DT-Web

DB00745 - Modafinil


Identification
Name Modafinil
Accession Number DB00745 (APRD00534)
Type small molecule
Description Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 273.35
Groups approved
Monoisotopic Weight 273.082349419
Pharmacology
Indication To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
Mechanism of action The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.
Absorption Rapid following oral administration.
Protein binding 60%
Biotransformation Hepatic
Route of elimination The major route of elimination is metabolism (~90%), primarily by the liver, with subsequent renal elimination of the metabolites.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Carisoprodol Strong CYP2C19 inhibitors such as modafinil may decrease the metabolism of CYP2C19 substrates such as carisoprodol. Consider an alternative for one of the interacting drugs in order to avoid toxicity of the substrate. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of the CYP substrate if a CYP inhibitor is initiated/dose increased, and decreased effects if a CYP inhibitor is discontinued/dose decreased.
Clozapine Modafinil increases the effect and toxicity of clozapine
Cyclosporine Modafinil decreases the effect of cyclosporine
Ethinyl Estradiol Modafinil may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be solely relied on during concomitant therapy with modafinil.
Mestranol Modafinil decreases the effect of the contraceptive
Roflumilast Affects CYP1A2 metabolism; decreases level or effect of roflumilast.
Telithromycin Telithromycin may reduce clearance of Modafinil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Modafinil if Telithromycin is initiated, discontinued or dose changed.
Triazolam Modafinil decreases the effect of triazolam
Trimipramine The strong CYP2C19 inhibitor, Modafinil, may decrease the metabolism and clearance of Trimipramine, a CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Modafinil is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of modafinil by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of modafinil if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.

Targets


Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions inhibitor
References
  • Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP: Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem. 2004 Nov 18;47(24):5821-4. - Pubmed
  • Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ: Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov;319(2):561-9. Epub 2006 Aug 2. - Pubmed
  • Swanson JM: Role of executive function in ADHD. J Clin Psychiatry. 2003;64 Suppl 14:35-9. - Pubmed
  • Dopheide MM, Morgan RE, Rodvelt KR, Schachtman TR, Miller DK: Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants. Eur J Pharmacol. 2007 Jul 30;568(1-3):112-23. Epub 2007 Apr 5. - Pubmed
  • Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM: Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001 Mar 1;21(5):1787-94. - Pubmed
DTHybrid score 0.4066
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions partial agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen CR, Qu WM, Qiu MH, Xu XH, Yao MH, Urade Y, Huang ZL: Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. Neuropharmacology. 2007 Sep;53(4):534-41. Epub 2007 Jun 30. - Pubmed
DTHybrid score 0.2394

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4333
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Robertson P Jr, Hellriegel ET: Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet. 2003;42(2):123-37. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6597
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.442
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3255
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4695
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3234

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.3778
1588 Multidrug resistance protein 1 ABCB1 0.2501
4924 Cytochrome P450 2C8 CYP2C8 0.2408
6107 Cytochrome P450 3A7 CYP3A7 0.2033
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1955
556 Alpha-1A adrenergic receptor ADRA1A 0.1703
6013 Cytochrome P450 2E1 CYP2E1 0.1609
824 Sodium-dependent serotonin transporter SLC6A4 0.1439
6024 Cytochrome P450 1A1 CYP1A1 0.1194
5718 Cytochrome P450 2A6 CYP2A6 0.1101
492 Histamine H1 receptor HRH1 0.102
587 Serum albumin ALB 0.0964
789 Alpha-1D adrenergic receptor ADRA1D 0.0904
20 Prostaglandin G/H synthase 1 PTGS1 0.0864
318 Alpha-2A adrenergic receptor ADRA2A 0.0847
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0832
502 5-hydroxytryptamine 2A receptor HTR2A 0.0827
831 D(2) dopamine receptor DRD2 0.0685
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0647
3941 Amine oxidase [flavin-containing] A MAOA 0.0644
23 D(1A) dopamine receptor DRD1 0.0635
6106 Cytochrome P450 2C18 CYP2C18 0.0626
6145 Solute carrier family 22 member 1 SLC22A1 0.0547
590 5-hydroxytryptamine 2C receptor HTR2C 0.0546
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0546
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0536
320 5-hydroxytryptamine 1A receptor HTR1A 0.0526
629 Alpha-2B adrenergic receptor ADRA2B 0.0518
131 Synaptic vesicular amine transporter SLC18A2 0.0517
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0503
3939 Amine oxidase [flavin-containing] B MAOB 0.0485
3811 Cytochrome P450 19A1 CYP19A1 0.0464
6144 Solute carrier family 22 member 2 SLC22A2 0.0453
862 Multidrug resistance-associated protein 1 ABCC1 0.0449
290 Prostaglandin G/H synthase 2 PTGS2 0.0442
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0441
341 5-hydroxytryptamine 3 receptor HTR3A 0.0439
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0427
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0425
378 Alpha-2C adrenergic receptor ADRA2C 0.0419
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0403
1729 Solute carrier family 22 member 6 SLC22A6 0.0396
1898 Cytochrome P450 1B1 CYP1B1 0.0382
766 Beta-2 adrenergic receptor ADRB2 0.0381
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0373
51 Muscarinic acetylcholine receptor M3 CHRM3 0.037
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0364
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0359
118 Organic cation/carnitine transporter 2 SLC22A5 0.0348
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0347
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0347
193 Beta-1 adrenergic receptor ADRB1 0.0346
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0345
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0339
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0336
731 HIV-1 protease HIV-1 protease 0.0323
638 D(3) dopamine receptor DRD3 0.0323
136 Estrogen receptor ESR1 0.0312
776 Bile salt export pump ABCB11 0.0309
432 D(4) dopamine receptor DRD4 0.0303
6147 Solute carrier family 22 member 3 SLC22A3 0.0301
725 5-hydroxytryptamine 1D receptor HTR1D 0.0296
260 Cytochrome P450 51 ERG11 0.0295
761 Cytochrome P450 51 ERG11 0.0295
3163 Cytochrome P450 51 cyp51 0.0295
885 5-hydroxytryptamine 1B receptor HTR1B 0.029
3923 Cholinesterase BCHE 0.0275
847 Mu-type opioid receptor OPRM1 0.027
871 Glucocorticoid receptor NR3C1 0.0264
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0262
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0261
36 Insulin receptor INSR 0.0258
1636 Trace amine-associated receptor 1 TAAR1 0.0255
6031 Cytochrome P450 3A43 CYP3A43 0.0253
6142 Solute carrier family 22 member 8 SLC22A8 0.0253
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.025
468 Cytochrome P450 4A11 CYP4A11 0.0247
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0246
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0244
122 P2Y purinoceptor 12 P2RY12 0.0239
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0238
817 DNA topoisomerase 2-alpha TOP2A 0.0238
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0235
6143 Solute carrier family 22 member 7 SLC22A7 0.023
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0229
2164 Multidrug resistance-associated protein 4 ABCC4 0.0227
1656 CYP2B protein CYP2B 0.0227
465 Calmodulin CALM1 0.0219
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0216
467 Delta-type opioid receptor OPRD1 0.0213
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0205
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0204
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.02
696 Kappa-type opioid receptor OPRK1 0.02
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0194
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0186
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0183
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0183
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0181
163 D(1B) dopamine receptor DRD5 0.018
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.018
436 5-hydroxytryptamine 2B receptor HTR2B 0.0179
6182 Cytochrome P450 2J2 CYP2J2 0.0177
6220 Aryl hydrocarbon receptor AHR 0.0175
146 Androgen receptor AR 0.0173
1757 Myeloperoxidase MPO 0.0172
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0171
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0171
716 5-hydroxytryptamine 7 receptor HTR7 0.0171
4120 NADPH--cytochrome P450 reductase POR 0.017
477 DNA topoisomerase 4 subunit A parC 0.017
886 DNA topoisomerase 4 subunit A parC 0.017
6226 DNA topoisomerase 4 subunit A parC 0.017
404 DNA gyrase subunit A gyrA 0.0167
6224 DNA gyrase subunit A gyrA 0.0167
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0164
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0161
1256 5-hydroxytryptamine 6 receptor HTR6 0.0159
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0159
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0159
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0159
891 Dihydropteroate synthase folP 0.0157
5359 Dihydropteroate synthase folP 0.0157
7175 Dihydropteroate synthase sulI 0.0157
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0153
833 Organic cation/carnitine transporter 1 SLC22A4 0.015
818 50S ribosomal protein L10 rplJ 0.015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0149
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0149
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0149
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0141
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.014
777 Tumor necrosis factor TNF 0.0139
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0139
6148 Multidrug resistance-associated protein 7 ABCC10 0.0138
1517 Beta-3 adrenergic receptor ADRB3 0.0136
614 Progesterone receptor PGR 0.0136
811 Translocator protein TSPO 0.0136
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0134
70 Type-1 angiotensin II receptor AGTR1 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
124 Histamine H2 receptor HRH2 0.0132
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0132
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0131
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0131
504 Mast/stem cell growth factor receptor KIT 0.0131
6137 Multidrug resistance-associated protein 6 ABCC6 0.0129
756 Sex hormone-binding globulin SHBG 0.0128
844 Epidermal growth factor receptor EGFR 0.0127
232 Corticosteroid-binding globulin SERPINA6 0.0127
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0126
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0125
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0125
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0125
4604 Liver carboxylesterase 1 CES1 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0122
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0122
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0122
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0122
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0121
407 Vascular endothelial growth factor receptor 2 KDR 0.012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.012
528 5-hydroxytryptamine 1E receptor HTR1E 0.012
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0119
705 Glutamate receptor 1 GRIA1 0.0119
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0119
6136 Multidrug resistance-associated protein 5 ABCC5 0.0117
1024 Solute carrier family 22 member 11 SLC22A11 0.0117
427 Substance-P receptor TACR1 0.0116
26 Vascular endothelial growth factor receptor 3 FLT4 0.0116
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0116
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0114
6138 Multidrug resistance protein 3 ABCB4 0.0114
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0113
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0113
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0111
32 Vascular endothelial growth factor receptor 1 FLT1 0.0111
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.011
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0108
6014 Cytochrome P450 2A13 CYP2A13 0.0108
1010 Cytochrome P450 51A1 CYP51A1 0.0108
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
482 Glycine receptor subunit alpha-1 GLRA1 0.0105
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.01
94 5-hydroxytryptamine 4 receptor HTR4 0.0098
869 Estrogen receptor beta ESR2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
174 Sigma 1-type opioid receptor SIGMAR1 0.0096
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0096
49 Endothelin B receptor EDNRB 0.0096
16 Adenosine A1 receptor ADORA1 0.0096
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0096
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0095
828 Phenylalanine-4-hydroxylase PAH 0.0095
3109 Phenylalanine-4-hydroxylase phhA 0.0095
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
29 Tubulin beta-1 chain TUBB1 0.0094
737 Mineralocorticoid receptor NR3C2 0.0094
6020 Aldehyde oxidase AOX1 0.0093
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0091
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0091
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0091
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0089
295 Carbonic anhydrase 1 CA1 0.0088
921 Glutamate receptor 2 GRIA2 0.0088
153 Dopamine beta-hydroxylase DBH 0.0087
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0087
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0087
161 Tubulin beta chain TUBB 0.0085
312 Tubulin beta chain TUB2 0.0085
6102 Arylamine N-acetyltransferase 2 NAT2 0.0085
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0085
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0083
3810 Catechol O-methyltransferase COMT 0.0083
1178 Adenosine A2a receptor ADORA2A 0.0082
3947 Xanthine dehydrogenase/oxidase XDH 0.0081
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0078
380 Cytochrome P450 17A1 CYP17A1 0.0077
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0077
275 Arachidonate 5-lipoxygenase ALOX5 0.0077
6141 Sodium/bile acid cotransporter SLC10A1 0.0076
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0075
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0074
4116 Dihydropteroate synthetase Not Available 0.0072
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0072
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0071
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.007
823 Fibroblast growth factor receptor 2 FGFR2 0.007
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
273 Apoptosis regulator Bcl-2 BCL2 0.0069
4122 Histone deacetylase 2 HDAC2 0.0069
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0069
537 ATP synthase delta chain, mitochondrial ATP5D 0.0068
2539 Tubulin alpha-1 chain TUBA4A 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0067
284 DNA-directed RNA polymerase beta chain rpoB 0.0067
5773 DNA-directed RNA polymerase beta chain rpoB 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
373 Transthyretin TTR 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0067
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0067
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0067
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0065
54 Prothrombin F2 0.0065
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
239 Coagulation factor X F10 0.0064
1618 High affinity nerve growth factor receptor NTRK1 0.0064
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0064
133 Dihydropterate synthase sulI 0.0063
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0063
183 Vascular endothelial growth factor A VEGFA 0.0062
365 Dihydrofolate reductase DHFR 0.0062
2381 Dihydrofolate reductase DFR1 0.0062
2833 Dihydrofolate reductase Not Available 0.0062
2931 Dihydrofolate reductase folA 0.0062
3544 Dihydrofolate reductase folA 0.0062
3682 Dihydrofolate reductase folA 0.0062
6642 Dihydrofolate reductase folA 0.0062
6756 Dihydrofolate reductase dfrA 0.0062
6085 Fatty acid-binding protein, intestinal FABP2 0.0061
474 Acetylcholinesterase ACHE 0.0061
4237 50S ribosomal protein L22 rplV 0.006
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0059
563 Thyroid peroxidase TPO 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
856 Vitamin D3 receptor VDR 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
780 Retinoic acid receptor RXR-gamma RXRG 0.0057
814 Ryanodine receptor 1 RYR1 0.0056
5300 Antigen peptide transporter 1 TAP1 0.0056
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0056
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0055
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0055
511 5-hydroxytryptamine 1F receptor HTR1F 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0054
738 Monocarboxylate transporter 1 SLC16A1 0.0053
33 Cystine/glutamate transporter SLC7A11 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
165 FL cytokine receptor FLT3 0.0053
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0052
6044 Serum paraoxonase/lactonase 3 PON3 0.0052
3932 Glutathione S-transferase A2 GSTA2 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
6432 Transporter snf 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
768 FK506-binding protein 1A FKBP1A 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
84 Nuclear receptor 0B1 NR0B1 0.005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0048
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0048
581 Cytochrome P450 2R1 CYP2R1 0.0047
4203 Histamine N-methyltransferase HNMT 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0047
6174 50S ribosomal protein L32 rpmF 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
208 DNA-directed RNA polymerase beta' chain rpoC 0.0046
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0046
173 Toll-like receptor 7 TLR7 0.0046
904 Glutathione S-transferase P GSTP1 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
319 Opioid receptor, sigma 1 OPRS1 0.0045
518 Peroxidase/catalase T katG 0.0045
1196 Complement decay-accelerating factor CD55 0.0045
4238 50S ribosomal protein L4 rplD 0.0045
5578 50S ribosomal protein L4 rplD 0.0045
6173 50S ribosomal protein L4 rplD 0.0045
6219 50S ribosomal protein L4 rplD 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0044
1483 Membrane copper amine oxidase AOC3 0.0043
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0043
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0043
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0043
1630 Integrin beta-2 ITGB2 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
1192 Sulfotransferase 1A1 SULT1A1 0.0042
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
1648 Elastin ELN 0.0041
6146 High affinity copper uptake protein 1 SLC31A1 0.0041
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0041
233 Potassium channel subfamily K member 2 KCNK2 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
469 Annexin A1 ANXA1 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
1541 Metalloproteinase mmp20 0.0039
2808 Chloramphenicol acetyltransferase 3 cat3 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0038
85 Growth hormone receptor GHR 0.0038
976 Platelet glycoprotein IX GP9 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0037
1852 Microtubule-associated protein 2 MAP2 0.0037
1629 Transcription factor AP-1 JUN 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
936 Ephrin type-A receptor 2 EPHA2 0.0037
7 Nitric oxide synthase, inducible NOS2 0.0037
164 Histamine H4 receptor HRH4 0.0037
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
3601 Dihydropteroate synthase 1 folP1 0.0036
3807 Dihydropteroate synthase 1 folP1 0.0036
3808 Dihydropteroate synthase 2 folP2 0.0036
2417 Chloramphenicol acetyltransferase cat 0.0036
3278 Chloramphenicol acetyltransferase cat 0.0036
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0035
1992 Vitamin D-binding protein GC 0.0035
939 50S ribosomal protein L3 rplC 0.0035
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
5787 Angiopoietin-1 receptor TEK 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
1039 Histone deacetylase 9 HDAC9 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
444 Alcohol dehydrogenase 1B ADH1B 0.0032
3086 Plasmepsin-2 Not Available 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
5923 Microtubule-associated protein tau MAPT 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0029
770 Retinoic acid-induced protein 3 GPRC5A 0.0029
3957 Adenosine deaminase ADA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0028
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0028
3937 Fatty-acid amide hydrolase FAAH 0.0028
4773 Deoxycytidine kinase DCK 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0028
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0028
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0028
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0028
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0028
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0028
1932 Apolipoprotein E APOE 0.0028
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0028
517 Alcohol dehydrogenase 1C ADH1C 0.0028
1864 RET proto-oncogene RET 0.0027
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0027
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0027
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1050 Bile salt sulfotransferase SULT2A1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
3913 Glutamic acid decarboxylase GAD65 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2112 Toll-like receptor 9 TLR9 0.0025
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0025
5798 Mitogen-activated protein kinase 11 MAPK11 0.0025
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0023
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0023
1262 Corticotropin-lipotropin POMC 0.0023
572 Integrin alpha-L ITGAL 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
6506 Stathmin-4 STMN4 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
2091 Endoplasmin HSP90B1 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0021
291 Nitric-oxide synthase, endothelial NOS3 0.0021
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1360 Sphingomyelin phosphodiesterase SMPD1 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6151 Monocarboxylate transporter 10 SLC16A10 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
1525 Heparin-binding growth factor 2 FGF2 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
1253 Interferon gamma IFNG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
268 Adenosine A2b receptor ADORA2B 0.0015
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0014
1341 Histamine H3 receptor HRH3 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6859 Protein S100-A4 S100A4 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
6218 Pannexin-1 PANX1 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
2207 Rhodopsin RHO 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
229 Retinoic acid receptor beta RARB 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2298 Cytochrome P450-cam camC 0.0009
2132 Protein S100-B S100B 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
3404 Exotoxin A eta 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
3221 Cytochrome c4 cc4 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
798 Osteocalcin BGLAP 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
358 Cystathionine beta-synthase CBS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
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