DT-Web

DB00005 - Etanercept


Identification
Name Etanercept
Accession Number DB00005 (BTD00052, BIOD00052)
Type biotech
Description Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 51234.9000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis.
Mechanism of action There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Tofacitinib Etanercept increases the risk of added immunosuppression. It is recommended to avoid concurrent therapy.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action yes
Actions antibody
References
  • Park YC, Burkitt V, Villa AR, Tong L, Wu H: Structural basis for self-association and receptor recognition of human TRAF2. Nature. 1999 Apr 8;398(6727):533-8. - Pubmed
  • Sandborn WJ, Hanauer SB: Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. Inflamm Bowel Dis. 1999 May;5(2):119-33. - Pubmed
  • Grell M, Zimmermann G, Gottfried E, Chen CM, Grunwald U, Huang DC, Wu Lee YH, Durkop H, Engelmann H, Scheurich P, Wajant H, Strasser A: Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J. 1999 Jun 1;18(11):3034-43. - Pubmed
  • Moreland LW: Inhibitors of tumor necrosis factor: new treatment options for rheumatoid arthritis. Cleve Clin J Med. 1999 Jun;66(6):367-74. - Pubmed
  • Calabrese LH: Rheumatoid arthritis and primary care: the case for early diagnosis and treatment. J Am Osteopath Assoc. 1999 Jun;99(6):313-21. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9688
Tumor necrosis factor receptor superfamily member 1B
Name Tumor necrosis factor receptor superfamily member 1B
Gene Name TNFRSF1B
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3908
High affinity immunoglobulin gamma Fc receptor I
Name High affinity immunoglobulin gamma Fc receptor I
Gene Name FCGR1A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7847
Low affinity immunoglobulin gamma Fc region receptor III-A
Name Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Name FCGR3A
Pharmacological action unknown
Actions Not Available
References
  • Criswell LA, Lum RF, Turner KN, Woehl B, Zhu Y, Wang J, Tiwari HK, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL Jr: The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum. 2004 Sep;50(9):2750-6. - Pubmed
  • Hughes LB, Criswell LA, Beasley TM, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL: Genetic risk factors for infection in patients with early rheumatoid arthritis. Genes Immun. 2004 Dec;5(8):641-7. - Pubmed
DTHybrid score 1.7012
Low affinity immunoglobulin gamma Fc region receptor II-a
Name Low affinity immunoglobulin gamma Fc region receptor II-a
Gene Name FCGR2A
Pharmacological action unknown
Actions Not Available
References
  • Criswell LA, Lum RF, Turner KN, Woehl B, Zhu Y, Wang J, Tiwari HK, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL Jr: The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum. 2004 Sep;50(9):2750-6. - Pubmed
  • Hughes LB, Criswell LA, Beasley TM, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL: Genetic risk factors for infection in patients with early rheumatoid arthritis. Genes Immun. 2004 Dec;5(8):641-7. - Pubmed
DTHybrid score 1.7097
Low affinity immunoglobulin gamma Fc region receptor II-b
Name Low affinity immunoglobulin gamma Fc region receptor II-b
Gene Name FCGR2B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7038
Low affinity immunoglobulin gamma Fc region receptor II-c
Name Low affinity immunoglobulin gamma Fc region receptor II-c
Gene Name FCGR2C
Pharmacological action unknown
Actions Not Available
References
  • Hart SP, Ross JA, Ross K, Haslett C, Dransfield I: Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ. 2000 May;7(5):493-503. - Pubmed
  • Ranheim EA, Kipps TJ: Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L. Cell Immunol. 1995 Apr 1;161(2):226-35. - Pubmed
DTHybrid score 1.7153
Lymphotoxin-alpha
Name Lymphotoxin-alpha
Gene Name LTA
Pharmacological action unknown
Actions Not Available
References
  • Johnson CJ, Reilly KM, Murray KM: Etanercept in juvenile rheumatoid arthritis. Ann Pharmacother. 2001 Apr;35(4):464-71. - Pubmed
  • Pennica D, Lam VT, Mize NK, Weber RF, Lewis M, Fendly BM, Lipari MT, Goeddel DV: Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation. J Biol Chem. 1992 Oct 15;267(29):21172-8. - Pubmed
  • Gudbrandsdottir S, Larsen R, Sorensen LK, Nielsen S, Hansen MB, Svenson M, Bendtzen K, Muller K: TNF and LT binding capacities in the plasma of arthritis patients: effect of etanercept treatment in juvenile idiopathic arthritis. Clin Exp Rheumatol. 2004 Jan-Feb;22(1):118-24. - Pubmed
  • Buch MH, Conaghan PG, Quinn MA, Bingham SJ, Veale D, Emery P: True infliximab resistance in rheumatoid arthritis: a role for lymphotoxin alpha? Ann Rheum Dis. 2004 Oct;63(10):1344-6. Epub 2004 Mar 19. - Pubmed
  • Kang CP, Lee KW, Yoo DH, Kang C, Bae SC: The influence of a polymorphism at position -857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis. Rheumatology (Oxford). 2005 Apr;44(4):547-52. Epub 2005 Feb 3. - Pubmed
DTHybrid score 0.3909
Low affinity immunoglobulin gamma Fc region receptor III-B
Name Low affinity immunoglobulin gamma Fc region receptor III-B
Gene Name FCGR3B
Pharmacological action unknown
Actions Not Available
References
  • Hart SP, Ross JA, Ross K, Haslett C, Dransfield I: Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ. 2000 May;7(5):493-503. - Pubmed
  • Ozgocmen S, Godekmerdan A, Ozkurt-Zengin F: Acute-phase response, clinical measures and disease activity in ankylosing spondylitis. Joint Bone Spine. 2007 May;74(3):249-53. Epub 2007 Mar 5. - Pubmed
  • Criswell LA, Lum RF, Turner KN, Woehl B, Zhu Y, Wang J, Tiwari HK, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL Jr: The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum. 2004 Sep;50(9):2750-6. - Pubmed
  • Hughes LB, Criswell LA, Beasley TM, Edberg JC, Kimberly RP, Moreland LW, Seldin MF, Bridges SL: Genetic risk factors for infection in patients with early rheumatoid arthritis. Genes Immun. 2004 Dec;5(8):641-7. - Pubmed
DTHybrid score 1.7016
Complement C1s subcomponent
Name Complement C1s subcomponent
Gene Name C1S
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2564
Complement C1r subcomponent
Name Complement C1r subcomponent
Gene Name C1R
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6093
Complement C1q subcomponent subunit A
Name Complement C1q subcomponent subunit A
Gene Name C1QA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6282
Complement C1q subcomponent subunit B
Name Complement C1q subcomponent subunit B
Gene Name C1QB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6291
Complement C1q subcomponent subunit C
Name Complement C1q subcomponent subunit C
Gene Name C1QC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6291

Enzymes


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inhibitor
References
  • Bawolak MT, Touzin K, Moreau ME, Desormeaux A, Adam A, Marceau F: Cardiovascular expression of inflammatory signaling molecules, the kinin B1 receptor and COX2, in the rabbit: effects of LPS, anti-inflammatory and anti-hypertensive drugs. Regul Pept. 2008 Feb 7;146(1-3):157-68. Epub 2007 Sep 14. - Pubmed
  • Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, Bramanti P, Cuzzocrea S: Immunomodulatory effects of etanercept in an experimental model of spinal cord injury. J Pharmacol Exp Ther. 2006 Mar;316(3):1006-16. Epub 2005 Nov 22. - Pubmed
DTHybrid score 0.5389

Predictions


Id Partner name Gene Name Score
75 B-lymphocyte antigen CD20 MS4A1 0.368
724 Interleukin-2 receptor alpha chain IL2RA 0.2164
717 Interleukin-2 receptor subunit beta IL2RB 0.2163
20 Prostaglandin G/H synthase 1 PTGS1 0.1769
844 Epidermal growth factor receptor EGFR 0.1751
744 Myeloid cell surface antigen CD33 CD33 0.1557
93 CAMPATH-1 antigen CD52 0.1474
757 Fusion glycoprotein F0 F 0.147
4875 Fusion glycoprotein F0 F 0.147
1733 Vitronectin VTN 0.1334
793 T-cell surface antigen CD2 CD2 0.1302
5901 T-cell surface glycoprotein CD3 zeta chain CD247 0.1247
302 T-cell surface glycoprotein CD3 epsilon chain CD3E 0.1247
5900 T-cell surface glycoprotein CD3 gamma chain CD3G 0.1247
5899 T-cell surface glycoprotein CD3 delta chain CD3D 0.1246
1783 Intercellular adhesion molecule 1 ICAM1 0.1174
647 Integrin alpha-4 ITGA4 0.1173
488 Integrin alpha-IIb ITGA2B 0.1156
2039 Integrin beta-3 ITGB3 0.1139
572 Integrin alpha-L ITGAL 0.1081
955 Complement C5 C5 0.1033
5898 Complement C3 C3 0.103
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0964
183 Vascular endothelial growth factor A VEGFA 0.0927
554 Low-density lipoprotein receptor LDLR 0.0664
3811 Cytochrome P450 19A1 CYP19A1 0.0657
4757 Cytochrome P450 2C9 CYP2C9 0.0544
4200 Cytochrome P450 1A2 CYP1A2 0.0458
4512 Cytochrome P450 3A4 CYP3A4 0.0425
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0384
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0367
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0326
1729 Solute carrier family 22 member 6 SLC22A6 0.0322
6024 Cytochrome P450 1A1 CYP1A1 0.0318
1588 Multidrug resistance protein 1 ABCB1 0.0285
1820 Beta-nerve growth factor NGF 0.0274
6016 Cytochrome P450 2C19 CYP2C19 0.0266
3090 Chitosanase csn 0.0265
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0265
587 Serum albumin ALB 0.0261
6013 Cytochrome P450 2E1 CYP2E1 0.0257
4924 Cytochrome P450 2C8 CYP2C8 0.0254
1253 Interferon gamma IFNG 0.023
2232 Interleukin-5 IL5 0.0211
1593 Mucin-2 MUC2 0.021
275 Arachidonate 5-lipoxygenase ALOX5 0.0194
1757 Myeloperoxidase MPO 0.0192
1159 Interleukin-6 IL6 0.0185
2112 Toll-like receptor 9 TLR9 0.0185
4118 Cytochrome P450 3A5 CYP3A5 0.0174
660 T-cell surface glycoprotein CD1a CD1A 0.0172
6063 Major histocompatibility complex class I-related gene protein MR1 0.0172
5955 T-cell surface glycoprotein CD4 CD4 0.0172
6065 Integrin beta-1 ITGB1 0.0172
6066 Integrin alpha-V ITGAV 0.0172
1517 Beta-3 adrenergic receptor ADRB3 0.0172
65 Matrix metalloproteinase-9 Not Available 0.0171
1123 Eosinophil cationic protein RNASE3 0.0168
823 Fibroblast growth factor receptor 2 FGFR2 0.0153
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0152
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0149
3932 Glutathione S-transferase A2 GSTA2 0.0138
942 T-lymphocyte activation antigen CD86 CD86 0.0138
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
6142 Solute carrier family 22 member 8 SLC22A8 0.0133
193 Beta-1 adrenergic receptor ADRB1 0.0126
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
766 Beta-2 adrenergic receptor ADRB2 0.0124
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0121
2164 Multidrug resistance-associated protein 4 ABCC4 0.0117
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0117
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0112
1439 Lactotransferrin LTF 0.0112
4119 Cytochrome P450 2D6 CYP2D6 0.0111
3923 Cholinesterase BCHE 0.011
1024 Solute carrier family 22 member 11 SLC22A11 0.0109
6220 Aryl hydrocarbon receptor AHR 0.0094
373 Transthyretin TTR 0.009
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0071
850 Vasopressin V1b receptor AVPR1B 0.007
6143 Solute carrier family 22 member 7 SLC22A7 0.0067
3947 Xanthine dehydrogenase/oxidase XDH 0.0067
146 Androgen receptor AR 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
185 Vasopressin V1a receptor AVPR1A 0.0061
6012 Tryptophan 2,3-dioxygenase TDO2 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
723 Cytosolic phospholipase A2 PLA2G4A 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
322 Vasopressin V2 receptor AVPR2 0.006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0056
676 Tyrosine 3-monooxygenase TH 0.0054
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0052
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
1648 Elastin ELN 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
6500 Phospholipase A2 PLA2G1B 0.0045
1656 CYP2B protein CYP2B 0.0045
737 Mineralocorticoid receptor NR3C2 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0043
6043 Putative G-protein coupled receptor 44 GPR44 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0041
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0041
614 Progesterone receptor PGR 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0038
130 Prostacyclin synthase PTGIS 0.0037
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
6106 Cytochrome P450 2C18 CYP2C18 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
871 Glucocorticoid receptor NR3C1 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
6033 High affinity interleukin-8 receptor A CXCR1 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
6137 Multidrug resistance-associated protein 6 ABCC6 0.003
489 Monocarboxylate transporter 2 SLC16A7 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0029
1714 Mitogen-activated protein kinase 3 MAPK3 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
862 Multidrug resistance-associated protein 1 ABCC1 0.0027
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
1650 Heme carrier protein 1 SLC46A1 0.0026
6141 Sodium/bile acid cotransporter SLC10A1 0.0026
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0025
4878 Glycoprotein hormones alpha chain CGA 0.0024
1072 Granzyme B GZMB 0.0024
4189 Alpha-galactosidase A GLA 0.0024
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0024
4889 Ig epsilon chain C region IGHE 0.0024
4877 Beta-mannanase man 0.0024
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0024
4850 Beta-2-glycoprotein 1 APOH 0.0024
4852 Reticulon-4 receptor RTN4R 0.0024
4880 Membrane cofactor protein CD46 0.0024
4856 CD209 antigen CD209 0.0024
4869 Major capsid protein A430L 0.0024
4845 ADAM 33 ADAM33 0.0024
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0024
1354 Beta-glucuronidase GUSB 0.0024
442 Envelope glycoprotein gp41 0.0024
4859 Envelope glycoprotein env 0.0024
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0024
4721 Beta-1,4-mannanase manA 0.0024
3352 Structural polyprotein Not Available 0.0024
3628 Structural polyprotein Not Available 0.0024
4892 Structural polyprotein Not Available 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
6030 Cytochrome P450 2B6 CYP2B6 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0022
1184 Interferon beta IFNB1 0.0021
6858 Inactive carboxylesterase 4 CES1P1 0.0021
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0021
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0021
4890 Hemagglutinin HA 0.0021
6566 Hemagglutinin Not Available 0.0021
4861 Interleukin-6 receptor alpha chain IL6R 0.0021
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0021
1379 Interleukin-12 subunit beta IL12B 0.0021
3837 Cytokine receptor common beta chain CSF2RB 0.0021
1898 Cytochrome P450 1B1 CYP1B1 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
4604 Liver carboxylesterase 1 CES1 0.002
822 Aldose reductase AKR1B1 0.002
1181 Alpha-1-acid glycoprotein 1 ORM1 0.002
904 Glutathione S-transferase P GSTP1 0.002
3444 Cyanovirin-N Not Available 0.002
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.002
1859 Prostatic acid phosphatase ACPP 0.002
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.002
852 Heparin cofactor 2 SERPIND1 0.002
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.002
3140 Hemagglutinin-neuraminidase HN 0.002
3609 Hemagglutinin-neuraminidase HN 0.002
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.002
2297 Genome polyprotein Not Available 0.002
2322 Genome polyprotein Not Available 0.002
2694 Genome polyprotein Not Available 0.002
2719 Genome polyprotein Not Available 0.002
2860 Genome polyprotein Not Available 0.002
2928 Genome polyprotein Not Available 0.002
3160 Genome polyprotein Not Available 0.002
3260 Genome polyprotein Not Available 0.002
4783 Genome polyprotein Not Available 0.002
5726 Genome polyprotein Not Available 0.002
5779 Genome polyprotein Not Available 0.002
5867 Genome polyprotein Not Available 0.002
6253 Genome polyprotein Not Available 0.002
6301 Genome polyprotein Not Available 0.002
6380 Genome polyprotein Not Available 0.002
6381 Genome polyprotein Not Available 0.002
6437 Genome polyprotein Not Available 0.002
6520 Genome polyprotein Not Available 0.002
6521 Genome polyprotein Not Available 0.002
6652 Genome polyprotein Not Available 0.002
6734 Genome polyprotein Not Available 0.002
6735 Genome polyprotein Not Available 0.002
6736 Genome polyprotein Not Available 0.002
6737 Genome polyprotein Not Available 0.002
6738 Genome polyprotein Not Available 0.002
6739 Genome polyprotein Not Available 0.002
6744 Genome polyprotein Not Available 0.002
6748 Genome polyprotein Not Available 0.002
6894 Genome polyprotein Not Available 0.002
6898 Genome polyprotein Not Available 0.002
558 Solute carrier family 12 member 1 SLC12A1 0.0019
4666 Fucose-binding lectin PA-IIL lecB 0.0019
2372 Bifunctional tail protein 9 0.0019
4787 Envelope glycoprotein gp160 env 0.0019
4820 Envelope glycoprotein gp160 env 0.0019
5727 Envelope glycoprotein gp160 env 0.0019
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
3480 Mannan endo-1,4-beta-mannosidase manA 0.0017
64 Neuraminidase NA 0.0017
641 Neuraminidase NA 0.0017
2676 Neuraminidase NA 0.0017
3026 Neuraminidase NA 0.0017
3519 Neuraminidase NA 0.0017
6007 Neuraminidase NA 0.0017
595 Fibrinogen alpha chain FGA 0.0017
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0017
2021 Thrombomodulin THBD 0.0016
1243 Cathepsin D CTSD 0.0016
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0016
2430 Chondroitinase B cslB 0.0016
958 Insulin-like growth factor 1 receptor IGF1R 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0015
6307 Ig gamma-2 chain C region IGHG2 0.0015
309 Antithrombin-III SERPINC1 0.0015
2581 Chondroitinase AC cslA 0.0015
6847 Lactase-phlorizin hydrolase LCT 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
76 Nitric-oxide synthase, brain NOS1 0.0015
2207 Rhodopsin RHO 0.0014
1050 Bile salt sulfotransferase SULT2A1 0.0014
4192 DNA topoisomerase 2-beta TOP2B 0.0014
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
4785 Ig gamma-1 chain C region IGHG1 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
952 Dipeptidyl peptidase 4 DPP4 0.0011
6148 Multidrug resistance-associated protein 7 ABCC10 0.0011
6085 Fatty acid-binding protein, intestinal FABP2 0.0011
817 DNA topoisomerase 2-alpha TOP2A 0.001
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
1313 Lactoylglutathione lyase GLO1 0.0009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
6144 Solute carrier family 22 member 2 SLC22A2 0.0007
4943 Cytochrome c6 petJ 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4984 Neuroglobin NGB 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4961 Hemophore HasA hasA 0.0005
4910 Cytoglobin CYGB 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4916 Cyanoglobin glbN 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
5000 HemO hemO 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4909 CooA protein cooA 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4972 P450cin cinA 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4952 Catalase/peroxidase katA 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
4920 Peroxidase/catalase katG 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4948 Cytochrome c-553 Not Available 0.0004
2119 Cytochrome b5 CYB5A 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4990 PpcA ppcA 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
518 Peroxidase/catalase T katG 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
605 Fumarate reductase flavoprotein subunit frdA 0.0003
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0003
3673 Fumarate reductase flavoprotein subunit fccA 0.0003
4912 Fumarate reductase flavoprotein subunit ifcA 0.0003
6549 Fumarate reductase flavoprotein subunit frdA 0.0003
3221 Cytochrome c4 cc4 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0003
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
7 Nitric oxide synthase, inducible NOS2 0.0002
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