DT-Web

DB00273 - Topiramate


Identification
Name Topiramate
Accession Number DB00273 (APRD00237)
Type small molecule
Description Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson & Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. [Wikipedia]. A combination product containing phentermine + topiramate extended-release called QSYMIA(R) is indicated for the management of obesity.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 339.362
Groups approved
Monoisotopic Weight 339.098787343
Pharmacology
Indication Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia(R) is indicated for the treatment and management of obesity.
Mechanism of action The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time-dependent manner, suggesting a state-dependent sodium channel blocking action. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), indicating a possible mechanism through potentiation of the activity of GABA. Topiramate also demonstrates antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this action is weak and unlikely to be related to its anticonvulsant actions.
Absorption Rapid with pleak plasma concentrations occurring after 2 hours and a bioavailability of 80%.
Protein binding 15-41% (over the blood concentration range of 0.5 - 250 mg/mL).
Biotransformation Not extensively metabolized, 70% of the dose is eliminated unchanged in the urine. The other 30% is metabolized hepatically to six metabolites (formed by hydroxylation, hydrolysis, and glucuronidation), none of which constitute more than 5% of an administered dose.
Route of elimination Topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine (approximately 70% of an administered dose).
Toxicity Symptoms of overdose include abdominal pain, agitation, blurred vision, convulsions, depression, dizziness, double vision, drowsiness, impaired coordination, impaired mental activity, low blood pressure, reduced consciousness, severe diarrhea, sluggishness, and speech problems.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetazolamide Additive renal carbonic anhydrase inhibition may occur increasing the risk of crystaluria and renal calculi. Increased risk of nephrolithiasis. Consider altnerate therapy.
Brinzolamide As both brinzolamide and topiramate are carbonic anhydrase inhibitors, there is an increased risk of adverse effects.The development of acid-base disorders with concurrent use of ophthalmic and oral carbonic anhydrase inhibitors has been reported. Avoid concurrent use of different carbonic anhydrase inhibitors when possible.
Carbamazepine Carbamazepine may decrease the effectiveness of Topiramate by increase its clearance. Monitor for changes in the therapeutic and adverse effects of Topiramate if Carbamazepine is initiated, discontinued or dose changed. Adverse effects related to CNS depression have also been observed during concomitant therapy.
Chlorothiazide Thiazide diuretics such as chlorothiazide may enhance the hypokalemic effect of topiramate. Thiazide diuretics may increase the serum concentration of topiramate. Monitor for increased topiramate concentrations/adverse effects (e.g., hypokalemia) with initiation/dose increase of a thiazide diuretic. Closely monitor serum potassium concentrations with concomitant therapy. Topiramate dose reductions may be necessary.
Ethinyl Estradiol Topiramate may decrease the effect of the oral contraceptive, Ethinyl estradiol. An alternate form of contraception should be used during concomitant therapy.
Fosphenytoin Increased phenytoin/decreased topiramate
Lithium Topiramate could modify lithium levels
Maraviroc Topiramate, a CYP3A4 inducer, may decrease the serum concentration of Maraviroc by increasing Maraviroc metabolism and clearance. A dose adjustment of Maraviroc may be required. Monitor for changes in Maraviroc therapeutic and adverse effects if Topiramate is initiated, discontinued or dose changed.
Mestranol Topiramate may decrease the effect of the oral contraceptive, Mestranol. An alternate form of contraception should be used during concomitant therapy.
Phenytoin Increased phenytoin/decreased topiramate
Tobramycin Increased risk of nephrotoxicity
Triprolidine The CNS depressants, Triprolidine and Topiramate, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Ulipristal Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nowakowska E, Kus K, Czubak A, Jedrzejewska J: Memory improving and antidepressant effects of topiramate in rats. Arzneimittelforschung. 2009;59(10):487-92. - Pubmed
  • Braga MF, Aroniadou-Anderjaska V, Li H, Rogawski MA: Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons. J Pharmacol Exp Ther. 2009 Aug;330(2):558-66. Epub 2009 May 5. - Pubmed
DTHybrid score 0.2701
Sodium channel protein type 1 subunit alpha
Name Sodium channel protein type 1 subunit alpha
Gene Name SCN1A
Pharmacological action yes
Actions inhibitor
References
  • Coppola G, Capovilla G, Montagnini A, Romeo A, Spano M, Tortorella G, Veggiotti P, Viri M, Pascotto A: Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial. Epilepsy Res. 2002 Mar;49(1):45-8. - Pubmed
  • Ceulemans B, Cras P: - Severe myoclonic epilepsy in infancy
  • Ceulemans B, Boel M, Claes L, Dom L, Willekens H, Thiry P, Lagae L: Severe myoclonic epilepsy in infancy: toward an optimal treatment. J Child Neurol. 2004 Jul;19(7):516-21. - Pubmed
  • Korff C, Laux L, Kelley K, Goldstein J, Koh S, Nordli D Jr: Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients. J Child Neurol. 2007 Feb;22(2):185-94. - Pubmed
  • Nieto Barrera M, Candau Fernandez Mensaque R, Nieto Jimenez M: [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects] Rev Neurol. 2003 Jul 1-15;37(1):64-8. - Pubmed
DTHybrid score 0.5813
Glutamate receptor, ionotropic kainate 1
Name Glutamate receptor, ionotropic kainate 1
Gene Name GRIK1
Pharmacological action yes
Actions antagonist
References
  • Rogawski MA, Gryder D, Castaneda D, Yonekawa W, Banks MK, Lia H: GluR5 kainate receptors, seizures, and the amygdala. Ann N Y Acad Sci. 2003 Apr;985:150-62. - Pubmed
  • Gryder DS, Rogawski MA: Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J Neurosci. 2003 Aug 6;23(18):7069-74. - Pubmed
  • Kaminski RM, Banerjee M, Rogawski MA: Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104. - Pubmed
  • Braga MF, Aroniadou-Anderjaska V, Li H, Rogawski MA: Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons. J Pharmacol Exp Ther. 2009 Aug;330(2):558-66. Epub 2009 May 5. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.1783
Carbonic anhydrase 2
Name Carbonic anhydrase 2
Gene Name CA2
Pharmacological action yes
Actions inhibitor
References
  • Maryanoff BE, McComsey DF, Costanzo MJ, Hochman C, Smith-Swintosky V, Shank RP: Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7. - Pubmed
  • Ma L, Huang YG, Deng YC, Tian JY, Rao ZR, Che HL, Zhang HF, Zhao G: Topiramate reduced sweat secretion and aquaporin-5 expression in sweat glands of mice. Life Sci. 2007 Jun 6;80(26):2461-8. Epub 2007 Apr 29. - Pubmed
  • Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G: Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1726-31. Epub 2007 Jan 8. - Pubmed
  • Casini A, Antel J, Abbate F, Scozzafava A, David S, Waldeck H, Schafer S, Supuran CT: Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV. Bioorg Med Chem Lett. 2003 Mar 10;13(5):841-5. - Pubmed
  • Winum JY, Scozzafava A, Montero JL, Supuran CT: Sulfamates and their therapeutic potential. Med Res Rev. 2005 Mar;25(2):186-228. - Pubmed
DTHybrid score 1.5528
Carbonic anhydrase 4
Name Carbonic anhydrase 4
Gene Name CA4
Pharmacological action yes
Actions inhibitor
References
  • Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. - Pubmed
  • Dodgson SJ, Shank RP, Maryanoff BE: Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41 Suppl 1:S35-9. - Pubmed
  • Masereel B, Rolin S, Abbate F, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20. - Pubmed
  • Vullo D, Franchi M, Gallori E, Antel J, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides. J Med Chem. 2004 Feb 26;47(5):1272-9. - Pubmed
DTHybrid score 0.3592

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2796
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4321

Predictions


Id Partner name Gene Name Score
295 Carbonic anhydrase 1 CA1 0.2558
4757 Cytochrome P450 2C9 CYP2C9 0.1732
4119 Cytochrome P450 2D6 CYP2D6 0.1328
6030 Cytochrome P450 2B6 CYP2B6 0.1038
1588 Multidrug resistance protein 1 ABCB1 0.1004
4200 Cytochrome P450 1A2 CYP1A2 0.0942
4118 Cytochrome P450 3A5 CYP3A5 0.0935
4924 Cytochrome P450 2C8 CYP2C8 0.0891
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0844
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0841
6013 Cytochrome P450 2E1 CYP2E1 0.0824
6126 Carbonic anhydrase 7 CA7 0.0815
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.08
466 Solute carrier family 12 member 3 SLC12A3 0.0762
1729 Solute carrier family 22 member 6 SLC22A6 0.0717
6107 Cytochrome P450 3A7 CYP3A7 0.0671
3007 Carbonic anhydrase 12 CA12 0.0627
4205 Carbonic anhydrase 9 CA9 0.0627
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0603
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0598
558 Solute carrier family 12 member 1 SLC12A1 0.0575
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0527
587 Serum albumin ALB 0.052
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0474
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0453
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0408
921 Glutamate receptor 2 GRIA2 0.0386
5718 Cytochrome P450 2A6 CYP2A6 0.0383
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0382
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.038
6024 Cytochrome P450 1A1 CYP1A1 0.038
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0377
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0372
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0371
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.037
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0368
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0368
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.036
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0346
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0345
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0345
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0345
1405 Thiopurine S-methyltransferase TPMT 0.034
20 Prostaglandin G/H synthase 1 PTGS1 0.0331
6106 Cytochrome P450 2C18 CYP2C18 0.0331
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0324
6131 Carbonic anhydrase 14 CA14 0.0314
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0313
6122 Carbonic anhydrase 3 CA3 0.0298
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0281
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0269
811 Translocator protein TSPO 0.0237
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0237
3811 Cytochrome P450 19A1 CYP19A1 0.023
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0229
556 Alpha-1A adrenergic receptor ADRA1A 0.0225
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0217
492 Histamine H1 receptor HRH1 0.0216
705 Glutamate receptor 1 GRIA1 0.0215
824 Sodium-dependent serotonin transporter SLC6A4 0.0214
1181 Alpha-1-acid glycoprotein 1 ORM1 0.021
3623 Divalent-cation tolerance protein cutA cutA 0.0206
318 Alpha-2A adrenergic receptor ADRA2A 0.0195
3426 Glutamine synthetase glnA 0.0192
3987 Glutamine synthetase GLUL 0.0192
482 Glycine receptor subunit alpha-1 GLRA1 0.019
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0189
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.018
871 Glucocorticoid receptor NR3C1 0.0176
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0174
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0174
1025 Aquaporin-1 AQP1 0.0172
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0165
502 5-hydroxytryptamine 2A receptor HTR2A 0.0161
260 Cytochrome P450 51 ERG11 0.0161
761 Cytochrome P450 51 ERG11 0.0161
3163 Cytochrome P450 51 cyp51 0.0161
731 HIV-1 protease HIV-1 protease 0.0157
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0153
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0148
862 Multidrug resistance-associated protein 1 ABCC1 0.0146
632 Alpha-1B adrenergic receptor ADRA1B 0.0146
23 D(1A) dopamine receptor DRD1 0.0145
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0145
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0142
537 ATP synthase delta chain, mitochondrial ATP5D 0.0141
629 Alpha-2B adrenergic receptor ADRA2B 0.0139
831 D(2) dopamine receptor DRD2 0.0138
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0138
6144 Solute carrier family 22 member 2 SLC22A2 0.0137
6020 Aldehyde oxidase AOX1 0.0135
3226 UPF0234 protein HI1034 HI_1034 0.0135
3941 Amine oxidase [flavin-containing] A MAOA 0.0134
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0132
3384 Macrophage migration inhibitory factor MIF 0.0132
6145 Solute carrier family 22 member 1 SLC22A1 0.0131
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0129
789 Alpha-1D adrenergic receptor ADRA1D 0.0128
136 Estrogen receptor ESR1 0.0128
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0123
290 Prostaglandin G/H synthase 2 PTGS2 0.0122
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0121
6133 Sodium channel subunit beta-2 SCN2B 0.012
6127 Carbonic anhydrase-related protein CA8 0.012
6132 Sodium channel subunit beta-1 SCN1B 0.012
6135 Sodium channel subunit beta-4 SCN4B 0.012
6128 Carbonic anhydrase-related protein 10 CA10 0.012
6129 Carbonic anhydrase-related protein 11 CA11 0.012
6134 Sodium channel subunit beta-3 SCN3B 0.012
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0119
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0119
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0119
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0119
3939 Amine oxidase [flavin-containing] B MAOB 0.0118
193 Beta-1 adrenergic receptor ADRB1 0.0118
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0118
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0117
1898 Cytochrome P450 1B1 CYP1B1 0.0117
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0117
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0115
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0113
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0112
320 5-hydroxytryptamine 1A receptor HTR1A 0.0111
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0111
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.011
922 Glutamate receptor 4 GRIA4 0.011
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.011
6142 Solute carrier family 22 member 8 SLC22A8 0.011
4027 Glutamate receptor delta-1 subunit GRID1 0.011
4018 Glutamate receptor delta-2 subunit GRID2 0.011
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0109
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0109
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0109
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0109
1912 Excitatory amino acid transporter 1 SLC1A3 0.0109
4016 Excitatory amino acid transporter 5 SLC1A7 0.0109
664 Glutamate decarboxylase 2 GAD2 0.0109
3890 Glutamate decarboxylase 2 GAD2 0.0109
4026 Aspartyl aminopeptidase DNPEP 0.0109
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0109
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0109
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0109
4019 Excitatory amino acid transporter 4 SLC1A6 0.0109
1047 Excitatory amino acid transporter 2 SLC1A2 0.0109
927 Metabotropic glutamate receptor 8 GRM8 0.0109
925 Metabotropic glutamate receptor 4 GRM4 0.0109
926 Metabotropic glutamate receptor 7 GRM7 0.0109
4020 Glutamyl aminopeptidase ENPEP 0.0109
4017 5-oxoprolinase OPLAH 0.0109
713 Sodium-dependent dopamine transporter SLC6A3 0.0109
6130 Carbonic anhydrase 13 CA13 0.0109
3105 M-phase inducer phosphatase 2 CDC25B 0.0108
766 Beta-2 adrenergic receptor ADRB2 0.0108
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0107
233 Potassium channel subfamily K member 2 KCNK2 0.0107
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0106
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0105
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0104
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0103
468 Cytochrome P450 4A11 CYP4A11 0.0102
776 Bile salt export pump ABCB11 0.0101
378 Alpha-2C adrenergic receptor ADRA2C 0.0101
847 Mu-type opioid receptor OPRM1 0.01
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0098
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0097
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0096
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0095
1024 Solute carrier family 22 member 11 SLC22A11 0.0094
6031 Cytochrome P450 3A43 CYP3A43 0.0091
590 5-hydroxytryptamine 2C receptor HTR2C 0.009
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0089
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0089
5 Glutaminase liver isoform, mitochondrial GLS2 0.0089
917 Glutaminase kidney isoform, mitochondrial GLS 0.0089
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0089
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0089
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0089
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0089
5261 Phosphoribosylformylglycinamidine synthase purL 0.0089
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0089
467 Delta-type opioid receptor OPRD1 0.0089
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0088
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0088
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0087
118 Organic cation/carnitine transporter 2 SLC22A5 0.0084
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0083
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0083
665 Phosphoserine aminotransferase PSAT1 0.0083
4652 Phosphoserine aminotransferase serC 0.0083
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0083
420 Glutamate decarboxylase 1 GAD1 0.0083
3900 Glutamate decarboxylase 1 GAD1 0.0083
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0083
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0082
735 Alanine aminotransferase 1 GPT 0.0082
3904 Alanine aminotransferase 2 GPT2 0.0082
625 Glutamate carboxypeptidase 2 FOLH1 0.0081
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0081
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
146 Androgen receptor AR 0.0079
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0079
1671 Excitatory amino acid transporter 3 SLC1A1 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0077
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0076
614 Progesterone receptor PGR 0.0076
916 Metabotropic glutamate receptor 1 GRM1 0.0076
3877 Growth-inhibiting protein 18 GIG18 0.0076
696 Kappa-type opioid receptor OPRK1 0.0076
6143 Solute carrier family 22 member 7 SLC22A7 0.0075
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0075
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0074
820 Glycine receptor subunit alpha-2 GLRA2 0.0074
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0074
122 P2Y purinoceptor 12 P2RY12 0.0074
923 Glutamate receptor 3 GRIA3 0.0073
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0072
634 Squalene monooxygenase SQLE 0.0072
7196 Squalene monooxygenase ERG1 0.0072
818 50S ribosomal protein L10 rplJ 0.0071
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0071
33 Cystine/glutamate transporter SLC7A11 0.007
763 Tyrosine aminotransferase TAT 0.007
5493 Tyrosine aminotransferase Not Available 0.007
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.007
914 Formimidoyltransferase-cyclodeaminase FTCD 0.007
426 Aspartate aminotransferase, mitochondrial GOT2 0.007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0069
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0069
885 5-hydroxytryptamine 1B receptor HTR1B 0.0068
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0068
6182 Cytochrome P450 2J2 CYP2J2 0.0068
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0067
3627 UPF0190 protein yedY yedY 0.0067
1392 Catenin beta-1 CTNNB1 0.0067
3352 Structural polyprotein Not Available 0.0067
3628 Structural polyprotein Not Available 0.0067
4892 Structural polyprotein Not Available 0.0067
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0067
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0067
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0066
3923 Cholinesterase BCHE 0.0066
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0065
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0065
817 DNA topoisomerase 2-alpha TOP2A 0.0065
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0064
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0064
172 Potassium channel subfamily K member 1 KCNK1 0.0064
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0064
638 D(3) dopamine receptor DRD3 0.0063
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0062
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0062
465 Calmodulin CALM1 0.0061
725 5-hydroxytryptamine 1D receptor HTR1D 0.0061
738 Monocarboxylate transporter 1 SLC16A1 0.0061
997 Protein kinase C beta type PRKCB 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0058
124 Histamine H2 receptor HRH2 0.0058
1970 Protein kinase C alpha type PRKCA 0.0054
2408 Tyrosine-protein kinase SYK SYK 0.0054
161 Tubulin beta chain TUBB 0.0054
312 Tubulin beta chain TUB2 0.0054
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0054
461 Glycine receptor subunit alpha-3 GLRA3 0.0053
49 Endothelin B receptor EDNRB 0.0052
6147 Solute carrier family 22 member 3 SLC22A3 0.0052
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0052
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0051
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0051
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
777 Tumor necrosis factor TNF 0.0049
833 Organic cation/carnitine transporter 1 SLC22A4 0.0049
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
432 D(4) dopamine receptor DRD4 0.0047
6102 Arylamine N-acetyltransferase 2 NAT2 0.0047
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0047
756 Sex hormone-binding globulin SHBG 0.0046
310 Solute carrier family 12 member 2 SLC12A2 0.0046
2236 Casein kinase II subunit alpha CSNK2A1 0.0046
844 Epidermal growth factor receptor EGFR 0.0046
6151 Monocarboxylate transporter 10 SLC16A10 0.0046
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0045
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
70 Type-1 angiotensin II receptor AGTR1 0.0044
571 Melatonin receptor type 1A MTNR1A 0.0044
362 Melatonin receptor type 1B MTNR1B 0.0044
716 5-hydroxytryptamine 7 receptor HTR7 0.0044
952 Dipeptidyl peptidase 4 DPP4 0.0043
436 5-hydroxytryptamine 2B receptor HTR2B 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
856 Vitamin D3 receptor VDR 0.0042
407 Vascular endothelial growth factor receptor 2 KDR 0.0042
6137 Multidrug resistance-associated protein 6 ABCC6 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6220 Aryl hydrocarbon receptor AHR 0.0041
2981 Phospholipase A2, membrane associated PLA2G2A 0.0041
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
373 Transthyretin TTR 0.004
29 Tubulin beta-1 chain TUBB1 0.004
26 Vascular endothelial growth factor receptor 3 FLT4 0.004
1656 CYP2B protein CYP2B 0.004
315 Arginase-1 ARG1 0.004
6014 Cytochrome P450 2A13 CYP2A13 0.0039
4604 Liver carboxylesterase 1 CES1 0.0039
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
32 Vascular endothelial growth factor receptor 1 FLT1 0.0038
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
85 Growth hormone receptor GHR 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0037
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0037
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
504 Mast/stem cell growth factor receptor KIT 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0034
6136 Multidrug resistance-associated protein 5 ABCC5 0.0034
474 Acetylcholinesterase ACHE 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
380 Cytochrome P450 17A1 CYP17A1 0.0033
284 DNA-directed RNA polymerase beta chain rpoB 0.0033
5773 DNA-directed RNA polymerase beta chain rpoB 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
427 Substance-P receptor TACR1 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0032
1010 Cytochrome P450 51A1 CYP51A1 0.0032
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6141 Sodium/bile acid cotransporter SLC10A1 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
163 D(1B) dopamine receptor DRD5 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
251 Alcohol dehydrogenase 1A ADH1A 0.003
228 Beta platelet-derived growth factor receptor PDGFRB 0.003
891 Dihydropteroate synthase folP 0.0029
5359 Dihydropteroate synthase folP 0.0029
7175 Dihydropteroate synthase sulI 0.0029
869 Estrogen receptor beta ESR2 0.0029
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0028
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0028
528 5-hydroxytryptamine 1E receptor HTR1E 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0027
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0027
737 Mineralocorticoid receptor NR3C2 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0026
1256 5-hydroxytryptamine 6 receptor HTR6 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0025
3947 Xanthine dehydrogenase/oxidase XDH 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0025
1757 Myeloperoxidase MPO 0.0024
581 Cytochrome P450 2R1 CYP2R1 0.0024
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6432 Transporter snf 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
365 Dihydrofolate reductase DHFR 0.0021
2381 Dihydrofolate reductase DFR1 0.0021
2833 Dihydrofolate reductase Not Available 0.0021
2931 Dihydrofolate reductase folA 0.0021
3544 Dihydrofolate reductase folA 0.0021
3682 Dihydrofolate reductase folA 0.0021
6642 Dihydrofolate reductase folA 0.0021
6756 Dihydrofolate reductase dfrA 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.002
1618 High affinity nerve growth factor receptor NTRK1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
4311 tRNA TRDMT1 0.002
4325 tRNA trmD 0.002
4328 tRNA trmD 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
518 Peroxidase/catalase T katG 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.002
106 Cannabinoid receptor 2 CNR2 0.002
3932 Glutathione S-transferase A2 GSTA2 0.0019
6174 50S ribosomal protein L32 rpmF 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
239 Coagulation factor X F10 0.0019
4122 Histone deacetylase 2 HDAC2 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
1253 Interferon gamma IFNG 0.0018
563 Thyroid peroxidase TPO 0.0018
904 Glutathione S-transferase P GSTP1 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0017
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
1050 Bile salt sulfotransferase SULT2A1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
6073 Potassium channel subfamily K member 9 KCNK9 0.0016
6072 Potassium channel subfamily K member 3 KCNK3 0.0016
94 5-hydroxytryptamine 4 receptor HTR4 0.0016
1517 Beta-3 adrenergic receptor ADRB3 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0016
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0016
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
3601 Dihydropteroate synthase 1 folP1 0.0015
3807 Dihydropteroate synthase 1 folP1 0.0015
3808 Dihydropteroate synthase 2 folP2 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
153 Dopamine beta-hydroxylase DBH 0.0015
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
1541 Metalloproteinase mmp20 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
165 FL cytokine receptor FLT3 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
1992 Vitamin D-binding protein GC 0.0013
319 Opioid receptor, sigma 1 OPRS1 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0013
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
976 Platelet glycoprotein IX GP9 0.0013
1630 Integrin beta-2 ITGB2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4103 Proteasome subunit beta type 2 PSMB2 0.0012
4102 Proteasome subunit beta type 5 PSMB5 0.0012
4101 Proteasome subunit beta type 1 PSMB1 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
2207 Rhodopsin RHO 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
1178 Adenosine A2a receptor ADORA2A 0.0011
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
469 Annexin A1 ANXA1 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
174 Sigma 1-type opioid receptor SIGMAR1 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
936 Ephrin type-A receptor 2 EPHA2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3809 Estrogen-related receptor gamma ESRRG 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
54 Prothrombin F2 0.001
7 Nitric oxide synthase, inducible NOS2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4116 Dihydropteroate synthetase Not Available 0.001
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
6044 Serum paraoxonase/lactonase 3 PON3 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
1144 Hepatocyte growth factor receptor MET 0.001
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
164 Histamine H4 receptor HRH4 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
3810 Catechol O-methyltransferase COMT 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
572 Integrin alpha-L ITGAL 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
4773 Deoxycytidine kinase DCK 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
267 Plasminogen activator inhibitor 1 SERPINE1 0.0009
3830 Calreticulin CALR 0.0009
1864 RET proto-oncogene RET 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6218 Pannexin-1 PANX1 0.0008
6221 Steroid hormone receptor ERR1 ESRRA 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
5934 Cytochrome P450 26A1 CYP26A1 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4527 Putative hydrolase ycdX ycdX 0.0008
4536 Transcriptional regulator, IclR family TM_0065 0.0008
2501 Protein ygbM ygbM 0.0008
4545 Molybdopterin-converting factor subunit 2 moaE 0.0008
4522 Arginine N-succinyltransferase subunit alpha astA 0.0008
4106 Guanylate kinase GUK1 0.0008
4516 Guanylate kinase gmk 0.0008
4538 Hypothetical protein VC1899 VC_1899 0.0008
4529 Oxalate decarboxylase oxdC oxdC 0.0008
4514 Citrate lyase beta subunit-like protein citE 0.0008
4781 Citrate lyase beta subunit-like protein DR_1240 0.0008
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0008
4524 Mannose-6-phosphate isomerase yvyI 0.0008
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0008
4547 Iron binding protein FbpA fbpA 0.0008
4548 Gyrase B gyrB 0.0008
4546 Aminotransferase, putative TM_1131 0.0008
658 Para-aminobenzoate synthase component 1 pabB 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
4515 Peripheral plasma membrane protein CASK CASK 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
4496 C-terminal-binding protein 1 CTBP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0007
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
4517 Probable butyrate kinase 2 buk2 0.0007
3261 Signal recognition particle protein ffh 0.0007
4528 Phenazine biosynthesis protein PhzD phzD1 0.0007
4533 Glyoxalase family protein BC_1747 0.0007
56 Delta-aminolevulinic acid dehydratase ALAD 0.0007
2356 Delta-aminolevulinic acid dehydratase hemB 0.0007
3613 Delta-aminolevulinic acid dehydratase hemB 0.0007
3674 Delta-aminolevulinic acid dehydratase hemB 0.0007
3759 Glutathione S-transferase gst 0.0007
4541 Glutathione S-transferase GST 0.0007
4542 Glutaminase 1 glsA1 0.0007
4544 Glutaminase 1 glsA1 0.0007
2929 (S)-2-haloacid dehalogenase dhlB 0.0007
2995 (S)-2-haloacid dehalogenase Not Available 0.0007
3237 Beta-lactamase OXA-2 bla 0.0007
4532 Gephyrin GPHN 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2021 Thrombomodulin THBD 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
4531 Putative ketoacyl reductase actIII 0.0007
2775 Dihydroorotate dehydrogenase pyrD 0.0007
3467 Methylglyoxal synthase mgsA 0.0007
3583 6-phosphogluconolactonase pgl 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0006
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2688 Peptide deformylase def 0.0006
2708 Peptide deformylase def 0.0006
3004 Peptide deformylase def 0.0006
4337 Peptide deformylase def 0.0006
4338 Peptide deformylase def 0.0006
5368 Peptide deformylase def 0.0006
5371 Peptide deformylase def 0.0006
6375 Peptide deformylase def 0.0006
6378 Peptide deformylase def 0.0006
6379 Peptide deformylase def 0.0006
6776 Peptide deformylase def 0.0006
6900 Peptide deformylase def 0.0006
4534 Cytohesin-2 CYTH2 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
2548 Subtilisin Carlsberg apr 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
3027 Streptavidin Not Available 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
500 Monocarboxylate transporter 4 SLC16A3 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
5682 Ribonuclease pancreatic RNASE1 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1275 Estrogen sulfotransferase SULT1E1 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
751 Potassium channel subfamily K member 6 KCNK6 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
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