Identification | |
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Name | Gemtuzumab ozogamicin |
Accession Number | DB00056 (BIOD00077, BTD00077) |
Type | biotech |
Description | Recombinant humanized IgG4, kappa antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin, isolated from fermentation of a bacterium, Micromonospora echinospora ssp. calichensis. The antibody portion of Mylotarg binds specifically to the CD33 antigen, The anti-CD33 hP67.6 antibody is produced by mammalian cell suspension culture using a myeloma NS0 cell line. |
Structure |
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Categories (*) | |
Molecular Weight | Not Available |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For treatment of CD33-positive acute myeloid leukemia in patients 60 and over who are not candidates for other chemotherapy. |
Mechanism of action | Mylotarg is directed against the CD33 antigen expressed by hematopoietic cells. Binding of the anti-CD33 antibody portion of Mylotarg with the CD33 antigen results in the formation of a complex that is internalized. Upon internalization, the calicheamicin derivative is released inside the lysosomes of the myeloid cell. The released calicheamicin derivative binds to DNA in the minor groove resulting in DNA double strand breaks and cell death. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Most likely removed by opsonization via the reticuloendothelial system. |
Route of elimination | Not Available |
Toxicity | The most frequently reported toxicities are myelosuppression and hepatic veno-occlusive disorder. |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Myeloid cell surface antigen CD33 | |
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Name | Myeloid cell surface antigen CD33 |
Gene Name | CD33 |
Pharmacological action | yes |
Actions | antibody |
References |
|
DTHybrid score | 0.3224 |
Low affinity immunoglobulin gamma Fc region receptor III-B | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-B |
Gene Name | FCGR3B |
Pharmacological action | unknown |
Actions | Not Available |
References |
|
DTHybrid score | 1.6327 |
Complement C1r subcomponent | |
Name | Complement C1r subcomponent |
Gene Name | C1R |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5405 |
Complement C1q subcomponent subunit A | |
Name | Complement C1q subcomponent subunit A |
Gene Name | C1QA |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5586 |
Complement C1q subcomponent subunit B | |
Name | Complement C1q subcomponent subunit B |
Gene Name | C1QB |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5595 |
Complement C1q subcomponent subunit C | |
Name | Complement C1q subcomponent subunit C |
Gene Name | C1QC |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5596 |
Low affinity immunoglobulin gamma Fc region receptor III-A | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-A |
Gene Name | FCGR3A |
Pharmacological action | unknown |
Actions | Not Available |
References |
|
DTHybrid score | 1.6323 |
Complement C1s subcomponent | |
Name | Complement C1s subcomponent |
Gene Name | C1S |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.1801 |
High affinity immunoglobulin gamma Fc receptor I | |
Name | High affinity immunoglobulin gamma Fc receptor I |
Gene Name | FCGR1A |
Pharmacological action | unknown |
Actions | Not Available |
References |
|
DTHybrid score | 1.7178 |
Low affinity immunoglobulin gamma Fc region receptor II-a | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-a |
Gene Name | FCGR2A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6409 |
Low affinity immunoglobulin gamma Fc region receptor II-b | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
Gene Name | FCGR2B |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6357 |
Low affinity immunoglobulin gamma Fc region receptor II-c | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-c |
Gene Name | FCGR2C |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6465 |