DT-Web

DB00972 - Azelastine


Identification
Name Azelastine
Accession Number DB00972 (APRD00813)
Type small molecule
Description Azelastine, a phthalazine derivative, is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis. Azelastine is also available as a combination product of azelastine hydrochloride and fluticasone propionate called Dymista(TM). Dymista(TM) is indicated in patient over 12 years old for symptomatic relief of seasonal allergic rhinitis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 381.898
Groups approved
Monoisotopic Weight 381.160790112
Pharmacology
Indication For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis.
Mechanism of action Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.
Absorption Absorption of azelastine following ocular administration was relatively low. Systemic bioavailability is approximately 40% after nasal administration.
Protein binding In-vitro studies in human plasma indicate that the plasma protein binding of azelastine and N-desmethylazelastine are approximately 88% and 97%, respectively.
Biotransformation Azelastine hydrochloride is oxidatively metabolized to the principal metabolite, N-desmethylazelastine, by the cytochrome P450 enzyme system, however the exact cytochrome P450 isoenzyme involved has not been determined. The major metabolite, desmethylazelastine, also has H1-receptor antagonist activity.
Route of elimination Approximately 75% of an oral dose of radiolabeled azelastine hydrochloride was excreted in the feces with less than 10% as unchanged azelastine. Azelastine hydrochloride is oxidatively metabolized to the principal metabolite, N-desmethylazelastine, by the cytochrome P450 enzyme system.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Dihydrocodeine Enhanced CNS depressant effects contraindicates concurrent use.
gabapentin enacarbil Avoid combination due to increased CNS depression.
Perampanel Avoid combination with azelastine or other CNS depressants due to the combined increase of CNS depression.
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Azelastine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide Trimethobenzamide and Azelastine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Concomitant therapy with triprolidine and azelastine, two anticholinergics and CNS depressants, may result in additive adverse/toxic effects. Monitor for enhanced anticholinergic and CNS depressant effects during concomitant therapy.
Trospium Trospium and Azelastine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions Not Available

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Casale TB: The interaction of azelastine with human lung histamine H1, beta, and muscarinic receptor-binding sites. J Allergy Clin Immunol. 1989 Apr;83(4):771-6. - Pubmed
  • Conde Hernandez DJ, Palma Aqilar JL, Delgado Romero J: Comparison of azelastine nasal spray and oral ebastine in treating seasonal allergic rhinitis. Curr Med Res Opin. 1995;13(6):299-304. - Pubmed
  • Antepara I, Jauregui I, Basomba A, Cadahia A, Feo F, Garcia JJ, Gonzalo MA, Luna I, Rubio M, Vazquez M: [Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis] Allergol Immunopathol (Madr). 1998 Jan-Feb;26(1):9-16. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Horak F: Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis. Ther Clin Risk Manag. 2008 Oct;4(5):1009-22. - Pubmed
  • Bernstein JA: Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability. Curr Med Res Opin. 2007 Oct;23(10):2441-52. - Pubmed
  • Golden SJ, Craig TJ: Efficacy and safety of azelastine nasal spray for the treatment of allergic rhinitis. J Am Osteopath Assoc. 1999 Jul;99(7 Suppl):S7-12. - Pubmed
DTHybrid score 0.5881

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6842
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.0226
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6411
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3738
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4701
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7319
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5215
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7638
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4176
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.475
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4484

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. Eur J Pharm Sci. 2001 Feb;12(4):505-13. - Pubmed
  • Hu YP, Robert J: Azelastine and flezelastine as reversing agents of multidrug resistance: pharmacological and molecular studies. Biochem Pharmacol. 1995 Jul 17;50(2):169-75. - Pubmed
DTHybrid score 0.5876

Predictions


Id Partner name Gene Name Score
6107 Cytochrome P450 3A7 CYP3A7 0.3117
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1578
587 Serum albumin ALB 0.153
20 Prostaglandin G/H synthase 1 PTGS1 0.1508
6106 Cytochrome P450 2C18 CYP2C18 0.116
824 Sodium-dependent serotonin transporter SLC6A4 0.1087
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1029
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1027
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1025
502 5-hydroxytryptamine 2A receptor HTR2A 0.0984
556 Alpha-1A adrenergic receptor ADRA1A 0.0981
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0975
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0951
1898 Cytochrome P450 1B1 CYP1B1 0.0939
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0925
831 D(2) dopamine receptor DRD2 0.0886
3811 Cytochrome P450 19A1 CYP19A1 0.0878
862 Multidrug resistance-associated protein 1 ABCC1 0.0859
1729 Solute carrier family 22 member 6 SLC22A6 0.0824
6145 Solute carrier family 22 member 1 SLC22A1 0.0802
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0789
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0788
290 Prostaglandin G/H synthase 2 PTGS2 0.0747
318 Alpha-2A adrenergic receptor ADRA2A 0.0738
6144 Solute carrier family 22 member 2 SLC22A2 0.0737
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0735
713 Sodium-dependent dopamine transporter SLC6A3 0.0725
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0715
590 5-hydroxytryptamine 2C receptor HTR2C 0.0701
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0661
776 Bile salt export pump ABCB11 0.0656
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0636
766 Beta-2 adrenergic receptor ADRB2 0.063
118 Organic cation/carnitine transporter 2 SLC22A5 0.0611
320 5-hydroxytryptamine 1A receptor HTR1A 0.0611
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0598
23 D(1A) dopamine receptor DRD1 0.0597
136 Estrogen receptor ESR1 0.0594
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0582
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0574
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0566
632 Alpha-1B adrenergic receptor ADRA1B 0.0559
468 Cytochrome P450 4A11 CYP4A11 0.0542
341 5-hydroxytryptamine 3 receptor HTR3A 0.0536
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0534
193 Beta-1 adrenergic receptor ADRB1 0.0525
871 Glucocorticoid receptor NR3C1 0.052
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0515
260 Cytochrome P450 51 ERG11 0.05
761 Cytochrome P450 51 ERG11 0.05
3163 Cytochrome P450 51 cyp51 0.05
847 Mu-type opioid receptor OPRM1 0.0494
3941 Amine oxidase [flavin-containing] A MAOA 0.0492
465 Calmodulin CALM1 0.0488
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0481
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0472
731 HIV-1 protease HIV-1 protease 0.0457
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0454
6142 Solute carrier family 22 member 8 SLC22A8 0.0452
6147 Solute carrier family 22 member 3 SLC22A3 0.0444
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0443
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0443
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0441
638 D(3) dopamine receptor DRD3 0.0438
6031 Cytochrome P450 3A43 CYP3A43 0.0435
2164 Multidrug resistance-associated protein 4 ABCC4 0.0432
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0423
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.042
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0417
6143 Solute carrier family 22 member 7 SLC22A7 0.0411
467 Delta-type opioid receptor OPRD1 0.0411
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0411
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0409
696 Kappa-type opioid receptor OPRK1 0.0408
817 DNA topoisomerase 2-alpha TOP2A 0.0406
833 Organic cation/carnitine transporter 1 SLC22A4 0.0394
885 5-hydroxytryptamine 1B receptor HTR1B 0.0393
3939 Amine oxidase [flavin-containing] B MAOB 0.038
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0377
6182 Cytochrome P450 2J2 CYP2J2 0.0376
789 Alpha-1D adrenergic receptor ADRA1D 0.0374
629 Alpha-2B adrenergic receptor ADRA2B 0.0358
6014 Cytochrome P450 2A13 CYP2A13 0.0348
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0348
725 5-hydroxytryptamine 1D receptor HTR1D 0.0342
122 P2Y purinoceptor 12 P2RY12 0.034
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0332
378 Alpha-2C adrenergic receptor ADRA2C 0.033
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0327
432 D(4) dopamine receptor DRD4 0.0322
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.032
3923 Cholinesterase BCHE 0.0319
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0318
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0313
777 Tumor necrosis factor TNF 0.0308
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0304
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0299
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0284
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.028
146 Androgen receptor AR 0.0278
844 Epidermal growth factor receptor EGFR 0.0277
891 Dihydropteroate synthase folP 0.0276
5359 Dihydropteroate synthase folP 0.0276
7175 Dihydropteroate synthase sulI 0.0276
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0274
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0274
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0268
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0268
716 5-hydroxytryptamine 7 receptor HTR7 0.0266
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0263
36 Insulin receptor INSR 0.0258
124 Histamine H2 receptor HRH2 0.0257
6148 Multidrug resistance-associated protein 7 ABCC10 0.0256
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0255
6102 Arylamine N-acetyltransferase 2 NAT2 0.0255
6220 Aryl hydrocarbon receptor AHR 0.0255
4604 Liver carboxylesterase 1 CES1 0.025
1656 CYP2B protein CYP2B 0.0249
436 5-hydroxytryptamine 2B receptor HTR2B 0.0246
477 DNA topoisomerase 4 subunit A parC 0.0241
886 DNA topoisomerase 4 subunit A parC 0.0241
6226 DNA topoisomerase 4 subunit A parC 0.0241
6136 Multidrug resistance-associated protein 5 ABCC5 0.024
404 DNA gyrase subunit A gyrA 0.0237
6224 DNA gyrase subunit A gyrA 0.0237
1024 Solute carrier family 22 member 11 SLC22A11 0.0236
1010 Cytochrome P450 51A1 CYP51A1 0.0235
504 Mast/stem cell growth factor receptor KIT 0.0234
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0233
482 Glycine receptor subunit alpha-1 GLRA1 0.0233
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.023
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.023
811 Translocator protein TSPO 0.0227
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0226
614 Progesterone receptor PGR 0.0224
705 Glutamate receptor 1 GRIA1 0.0219
6137 Multidrug resistance-associated protein 6 ABCC6 0.0218
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0218
380 Cytochrome P450 17A1 CYP17A1 0.0217
16 Adenosine A1 receptor ADORA1 0.0217
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0217
869 Estrogen receptor beta ESR2 0.0217
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0212
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0211
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.021
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0208
6141 Sodium/bile acid cotransporter SLC10A1 0.0207
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0207
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0207
70 Type-1 angiotensin II receptor AGTR1 0.0206
4120 NADPH--cytochrome P450 reductase POR 0.0204
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
94 5-hydroxytryptamine 4 receptor HTR4 0.0203
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0201
1178 Adenosine A2a receptor ADORA2A 0.0199
1341 Histamine H3 receptor HRH3 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
1757 Myeloperoxidase MPO 0.0197
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0197
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0196
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0196
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0196
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0194
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0193
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0192
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0192
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.019
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0187
756 Sex hormone-binding globulin SHBG 0.0187
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0186
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0186
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0186
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0186
1256 5-hydroxytryptamine 6 receptor HTR6 0.0184
1192 Sulfotransferase 1A1 SULT1A1 0.0183
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0182
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0182
232 Corticosteroid-binding globulin SERPINA6 0.0182
537 ATP synthase delta chain, mitochondrial ATP5D 0.0182
3947 Xanthine dehydrogenase/oxidase XDH 0.018
1275 Estrogen sulfotransferase SULT1E1 0.018
613 Atrial natriuretic peptide receptor A NPR1 0.0179
3932 Glutathione S-transferase A2 GSTA2 0.0178
407 Vascular endothelial growth factor receptor 2 KDR 0.0177
818 50S ribosomal protein L10 rplJ 0.0176
26 Vascular endothelial growth factor receptor 3 FLT4 0.0174
161 Tubulin beta chain TUBB 0.0174
312 Tubulin beta chain TUB2 0.0174
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0174
373 Transthyretin TTR 0.0172
737 Mineralocorticoid receptor NR3C2 0.0171
228 Beta platelet-derived growth factor receptor PDGFRB 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
163 D(1B) dopamine receptor DRD5 0.0168
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0167
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0167
32 Vascular endothelial growth factor receptor 1 FLT1 0.0166
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0166
528 5-hydroxytryptamine 1E receptor HTR1E 0.0164
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0163
29 Tubulin beta-1 chain TUBB1 0.0163
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0163
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0162
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0159
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0158
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0157
474 Acetylcholinesterase ACHE 0.0153
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0153
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0152
952 Dipeptidyl peptidase 4 DPP4 0.0151
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
921 Glutamate receptor 2 GRIA2 0.015
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.015
4203 Histamine N-methyltransferase HNMT 0.0149
295 Carbonic anhydrase 1 CA1 0.0149
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0149
2449 Tubulin alpha-3 chain TUBA1A 0.0148
1517 Beta-3 adrenergic receptor ADRB3 0.0145
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
365 Dihydrofolate reductase DHFR 0.0143
2381 Dihydrofolate reductase DFR1 0.0143
2833 Dihydrofolate reductase Not Available 0.0143
2931 Dihydrofolate reductase folA 0.0143
3544 Dihydrofolate reductase folA 0.0143
3682 Dihydrofolate reductase folA 0.0143
6642 Dihydrofolate reductase folA 0.0143
6756 Dihydrofolate reductase dfrA 0.0143
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0142
427 Substance-P receptor TACR1 0.0142
174 Sigma 1-type opioid receptor SIGMAR1 0.0142
4237 50S ribosomal protein L22 rplV 0.0141
4122 Histone deacetylase 2 HDAC2 0.0141
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.014
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0137
6020 Aldehyde oxidase AOX1 0.0136
251 Alcohol dehydrogenase 1A ADH1A 0.0136
275 Arachidonate 5-lipoxygenase ALOX5 0.0136
131 Synaptic vesicular amine transporter SLC18A2 0.0136
571 Melatonin receptor type 1A MTNR1A 0.0136
362 Melatonin receptor type 1B MTNR1B 0.0136
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0134
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0134
4238 50S ribosomal protein L4 rplD 0.0133
5578 50S ribosomal protein L4 rplD 0.0133
6173 50S ribosomal protein L4 rplD 0.0133
6219 50S ribosomal protein L4 rplD 0.0133
823 Fibroblast growth factor receptor 2 FGFR2 0.0132
444 Alcohol dehydrogenase 1B ADH1B 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
790 DNA polymerase subunit alpha B POLA2 0.0129
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0128
2112 Toll-like receptor 9 TLR9 0.0126
84 Nuclear receptor 0B1 NR0B1 0.0126
3810 Catechol O-methyltransferase COMT 0.0126
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0126
592 Carbonic anhydrase 4 CA4 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0124
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0123
518 Peroxidase/catalase T katG 0.0122
68 Cannabinoid receptor 1 CNR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0117
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0117
48 Pyridoxal kinase PDXK 0.0116
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0116
563 Thyroid peroxidase TPO 0.0116
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0115
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0115
6085 Fatty acid-binding protein, intestinal FABP2 0.0114
6432 Transporter snf 0.0114
239 Coagulation factor X F10 0.0114
738 Monocarboxylate transporter 1 SLC16A1 0.0114
2230 Catalase CAT 0.0114
3249 Catalase katA 0.0114
3625 Catalase katA 0.0114
4539 Catalase katA 0.0114
4941 Catalase katB 0.0114
4311 tRNA TRDMT1 0.0113
4325 tRNA trmD 0.0113
4328 tRNA trmD 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0109
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0109
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0108
517 Alcohol dehydrogenase 1C ADH1C 0.0107
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0107
88 Retinoic acid receptor RXR-beta RXRB 0.0106
814 Ryanodine receptor 1 RYR1 0.0106
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
1618 High affinity nerve growth factor receptor NTRK1 0.0105
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0105
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0105
6138 Multidrug resistance protein 3 ABCB4 0.0105
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0103
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0102
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0102
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0102
6174 50S ribosomal protein L32 rpmF 0.0102
1050 Bile salt sulfotransferase SULT2A1 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
1629 Transcription factor AP-1 JUN 0.0101
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.01
319 Opioid receptor, sigma 1 OPRS1 0.01
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0098
2539 Tubulin alpha-1 chain TUBA4A 0.0098
106 Cannabinoid receptor 2 CNR2 0.0098
3809 Estrogen-related receptor gamma ESRRG 0.0098
904 Glutathione S-transferase P GSTP1 0.0098
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6146 High affinity copper uptake protein 1 SLC31A1 0.0097
469 Annexin A1 ANXA1 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
33 Cystine/glutamate transporter SLC7A11 0.0096
153 Dopamine beta-hydroxylase DBH 0.0095
183 Vascular endothelial growth factor A VEGFA 0.0095
511 5-hydroxytryptamine 1F receptor HTR1F 0.0095
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0094
273 Apoptosis regulator Bcl-2 BCL2 0.0094
6126 Carbonic anhydrase 7 CA7 0.0094
820 Glycine receptor subunit alpha-2 GLRA2 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0094
780 Retinoic acid receptor RXR-gamma RXRG 0.0093
54 Prothrombin F2 0.0093
357 Carbonic anhydrase 2 CA2 0.0093
284 DNA-directed RNA polymerase beta chain rpoB 0.0092
5773 DNA-directed RNA polymerase beta chain rpoB 0.0092
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0092
164 Histamine H4 receptor HRH4 0.0092
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0092
24 Thymidylate synthase TMP1 0.0091
359 Thymidylate synthase TYMS 0.0091
2626 Thymidylate synthase thyA 0.0091
2729 Thymidylate synthase thyA 0.0091
5352 Thymidylate synthase THYA 0.0091
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.009
976 Platelet glycoprotein IX GP9 0.009
578 Endothelin-1 receptor EDNRA 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0088
165 FL cytokine receptor FLT3 0.0088
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0087
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0087
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0086
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0086
581 Cytochrome P450 2R1 CYP2R1 0.0085
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0084
856 Vitamin D3 receptor VDR 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
5934 Cytochrome P450 26A1 CYP26A1 0.0083
7 Nitric oxide synthase, inducible NOS2 0.0083
4103 Proteasome subunit beta type 2 PSMB2 0.0083
4102 Proteasome subunit beta type 5 PSMB5 0.0083
4101 Proteasome subunit beta type 1 PSMB1 0.0083
3937 Fatty-acid amide hydrolase FAAH 0.0081
162 Retinoic acid receptor gamma-1 RARG 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
208 DNA-directed RNA polymerase beta' chain rpoC 0.008
5774 DNA-directed RNA polymerase beta' chain rpoC 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.008
634 Squalene monooxygenase SQLE 0.0079
7196 Squalene monooxygenase ERG1 0.0079
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0079
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
173 Toll-like receptor 7 TLR7 0.0079
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0078
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6043 Putative G-protein coupled receptor 44 GPR44 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0075
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
1541 Metalloproteinase mmp20 0.0074
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0073
908 Glutathione S-transferase theta-1 GSTT1 0.0073
569 Retinal dehydrogenase 2 ALDH1A2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0071
6044 Serum paraoxonase/lactonase 3 PON3 0.0071
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0071
1992 Vitamin D-binding protein GC 0.007
1852 Microtubule-associated protein 2 MAP2 0.007
4192 DNA topoisomerase 2-beta TOP2B 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0069
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0069
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0069
719 Retinoic acid receptor responder protein 1 RARRES1 0.0068
770 Retinoic acid-induced protein 3 GPRC5A 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
611 Retinal dehydrogenase 1 ALDH1A1 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
3856 Fibroblast growth factor receptor 3 FGFR3 0.0066
1630 Integrin beta-2 ITGB2 0.0066
936 Ephrin type-A receptor 2 EPHA2 0.0065
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0064
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
3957 Adenosine deaminase ADA 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
1360 Sphingomyelin phosphodiesterase SMPD1 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
2298 Cytochrome P450-cam camC 0.0061
1374 Natriuretic peptides B NPPB 0.0061
1827 Gap junction alpha-1 protein GJA1 0.0061
1908 Vascular cell adhesion protein 1 VCAM1 0.0061
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0061
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1196 Complement decay-accelerating factor CD55 0.006
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0059
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0059
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0059
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0059
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0059
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0059
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0059
5787 Angiopoietin-1 receptor TEK 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0058
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
400 Coagulation factor IX F9 0.0057
5461 Coagulation factor IX F9 0.0057
2981 Phospholipase A2, membrane associated PLA2G2A 0.0055
751 Potassium channel subfamily K member 6 KCNK6 0.0055
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
268 Adenosine A2b receptor ADORA2B 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0052
604 Vitamin K-dependent protein Z PROZ 0.0052
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0052
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0052
712 Tubulin alpha chain TUB1 0.0052
1039 Histone deacetylase 9 HDAC9 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
3090 Chitosanase csn 0.0052
1048 Protein S100-A13 S100A13 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
2226 Protein S100-A12 S100A12 0.0052
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3913 Glutamic acid decarboxylase GAD65 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
267 Plasminogen activator inhibitor 1 SERPINE1 0.0051
172 Potassium channel subfamily K member 1 KCNK1 0.005
3404 Exotoxin A eta 0.0049
2132 Protein S100-B S100B 0.0049
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0048
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
422 Vitamin K-dependent protein C PROC 0.0048
1245 Vitamin K-dependent protein S PROS1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
4773 Deoxycytidine kinase DCK 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
1253 Interferon gamma IFNG 0.0046
6221 Steroid hormone receptor ERR1 ESRRA 0.0046
2236 Casein kinase II subunit alpha CSNK2A1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0044
1063 Signal transducer and activator of transcription 5B STAT5B 0.0044
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
1268 Neuropeptide S receptor NPSR1 0.0044
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0044
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3830 Calreticulin CALR 0.0043
117 Sterol O-acyltransferase 1 SOAT1 0.0043
6163 Copper-transporting ATPase 2 ATP7B 0.0043
6165 Copper-transporting ATPase 1 ATP7A 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
896 Glutathione S-transferase Mu 1 GSTM1 0.0043
2207 Rhodopsin RHO 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
291 Nitric-oxide synthase, endothelial NOS3 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6036 Eosinophil peroxidase EPX 0.0041
730 Retinoic acid receptor alpha RARA 0.004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
572 Integrin alpha-L ITGAL 0.004
3868 Calcineurin subunit B isoform 2 PPP3R2 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.004
6072 Potassium channel subfamily K member 3 KCNK3 0.004
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
798 Osteocalcin BGLAP 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
484 Tyrosine-protein kinase ABL2 ABL2 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
6048 Troponin C, skeletal muscle TNNC2 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
1864 RET proto-oncogene RET 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0037
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6131 Carbonic anhydrase 14 CA14 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
369 Coagulation factor VII F7 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
6122 Carbonic anhydrase 3 CA3 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1650 Heme carrier protein 1 SLC46A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
6459 Glycodelin PAEP 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
358 Cystathionine beta-synthase CBS 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
3007 Carbonic anhydrase 12 CA12 0.0025
4205 Carbonic anhydrase 9 CA9 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6218 Pannexin-1 PANX1 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
822 Aldose reductase AKR1B1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
3221 Cytochrome c4 cc4 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
1970 Protein kinase C alpha type PRKCA 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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