DT-Web

DB02134 - Xanthine


Identification
Name Xanthine
Accession Number DB02134 (EXPT03251)
Type small molecule
Description A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 152.1109
Groups experimental
Monoisotopic Weight 152.033425392
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Xanthosine phosphorylase
Name Xanthosine phosphorylase
Gene Name xapA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0429
Xanthine phosphoribosyltransferase
Name Xanthine phosphoribosyltransferase
Gene Name gpt
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0749

Predictions


Id Partner name Gene Name Score
3300 Xanthine phosphoribosyltransferase xpt 1.0749
1673 GTP cyclohydrolase I GCH1 0.3084
3302 GTP cyclohydrolase I folE 0.3084
3015 Pur operon repressor purR 0.1876
277 Purine nucleoside phosphorylase PNP 0.1658
2870 Purine nucleoside phosphorylase punA 0.1658
2945 Purine nucleoside phosphorylase punA 0.1658
4659 Purine nucleoside phosphorylase TM_1596 0.1658
4825 Purine nucleoside phosphorylase TTHA1435 0.1658
2361 Response regulator pleD pleD 0.0433
2516 GMP reductase 1 GMPR 0.0432
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0377
4106 Guanylate kinase GUK1 0.0377
4516 Guanylate kinase gmk 0.0377
413 Amidophosphoribosyltransferase PPAT 0.0376
2515 Amidophosphoribosyltransferase purF 0.0376
3714 Amidophosphoribosyltransferase purF 0.0376
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0348
338 DNA polymerase UL30 0.0347
379 DNA polymerase UL54 0.0347
697 DNA polymerase ORF28 0.0347
2482 DNA polymerase 43 0.0347
4104 DNA polymerase BALF5 0.0347
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0298
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0287
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0247
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0217
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