DT-Web

DB02745 - Uridine


Identification
Name Uridine
Accession Number DB02745 (EXPT03205)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 244.2014
Groups experimental
Monoisotopic Weight 244.069536126
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


U6 snRNA-associated Sm-like protein LSm6
Name U6 snRNA-associated Sm-like protein LSm6
Gene Name LSM6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Nucleoside-specific channel-forming protein tsx precursor
Name Nucleoside-specific channel-forming protein tsx precursor
Gene Name tsx
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.71

Transporters


Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions Not Available
References
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
DTHybrid score 0.4969

Predictions


Id Partner name Gene Name Score
6171 Solute carrier family 28 member 3 SLC28A3 0.1362
2251 Thymidylate kinase tmk 0.0817
2254 Thymidylate kinase DTYMK 0.0817
3522 Thymidylate kinase tmk 0.0817
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0817
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0817
4773 Deoxycytidine kinase DCK 0.08
2257 Uridine phosphorylase udp 0.0784
5132 Uridine phosphorylase udp 0.0784
509 Thymidine kinase TK 0.0682
570 Thymidine kinase TK 0.0682
2559 Thymidine kinase TK 0.0682
3430 Thymidine kinase tdk 0.0682
3518 Thymidine kinase TK 0.0682
5301 Thymidine kinase tdk 0.0682
5771 Thymidine kinase ORF36 0.0682
7009 Thymidine kinase ORF36 0.0682
6145 Solute carrier family 22 member 1 SLC22A1 0.0432
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0408
277 Purine nucleoside phosphorylase PNP 0.033
2870 Purine nucleoside phosphorylase punA 0.033
2945 Purine nucleoside phosphorylase punA 0.033
4659 Purine nucleoside phosphorylase TM_1596 0.033
4825 Purine nucleoside phosphorylase TTHA1435 0.033
24 Thymidylate synthase TMP1 0.032
359 Thymidylate synthase TYMS 0.032
2626 Thymidylate synthase thyA 0.032
2729 Thymidylate synthase thyA 0.032
5352 Thymidylate synthase THYA 0.032
3611 Cytidine deaminase cdd 0.0303
3707 Cytidine deaminase cdd 0.0303
4211 Cytidine deaminase CDA 0.0303
603 DNA polymerase alpha catalytic subunit POLA1 0.0285
1729 Solute carrier family 22 member 6 SLC22A6 0.0269
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0227
752 Large structural protein L 0.0227
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0225
6148 Multidrug resistance-associated protein 7 ABCC10 0.021
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0196
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0192
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0179
1830 5'-nucleotidase NT5E 0.0176
125 DNA polymerase beta POLB 0.0163
6021 Adenosine kinase ADK 0.0159
6136 Multidrug resistance-associated protein 5 ABCC5 0.0156
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0153
702 UMP-CMP kinase CMPK1 0.0144
365 Dihydrofolate reductase DHFR 0.0142
2381 Dihydrofolate reductase DFR1 0.0142
2833 Dihydrofolate reductase Not Available 0.0142
2931 Dihydrofolate reductase folA 0.0142
3544 Dihydrofolate reductase folA 0.0142
3682 Dihydrofolate reductase folA 0.0142
6642 Dihydrofolate reductase folA 0.0142
6756 Dihydrofolate reductase dfrA 0.0142
2164 Multidrug resistance-associated protein 4 ABCC4 0.0128
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0125
1405 Thiopurine S-methyltransferase TPMT 0.0123
6143 Solute carrier family 22 member 7 SLC22A7 0.0121
4512 Cytochrome P450 3A4 CYP3A4 0.0114
6020 Aldehyde oxidase AOX1 0.0107
4757 Cytochrome P450 2C9 CYP2C9 0.0101
6031 Cytochrome P450 3A43 CYP3A43 0.0099
3947 Xanthine dehydrogenase/oxidase XDH 0.0097
4226 Uridine phosphorylase 2 UPP2 0.0094
6107 Cytochrome P450 3A7 CYP3A7 0.0085
4225 Uridine phosphorylase 1 UPP1 0.0085
4118 Cytochrome P450 3A5 CYP3A5 0.008
6144 Solute carrier family 22 member 2 SLC22A2 0.0079
413 Amidophosphoribosyltransferase PPAT 0.0077
2515 Amidophosphoribosyltransferase purF 0.0077
3714 Amidophosphoribosyltransferase purF 0.0077
6142 Solute carrier family 22 member 8 SLC22A8 0.0074
3639 Thymidine phosphorylase deoA 0.007
3936 Thymidine phosphorylase TYMP 0.007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0067
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0062
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
3917 Methylenetetrahydrofolate reductase MTHFR 0.0057
1588 Multidrug resistance protein 1 ABCB1 0.0057
4924 Cytochrome P450 2C8 CYP2C8 0.0054
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
4119 Cytochrome P450 2D6 CYP2D6 0.005
3809 Estrogen-related receptor gamma ESRRG 0.0045
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0045
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0045
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0045
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
5718 Cytochrome P450 2A6 CYP2A6 0.0037
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0037
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0036
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0034
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0033
587 Serum albumin ALB 0.0033
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0032
776 Bile salt export pump ABCB11 0.0032
3811 Cytochrome P450 19A1 CYP19A1 0.0032
4200 Cytochrome P450 1A2 CYP1A2 0.003
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0029
6024 Cytochrome P450 1A1 CYP1A1 0.0027
6030 Cytochrome P450 2B6 CYP2B6 0.0025
6016 Cytochrome P450 2C19 CYP2C19 0.0022
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