DT-Web: DB01011

Identification

Name

Metyrapone

Accession Number

DB01011 (APRD01111, EXPT02271)

Type

small molecule

Description

An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

226.2738

Groups

approved

Monoisotopic Weight

226.11061308

Pharmacology

Indication

Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.

Mechanism of action

The pharmacological effect of Metopirone is to reduce cortisol and corticosterone production by inhibiting the 11-ß-hydroxylation reaction in the adrenal cortex. Removal of the strong inhibitory feedback mechanism exerted by cortisol results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary. With continued blockade of the enzymatic steps leading to production of cortisol and corticosterone, there is a marked increase in adrenocortical secretion of their immediate precursors, 11-desoxycortisol and desoxycorticosterone, which are weak suppressors of ACTH release, and a corresponding elevation of these steroids in the plasma and of their metabolites in the urine. These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). Because of these actions, metopirone is used as a diagnostic test, with urinary 17-OHCS measured as an index of pituitary ACTH responsiveness. Metopirone may also suppress biosynthesis of aldosterone, resulting in a mild natriuresis.

Absorption

Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.

Protein binding

Not Available

Biotransformation

Hepatic. The major biotransformation is reduction of the ketone to metyrapol, an active alcohol metabolite. Metyrapone and metyrapol are both conjugated with glucuronide.

Route of elimination

After administration of 4.5 g metyrapone (750 mg every 4 hours), an average of 5.3% of the dose was excreted in the urine in the form of metyrapone (9.2% free and 90.8% as glucuronide) and 38.5% in the form of metyrapol (8.1% free and 91.9% as glucuronide) within 72 hours after the first dose was given.

Toxicity

Oral LD₅₀ in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Cyproheptadine	This combination renders test invalid
Fosphenytoin	The combination renders the test invalid
Phenytoin	The combination renders the test invalid

Food Interactions

Not Available

Cytochrome P450 11B1, mitochondrial
Name	Cytochrome P450 11B1, mitochondrial
Gene Name	CYP11B1
Pharmacological action	yes
Actions	inhibitor
References	Young EA, Ribeiro SC, Ye W: Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression. Psychoneuroendocrinology. 2007 Jun;32(5):503-7. Epub 2007 Apr 25. - Pubmed Johansson MK, Sanderson JT, Lund BO: Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicol In Vitro. 2002 Apr;16(2):113-21. - Pubmed Hermansson V, Asp V, Bergman A, Bergstrom U, Brandt I: Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells. Arch Toxicol. 2007 Nov;81(11):793-801. Epub 2007 May 9. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3101
Cytochrome P450-cam
Name	Cytochrome P450-cam
Gene Name	camC
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Bistolas N, Christenson A, Ruzgas T, Jung C, Scheller FW, Wollenberger U: Spectroelectrochemistry of cytochrome P450cam. Biochem Biophys Res Commun. 2004 Feb 13;314(3):810-6. - Pubmed Shiro Y, Fujii M, Isogai Y, Adachi S, Iizuka T, Obayashi E, Makino R, Nakahara K, Shoun H: Iron-ligand structure and iron redox property of nitric oxide reductase cytochrome P450nor from Fusarium oxysporum: relevance to its NO reduction activity. Biochemistry. 1995 Jul 18;34(28):9052-8. - Pubmed Schunemann V, Jung C, Terner J, Trautwein AX, Weiss R: Spectroscopic studies of peroxyacetic acid reaction intermediates of cytochrome P450cam and chloroperoxidase. J Inorg Biochem. 2002 Sep 20;91(4):586-96. - Pubmed
DTHybrid score	1.7047

Cytochrome P450 11B2, mitochondrial
Name	Cytochrome P450 11B2, mitochondrial
Gene Name	CYP11B2
Actions	inhibitor
References	- Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, de Gooyer M, Smits JF, Beugels I, Emmen J, Ottenheijm HC, Leysen D, Hermans JJ: Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics. J Comput Aided Mol Des. 2007 Aug;21(8):455-71. Epub 2007 Jul 24. - Pubmed Gomez-Sanchez CE, Zhou MY, Cozza EN, Morita H, Foecking MF, Gomez-Sanchez EP: Aldosterone biosynthesis in the rat brain. Endocrinology. 1997 Aug;138(8):3369-73. - Pubmed
DTHybrid score	0.3072
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3098
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4302
Cytochrome P450 11B1, mitochondrial
Name	Cytochrome P450 11B1, mitochondrial
Gene Name	CYP11B1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3101
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2712

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inducer
References	Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. - Pubmed
DTHybrid score	0.145

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.1709
4119	Cytochrome P450 2D6	CYP2D6	0.17
4757	Cytochrome P450 2C9	CYP2C9	0.1633
4200	Cytochrome P450 1A2	CYP1A2	0.1478
6016	Cytochrome P450 2C19	CYP2C19	0.1449
4118	Cytochrome P450 3A5	CYP3A5	0.1367
4924	Cytochrome P450 2C8	CYP2C8	0.1334
6107	Cytochrome P450 3A7	CYP3A7	0.1206
6030	Cytochrome P450 2B6	CYP2B6	0.1105
6024	Cytochrome P450 1A1	CYP1A1	0.0808
737	Mineralocorticoid receptor	NR3C2	0.0801
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0784
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0763
380	Cytochrome P450 17A1	CYP17A1	0.0759
3811	Cytochrome P450 19A1	CYP19A1	0.0729
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0637
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0498
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0497
4385	Cytochrome c'	Not Available	0.0492
4967	Cytochrome c'	cycA	0.0492
5038	Cytochrome c'	Not Available	0.0492
5223	Cytochrome c'	cycP	0.0492
2164	Multidrug resistance-associated protein 4	ABCC4	0.0459
4386	Hemoglobin-like protein HbN	glbN	0.0454
260	Cytochrome P450 51	ERG11	0.044
761	Cytochrome P450 51	ERG11	0.044
3163	Cytochrome P450 51	cyp51	0.044
94	5-hydroxytryptamine 4 receptor	HTR4	0.044
756	Sex hormone-binding globulin	SHBG	0.0425
862	Multidrug resistance-associated protein 1	ABCC1	0.0414
118	Organic cation/carnitine transporter 2	SLC22A5	0.0402
587	Serum albumin	ALB	0.0387
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0378
831	D(2) dopamine receptor	DRD2	0.0362
629	Alpha-2B adrenergic receptor	ADRA2B	0.0359
269	Adrenodoxin, mitochondrial	FDX1	0.0358
871	Glucocorticoid receptor	NR3C1	0.0355
20	Prostaglandin G/H synthase 1	PTGS1	0.0348
6106	Cytochrome P450 2C18	CYP2C18	0.0347
776	Bile salt export pump	ABCB11	0.0343
1729	Solute carrier family 22 member 6	SLC22A6	0.0327
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0314
232	Corticosteroid-binding globulin	SERPINA6	0.0301
469	Annexin A1	ANXA1	0.0285
1898	Cytochrome P450 1B1	CYP1B1	0.0263
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0262
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0258
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0256
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0254
492	Histamine H1 receptor	HRH1	0.0246
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0243
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0233
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0228
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0224
6144	Solute carrier family 22 member 2	SLC22A2	0.0211
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0209
6143	Solute carrier family 22 member 7	SLC22A7	0.0208
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0207
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0206
468	Cytochrome P450 4A11	CYP4A11	0.0203
290	Prostaglandin G/H synthase 2	PTGS2	0.0197
6145	Solute carrier family 22 member 1	SLC22A1	0.0195
824	Sodium-dependent serotonin transporter	SLC6A4	0.0191
136	Estrogen receptor	ESR1	0.0191
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0189
6147	Solute carrier family 22 member 3	SLC22A3	0.0187
6148	Multidrug resistance-associated protein 7	ABCC10	0.0181
6136	Multidrug resistance-associated protein 5	ABCC5	0.0181
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0179
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0173
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0172
6137	Multidrug resistance-associated protein 6	ABCC6	0.0171
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.017
24	Thymidylate synthase	TMP1	0.0167
359	Thymidylate synthase	TYMS	0.0167
2626	Thymidylate synthase	thyA	0.0167
2729	Thymidylate synthase	thyA	0.0167
5352	Thymidylate synthase	THYA	0.0167
6142	Solute carrier family 22 member 8	SLC22A8	0.0166
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0165
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0165
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0165
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0163
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0163
556	Alpha-1A adrenergic receptor	ADRA1A	0.0159
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0158
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0156
6014	Cytochrome P450 2A13	CYP2A13	0.0152
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.015
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0149
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0147
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0145
6141	Sodium/bile acid cotransporter	SLC10A1	0.0142
6031	Cytochrome P450 3A43	CYP3A43	0.0142
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0141
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0141
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0138
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0137
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0137
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0134
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0133
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0133
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0133
766	Beta-2 adrenergic receptor	ADRB2	0.0131
1024	Solute carrier family 22 member 11	SLC22A11	0.0129
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0129
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0128
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0125
146	Androgen receptor	AR	0.0123
6102	Arylamine N-acetyltransferase 2	NAT2	0.0122
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0121
482	Glycine receptor subunit alpha-1	GLRA1	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
2230	Catalase	CAT	0.0119
3249	Catalase	katA	0.0119
3625	Catalase	katA	0.0119
4539	Catalase	katA	0.0119
4941	Catalase	katB	0.0119
705	Glutamate receptor 1	GRIA1	0.0118
465	Calmodulin	CALM1	0.0117
817	DNA topoisomerase 2-alpha	TOP2A	0.0116
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0116
318	Alpha-2A adrenergic receptor	ADRA2A	0.0116
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0115
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0114
1010	Cytochrome P450 51A1	CYP51A1	0.0113
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.011
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0109
3941	Amine oxidase [flavin-containing] A	MAOA	0.0109
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0107
833	Organic cation/carnitine transporter 1	SLC22A4	0.0107
23	D(1A) dopamine receptor	DRD1	0.0106
847	Mu-type opioid receptor	OPRM1	0.0104
713	Sodium-dependent dopamine transporter	SLC6A3	0.0103
293	Gamma-glutamyl hydrolase	GGH	0.0098
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0097
3947	Xanthine dehydrogenase/oxidase	XDH	0.0097
731	HIV-1 protease	HIV-1 protease	0.0095
3939	Amine oxidase [flavin-containing] B	MAOB	0.0091
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0091
632	Alpha-1B adrenergic receptor	ADRA1B	0.009
4237	50S ribosomal protein L22	rplV	0.009
251	Alcohol dehydrogenase 1A	ADH1A	0.0089
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0089
161	Tubulin beta chain	TUBB	0.0088
312	Tubulin beta chain	TUB2	0.0088
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0088
444	Alcohol dehydrogenase 1B	ADH1B	0.0086
4604	Liver carboxylesterase 1	CES1	0.0086
299	Folate receptor beta	FOLR2	0.0086
718	Folate receptor gamma	FOLR3	0.0086
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0086
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0086
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0086
1650	Heme carrier protein 1	SLC46A1	0.0086
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0086
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0085
467	Delta-type opioid receptor	OPRD1	0.0084
908	Glutathione S-transferase theta-1	GSTT1	0.0084
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0084
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0083
16	Adenosine A1 receptor	ADORA1	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
517	Alcohol dehydrogenase 1C	ADH1C	0.0082
904	Glutathione S-transferase P	GSTP1	0.0082
3923	Cholinesterase	BCHE	0.0082
811	Translocator protein	TSPO	0.0081
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0081
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.008
3932	Glutathione S-transferase A2	GSTA2	0.0079
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0079
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0079
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0079
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0079
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0079
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0079
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0079
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0078
4238	50S ribosomal protein L4	rplD	0.0077
5578	50S ribosomal protein L4	rplD	0.0077
6173	50S ribosomal protein L4	rplD	0.0077
6219	50S ribosomal protein L4	rplD	0.0077
891	Dihydropteroate synthase	folP	0.0077
5359	Dihydropteroate synthase	folP	0.0077
7175	Dihydropteroate synthase	sulI	0.0077
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0074
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0074
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0074
7	Nitric oxide synthase, inducible	NOS2	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0074
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0073
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0072
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0072
789	Alpha-1D adrenergic receptor	ADRA1D	0.0071
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0071
638	D(3) dopamine receptor	DRD3	0.0071
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0071
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0071
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0071
614	Progesterone receptor	PGR	0.0071
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0071
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.007
696	Kappa-type opioid receptor	OPRK1	0.007
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.007
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0069
284	DNA-directed RNA polymerase beta chain	rpoB	0.0068
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0068
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0068
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0067
3810	Catechol O-methyltransferase	COMT	0.0067
518	Peroxidase/catalase T	katG	0.0067
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0067
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0067
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0066
6020	Aldehyde oxidase	AOX1	0.0066
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0066
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0066
5934	Cytochrome P450 26A1	CYP26A1	0.0065
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0065
68	Cannabinoid receptor 1	CNR1	0.0065
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0065
921	Glutamate receptor 2	GRIA2	0.0065
2539	Tubulin alpha-1 chain	TUBA4A	0.0065
777	Tumor necrosis factor	TNF	0.0064
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0063
1760	Aminopeptidase N	ANPEP	0.0063
6843	Aminopeptidase N	pepN	0.0063
378	Alpha-2C adrenergic receptor	ADRA2C	0.0062
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0062
4226	Uridine phosphorylase 2	UPP2	0.0062
117	Sterol O-acyltransferase 1	SOAT1	0.0062
716	5-hydroxytryptamine 7 receptor	HTR7	0.0062
738	Monocarboxylate transporter 1	SLC16A1	0.006
1178	Adenosine A2a receptor	ADORA2A	0.006
291	Nitric-oxide synthase, endothelial	NOS3	0.0059
869	Estrogen receptor beta	ESR2	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0058
4225	Uridine phosphorylase 1	UPP1	0.0057
124	Histamine H2 receptor	HRH2	0.0056
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0055
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0055
295	Carbonic anhydrase 1	CA1	0.0055
3809	Estrogen-related receptor gamma	ESRRG	0.0055
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0055
29	Tubulin beta-1 chain	TUBB1	0.0054
563	Thyroid peroxidase	TPO	0.0054
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0054
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0053
413	Amidophosphoribosyltransferase	PPAT	0.0053
2515	Amidophosphoribosyltransferase	purF	0.0053
3714	Amidophosphoribosyltransferase	purF	0.0053
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0053
6043	Putative G-protein coupled receptor 44	GPR44	0.0053
275	Arachidonate 5-lipoxygenase	ALOX5	0.0053
6149	Solute carrier family 22 member 10	SLC22A10	0.0053
1757	Myeloperoxidase	MPO	0.0053
432	D(4) dopamine receptor	DRD4	0.0052
6085	Fatty acid-binding protein, intestinal	FABP2	0.0052
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0052
592	Carbonic anhydrase 4	CA4	0.0052
6167	Organic solute transporter subunit beta	OSTB	0.0051
6166	Organic solute transporter subunit alpha	OSTA	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
122	P2Y purinoceptor 12	P2RY12	0.005
193	Beta-1 adrenergic receptor	ADRB1	0.005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0049
1192	Sulfotransferase 1A1	SULT1A1	0.0048
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0047
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0047
6220	Aryl hydrocarbon receptor	AHR	0.0047
896	Glutathione S-transferase Mu 1	GSTM1	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
4122	Histone deacetylase 2	HDAC2	0.0046
373	Transthyretin	TTR	0.0046
814	Ryanodine receptor 1	RYR1	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
4192	DNA topoisomerase 2-beta	TOP2B	0.0044
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
3639	Thymidine phosphorylase	deoA	0.0043
3936	Thymidine phosphorylase	TYMP	0.0043
3587	Gastrotropin	FABP6	0.0043
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0043
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0043
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0043
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0042
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
365	Dihydrofolate reductase	DHFR	0.0041
2381	Dihydrofolate reductase	DFR1	0.0041
2833	Dihydrofolate reductase	Not Available	0.0041
2931	Dihydrofolate reductase	folA	0.0041
3544	Dihydrofolate reductase	folA	0.0041
3682	Dihydrofolate reductase	folA	0.0041
6642	Dihydrofolate reductase	folA	0.0041
6756	Dihydrofolate reductase	dfrA	0.0041
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0039
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0039
3937	Fatty-acid amide hydrolase	FAAH	0.0039
1050	Bile salt sulfotransferase	SULT2A1	0.0039
4773	Deoxycytidine kinase	DCK	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
84	Nuclear receptor 0B1	NR0B1	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0039
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
844	Epidermal growth factor receptor	EGFR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
477	DNA topoisomerase 4 subunit A	parC	0.0038
886	DNA topoisomerase 4 subunit A	parC	0.0038
6226	DNA topoisomerase 4 subunit A	parC	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
106	Cannabinoid receptor 2	CNR2	0.0038
404	DNA gyrase subunit A	gyrA	0.0038
6224	DNA gyrase subunit A	gyrA	0.0038
6146	High affinity copper uptake protein 1	SLC31A1	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0037
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0037
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0037
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0037
6174	50S ribosomal protein L32	rpmF	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
6126	Carbonic anhydrase 7	CA7	0.0036
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0036
5626	Nucleoside diphosphate kinase B	NME2	0.0036
6182	Cytochrome P450 2J2	CYP2J2	0.0036
4120	NADPH--cytochrome P450 reductase	POR	0.0036
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0036
702	UMP-CMP kinase	CMPK1	0.0036
1636	Trace amine-associated receptor 1	TAAR1	0.0036
3404	Exotoxin A	eta	0.0036
856	Vitamin D3 receptor	VDR	0.0035
6165	Copper-transporting ATPase 1	ATP7A	0.0035
6163	Copper-transporting ATPase 2	ATP7B	0.0035
131	Synaptic vesicular amine transporter	SLC18A2	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0034
6138	Multidrug resistance protein 3	ABCB4	0.0034
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0034
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0033
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
400	Coagulation factor IX	F9	0.0033
5461	Coagulation factor IX	F9	0.0033
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0033
6218	Pannexin-1	PANX1	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0032
1313	Lactoylglutathione lyase	GLO1	0.0031
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0031
358	Cystathionine beta-synthase	CBS	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.003
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.003
604	Vitamin K-dependent protein Z	PROZ	0.003
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.003
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0029
5294	Nucleoside diphosphate kinase A	NME1	0.0029
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0029
6432	Transporter	snf	0.0029
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0028
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0028
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0028
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0028
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0028
422	Vitamin K-dependent protein C	PROC	0.0028
1245	Vitamin K-dependent protein S	PROS1	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0027
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0027
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
6168	Solute carrier family 22 member 16	SLC22A16	0.0027
5818	Folate receptor alpha	FOLR1	0.0027
239	Coagulation factor X	F10	0.0027
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
1275	Estrogen sulfotransferase	SULT1E1	0.0026
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0026
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0026
1268	Neuropeptide S receptor	NPSR1	0.0026
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0026
6042	Prostaglandin reductase 2	PTGR2	0.0026
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0025
76	Nitric-oxide synthase, brain	NOS1	0.0025
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0025
780	Retinoic acid receptor RXR-gamma	RXRG	0.0025
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0024
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0024
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0024
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0024
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
2391	Ferrochelatase	hemH	0.0023
6502	Ferrochelatase	DKFZp686P18130	0.0023
1591	Ferrochelatase, mitochondrial	FECH	0.0023
33	Cystine/glutamate transporter	SLC7A11	0.0023
6073	Potassium channel subfamily K member 9	KCNK9	0.0023
6072	Potassium channel subfamily K member 3	KCNK3	0.0023
54	Prothrombin	F2	0.0023
4217	Telomerase reverse transcriptase	TERT	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0022
798	Osteocalcin	BGLAP	0.0022
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0022
88	Retinoic acid receptor RXR-beta	RXRB	0.0022
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0022
504	Mast/stem cell growth factor receptor	KIT	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
823	Fibroblast growth factor receptor 2	FGFR2	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
65	Matrix metalloproteinase-9	Not Available	0.0021
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1656	CYP2B protein	CYP2B	0.0021
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
3601	Dihydropteroate synthase 1	folP1	0.0021
3807	Dihydropteroate synthase 1	folP1	0.0021
3808	Dihydropteroate synthase 2	folP2	0.0021
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.002
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.002
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.002
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.002
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.002
6493	Cytochrome c oxidase subunit 6C	COX6C	0.002
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.002
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.002
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.002
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.002
6559	Cytochrome c oxidase subunit 2	ctaC	0.002
6669	Cytochrome c oxidase subunit 2	ctaC	0.002
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.002
371	Cytochrome c oxidase subunit 1	MT-CO1	0.002
6558	Cytochrome c oxidase subunit 1	ctaD	0.002
369	Coagulation factor VII	F7	0.002
3221	Cytochrome c4	cc4	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
489	Monocarboxylate transporter 2	SLC16A7	0.002
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
164	Histamine H4 receptor	HRH4	0.002
605	Fumarate reductase flavoprotein subunit	frdA	0.002
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.002
3673	Fumarate reductase flavoprotein subunit	fccA	0.002
4912	Fumarate reductase flavoprotein subunit	ifcA	0.002
6549	Fumarate reductase flavoprotein subunit	frdA	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4031	Glutathione S-transferase A1	GSTA1	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
183	Vascular endothelial growth factor A	VEGFA	0.0019
2540	Choloylglycine hydrolase	cbh	0.0019
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0019
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0018
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
319	Opioid receptor, sigma 1	OPRS1	0.0018
683	Potassium transporter	GK0582	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0018
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
2207	Rhodopsin	RHO	0.0018
6501	Fatty acid-binding protein, liver	FABP1	0.0018
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
976	Platelet glycoprotein IX	GP9	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0016
735	Alanine aminotransferase 1	GPT	0.0016
3904	Alanine aminotransferase 2	GPT2	0.0016
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
173	Toll-like receptor 7	TLR7	0.0016
4905	Cytochrome c2	Not Available	0.0016
4939	Cytochrome c2	cycA	0.0016
4964	Cytochrome c2	cycA	0.0016
4979	Cytochrome c2	cycA	0.0016
6673	Cytochrome c2	cycA	0.0016
4943	Cytochrome c6	petJ	0.0016
4936	Cytochrome c2 iso-2	Not Available	0.0016
4916	Cyanoglobin	glbN	0.0016
4994	Hemoglobin-like protein HbO	glbO	0.0016
4998	Hemoglobin-like protein yjbI	yjbI	0.0016
4984	Neuroglobin	NGB	0.0016
4942	Diheme cytochrome c napB	napB	0.0016
4954	Soluble cytochrome b558	Not Available	0.0016
4934	Cytochrome c-551	nirM	0.0016
5218	Cytochrome c-551	nirM	0.0016
4961	Hemophore HasA	hasA	0.0016
4915	Cytochrome c-550	psbV	0.0016
4959	Cytochrome c-550	psbV	0.0016
5216	Cytochrome c-550	psbV	0.0016
4925	Cytochrome c-type protein SHP	shp	0.0016
4910	Cytoglobin	CYGB	0.0016
4999	Cytochrome P450 165B3	CYP165B3	0.0016
4947	Bacterial hemoglobin	vhb	0.0016
4975	Cytochrome c-556	RPA3973	0.0016
4909	CooA protein	cooA	0.0016
4972	P450cin	cinA	0.0016
4904	Cytochrome c family protein	GSU1996	0.0016
4937	Cytochrome oxidase subunit II	rcoxA	0.0016
4989	Cytochrome c551 peroxidase	ccp	0.0016
5222	Cytochrome c551 peroxidase	ccpA	0.0016
4976	Apocytochrome f	petA	0.0016
6407	Apocytochrome f	petA	0.0016
4981	Iron-starvation protein PigA	pigA	0.0016
4907	Cytochrome c-L	moxG	0.0016
6865	Cytochrome c-L	moxG	0.0016
4993	Hydroxylamine oxidoreductase	hao1	0.0016
5000	HemO	hemO	0.0016
4960	Putative cytochrome P450-family protein	SCO7417	0.0016
4935	Cytochrome c-554	cycA1	0.0016
4764	Cytochrome P450 165C4	CYP165C4	0.0016
4931	Cytochrome P450 167A1	CYP167A1	0.0016
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0016
644	Heme oxygenase 2	HMOX2	0.0016
4982	Heme oxygenase 2	pbsA2	0.0016
4952	Catalase/peroxidase	katA	0.0016
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0016
4971	Nonaheme cytochrome c	hmcA	0.0016
4903	Methyl-accepting chemotaxis protein	Tar4	0.0016
3093	Catalase HPII	katE	0.0016
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0016
4922	Cytochrome c, putative	SO_4144	0.0016
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0016
1039	Histone deacetylase 9	HDAC9	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0015
174	Sigma 1-type opioid receptor	SIGMAR1	0.0015
898	Glutathione S-transferase A3	GSTA3	0.0015
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
427	Substance-P receptor	TACR1	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
6500	Phospholipase A2	PLA2G1B	0.0015
1629	Transcription factor AP-1	JUN	0.0015
4311	tRNA	TRDMT1	0.0015
4325	tRNA	trmD	0.0015
4328	tRNA	trmD	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
905	Glutathione transferase omega-1	GSTO1	0.0015
899	Glutathione S-transferase Mu 3	GSTM3	0.0015
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
1541	Metalloproteinase	mmp20	0.0014
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0014
820	Glycine receptor subunit alpha-2	GLRA2	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0014
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0013
2119	Cytochrome b5	CYB5A	0.0013
4948	Cytochrome c-553	Not Available	0.0013
4920	Peroxidase/catalase	katG	0.0013
4923	Cytochrome c3	DvMF_2499	0.0013
4945	Cytochrome c3	Not Available	0.0013
4949	Cytochrome c3	DVU_3171	0.0013
4968	Cytochrome c3	cytc3	0.0013
4997	Cytochrome c3	SO_2727	0.0013
5219	Cytochrome c3	cyd	0.0013
4990	PpcA	ppcA	0.0013
3189	High-molecular-weight cytochrome c	hmcA	0.0013
4902	Nine-heme cytochrome c	Ddes_2038	0.0013
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0013
3375	Acidic cytochrome c3	Not Available	0.0013
2915	Sensor protein fixL	fixL	0.0013
4944	Sensor protein fixL	fixL	0.0013
4813	Heme oxygenase	hmuO	0.0013
5769	Heme oxygenase	Not Available	0.0013
4988	Sulfite oxidase, mitochondrial	SUOX	0.0013
3570	Cytochrome P450 152A1	cypC	0.0013
4992	Cytochrome c peroxidase	Not Available	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
4289	Cytochrome P450	TT_P0059	0.0013
6262	Cytochrome P450	staP	0.0013
162	Retinoic acid receptor gamma-1	RARG	0.0013
207	Glutathione synthetase	GSS	0.0013
5269	Glutathione synthetase	gshB	0.0013
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
1618	High affinity nerve growth factor receptor	NTRK1	0.0012
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3411	Cytochrome P450 121	cyp121	0.0012
3670	Soluble cytochrome b562 precursor	cybC	0.0012
3291	Cytochrome c-552	cycA	0.0012
4927	Cytochrome c-552	nrfA	0.0012
4938	Cytochrome c-552	cycA	0.0012
4953	Cytochrome c-552	nrfA	0.0012
5217	Cytochrome c-552	cycM	0.0012
3102	Flavohemoprotein	hmp	0.0012
4969	Flavohemoprotein	hmp	0.0012
85	Growth hormone receptor	GHR	0.0012
2617	Nitric oxide synthase oxygenase	nos	0.0012
2701	Nitric oxide synthase oxygenase	nos	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0012
3127	Nitrite reductase	nirS	0.0011
3284	Nitrite reductase	nirS	0.0011
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
751	Potassium channel subfamily K member 6	KCNK6	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
4608	Putative cytochrome P450	SCO1207	0.0011
4963	Putative cytochrome P450	SCO2884	0.0011
6254	Putative cytochrome P450	SCO6998	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0011
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
172	Potassium channel subfamily K member 1	KCNK1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
1507	Cytochrome c	CYCS	0.001
693	Hemoglobin subunit beta	HBB	0.001
6268	Hydroxyacid oxidase 1	HAO1	0.001
3957	Adenosine deaminase	ADA	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0009
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
165	FL cytokine receptor	FLT3	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
810	Heme oxygenase 1	HMOX1	0.0009
3391	Heme oxygenase 1	pbsA1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01011 - Metyrapone

Targets

Enzymes

Transporters

Predictions