DT-Web

DB01435 - Antipyrine


Identification
Name Antipyrine
Accession Number DB01435
Type small molecule
Description An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 188.2258
Groups approved
Monoisotopic Weight 188.094963016
Pharmacology
Indication Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
Mechanism of action Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action unknown
Actions inhibitor
References
  • Brune K, Neubert A: Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective. Clin Exp Rheumatol. 2001 Nov-Dec;19(6 Suppl 25):S51-7. - Pubmed
DTHybrid score 0.5922
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • Brune K, Neubert A: Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective. Clin Exp Rheumatol. 2001 Nov-Dec;19(6 Suppl 25):S51-7. - Pubmed
DTHybrid score 0.7136

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. - Pubmed
DTHybrid score 0.53
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7832
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6151
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sharer JE, Wrighton SA: Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. - Pubmed
DTHybrid score 0.631
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. - Pubmed
DTHybrid score 0.8768
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Sharer JE, Wrighton SA: Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. - Pubmed
DTHybrid score 0.4088
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor
References
  • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. - Pubmed
DTHybrid score 0.4455
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. - Pubmed
DTHybrid score 0.2559
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. - Pubmed
DTHybrid score 0.6413
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Sharer JE, Wrighton SA: Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. - Pubmed
DTHybrid score 0.4187

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.3565

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.342
4118 Cytochrome P450 3A5 CYP3A5 0.2877
6107 Cytochrome P450 3A7 CYP3A7 0.2171
6024 Cytochrome P450 1A1 CYP1A1 0.2166
587 Serum albumin ALB 0.2011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1207
6142 Solute carrier family 22 member 8 SLC22A8 0.1124
492 Histamine H1 receptor HRH1 0.1059
824 Sodium-dependent serotonin transporter SLC6A4 0.0921
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0903
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.088
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0875
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0853
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0817
3811 Cytochrome P450 19A1 CYP19A1 0.0806
1024 Solute carrier family 22 member 11 SLC22A11 0.079
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0758
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0727
862 Multidrug resistance-associated protein 1 ABCC1 0.0722
2164 Multidrug resistance-associated protein 4 ABCC4 0.0701
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0698
6143 Solute carrier family 22 member 7 SLC22A7 0.0697
118 Organic cation/carnitine transporter 2 SLC22A5 0.0673
1898 Cytochrome P450 1B1 CYP1B1 0.0666
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0665
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0663
502 5-hydroxytryptamine 2A receptor HTR2A 0.0661
6145 Solute carrier family 22 member 1 SLC22A1 0.065
831 D(2) dopamine receptor DRD2 0.0633
275 Arachidonate 5-lipoxygenase ALOX5 0.0622
6144 Solute carrier family 22 member 2 SLC22A2 0.0619
556 Alpha-1A adrenergic receptor ADRA1A 0.0601
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0569
103 Muscarinic acetylcholine receptor M1 CHRM1 0.056
468 Cytochrome P450 4A11 CYP4A11 0.0516
1757 Myeloperoxidase MPO 0.0508
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.05
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0497
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0495
766 Beta-2 adrenergic receptor ADRB2 0.0488
776 Bile salt export pump ABCB11 0.0487
713 Sodium-dependent dopamine transporter SLC6A3 0.0487
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0486
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0461
3941 Amine oxidase [flavin-containing] A MAOA 0.0459
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0457
320 5-hydroxytryptamine 1A receptor HTR1A 0.0456
590 5-hydroxytryptamine 2C receptor HTR2C 0.045
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0448
318 Alpha-2A adrenergic receptor ADRA2A 0.0442
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0438
136 Estrogen receptor ESR1 0.0438
260 Cytochrome P450 51 ERG11 0.0435
761 Cytochrome P450 51 ERG11 0.0435
3163 Cytochrome P450 51 cyp51 0.0435
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.043
847 Mu-type opioid receptor OPRM1 0.0429
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0425
23 D(1A) dopamine receptor DRD1 0.0422
3923 Cholinesterase BCHE 0.041
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0408
341 5-hydroxytryptamine 3 receptor HTR3A 0.04
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0398
465 Calmodulin CALM1 0.0394
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0381
467 Delta-type opioid receptor OPRD1 0.0376
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0371
731 HIV-1 protease HIV-1 protease 0.0365
193 Beta-1 adrenergic receptor ADRB1 0.036
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0356
6031 Cytochrome P450 3A43 CYP3A43 0.0355
632 Alpha-1B adrenergic receptor ADRA1B 0.0351
6102 Arylamine N-acetyltransferase 2 NAT2 0.035
373 Transthyretin TTR 0.0345
696 Kappa-type opioid receptor OPRK1 0.0344
6147 Solute carrier family 22 member 3 SLC22A3 0.0344
871 Glucocorticoid receptor NR3C1 0.0343
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0338
833 Organic cation/carnitine transporter 1 SLC22A4 0.0337
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0337
3939 Amine oxidase [flavin-containing] B MAOB 0.0336
817 DNA topoisomerase 2-alpha TOP2A 0.0332
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0328
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0323
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0322
146 Androgen receptor AR 0.0315
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0314
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0314
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0312
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0311
404 DNA gyrase subunit A gyrA 0.0302
6224 DNA gyrase subunit A gyrA 0.0302
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0302
891 Dihydropteroate synthase folP 0.0295
5359 Dihydropteroate synthase folP 0.0295
7175 Dihydropteroate synthase sulI 0.0295
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0294
885 5-hydroxytryptamine 1B receptor HTR1B 0.0293
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0293
777 Tumor necrosis factor TNF 0.0293
6014 Cytochrome P450 2A13 CYP2A13 0.0292
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0291
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0289
6220 Aryl hydrocarbon receptor AHR 0.028
122 P2Y purinoceptor 12 P2RY12 0.0272
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0271
738 Monocarboxylate transporter 1 SLC16A1 0.0268
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0267
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0265
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0262
295 Carbonic anhydrase 1 CA1 0.0258
36 Insulin receptor INSR 0.0258
638 D(3) dopamine receptor DRD3 0.0258
592 Carbonic anhydrase 4 CA4 0.0257
789 Alpha-1D adrenergic receptor ADRA1D 0.0255
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0251
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
6136 Multidrug resistance-associated protein 5 ABCC5 0.0244
725 5-hydroxytryptamine 1D receptor HTR1D 0.0243
811 Translocator protein TSPO 0.024
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.024
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0238
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0237
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0235
477 DNA topoisomerase 4 subunit A parC 0.0229
886 DNA topoisomerase 4 subunit A parC 0.0229
6226 DNA topoisomerase 4 subunit A parC 0.0229
70 Type-1 angiotensin II receptor AGTR1 0.0228
380 Cytochrome P450 17A1 CYP17A1 0.0225
482 Glycine receptor subunit alpha-1 GLRA1 0.0221
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.022
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0219
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0218
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0214
723 Cytosolic phospholipase A2 PLA2G4A 0.0213
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0213
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0213
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0211
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0211
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0211
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0211
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0211
629 Alpha-2B adrenergic receptor ADRA2B 0.0209
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0209
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0209
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0209
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0209
6141 Sodium/bile acid cotransporter SLC10A1 0.0209
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0207
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0206
3947 Xanthine dehydrogenase/oxidase XDH 0.0205
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0204
357 Carbonic anhydrase 2 CA2 0.0202
6148 Multidrug resistance-associated protein 7 ABCC10 0.0201
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0201
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0201
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0199
3312 Fatty acid-binding protein, brain FABP7 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0196
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0196
6182 Cytochrome P450 2J2 CYP2J2 0.0193
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0192
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0192
6137 Multidrug resistance-associated protein 6 ABCC6 0.0191
436 5-hydroxytryptamine 2B receptor HTR2B 0.0187
1159 Interleukin-6 IL6 0.0185
4604 Liver carboxylesterase 1 CES1 0.0185
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0185
633 Penicillin-binding proteins 1A/1B pbpA 0.0185
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0184
378 Alpha-2C adrenergic receptor ADRA2C 0.0183
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0182
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
94 5-hydroxytryptamine 4 receptor HTR4 0.0182
432 D(4) dopamine receptor DRD4 0.0182
537 ATP synthase delta chain, mitochondrial ATP5D 0.0182
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0181
16 Adenosine A1 receptor ADORA1 0.018
844 Epidermal growth factor receptor EGFR 0.0179
705 Glutamate receptor 1 GRIA1 0.0176
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0175
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0175
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0174
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0174
614 Progesterone receptor PGR 0.0173
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0172
1656 CYP2B protein CYP2B 0.017
1010 Cytochrome P450 51A1 CYP51A1 0.0169
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0169
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0168
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0168
558 Solute carrier family 12 member 1 SLC12A1 0.0166
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0166
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0166
6126 Carbonic anhydrase 7 CA7 0.0166
232 Corticosteroid-binding globulin SERPINA6 0.0164
504 Mast/stem cell growth factor receptor KIT 0.0164
716 5-hydroxytryptamine 7 receptor HTR7 0.0162
921 Glutamate receptor 2 GRIA2 0.016
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0159
85 Growth hormone receptor GHR 0.0156
869 Estrogen receptor beta ESR2 0.0156
672 Prostaglandin F2-alpha receptor PTGFR 0.0155
1178 Adenosine A2a receptor ADORA2A 0.0154
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0154
6043 Putative G-protein coupled receptor 44 GPR44 0.0152
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0152
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0151
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0149
124 Histamine H2 receptor HRH2 0.0148
3639 Thymidine phosphorylase deoA 0.0147
3936 Thymidine phosphorylase TYMP 0.0147
3808 Dihydropteroate synthase 2 folP2 0.0145
1648 Elastin ELN 0.0145
3601 Dihydropteroate synthase 1 folP1 0.0145
3807 Dihydropteroate synthase 1 folP1 0.0145
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0143
4120 NADPH--cytochrome P450 reductase POR 0.0143
185 Vasopressin V1a receptor AVPR1A 0.0142
3932 Glutathione S-transferase A2 GSTA2 0.0142
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.014
322 Vasopressin V2 receptor AVPR2 0.014
6085 Fatty acid-binding protein, intestinal FABP2 0.0139
6174 50S ribosomal protein L32 rpmF 0.0139
1507 Cytochrome c CYCS 0.0138
1192 Sulfotransferase 1A1 SULT1A1 0.0138
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0137
427 Substance-P receptor TACR1 0.0136
365 Dihydrofolate reductase DHFR 0.0135
2381 Dihydrofolate reductase DFR1 0.0135
2833 Dihydrofolate reductase Not Available 0.0135
2931 Dihydrofolate reductase folA 0.0135
3544 Dihydrofolate reductase folA 0.0135
3682 Dihydrofolate reductase folA 0.0135
6642 Dihydrofolate reductase folA 0.0135
6756 Dihydrofolate reductase dfrA 0.0135
130 Prostacyclin synthase PTGIS 0.0134
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0134
818 50S ribosomal protein L10 rplJ 0.0134
518 Peroxidase/catalase T katG 0.0133
703 NADPH azoreductase azr 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
823 Fibroblast growth factor receptor 2 FGFR2 0.013
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.013
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0128
338 DNA polymerase UL30 0.0128
379 DNA polymerase UL54 0.0128
697 DNA polymerase ORF28 0.0128
2482 DNA polymerase 43 0.0128
4104 DNA polymerase BALF5 0.0128
174 Sigma 1-type opioid receptor SIGMAR1 0.0127
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0127
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0127
2230 Catalase CAT 0.0126
3249 Catalase katA 0.0126
3625 Catalase katA 0.0126
4539 Catalase katA 0.0126
4941 Catalase katB 0.0126
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0125
161 Tubulin beta chain TUBB 0.0125
312 Tubulin beta chain TUB2 0.0125
3810 Catechol O-methyltransferase COMT 0.0123
737 Mineralocorticoid receptor NR3C2 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
407 Vascular endothelial growth factor receptor 2 KDR 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
251 Alcohol dehydrogenase 1A ADH1A 0.0121
6432 Transporter snf 0.0121
1050 Bile salt sulfotransferase SULT2A1 0.012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0119
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0119
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0118
163 D(1B) dopamine receptor DRD5 0.0118
4122 Histone deacetylase 2 HDAC2 0.0117
84 Nuclear receptor 0B1 NR0B1 0.0116
563 Thyroid peroxidase TPO 0.0116
444 Alcohol dehydrogenase 1B ADH1B 0.0115
1275 Estrogen sulfotransferase SULT1E1 0.0114
26 Vascular endothelial growth factor receptor 3 FLT4 0.0114
474 Acetylcholinesterase ACHE 0.0113
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
756 Sex hormone-binding globulin SHBG 0.0113
6020 Aldehyde oxidase AOX1 0.0112
3823 Cytokine receptor common gamma chain IL2RG 0.0112
228 Beta platelet-derived growth factor receptor PDGFRB 0.0112
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0112
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
24 Thymidylate synthase TMP1 0.0111
359 Thymidylate synthase TYMS 0.0111
2626 Thymidylate synthase thyA 0.0111
2729 Thymidylate synthase thyA 0.0111
5352 Thymidylate synthase THYA 0.0111
68 Cannabinoid receptor 1 CNR1 0.0111
29 Tubulin beta-1 chain TUBB1 0.011
528 5-hydroxytryptamine 1E receptor HTR1E 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
7 Nitric oxide synthase, inducible NOS2 0.011
131 Synaptic vesicular amine transporter SLC18A2 0.0109
32 Vascular endothelial growth factor receptor 1 FLT1 0.0109
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0109
3917 Methylenetetrahydrofolate reductase MTHFR 0.0109
645 Penicillin-binding protein 1A mrcA 0.0107
5805 Penicillin-binding protein 1A ponA 0.0107
6185 Penicillin-binding protein 1A mrcA 0.0107
6799 Penicillin-binding protein 1A pbpA 0.0107
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0107
88 Retinoic acid receptor RXR-beta RXRB 0.0107
613 Atrial natriuretic peptide receptor A NPR1 0.0106
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0105
183 Vascular endothelial growth factor A VEGFA 0.0104
6149 Solute carrier family 22 member 10 SLC22A10 0.0103
6033 High affinity interleukin-8 receptor A CXCR1 0.0102
2981 Phospholipase A2, membrane associated PLA2G2A 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
3426 Glutamine synthetase glnA 0.01
3987 Glutamine synthetase GLUL 0.01
4237 50S ribosomal protein L22 rplV 0.01
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.01
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0099
634 Squalene monooxygenase SQLE 0.0099
7196 Squalene monooxygenase ERG1 0.0099
952 Dipeptidyl peptidase 4 DPP4 0.0098
1439 Lactotransferrin LTF 0.0098
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
459 Retinoic acid receptor RXR-alpha RXRA 0.0098
904 Glutathione S-transferase P GSTP1 0.0097
724 Interleukin-2 receptor alpha chain IL2RA 0.0097
717 Interleukin-2 receptor subunit beta IL2RB 0.0097
2320 Thymidine kinase, cytosolic TK1 0.0096
49 Endothelin B receptor EDNRB 0.0096
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0096
1256 5-hydroxytryptamine 6 receptor HTR6 0.0095
3937 Fatty-acid amide hydrolase FAAH 0.0095
511 5-hydroxytryptamine 1F receptor HTR1F 0.0094
780 Retinoic acid receptor RXR-gamma RXRG 0.0094
517 Alcohol dehydrogenase 1C ADH1C 0.0094
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
273 Apoptosis regulator Bcl-2 BCL2 0.0092
1039 Histone deacetylase 9 HDAC9 0.0092
1629 Transcription factor AP-1 JUN 0.0092
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0091
6146 High affinity copper uptake protein 1 SLC31A1 0.0091
578 Endothelin-1 receptor EDNRA 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.009
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0089
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
106 Cannabinoid receptor 2 CNR2 0.0086
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0086
1618 High affinity nerve growth factor receptor NTRK1 0.0085
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0085
1714 Mitogen-activated protein kinase 3 MAPK3 0.0084
284 DNA-directed RNA polymerase beta chain rpoB 0.0084
5773 DNA-directed RNA polymerase beta chain rpoB 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
1650 Heme carrier protein 1 SLC46A1 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
908 Glutathione S-transferase theta-1 GSTT1 0.0081
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0081
162 Retinoic acid receptor gamma-1 RARG 0.0081
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
291 Nitric-oxide synthase, endothelial NOS3 0.008
33 Cystine/glutamate transporter SLC7A11 0.008
719 Retinoic acid receptor responder protein 1 RARRES1 0.008
770 Retinoic acid-induced protein 3 GPRC5A 0.008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0078
65 Matrix metalloproteinase-9 Not Available 0.0078
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0077
489 Monocarboxylate transporter 2 SLC16A7 0.0077
6138 Multidrug resistance protein 3 ABCB4 0.0077
6131 Carbonic anhydrase 14 CA14 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
3809 Estrogen-related receptor gamma ESRRG 0.0075
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0075
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0075
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0075
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0075
1541 Metalloproteinase mmp20 0.0074
814 Ryanodine receptor 1 RYR1 0.0074
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
5626 Nucleoside diphosphate kinase B NME2 0.0073
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0072
1360 Sphingomyelin phosphodiesterase SMPD1 0.0072
856 Vitamin D3 receptor VDR 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
4203 Histamine N-methyltransferase HNMT 0.0071
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0071
859 Cellular retinoic acid-binding protein 2 CRABP2 0.007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.007
569 Retinal dehydrogenase 2 ALDH1A2 0.007
828 Phenylalanine-4-hydroxylase PAH 0.0069
3109 Phenylalanine-4-hydroxylase phhA 0.0069
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
2298 Cytochrome P450-cam camC 0.0068
2236 Casein kinase II subunit alpha CSNK2A1 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
4311 tRNA TRDMT1 0.0066
4325 tRNA trmD 0.0066
4328 tRNA trmD 0.0066
527 Prostacyclin receptor PTGIR 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
611 Retinal dehydrogenase 1 ALDH1A1 0.0065
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
1196 Complement decay-accelerating factor CD55 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
319 Opioid receptor, sigma 1 OPRS1 0.0065
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0064
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0064
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
4217 Telomerase reverse transcriptase TERT 0.0061
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0061
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.006
2021 Thrombomodulin THBD 0.006
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.006
239 Coagulation factor X F10 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0059
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0059
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0059
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
469 Annexin A1 ANXA1 0.0059
5294 Nucleoside diphosphate kinase A NME1 0.0058
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0058
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0058
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0057
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0057
2808 Chloramphenicol acetyltransferase 3 cat3 0.0057
6500 Phospholipase A2 PLA2G1B 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
4192 DNA topoisomerase 2-beta TOP2B 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
822 Aldose reductase AKR1B1 0.0056
759 Free fatty acid receptor 1 FFAR1 0.0056
976 Platelet glycoprotein IX GP9 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0056
1517 Beta-3 adrenergic receptor ADRB3 0.0055
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0055
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0055
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0055
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0055
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0055
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0055
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0055
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0055
2207 Rhodopsin RHO 0.0054
6122 Carbonic anhydrase 3 CA3 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
1374 Natriuretic peptides B NPPB 0.0053
1827 Gap junction alpha-1 protein GJA1 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
1908 Vascular cell adhesion protein 1 VCAM1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
54 Prothrombin F2 0.0052
1992 Vitamin D-binding protein GC 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
712 Tubulin alpha chain TUB1 0.0052
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0052
164 Histamine H4 receptor HRH4 0.0052
2810 Dr hemagglutinin structural subunit draA 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
5934 Cytochrome P450 26A1 CYP26A1 0.005
165 FL cytokine receptor FLT3 0.005
4773 Deoxycytidine kinase DCK 0.0049
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
1053 BC269730_2 FADS1 0.0049
244 Angiotensin-converting enzyme ACE 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
3404 Exotoxin A eta 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
1630 Integrin beta-2 ITGB2 0.0048
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0048
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
3007 Carbonic anhydrase 12 CA12 0.0046
4205 Carbonic anhydrase 9 CA9 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
3957 Adenosine deaminase ADA 0.0045
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
820 Glycine receptor subunit alpha-2 GLRA2 0.0045
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0044
1268 Neuropeptide S receptor NPSR1 0.0044
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0044
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
5787 Angiopoietin-1 receptor TEK 0.0044
663 Solute carrier family 12 member 4 SLC12A4 0.0044
53 Solute carrier family 12 member 5 SLC12A5 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
293 Gamma-glutamyl hydrolase GGH 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1792 Tissue-type plasminogen activator PLAT 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
408 Riboflavin kinase RFK 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
718 Folate receptor gamma FOLR3 0.004
299 Folate receptor beta FOLR2 0.004
804 Mitochondrial folate transporter/carrier SLC25A32 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
268 Adenosine A2b receptor ADORA2B 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.004
6072 Potassium channel subfamily K member 3 KCNK3 0.004
751 Potassium channel subfamily K member 6 KCNK6 0.004
896 Glutathione S-transferase Mu 1 GSTM1 0.0039
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
6163 Copper-transporting ATPase 2 ATP7B 0.0039
6165 Copper-transporting ATPase 1 ATP7A 0.0039
6042 Prostaglandin reductase 2 PTGR2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0038
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
172 Potassium channel subfamily K member 1 KCNK1 0.0036
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0036
358 Cystathionine beta-synthase CBS 0.0036
1867 Major prion protein PRNP 0.0036
1864 RET proto-oncogene RET 0.0036
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
707 72 kDa type IV collagenase MMP2 0.0036
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
1313 Lactoylglutathione lyase GLO1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
654 Flavin reductase BLVRB 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
6218 Pannexin-1 PANX1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
3221 Cytochrome c4 cc4 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
572 Integrin alpha-L ITGAL 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
4954 Soluble cytochrome b558 Not Available 0.0026
4943 Cytochrome c6 petJ 0.0026
4934 Cytochrome c-551 nirM 0.0026
5218 Cytochrome c-551 nirM 0.0026
4925 Cytochrome c-type protein SHP shp 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
4947 Bacterial hemoglobin vhb 0.0026
4915 Cytochrome c-550 psbV 0.0026
4959 Cytochrome c-550 psbV 0.0026
5216 Cytochrome c-550 psbV 0.0026
4984 Neuroglobin NGB 0.0026
4916 Cyanoglobin glbN 0.0026
4998 Hemoglobin-like protein yjbI yjbI 0.0026
4975 Cytochrome c-556 RPA3973 0.0026
4994 Hemoglobin-like protein HbO glbO 0.0026
4936 Cytochrome c2 iso-2 Not Available 0.0026
4942 Diheme cytochrome c napB napB 0.0026
4907 Cytochrome c-L moxG 0.0026
6865 Cytochrome c-L moxG 0.0026
4909 CooA protein cooA 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
4961 Hemophore HasA hasA 0.0026
4910 Cytoglobin CYGB 0.0026
4981 Iron-starvation protein PigA pigA 0.0026
5000 HemO hemO 0.0026
4904 Cytochrome c family protein GSU1996 0.0026
4971 Nonaheme cytochrome c hmcA 0.0026
4976 Apocytochrome f petA 0.0026
6407 Apocytochrome f petA 0.0026
4935 Cytochrome c-554 cycA1 0.0026
4989 Cytochrome c551 peroxidase ccp 0.0026
5222 Cytochrome c551 peroxidase ccpA 0.0026
4764 Cytochrome P450 165C4 CYP165C4 0.0026
4999 Cytochrome P450 165B3 CYP165B3 0.0026
4960 Putative cytochrome P450-family protein SCO7417 0.0026
4931 Cytochrome P450 167A1 CYP167A1 0.0026
4926 Heme-based aerotactic transducer hemAT hemAT 0.0026
4937 Cytochrome oxidase subunit II rcoxA 0.0026
4972 P450cin cinA 0.0026
4993 Hydroxylamine oxidoreductase hao1 0.0026
4903 Methyl-accepting chemotaxis protein Tar4 0.0026
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0026
4922 Cytochrome c, putative SO_4144 0.0026
4952 Catalase/peroxidase katA 0.0026
3093 Catalase HPII katE 0.0026
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0026
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0026
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0026
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
4948 Cytochrome c-553 Not Available 0.0025
4923 Cytochrome c3 DvMF_2499 0.0025
4945 Cytochrome c3 Not Available 0.0025
4949 Cytochrome c3 DVU_3171 0.0025
4968 Cytochrome c3 cytc3 0.0025
4997 Cytochrome c3 SO_2727 0.0025
5219 Cytochrome c3 cyd 0.0025
4902 Nine-heme cytochrome c Ddes_2038 0.0025
3189 High-molecular-weight cytochrome c hmcA 0.0025
3830 Calreticulin CALR 0.0025
369 Coagulation factor VII F7 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
3814 Complement C1r subcomponent C1R 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
4760 Mll3241 protein mll3241 0.0023
2782 Complement C1s subcomponent C1S 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
4386 Hemoglobin-like protein HbN glbN 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2091 Endoplasmin HSP90B1 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
76 Nitric-oxide synthase, brain NOS1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1820 Beta-nerve growth factor NGF 0.002
997 Protein kinase C beta type PRKCB 0.002
1243 Cathepsin D CTSD 0.0019
4920 Peroxidase/catalase katG 0.0019
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2119 Cytochrome b5 CYB5A 0.0019
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
4990 PpcA ppcA 0.0019
4037 Hypothetical protein GPX1 0.0019
4297 Hypothetical protein SP_1951 0.0019
4521 Hypothetical protein BC_2969 0.0019
4540 Hypothetical protein TM_1070 0.0019
4555 Hypothetical protein MT1739 0.0019
4569 Hypothetical protein mshD 0.0019
4578 Hypothetical protein PA3270 0.0019
4747 Hypothetical protein PA3967 0.0019
5177 Hypothetical protein TM_0096 0.0019
5194 Hypothetical protein PA1204 0.0019
5240 Hypothetical protein Rv2991 0.0019
5370 Hypothetical protein TM_1158 0.0019
5710 Hypothetical protein Tb927.5.1360 0.0019
4988 Sulfite oxidase, mitochondrial SUOX 0.0019
3375 Acidic cytochrome c3 Not Available 0.0019
3570 Cytochrome P450 152A1 cypC 0.0019
2915 Sensor protein fixL fixL 0.0019
4944 Sensor protein fixL fixL 0.0019
4992 Cytochrome c peroxidase Not Available 0.0019
4385 Cytochrome c' Not Available 0.0019
4967 Cytochrome c' cycA 0.0019
5038 Cytochrome c' Not Available 0.0019
5223 Cytochrome c' cycP 0.0019
4289 Cytochrome P450 TT_P0059 0.0019
6262 Cytochrome P450 staP 0.0019
4813 Heme oxygenase hmuO 0.0019
5769 Heme oxygenase Not Available 0.0019
1654 Interleukin-1 beta IL1B 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
1970 Protein kinase C alpha type PRKCA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
3670 Soluble cytochrome b562 precursor cybC 0.0017
3411 Cytochrome P450 121 cyp121 0.0017
3291 Cytochrome c-552 cycA 0.0017
4927 Cytochrome c-552 nrfA 0.0017
4938 Cytochrome c-552 cycA 0.0017
4953 Cytochrome c-552 nrfA 0.0017
5217 Cytochrome c-552 cycM 0.0017
2617 Nitric oxide synthase oxygenase nos 0.0017
2701 Nitric oxide synthase oxygenase nos 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
3102 Flavohemoprotein hmp 0.0016
4969 Flavohemoprotein hmp 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
3233 Bile acid receptor NR1H4 0.0015
494 Caspase-1 CASP1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0015
2972 6-deoxyerythronolide B hydroxylase eryF 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
4608 Putative cytochrome P450 SCO1207 0.0014
4963 Putative cytochrome P450 SCO2884 0.0014
6254 Putative cytochrome P450 SCO6998 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
6859 Protein S100-A4 S100A4 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
2077 Caspase-3 CASP3 0.0013
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0013
693 Hemoglobin subunit beta HBB 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0012
6268 Hydroxyacid oxidase 1 HAO1 0.0012
1295 Fatty acid synthase FASN 0.0012
702 UMP-CMP kinase CMPK1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
810 Heme oxygenase 1 HMOX1 0.0012
3391 Heme oxygenase 1 pbsA1 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4692 A/G-specific adenine glycosylase mutY 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2802 Endoglucanase G celCCG 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
5818 Folate receptor alpha FOLR1 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3587 Gastrotropin FABP6 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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