nitric-oxide synthase, brain	NOS1	0.0011
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0011
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.001
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.001
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
279	Tyrosinase	TYR	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
654	Flavin reductase	BLVRB	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6218	Pannexin-1	PANX1	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01028 - Methoxyflurane

Targets

Enzymes

Predictions