DT-Web: DB01159

Identification

Name

Halothane

Accession Number

DB01159 (APRD00598, DB02330, EXPT01754)

Type

small molecule

Description

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

197.382

Groups

approved

Monoisotopic Weight

195.890225001

Pharmacology

Indication

For the induction and maintenance of general anesthesia

Mechanism of action

Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halothane's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Halothane is metabolized in the liver, primarily by CYP2E1, and to a lesser extent by CYP3A4 and CYP2A6.

Route of elimination

Not Available

Toxicity

Toxic effects of halothane include malignant hyperthermia and hepatitis.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Aminophylline	Increased risk of cardiac arrhythmia
Labetalol	Monitor arterial pressure closely
Oxtriphylline	Increased risk of cardiac arrhythmia
Theophylline	Increased risk of cardiac arrhythmia

Food Interactions

Not Available

Potassium channel subfamily K member 3
Name	Potassium channel subfamily K member 3
Gene Name	KCNK3
Pharmacological action	yes
Actions	binder
References	Lazarenko RM, Willcox SC, Shu S, Berg AP, Jevtovic-Todorovic V, Talley EM, Chen X, Bayliss DA: Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. J Neurosci. 2010 Jun 2;30(22):7691-704. - Pubmed Pandit JJ, Buckler KJ: Halothane and sevoflurane exert different degrees of inhibition on carotid body glomus cell intracellular Ca2+ response to hypoxia. Adv Exp Med Biol. 2010;669:201-4. - Pubmed
DTHybrid score	1.1202
Potassium channel subfamily K member 9
Name	Potassium channel subfamily K member 9
Gene Name	KCNK9
Pharmacological action	yes
Actions	binder
References	Lazarenko RM, Willcox SC, Shu S, Berg AP, Jevtovic-Todorovic V, Talley EM, Chen X, Bayliss DA: Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. J Neurosci. 2010 Jun 2;30(22):7691-704. - Pubmed Pandit JJ, Buckler KJ: Halothane and sevoflurane exert different degrees of inhibition on carotid body glomus cell intracellular Ca2+ response to hypoxia. Adv Exp Med Biol. 2010;669:201-4. - Pubmed
DTHybrid score	1.1203
Calcium-activated potassium channel subunit alpha 1
Name	Calcium-activated potassium channel subunit alpha 1
Gene Name	KCNMA1
Pharmacological action	unknown
Actions	inhibitor
References	Namba T, Ishii TM, Ikeda M, Hisano T, Itoh T, Hirota K, Adelman JP, Fukuda K: Inhibition of the human intermediate conductance Ca(2+)-activated K(+) channel, hIK1, by volatile anesthetics. Eur J Pharmacol. 2000 Apr 28;395(2):95-101. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.5242
Glutamate [NMDA] receptor subunit 3A
Name	Glutamate [NMDA] receptor subunit 3A
Gene Name	GRIN3A
Pharmacological action	unknown
Actions	antagonist
References	Perouansky M, Kirson ED, Yaari Y: Halothane blocks synaptic excitation of inhibitory interneurons. Anesthesiology. 1996 Dec;85(6):1431-8; discussion 29A. - Pubmed
DTHybrid score	0.5269
Glutamate [NMDA] receptor subunit 3B
Name	Glutamate [NMDA] receptor subunit 3B
Gene Name	GRIN3B
Pharmacological action	unknown
Actions	antagonist
References	Perouansky M, Kirson ED, Yaari Y: Halothane blocks synaptic excitation of inhibitory interneurons. Anesthesiology. 1996 Dec;85(6):1431-8; discussion 29A. - Pubmed
DTHybrid score	0.3949
Glutamate [NMDA] receptor subunit epsilon-1
Name	Glutamate [NMDA] receptor subunit epsilon-1
Gene Name	GRIN2A
Pharmacological action	unknown
Actions	antagonist
References	Perouansky M, Kirson ED, Yaari Y: Halothane blocks synaptic excitation of inhibitory interneurons. Anesthesiology. 1996 Dec;85(6):1431-8; discussion 29A. - Pubmed
DTHybrid score	0.4261
Glycine receptor subunit alpha-1
Name	Glycine receptor subunit alpha-1
Gene Name	GLRA1
Pharmacological action	unknown
Actions	allosteric modulator
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Schofield CM, Trudell JR, Harrison NL: Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry. 2004 Aug 10;43(31):10058-63. - Pubmed
DTHybrid score	0.697
Rhodopsin
Name	Rhodopsin
Gene Name	RHO
Pharmacological action	unknown
Actions	other
References	Ishizawa Y, Sharp R, Liebman PA, Eckenhoff RG: Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling. Biochemistry. 2000 Jul 25;39(29):8497-502. - Pubmed Keller C, Grimm C, Wenzel A, Hafezi F, Reme C: Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration. Invest Ophthalmol Vis Sci. 2001 Feb;42(2):476-80. - Pubmed
DTHybrid score	0.6856
G protein-activated inward rectifier potassium channel 2
Name	G protein-activated inward rectifier potassium channel 2
Gene Name	KCNJ6
Pharmacological action	unknown
Actions	inhibitor
References	Milovic S, Steinecker-Frohnwieser B, Schreibmayer W, Weigl LG: The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus. J Biol Chem. 2004 Aug 13;279(33):34240-9. Epub 2004 Jun 2. - Pubmed Hara K, Yamakura T, Sata T, Harris RA: The effects of anesthetics and ethanol on alpha2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes. Anesth Analg. 2005 Nov;101(5):1381-8. - Pubmed
DTHybrid score	0.4715
G protein-activated inward rectifier potassium channel 1
Name	G protein-activated inward rectifier potassium channel 1
Gene Name	KCNJ3
Pharmacological action	unknown
Actions	inhibitor
References	Weigl LG, Schreibmayer W: G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics. Mol Pharmacol. 2001 Aug;60(2):282-9. - Pubmed Yamakura T, Lewohl JM, Harris RA: Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels. Anesthesiology. 2001 Jul;95(1):144-53. - Pubmed Milovic S, Steinecker-Frohnwieser B, Schreibmayer W, Weigl LG: The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus. J Biol Chem. 2004 Aug 13;279(33):34240-9. Epub 2004 Jun 2. - Pubmed
DTHybrid score	0.4714
NADH-ubiquinone oxidoreductase chain 1
Name	NADH-ubiquinone oxidoreductase chain 1
Gene Name	MT-ND1
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Hanley PJ, Ray J, Brandt U, Daut J: Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol. 2002 Nov 1;544(Pt 3):687-93. - Pubmed
DTHybrid score	0.6296
Intermediate conductance calcium-activated potassium channel protein 4
Name	Intermediate conductance calcium-activated potassium channel protein 4
Gene Name	KCNN4
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Namba T, Ishii TM, Ikeda M, Hisano T, Itoh T, Hirota K, Adelman JP, Fukuda K: Inhibition of the human intermediate conductance Ca(2+)-activated K(+) channel, hIK1, by volatile anesthetics. Eur J Pharmacol. 2000 Apr 28;395(2):95-101. - Pubmed
DTHybrid score	0.3421
ATP synthase delta chain, mitochondrial
Name	ATP synthase delta chain, mitochondrial
Gene Name	ATP5D
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6994
Calcium-transporting ATPase type 2C member 1
Name	Calcium-transporting ATPase type 2C member 1
Gene Name	ATP2C1
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.7341
Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.5814
Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit
Name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit
Gene Name	GNG2
Pharmacological action	unknown
Actions	other/unknown
References	Ishizawa Y, Sharp R, Liebman PA, Eckenhoff RG: Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling. Biochemistry. 2000 Jul 25;39(29):8497-502. - Pubmed Zang WJ, Yu XJ, Zang YM: [Effect of halothane on the muscarinic potassium current of the heart] Sheng Li Xue Bao. 2000 Apr;52(2):175-8. - Pubmed Yoshimura H, Jones KA, Perkins WJ, Warner DOh4. : Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle. Anesthesiology. 2003 Apr;98(4):871-80. - Pubmed Streiff J, Jones K, Perkins WJ, Warner DO, Jones KA: Effect of halothane on the guanosine 5' triphosphate binding activity of G-protein alphai subunits. Anesthesiology. 2003 Jul;99(1):105-11. - Pubmed Milovic S, Steinecker-Frohnwieser B, Schreibmayer W, Weigl LG: The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus. J Biol Chem. 2004 Aug 13;279(33):34240-9. Epub 2004 Jun 2. - Pubmed
DTHybrid score	0.4705
Neuropeptide S receptor
Name	Neuropeptide S receptor
Gene Name	NPSR1
Pharmacological action	unknown
Actions	other/unknown
References	Ishizawa Y, Sharp R, Liebman PA, Eckenhoff RG: Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling. Biochemistry. 2000 Jul 25;39(29):8497-502. - Pubmed Ishizawa Y, Pidikiti R, Liebman PA, Eckenhoff RG: G protein-coupled receptors as direct targets of inhaled anesthetics. Mol Pharmacol. 2002 May;61(5):945-52. - Pubmed Streiff J, Jones K, Perkins WJ, Warner DO, Jones KA: Effect of halothane on the guanosine 5' triphosphate binding activity of G-protein alphai subunits. Anesthesiology. 2003 Jul;99(1):105-11. - Pubmed
DTHybrid score	0.47

Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Restrepo JG, Garcia-Martin E, Martinez C, Agundez JA: Polymorphic drug metabolism in anaesthesia. Curr Drug Metab. 2009 Mar;10(3):236-46. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Spracklin DK, Hankins DC, Fisher JM, Thummel KE, Kharasch ED: Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. J Pharmacol Exp Ther. 1997 Apr;281(1):400-11. - Pubmed
DTHybrid score	0.641
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Restrepo JG, Garcia-Martin E, Martinez C, Agundez JA: Polymorphic drug metabolism in anaesthesia. Curr Drug Metab. 2009 Mar;10(3):236-46. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8217
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Restrepo JG, Garcia-Martin E, Martinez C, Agundez JA: Polymorphic drug metabolism in anaesthesia. Curr Drug Metab. 2009 Mar;10(3):236-46. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5617
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6205
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6205
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6298

Id	Partner name	Gene Name	Score
705	Glutamate receptor 1	GRIA1	0.3966
6016	Cytochrome P450 2C19	CYP2C19	0.3833
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.3554
4200	Cytochrome P450 1A2	CYP1A2	0.334
4924	Cytochrome P450 2C8	CYP2C8	0.2742
1588	Multidrug resistance protein 1	ABCB1	0.253
4118	Cytochrome P450 3A5	CYP3A5	0.1925
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.1723
6107	Cytochrome P450 3A7	CYP3A7	0.1546
6024	Cytochrome P450 1A1	CYP1A1	0.1499
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.1365
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.1165
20	Prostaglandin G/H synthase 1	PTGS1	0.1157
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.1138
2176	Protein S100-P	S100P	0.0971
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0958
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0951
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0914
492	Histamine H1 receptor	HRH1	0.0892
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0887
465	Calmodulin	CALM1	0.087
831	D(2) dopamine receptor	DRD2	0.0829
1181	Alpha-1-acid glycoprotein 1	ORM1	0.081
3811	Cytochrome P450 19A1	CYP19A1	0.0795
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0757
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0704
824	Sodium-dependent serotonin transporter	SLC6A4	0.0701
4278	N-acylamino acid racemase	Aaar	0.0697
5497	N-acylamino acid racemase	DR_0044	0.0697
295	Carbonic anhydrase 1	CA1	0.0694
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0688
820	Glycine receptor subunit alpha-2	GLRA2	0.068
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0674
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0669
1729	Solute carrier family 22 member 6	SLC22A6	0.0667
6106	Cytochrome P450 2C18	CYP2C18	0.0658
6144	Solute carrier family 22 member 2	SLC22A2	0.0635
3119	Fimbrial protein	pilE1	0.0611
3395	Iron(III) dicitrate transport protein fecA	fecA	0.06
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.06
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0599
466	Solute carrier family 12 member 3	SLC12A3	0.0594
592	Carbonic anhydrase 4	CA4	0.0593
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0587
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0578
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0572
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0558
290	Prostaglandin G/H synthase 2	PTGS2	0.0552
6145	Solute carrier family 22 member 1	SLC22A1	0.0551
713	Sodium-dependent dopamine transporter	SLC6A3	0.0544
260	Cytochrome P450 51	ERG11	0.0541
761	Cytochrome P450 51	ERG11	0.0541
3163	Cytochrome P450 51	cyp51	0.0541
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0539
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0537
357	Carbonic anhydrase 2	CA2	0.0533
3923	Cholinesterase	BCHE	0.0523
556	Alpha-1A adrenergic receptor	ADRA1A	0.0498
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0496
461	Glycine receptor subunit alpha-3	GLRA3	0.049
6638	Biotin biosynthesis cytochrome P450	bioI	0.0488
6636	NADPH:ferredoxin reductase	fpr	0.0487
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0487
62	Glycine receptor subunit beta	GLRB	0.0472
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0464
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0458
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0457
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0456
1108	Calpastatin	CAST	0.0448
1089	Cartilage oligomeric matrix protein	COMP	0.0448
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0446
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0445
174	Sigma 1-type opioid receptor	SIGMAR1	0.0442
921	Glutamate receptor 2	GRIA2	0.0438
862	Multidrug resistance-associated protein 1	ABCC1	0.0437
891	Dihydropteroate synthase	folP	0.0437
5359	Dihydropteroate synthase	folP	0.0437
7175	Dihydropteroate synthase	sulI	0.0437
617	Muscarinic acetylcholine receptor M2	CHRM2	0.043
118	Organic cation/carnitine transporter 2	SLC22A5	0.0421
468	Cytochrome P450 4A11	CYP4A11	0.0414
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0401
847	Mu-type opioid receptor	OPRM1	0.0398
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0398
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0397
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0396
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0394
6637	Acyl carrier protein	acpP	0.0393
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.039
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0388
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0386
696	Kappa-type opioid receptor	OPRK1	0.0385
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0384
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0382
4205	Carbonic anhydrase 9	CA9	0.0378
3007	Carbonic anhydrase 12	CA12	0.0378
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0371
1898	Cytochrome P450 1B1	CYP1B1	0.0362
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.036
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0359
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0359
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0358
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0358
23	D(1A) dopamine receptor	DRD1	0.035
5469	Head decoration protein	shp	0.035
3426	Glutamine synthetase	glnA	0.0347
3987	Glutamine synthetase	GLUL	0.0347
811	Translocator protein	TSPO	0.0347
766	Beta-2 adrenergic receptor	ADRB2	0.0345
318	Alpha-2A adrenergic receptor	ADRA2A	0.0342
136	Estrogen receptor	ESR1	0.0334
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0334
467	Delta-type opioid receptor	OPRD1	0.0329
6151	Monocarboxylate transporter 10	SLC16A10	0.0327
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0323
6142	Solute carrier family 22 member 8	SLC22A8	0.0315
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0309
776	Bile salt export pump	ABCB11	0.0294
6048	Troponin C, skeletal muscle	TNNC2	0.0291
3939	Amine oxidase [flavin-containing] B	MAOB	0.0288
2164	Multidrug resistance-associated protein 4	ABCC4	0.0286
2132	Protein S100-B	S100B	0.0282
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0278
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0278
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0278
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0277
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0277
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0276
632	Alpha-1B adrenergic receptor	ADRA1B	0.0274
251	Alcohol dehydrogenase 1A	ADH1A	0.0273
833	Organic cation/carnitine transporter 1	SLC22A4	0.0272
2530	Protein kinase C theta type	PRKCQ	0.0261
731	HIV-1 protease	HIV-1 protease	0.0259
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0255
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0255
976	Platelet glycoprotein IX	GP9	0.0254
3941	Amine oxidase [flavin-containing] A	MAOA	0.0252
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0251
274	Muscarinic acetylcholine receptor M5	CHRM5	0.025
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.025
444	Alcohol dehydrogenase 1B	ADH1B	0.0248
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0244
6143	Solute carrier family 22 member 7	SLC22A7	0.0243
871	Glucocorticoid receptor	NR3C1	0.0241
193	Beta-1 adrenergic receptor	ADRB1	0.0238
1405	Thiopurine S-methyltransferase	TPMT	0.0237
2178	Metabotropic glutamate receptor 5	GRM5	0.0234
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0229
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0227
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0226
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0225
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0224
6385	H subunit of photosynthetic reaction center complex	puhA	0.0223
1024	Solute carrier family 22 member 11	SLC22A11	0.0222
6147	Solute carrier family 22 member 3	SLC22A3	0.0222
4750	Protein S100-A11	S100A11	0.0218
122	P2Y purinoceptor 12	P2RY12	0.0218
916	Metabotropic glutamate receptor 1	GRM1	0.0218
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0217
3067	Aquaporin Z	aqpZ	0.0216
6320	Aquaporin Z	aqpZ	0.0216
6031	Cytochrome P450 3A43	CYP3A43	0.0216
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0212
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0211
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0211
4056	N-arachidonyl glycine receptor	GPR18	0.0211
4057	Glycine N-acyltransferase	GLYAT	0.0211
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0211
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0211
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0211
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0211
1466	Glycyl-tRNA synthetase	GARS	0.0211
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0211
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0211
517	Alcohol dehydrogenase 1C	ADH1C	0.0208
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0206
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0205
558	Solute carrier family 12 member 1	SLC12A1	0.0204
2211	Fatty acid-binding protein, heart	FABP3	0.0202
6014	Cytochrome P450 2A13	CYP2A13	0.0199
6102	Arylamine N-acetyltransferase 2	NAT2	0.0196
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0194
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0194
3005	Threonine-phosphate decarboxylase	cobD	0.0189
4751	Mitogen-activated protein kinase 12	MAPK12	0.0189
3482	Cell division protein kinase 7	CDK7	0.0189
6387	Ubiquinol-cytochrome c reductase iron-sulfur subunit	petA	0.0188
6388	Cytochrome c1	petC	0.0188
1227	Cytochrome b	MT-CYB	0.0188
6386	Cytochrome b	petB	0.0188
6937	Cytochrome b	MT-CYB	0.0188
3023	DNA polymerase I, thermostable	polA	0.0188
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0184
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0183
638	D(3) dopamine receptor	DRD3	0.0176
4604	Liver carboxylesterase 1	CES1	0.0174
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0174
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0174
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0174
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0174
4096	Metabotropic glutamate receptor 3	GRM3	0.0174
1362	Metabotropic glutamate receptor 2	GRM2	0.0174
411	Glycine N-methyltransferase	GNMT	0.0173
6085	Fatty acid-binding protein, intestinal	FABP2	0.0172
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0172
629	Alpha-2B adrenergic receptor	ADRA2B	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0168
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0167
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0164
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0162
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0162
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0162
6677	Myelin P2 protein	PMP2	0.0162
789	Alpha-1D adrenergic receptor	ADRA1D	0.0161
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.016
427	Substance-P receptor	TACR1	0.016
885	5-hydroxytryptamine 1B receptor	HTR1B	0.016
3884	SHMT2 protein	SHMT2	0.0159
3901	SHMT2 protein	SHMT2	0.0159
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0159
3879	Serine hydroxymethyltransferase 2	Not Available	0.0159
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0159
4784	Beta-mannosidase	manB	0.0159
6695	Beta-mannosidase	BT_0458	0.0159
7	Nitric oxide synthase, inducible	NOS2	0.0156
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0152
207	Glutathione synthetase	GSS	0.0152
5269	Glutathione synthetase	gshB	0.0152
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.015
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0149
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0148
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0148
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0147
3616	Fatty acid-binding protein, epidermal	FABP5	0.0146
5431	Lipid binding protein	Not Available	0.0146
5433	UPF0230 protein TM_1468	TM_1468	0.0146
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0146
383	Glycine amidinotransferase, mitochondrial	GATM	0.0145
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0145
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
817	DNA topoisomerase 2-alpha	TOP2A	0.0142
4787	Envelope glycoprotein gp160	env	0.014
4820	Envelope glycoprotein gp160	env	0.014
5727	Envelope glycoprotein gp160	env	0.014
6136	Multidrug resistance-associated protein 5	ABCC5	0.014
738	Monocarboxylate transporter 1	SLC16A1	0.0139
146	Androgen receptor	AR	0.0139
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0138
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0138
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0138
349	Serine--pyruvate aminotransferase	AGXT	0.0137
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0137
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0135
1422	Serine/threonine-protein kinase 6	AURKA	0.0135
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0134
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0134
2297	Genome polyprotein	Not Available	0.0134
2322	Genome polyprotein	Not Available	0.0134
2694	Genome polyprotein	Not Available	0.0134
2719	Genome polyprotein	Not Available	0.0134
2860	Genome polyprotein	Not Available	0.0134
2928	Genome polyprotein	Not Available	0.0134
3160	Genome polyprotein	Not Available	0.0134
3260	Genome polyprotein	Not Available	0.0134
4783	Genome polyprotein	Not Available	0.0134
5726	Genome polyprotein	Not Available	0.0134
5779	Genome polyprotein	Not Available	0.0134
5867	Genome polyprotein	Not Available	0.0134
6253	Genome polyprotein	Not Available	0.0134
6301	Genome polyprotein	Not Available	0.0134
6380	Genome polyprotein	Not Available	0.0134
6381	Genome polyprotein	Not Available	0.0134
6437	Genome polyprotein	Not Available	0.0134
6520	Genome polyprotein	Not Available	0.0134
6521	Genome polyprotein	Not Available	0.0134
6652	Genome polyprotein	Not Available	0.0134
6734	Genome polyprotein	Not Available	0.0134
6735	Genome polyprotein	Not Available	0.0134
6736	Genome polyprotein	Not Available	0.0134
6737	Genome polyprotein	Not Available	0.0134
6738	Genome polyprotein	Not Available	0.0134
6739	Genome polyprotein	Not Available	0.0134
6744	Genome polyprotein	Not Available	0.0134
6748	Genome polyprotein	Not Available	0.0134
6894	Genome polyprotein	Not Available	0.0134
6898	Genome polyprotein	Not Available	0.0134
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0134
70	Type-1 angiotensin II receptor	AGTR1	0.0133
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0132
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0131
378	Alpha-2C adrenergic receptor	ADRA2C	0.013
291	Nitric-oxide synthase, endothelial	NOS3	0.0129
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0129
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0128
432	D(4) dopamine receptor	DRD4	0.0127
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0127
94	5-hydroxytryptamine 4 receptor	HTR4	0.0127
756	Sex hormone-binding globulin	SHBG	0.0126
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0126
1176	Mitogen-activated protein kinase 1	MAPK1	0.0126
6459	Glycodelin	PAEP	0.0125
232	Corticosteroid-binding globulin	SERPINA6	0.0125
3932	Glutathione S-transferase A2	GSTA2	0.0125
3437	Eosinophil lysophospholipase	CLC	0.0122
380	Cytochrome P450 17A1	CYP17A1	0.0122
869	Estrogen receptor beta	ESR2	0.0122
844	Epidermal growth factor receptor	EGFR	0.0122
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0121
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0121
694	Matrix protein 2	M	0.0121
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0121
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
6020	Aldehyde oxidase	AOX1	0.0119
716	5-hydroxytryptamine 7 receptor	HTR7	0.0118
6131	Carbonic anhydrase 14	CA14	0.0116
6220	Aryl hydrocarbon receptor	AHR	0.0116
1010	Cytochrome P450 51A1	CYP51A1	0.0115
373	Transthyretin	TTR	0.0115
2230	Catalase	CAT	0.0114
3249	Catalase	katA	0.0114
3625	Catalase	katA	0.0114
4539	Catalase	katA	0.0114
4941	Catalase	katB	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
319	Opioid receptor, sigma 1	OPRS1	0.0112
283	SEC14-like protein 2	SEC14L2	0.0111
614	Progesterone receptor	PGR	0.0111
6141	Sodium/bile acid cotransporter	SLC10A1	0.011
2514	Phosphocarrier protein HPr	ptsH	0.0109
5689	Phosphocarrier protein HPr	ptsH	0.0109
131	Synaptic vesicular amine transporter	SLC18A2	0.0109
3602	Anti-sigma F factor antagonist	spoIIAA	0.0109
5686	Potassium voltage-gated channel subfamily C member 4	KCNC4	0.0109
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0108
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0108
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
6182	Cytochrome P450 2J2	CYP2J2	0.0104
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0103
6474	Outer membrane protein W	ompW	0.0103
1656	CYP2B protein	CYP2B	0.0103
6438	Outer membrane protein G	ompG	0.0103
3947	Xanthine dehydrogenase/oxidase	XDH	0.0103
2925	Long-chain fatty acid transport protein	fadL	0.0103
6480	Outer membrane usher protein papC	papC	0.0103
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0102
16	Adenosine A1 receptor	ADORA1	0.0101
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0101
183	Vascular endothelial growth factor A	VEGFA	0.01
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.01
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0099
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0098
504	Mast/stem cell growth factor receptor	KIT	0.0098
4120	NADPH--cytochrome P450 reductase	POR	0.0098
3810	Catechol O-methyltransferase	COMT	0.0098
474	Acetylcholinesterase	ACHE	0.0098
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0096
6137	Multidrug resistance-associated protein 6	ABCC6	0.0096
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0096
2679	Vitamin B12 transporter btuB	btuB	0.0095
922	Glutamate receptor 4	GRIA4	0.0095
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0095
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0095
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0095
4018	Glutamate receptor delta-2 subunit	GRID2	0.0095
4027	Glutamate receptor delta-1 subunit	GRID1	0.0095
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0095
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0095
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0095
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0095
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0095
4026	Aspartyl aminopeptidase	DNPEP	0.0095
4016	Excitatory amino acid transporter 5	SLC1A7	0.0095
664	Glutamate decarboxylase 2	GAD2	0.0095
3890	Glutamate decarboxylase 2	GAD2	0.0095
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0095
1912	Excitatory amino acid transporter 1	SLC1A3	0.0095
4019	Excitatory amino acid transporter 4	SLC1A6	0.0095
1047	Excitatory amino acid transporter 2	SLC1A2	0.0095
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0095
925	Metabotropic glutamate receptor 4	GRM4	0.0095
4020	Glutamyl aminopeptidase	ENPEP	0.0095
4017	5-oxoprolinase	OPLAH	0.0095
926	Metabotropic glutamate receptor 7	GRM7	0.0095
927	Metabotropic glutamate receptor 8	GRM8	0.0095
1130	Lithostathine 1 alpha	REG1A	0.0095
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0095
4542	Glutaminase 1	glsA1	0.0095
4544	Glutaminase 1	glsA1	0.0095
566	Serotransferrin	TF	0.0094
161	Tubulin beta chain	TUBB	0.0094
312	Tubulin beta chain	TUB2	0.0094
4785	Ig gamma-1 chain C region	IGHG1	0.0094
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0093
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0093
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0093
563	Thyroid peroxidase	TPO	0.0092
777	Tumor necrosis factor	TNF	0.0092
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0091
818	50S ribosomal protein L10	rplJ	0.009
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.009
4237	50S ribosomal protein L22	rplV	0.009
365	Dihydrofolate reductase	DHFR	0.0089
2381	Dihydrofolate reductase	DFR1	0.0089
2833	Dihydrofolate reductase	Not Available	0.0089
2931	Dihydrofolate reductase	folA	0.0089
3544	Dihydrofolate reductase	folA	0.0089
3682	Dihydrofolate reductase	folA	0.0089
6642	Dihydrofolate reductase	folA	0.0089
6756	Dihydrofolate reductase	dfrA	0.0089
4318	Siroheme synthase	cysG	0.0089
1178	Adenosine A2a receptor	ADORA2A	0.0087
172	Potassium channel subfamily K member 1	KCNK1	0.0087
1757	Myeloperoxidase	MPO	0.0086
6148	Multidrug resistance-associated protein 7	ABCC10	0.0086
3904	Alanine aminotransferase 2	GPT2	0.0085
735	Alanine aminotransferase 1	GPT	0.0085
275	Arachidonate 5-lipoxygenase	ALOX5	0.0085
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0085
3937	Fatty-acid amide hydrolase	FAAH	0.0083
163	D(1B) dopamine receptor	DRD5	0.0083
518	Peroxidase/catalase T	katG	0.0083
3453	Alkaline phosphatase	phoA	0.0082
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0082
952	Dipeptidyl peptidase 4	DPP4	0.0082
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0081
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0081
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0081
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0081
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0081
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0081
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0081
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0081
29	Tubulin beta-1 chain	TUBB1	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
1050	Bile salt sulfotransferase	SULT2A1	0.0079
625	Glutamate carboxypeptidase 2	FOLH1	0.0079
665	Phosphoserine aminotransferase	PSAT1	0.0079
4652	Phosphoserine aminotransferase	serC	0.0079
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0079
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0079
420	Glutamate decarboxylase 1	GAD1	0.0079
3900	Glutamate decarboxylase 1	GAD1	0.0079
33	Cystine/glutamate transporter	SLC7A11	0.0078
124	Histamine H2 receptor	HRH2	0.0078
5150	Endo-1,4-beta-xylanase Y	xynY	0.0078
2503	Phosphomannomutase/phosphoglucomutase	algC	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
3715	Outer membrane protein A precursor	ompA	0.0078
4340	Hypothetical conserved protein	GK2698	0.0078
6484	Hypothetical conserved protein	TT_C0834	0.0078
6481	TbuX	tbuX	0.0078
3720	Outer membrane protein X precursor	ompX	0.0078
6479	Vanillate porin OpdK	opdK	0.0078
6476	Porin P	oprP	0.0078
6477	Porin D	oprD	0.0078
6482	Membrane protein involved in aromatic hydrocarbon degradation	Pput_2883	0.0078
6483	Probable outer membrane protein	PA4589	0.0078
2961	Porin	opmA	0.0078
6478	Porin	Not Available	0.0078
6485	Esterase estA	estA	0.0078
6475	Adhesin	hia	0.0078
4238	50S ribosomal protein L4	rplD	0.0077
5578	50S ribosomal protein L4	rplD	0.0077
6173	50S ribosomal protein L4	rplD	0.0077
6219	50S ribosomal protein L4	rplD	0.0077
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0077
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0076
68	Cannabinoid receptor 1	CNR1	0.0075
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0074
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0074
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0074
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0073
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0073
2828	Squalene--hopene cyclase	shc	0.0073
1192	Sulfotransferase 1A1	SULT1A1	0.0073
1671	Excitatory amino acid transporter 3	SLC1A1	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
3877	Growth-inhibiting protein 18	GIG18	0.0072
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0071
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0071
923	Glutamate receptor 3	GRIA3	0.0071
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
780	Retinoic acid receptor RXR-gamma	RXRG	0.007
6126	Carbonic anhydrase 7	CA7	0.007
763	Tyrosine aminotransferase	TAT	0.007
5493	Tyrosine aminotransferase	Not Available	0.007
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.007
49	Endothelin B receptor	EDNRB	0.0069
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
407	Vascular endothelial growth factor receptor 2	KDR	0.0069
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0069
84	Nuclear receptor 0B1	NR0B1	0.0068
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0068
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0068
6400	Colipase	CLPS	0.0068
6443	Outer membrane porin C	ompC	0.0068
2863	Outer membrane protein F	ompF	0.0068
4627	Lignostilbene-alpha,beta-dioxygenase	sll1541	0.0068
1636	Trace amine-associated receptor 1	TAAR1	0.0067
754	Pancreatic triacylglycerol lipase	PNLIP	0.0066
36	Insulin receptor	INSR	0.0066
1275	Estrogen sulfotransferase	SULT1E1	0.0066
6432	Transporter	snf	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0065
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0065
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0065
4122	Histone deacetylase 2	HDAC2	0.0065
88	Retinoic acid receptor RXR-beta	RXRB	0.0064
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0064
6138	Multidrug resistance protein 3	ABCB4	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
459	Retinoic acid receptor RXR-alpha	RXRA	0.0062
10	Glycogen phosphorylase, liver form	PYGL	0.0062
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0062
2298	Cytochrome P450-cam	camC	0.0062
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0061
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.006
6353	Reaction center protein L chain	pufL	0.006
6454	Reaction center protein L chain	pufL	0.006
6683	Reaction center protein L chain	pufL	0.006
6352	Reaction center protein H chain	puhA	0.006
6456	Reaction center protein H chain	puhA	0.006
6682	Reaction center protein H chain	puhA	0.006
6354	Reaction center protein M chain	pufM	0.006
6455	Reaction center protein M chain	pufM	0.006
6684	Reaction center protein M chain	pufM	0.006
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.006
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.006
3917	Methylenetetrahydrofolate reductase	MTHFR	0.006
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0059
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0059
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0058
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0058
814	Ryanodine receptor 1	RYR1	0.0058
1618	High affinity nerve growth factor receptor	NTRK1	0.0057
309	Antithrombin-III	SERPINC1	0.0057
856	Vitamin D3 receptor	VDR	0.0056
3175	Glutamate--cysteine ligase	gshA	0.0056
24	Thymidylate synthase	TMP1	0.0056
359	Thymidylate synthase	TYMS	0.0056
2626	Thymidylate synthase	thyA	0.0056
2729	Thymidylate synthase	thyA	0.0056
5352	Thymidylate synthase	THYA	0.0056
3809	Estrogen-related receptor gamma	ESRRG	0.0056
284	DNA-directed RNA polymerase beta chain	rpoB	0.0056
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0056
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0056
6506	Stathmin-4	STMN4	0.0055
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0055
904	Glutathione S-transferase P	GSTP1	0.0054
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0054
473	L-lactate dehydrogenase A chain	LDHA	0.0054
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0054
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0053
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0053
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0053
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0053
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0053
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0053
1992	Vitamin D-binding protein	GC	0.0052
595	Fibrinogen alpha chain	FGA	0.0052
5934	Cytochrome P450 26A1	CYP26A1	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0051
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
6589	Delta-hemolysin	hld	0.0051
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0051
6586	Protein S100-G	S100G	0.0051
6591	ATP synthase C chain	atpH	0.0051
6587	Rubredoxin	rub	0.0051
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0051
26	Vascular endothelial growth factor receptor 3	FLT4	0.0051
6588	Methionyl-tRNA formyltransferase	fmt	0.005
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.005
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.005
6593	Immunoglobulin G-binding protein G	spg	0.005
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.005
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0049
54	Prothrombin	F2	0.0049
65	Matrix metalloproteinase-9	Not Available	0.0049
1152	Glycogen phosphorylase, muscle form	PYGM	0.0049
3404	Exotoxin A	eta	0.0049
173	Toll-like receptor 7	TLR7	0.0049
32	Vascular endothelial growth factor receptor 1	FLT1	0.0048
106	Cannabinoid receptor 2	CNR2	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
6174	50S ribosomal protein L32	rpmF	0.0048
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0046
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
823	Fibroblast growth factor receptor 2	FGFR2	0.0046
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0046
737	Mineralocorticoid receptor	NR3C2	0.0046
5787	Angiopoietin-1 receptor	TEK	0.0045
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0045
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0045
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
768	FK506-binding protein 1A	FKBP1A	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
581	Cytochrome P450 2R1	CYP2R1	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
569	Retinal dehydrogenase 2	ALDH1A2	0.0044
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0044
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0044
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0044
6279	Beta-2-microglobulin	B2M	0.0044
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0044
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0044
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0044
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0044
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0044
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0044
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0044
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0044
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0044
6559	Cytochrome c oxidase subunit 2	ctaC	0.0044
6669	Cytochrome c oxidase subunit 2	ctaC	0.0044
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0044
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0044
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0044
6558	Cytochrome c oxidase subunit 1	ctaD	0.0044
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0043
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0042
6103	Arylamine N-acetyltransferase 1	NAT1	0.0042
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0042
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0042
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0042
611	Retinal dehydrogenase 1	ALDH1A1	0.0042
164	Histamine H4 receptor	HRH4	0.0042
4217	Telomerase reverse transcriptase	TERT	0.0042
1629	Transcription factor AP-1	JUN	0.0041
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0041
3639	Thymidine phosphorylase	deoA	0.0041
3936	Thymidine phosphorylase	TYMP	0.0041
6689	TraN protein	traN	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6687	TraO protein	traO	0.0041
6670	Ig kappa chain V-I region Bi	Not Available	0.0041
6671	Ig heavy chain V-III region VH26	Not Available	0.0041
6404	Rhomboid protease glpG	glpG	0.0041
6797	Rhomboid protease glpG	glpG	0.0041
3710	Acyl-CoA thioesterase 2	tesB	0.0041
6672	Destrin	DSTN	0.0041
6680	Cofilin-1	CFL1	0.0041
6688	TraF protein	traF	0.0041
6690	BenF-like porin	PFL_1329	0.0041
6681	Probable N-acetylneuraminic acid outer membrane channel protein nanC	nanC	0.0041
6668	Cytochrome c oxidase subunit 1-beta	ctaDII	0.0041
6685	Outer membrane protein II	porB	0.0041
6679	Colicin-Ia	cia	0.0041
6676	Fe(3+)-pyochelin receptor	fptA	0.0041
6674	Nuclear factor erythroid 2-related factor 1	NFE2L1	0.0041
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.004
162	Retinoic acid receptor gamma-1	RARG	0.0039
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0039
1541	Metalloproteinase	mmp20	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0039
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0039
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0038
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
477	DNA topoisomerase 4 subunit A	parC	0.0038
886	DNA topoisomerase 4 subunit A	parC	0.0038
6226	DNA topoisomerase 4 subunit A	parC	0.0038
469	Annexin A1	ANXA1	0.0038
4226	Uridine phosphorylase 2	UPP2	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
404	DNA gyrase subunit A	gyrA	0.0038
6224	DNA gyrase subunit A	gyrA	0.0038
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0037
719	Retinoic acid receptor responder protein 1	RARRES1	0.0037
770	Retinoic acid-induced protein 3	GPRC5A	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
6524	Protein tonB	tonB	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0037
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0036
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0036
6149	Solute carrier family 22 member 10	SLC22A10	0.0036
6146	High affinity copper uptake protein 1	SLC31A1	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
3578	Protein crcA	crcA	0.0035
6678	Colicin I receptor	cirA	0.0035
6675	Colicin-E3	ceaC	0.0035
4760	Mll3241 protein	mll3241	0.0035
2447	Ammonia channel	amtB	0.0035
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0035
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
4225	Uridine phosphorylase 1	UPP1	0.0035
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0033
239	Coagulation factor X	F10	0.0033
400	Coagulation factor IX	F9	0.0033
5461	Coagulation factor IX	F9	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
634	Squalene monooxygenase	SQLE	0.0033
7196	Squalene monooxygenase	ERG1	0.0033
413	Amidophosphoribosyltransferase	PPAT	0.0033
2515	Amidophosphoribosyltransferase	purF	0.0033
3714	Amidophosphoribosyltransferase	purF	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0032
1353	DNA topoisomerase 1	TOP1	0.0032
3552	DNA topoisomerase 1	topA	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
1867	Major prion protein	PRNP	0.0032
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4878	Glycoprotein hormones alpha chain	CGA	0.0031
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0031
4877	Beta-mannanase	man	0.0031
4869	Major capsid protein	A430L	0.0031
1072	Granzyme B	GZMB	0.0031
4850	Beta-2-glycoprotein 1	APOH	0.0031
4880	Membrane cofactor protein	CD46	0.0031
4856	CD209 antigen	CD209	0.0031
4889	Ig epsilon chain C region	IGHE	0.0031
757	Fusion glycoprotein F0	F	0.0031
4875	Fusion glycoprotein F0	F	0.0031
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0031
1354	Beta-glucuronidase	GUSB	0.0031
4189	Alpha-galactosidase A	GLA	0.0031
4845	ADAM 33	ADAM33	0.0031
4852	Reticulon-4 receptor	RTN4R	0.0031
4721	Beta-1,4-mannanase	manA	0.0031
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0031
3352	Structural polyprotein	Not Available	0.0031
3628	Structural polyprotein	Not Available	0.0031
4892	Structural polyprotein	Not Available	0.0031
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0031
908	Glutathione S-transferase theta-1	GSTT1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1630	Integrin beta-2	ITGB2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.003
604	Vitamin K-dependent protein Z	PROZ	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
1374	Natriuretic peptides B	NPPB	0.003
1827	Gap junction alpha-1 protein	GJA1	0.003
1908	Vascular cell adhesion protein 1	VCAM1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
3027	Streptavidin	Not Available	0.0029
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
3808	Dihydropteroate synthase 2	folP2	0.0029
3601	Dihydropteroate synthase 1	folP1	0.0029
3807	Dihydropteroate synthase 1	folP1	0.0029
244	Angiotensin-converting enzyme	ACE	0.0029
165	FL cytokine receptor	FLT3	0.0029
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0029
1039	Histone deacetylase 9	HDAC9	0.0028
751	Potassium channel subfamily K member 6	KCNK6	0.0028
1253	Interferon gamma	IFNG	0.0028
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
422	Vitamin K-dependent protein C	PROC	0.0028
1245	Vitamin K-dependent protein S	PROS1	0.0028
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
793	T-cell surface antigen CD2	CD2	0.0027
4861	Interleukin-6 receptor alpha chain	IL6R	0.0027
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0027
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0027
3837	Cytokine receptor common beta chain	CSF2RB	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
76	Nitric-oxide synthase, brain	NOS1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0027
5682	Ribonuclease pancreatic	RNASE1	0.0027
6858	Inactive carboxylesterase 4	CES1P1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0026
4210	Toll-like receptor 4	TLR4	0.0026
1379	Interleukin-12 subunit beta	IL12B	0.0026
1184	Interferon beta	IFNB1	0.0026
4890	Hemagglutinin	HA	0.0026
6566	Hemagglutinin	Not Available	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
4311	tRNA	TRDMT1	0.0025
4325	tRNA	trmD	0.0025
4328	tRNA	trmD	0.0025
896	Glutathione S-transferase Mu 1	GSTM1	0.0025
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0025
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0025
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0025
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0025
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0025
1648	Elastin	ELN	0.0024
3140	Hemagglutinin-neuraminidase	HN	0.0024
3609	Hemagglutinin-neuraminidase	HN	0.0024
1859	Prostatic acid phosphatase	ACPP	0.0024
3444	Cyanovirin-N	Not Available	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
293	Gamma-glutamyl hydrolase	GGH	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
4666	Fucose-binding lectin PA-IIL	lecB	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
2372	Bifunctional tail protein	9	0.0023
554	Low-density lipoprotein receptor	LDLR	0.0022
798	Osteocalcin	BGLAP	0.0022
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0022
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0022
852	Heparin cofactor 2	SERPIND1	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0022
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0022
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
1864	RET proto-oncogene	RET	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0022
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0022
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0022
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6163	Copper-transporting ATPase 2	ATP7B	0.0021
6165	Copper-transporting ATPase 1	ATP7A	0.0021
273	Apoptosis regulator Bcl-2	BCL2	0.0021
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
64	Neuraminidase	NA	0.0021
641	Neuraminidase	NA	0.0021
2676	Neuraminidase	NA	0.0021
3026	Neuraminidase	NA	0.0021
3519	Neuraminidase	NA	0.0021
6007	Neuraminidase	NA	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1650	Heme carrier protein 1	SLC46A1	0.002
369	Coagulation factor VII	F7	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
1439	Lactotransferrin	LTF	0.002
1243	Cathepsin D	CTSD	0.002
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.002
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.002
958	Insulin-like growth factor 1 receptor	IGF1R	0.002
822	Aldose reductase	AKR1B1	0.002
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
2430	Chondroitinase B	cslB	0.0019
2581	Chondroitinase AC	cslA	0.0019
6307	Ig gamma-2 chain C region	IGHG2	0.0019
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0019
3221	Cytochrome c4	cc4	0.0018
5798	Mitogen-activated protein kinase 11	MAPK11	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6847	Lactase-phlorizin hydrolase	LCT	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6500	Phospholipase A2	PLA2G1B	0.0018
712	Tubulin alpha chain	TUB1	0.0018
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
267	Plasminogen activator inhibitor 1	SERPINE1	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
936	Ephrin type-A receptor 2	EPHA2	0.0017
3814	Complement C1r subcomponent	C1R	0.0017
4103	Proteasome subunit beta type 2	PSMB2	0.0017
4102	Proteasome subunit beta type 5	PSMB5	0.0017
4101	Proteasome subunit beta type 1	PSMB1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3957	Adenosine deaminase	ADA	0.0017
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
6221	Steroid hormone receptor ERR1	ESRRA	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
6218	Pannexin-1	PANX1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2021	Thrombomodulin	THBD	0.0015
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
6044	Serum paraoxonase/lactonase 3	PON3	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
605	Fumarate reductase flavoprotein subunit	frdA	0.0014
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0014
3673	Fumarate reductase flavoprotein subunit	fccA	0.0014
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0014
6549	Fumarate reductase flavoprotein subunit	frdA	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0013
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0013
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0013
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0013
597	Dihydropteridine reductase	QDPR	0.0013
328	Sorbitol dehydrogenase	SORD	0.0013
396	Alcohol dehydrogenase 4	ADH4	0.0013
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0013
572	Integrin alpha-L	ITGAL	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
810	Heme oxygenase 1	HMOX1	0.0013
3391	Heme oxygenase 1	pbsA1	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0013
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0012
666	NADP-dependent malic enzyme	ME1	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
857	Malate dehydrogenase, mitochondrial	MDH2	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
77	L-lactate dehydrogenase B chain	LDHB	0.0012
12	Alcohol dehydrogenase class 3	ADH5	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1295	Fatty acid synthase	FASN	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0012
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0012
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0011
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0011
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
13	Aminomethyltransferase, mitochondrial	AMT	0.0011
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.0011
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.001
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.001
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
279	Tyrosinase	TYR	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
489	Monocarboxylate transporter 2	SLC16A7	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
654	Flavin reductase	BLVRB	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
1313	Lactoylglutathione lyase	GLO1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4943	Cytochrome c6	petJ	0.0009
4916	Cyanoglobin	glbN	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4984	Neuroglobin	NGB	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
5000	HemO	hemO	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4910	Cytoglobin	CYGB	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4935	Cytochrome c-554	cycA1	0.0009
4909	CooA protein	cooA	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
4961	Hemophore HasA	hasA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4972	P450cin	cinA	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4952	Catalase/peroxidase	katA	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
3093	Catalase HPII	katE	0.0009
714	Glutathione reductase, mitochondrial	GSR	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
1507	Cytochrome c	CYCS	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3830	Calreticulin	CALR	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
4920	Peroxidase/catalase	katG	0.0007
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
3291	Cytochrome c-552	cycA	0.0006
4927	Cytochrome c-552	nrfA	0.0006
4938	Cytochrome c-552	cycA	0.0006
4953	Cytochrome c-552	nrfA	0.0006
5217	Cytochrome c-552	cycM	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3102	Flavohemoprotein	hmp	0.0006
4969	Flavohemoprotein	hmp	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01159 - Halothane

Targets

Enzymes

Carriers

Predictions