DT-Web

DB00957 - Norgestimate


Identification
Name Norgestimate
Accession Number DB00957 (APRD00569)
Type small molecule
Description Norgestimate is a form of progesterone, which is a female hormone important for the regulation of ovulation and menstruation. Norgestimate is used with estradiol to treat the symptoms of menopause.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 369.4971
Groups approved
Monoisotopic Weight 369.230393863
Pharmacology
Indication For the prevention of pregnancy
Mechanism of action Norgestimate binds to androgen and progestogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Norgestimate will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
Absorption Not Available
Protein binding Not Available
Biotransformation GI tract/Hepatic
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Artemether may decrease the effectiveness of norgestimate by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Bexarotene Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of norgestimate, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Colesevelam Bile Acid Sequestrants may decrease the serum concentration of Contraceptives (Progestins). Administer oral progestin-containing contraceptives at least 1-4 hours prior to or 4-6 hours after administration of a bile acid sequestrant. Consider alternatives in order to avoid this combination when possible, due to the risk for impaired contraceptive effectiveness.
Thiopental Thiopental may decrease the effect of Norgestimate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Tretinoin Oral Tretinoin may decrease the effect of oral contraceptive, Norgestimate. An alternate form of contraception should be used during concomitant therapy.
Warfarin Norgestimate may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if norgestimate is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid alcohol.
  • Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
  • Take at the same time everyday.

Targets


Progesterone receptor
Name Progesterone receptor
Gene Name PGR
Pharmacological action yes
Actions agonist
References
  • London RS, Chapdelaine A, Upmalis D, Olson W, Smith J: Comparative contraceptive efficacy and mechanism of action of the norgestimate-containing triphasic oral contraceptive. Acta Obstet Gynecol Scand Suppl. 1992;156:9-14. - Pubmed
  • Graziottin A: A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch. Treat Endocrinol. 2006;5(6):359-65. - Pubmed
  • Kuhnz W, Fritzemeier KH, Hegele-Hartung C, Krattenmacher R: Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Contraception. 1995 Feb;51(2):131-9. - Pubmed
  • Juchem M, Pollow K, Elger W, Hoffmann G, Mobus V: Receptor binding of norgestimate--a new orally active synthetic progestational compound. Contraception. 1993 Mar;47(3):283-94. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6379
Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Pasqualini JR: Differential effects of progestins on breast tissue enzymes. Maturitas. 2003 Dec 10;46 Suppl 1:S45-54. - Pubmed
  • Juchem M, Pollow K: Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor. Am J Obstet Gynecol. 1990 Dec;163(6 Pt 2):2171-83. - Pubmed
  • Shields-Botella J, Duc I, Duranti E, Puccio F, Bonnet P, Delansorne R, Paris J: An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells. J Steroid Biochem Mol Biol. 2003 Nov;87(2-3):111-22. - Pubmed
DTHybrid score 0.8218

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Lindenmaier H, Becker M, Haefeli WE, Weiss J: Interaction of progestins with the human multidrug resistance-associated protein 2 (MRP2). Drug Metab Dispos. 2005 Nov;33(11):1576-9. Epub 2005 Jul 27. - Pubmed
DTHybrid score 0.1695

Predictions


Id Partner name Gene Name Score
6241 Nuclear receptor coactivator 2 NCOA2 0.2512
4512 Cytochrome P450 3A4 CYP3A4 0.1109
1588 Multidrug resistance protein 1 ABCB1 0.0829
869 Estrogen receptor beta ESR2 0.0812
146 Androgen receptor AR 0.0625
2202 Steryl-sulfatase STS 0.0552
4757 Cytochrome P450 2C9 CYP2C9 0.0459
3811 Cytochrome P450 19A1 CYP19A1 0.0448
871 Glucocorticoid receptor NR3C1 0.0407
4118 Cytochrome P450 3A5 CYP3A5 0.0394
862 Multidrug resistance-associated protein 1 ABCC1 0.0387
4924 Cytochrome P450 2C8 CYP2C8 0.0386
6107 Cytochrome P450 3A7 CYP3A7 0.036
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0339
737 Mineralocorticoid receptor NR3C2 0.0336
756 Sex hormone-binding globulin SHBG 0.0335
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0316
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0294
776 Bile salt export pump ABCB11 0.0294
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.027
4200 Cytochrome P450 1A2 CYP1A2 0.0266
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0259
6016 Cytochrome P450 2C19 CYP2C19 0.0254
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0229
2164 Multidrug resistance-associated protein 4 ABCC4 0.0213
6030 Cytochrome P450 2B6 CYP2B6 0.02
6141 Sodium/bile acid cotransporter SLC10A1 0.0195
587 Serum albumin ALB 0.0194
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0186
1649 Small inducible cytokine A2 CCL2 0.0172
6024 Cytochrome P450 1A1 CYP1A1 0.0169
4119 Cytochrome P450 2D6 CYP2D6 0.0169
70 Type-1 angiotensin II receptor AGTR1 0.0158
13 Aminomethyltransferase, mitochondrial AMT 0.0154
1898 Cytochrome P450 1B1 CYP1B1 0.0153
6145 Solute carrier family 22 member 1 SLC22A1 0.0145
226 Gonadotropin-releasing hormone receptor GNRHR 0.0143
6144 Solute carrier family 22 member 2 SLC22A2 0.0138
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0134
817 DNA topoisomerase 2-alpha TOP2A 0.013
6148 Multidrug resistance-associated protein 7 ABCC10 0.0127
290 Prostaglandin G/H synthase 2 PTGS2 0.0125
1729 Solute carrier family 22 member 6 SLC22A6 0.0124
118 Organic cation/carnitine transporter 2 SLC22A5 0.0124
6013 Cytochrome P450 2E1 CYP2E1 0.0123
6228 Nuclear receptor coactivator 1 NCOA1 0.0122
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
3923 Cholinesterase BCHE 0.011
6142 Solute carrier family 22 member 8 SLC22A8 0.0109
2443 Azurin azu 0.0108
5718 Cytochrome P450 2A6 CYP2A6 0.0106
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0096
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0096
381 Prolactin receptor PRLR 0.0093
723 Cytosolic phospholipase A2 PLA2G4A 0.0091
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
232 Corticosteroid-binding globulin SERPINA6 0.0088
1852 Microtubule-associated protein 2 MAP2 0.0086
6147 Solute carrier family 22 member 3 SLC22A3 0.0085
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0085
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0083
850 Vasopressin V1b receptor AVPR1B 0.0081
1024 Solute carrier family 22 member 11 SLC22A11 0.0076
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0075
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0075
2107 Microtubule-associated protein 1A MAP1A 0.0075
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
322 Vasopressin V2 receptor AVPR2 0.007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
6143 Solute carrier family 22 member 7 SLC22A7 0.0065
3270 Elongation factor G fusA 0.0062
275 Arachidonate 5-lipoxygenase ALOX5 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0061
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.006
380 Cytochrome P450 17A1 CYP17A1 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0058
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0057
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0056
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
20 Prostaglandin G/H synthase 1 PTGS1 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0052
4604 Liver carboxylesterase 1 CES1 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0051
238 Peroxisome proliferator-activated receptor gamma PPARG 0.005
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.005
468 Cytochrome P450 4A11 CYP4A11 0.0049
5626 Nucleoside diphosphate kinase B NME2 0.0048
904 Glutathione S-transferase P GSTP1 0.0047
1757 Myeloperoxidase MPO 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0046
6165 Copper-transporting ATPase 1 ATP7A 0.0046
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
833 Organic cation/carnitine transporter 1 SLC22A4 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
6020 Aldehyde oxidase AOX1 0.0042
1629 Transcription factor AP-1 JUN 0.0041
731 HIV-1 protease HIV-1 protease 0.0041
373 Transthyretin TTR 0.004
3947 Xanthine dehydrogenase/oxidase XDH 0.004
5294 Nucleoside diphosphate kinase A NME1 0.0039
3810 Catechol O-methyltransferase COMT 0.0039
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0037
4210 Toll-like receptor 4 TLR4 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
6167 Organic solute transporter subunit beta OSTB 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
6166 Organic solute transporter subunit alpha OSTA 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
992 Protein tyrosine kinase 2 beta PTK2B 0.0033
5923 Microtubule-associated protein tau MAPT 0.0033
5924 Microtubule-associated protein 4 MAP4 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
1291 cAMP response element-binding protein CREB1 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0033
6085 Fatty acid-binding protein, intestinal FABP2 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
33 Cystine/glutamate transporter SLC7A11 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.003
165 FL cytokine receptor FLT3 0.0029
273 Apoptosis regulator Bcl-2 BCL2 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
777 Tumor necrosis factor TNF 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
228 Beta platelet-derived growth factor receptor PDGFRB 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
29 Tubulin beta-1 chain TUBB1 0.0026
3830 Calreticulin CALR 0.0025
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
1192 Sulfotransferase 1A1 SULT1A1 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
504 Mast/stem cell growth factor receptor KIT 0.0025
117 Sterol O-acyltransferase 1 SOAT1 0.0025
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
6035 Nuclear receptor ROR-beta RORB 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0024
6036 Eosinophil peroxidase EPX 0.0024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0023
407 Vascular endothelial growth factor receptor 2 KDR 0.0023
6106 Cytochrome P450 2C18 CYP2C18 0.0022
465 Calmodulin CALM1 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
571 Melatonin receptor type 1A MTNR1A 0.0021
362 Melatonin receptor type 1B MTNR1B 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
4120 NADPH--cytochrome P450 reductase POR 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
1630 Integrin beta-2 ITGB2 0.002
696 Kappa-type opioid receptor OPRK1 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
467 Delta-type opioid receptor OPRD1 0.002
3587 Gastrotropin FABP6 0.002
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
2539 Tubulin alpha-1 chain TUBA4A 0.002
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
847 Mu-type opioid receptor OPRM1 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
2449 Tubulin alpha-3 chain TUBA1A 0.0017
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0016
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
702 UMP-CMP kinase CMPK1 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
572 Integrin alpha-L ITGAL 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0014
1353 DNA topoisomerase 1 TOP1 0.0014
3552 DNA topoisomerase 1 topA 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
4773 Deoxycytidine kinase DCK 0.0013
7 Nitric oxide synthase, inducible NOS2 0.0013
6218 Pannexin-1 PANX1 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
260 Cytochrome P450 51 ERG11 0.0011
761 Cytochrome P450 51 ERG11 0.0011
3163 Cytochrome P450 51 cyp51 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0011
5818 Folate receptor alpha FOLR1 0.0011
6220 Aryl hydrocarbon receptor AHR 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
6168 Solute carrier family 22 member 16 SLC22A16 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
469 Annexin A1 ANXA1 0.001
6043 Putative G-protein coupled receptor 44 GPR44 0.001
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
921 Glutamate receptor 2 GRIA2 0.0006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0006
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
3932 Glutathione S-transferase A2 GSTA2 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
824 Sodium-dependent serotonin transporter SLC6A4 0.0004
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