DT-Web

DB00973 - Ezetimibe


Identification
Name Ezetimibe
Accession Number DB00973 (APRD00619)
Type small molecule
Description Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 409.4252
Groups approved
Monoisotopic Weight 409.148949953
Pharmacology
Indication For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia.
Mechanism of action Ezetimibe localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol. This leads to a decrease in the delivery of intestinal cholesterol to the liver.
Absorption After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide (ezetimibe-glucuronide). When a single 10 mg dose of ezetimibe is given to a fasted, male, adult subject, the pharmacokinetic parameters are as follows: Cmax = 3.5 - 5.5 ng/mL; Tmax = 4- 12 hours. The pharmacokinetic parameters for ezetimibe-glucuronide are as follows: Cmax = 45 - 71 ng/mL; Tmax = 1-2 hours. Food has not impact on the extent of absorption of ezetimibe. However, Cmax increases by 38% with a high-fat meal.
Protein binding >90% bound to human plasma protein
Biotransformation Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a phase II reaction) with subsequent biliary and renal excretion. In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide.
Route of elimination 78% of the dose is excreted into feces. 11% of the dose is excreted into urine. Ezetimibe was the major component in feces and accounted for 69% of the administered dose, while ezetimibe-glucuronide was the major component in urine and accounted for 9% of the administered dose.
Toxicity The most common adverse reactions in the group of patients treated with ezetimibe that led to treatment discontinuation and occurred at a rate greater than placebo were, arthralgia (0.3%), dizziness (0.2%), and gamma-glutamyltransferase increase (0.2%).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cholestyramine Cholestyramine may decrease the levels of ezetimibe.
Cyclosporine Cyclosporine may increase the therapeutic and adverse effects of ezetimibe.
Warfarin If ezetimibe is added to warfarin, a coumarin anticoagulant, the International Normalized Ratio (INR) should be appropriately monitored.
Food Interactions
  • Take without regard to meals.

Targets


Sterol O-acyltransferase 1
Name Sterol O-acyltransferase 1
Gene Name SOAT1
Pharmacological action yes
Actions inhibitor
References
  • Singh A, Basit A, Banerjee UC: Burkholderia cenocepacia: a new biocatalyst for efficient bioreduction of ezetimibe intermediate. J Ind Microbiol Biotechnol. 2009 Nov;36(11):1369-74. Epub 2009 Aug 8. - Pubmed
  • Costet P: Molecular pathways and agents for lowering LDL-cholesterol in addition to statins. Pharmacol Ther. 2010 Mar 19. - Pubmed
  • Wang HH, Portincasa P, Mendez-Sanchez N, Uribe M, Wang DQ: Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology. 2008 Jun;134(7):2101-10. Epub 2008 Mar 10. - Pubmed
DTHybrid score 0.4824
Niemann-Pick C1-like protein 1
Name Niemann-Pick C1-like protein 1
Gene Name NPC1L1
Pharmacological action yes
Actions inhibitor
References
  • Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP: Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4. - Pubmed
  • Wang J, Williams CM, Hegele RA: Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe. Clin Genet. 2005 Feb;67(2):175-7. - Pubmed
  • Sudhop T, Lutjohann D, von Bergmann K: Sterol transporters: targets of natural sterols and new lipid lowering drugs. Pharmacol Ther. 2005 Mar;105(3):333-41. Epub 2004 Dec 9. - Pubmed
  • Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA: The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31. - Pubmed
  • von Bergmann K, Sudhop T, Lutjohann D: Cholesterol and plant sterol absorption: recent insights. Am J Cardiol. 2005 Jul 4;96(1A):10D-14D. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3374
Aminopeptidase N
Name Aminopeptidase N
Gene Name ANPEP
Pharmacological action unknown
Actions other
References
  • Kramer W, Girbig F, Corsiero D, Pfenninger A, Frick W, Jahne G, Rhein M, Wendler W, Lottspeich F, Hochleitner EO, Orso E, Schmitz G: Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. J Biol Chem. 2005 Jan 14;280(2):1306-20. Epub 2004 Oct 19. - Pubmed
DTHybrid score 0.6689

Enzymes


UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. Epub 2011 Mar 2. - Pubmed
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. - Pubmed
DTHybrid score 0.4053
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. Epub 2011 Mar 2. - Pubmed
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. - Pubmed
DTHybrid score 0.3703
UDP-glucuronosyltransferase 2B15
Name UDP-glucuronosyltransferase 2B15
Gene Name Not Available
Actions substrate
References
  • Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S: Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia). Drug Metab Dispos. 2004 Mar;32(3):314-20. - Pubmed
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. - Pubmed
DTHybrid score Not Available
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S: Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia). Drug Metab Dispos. 2004 Mar;32(3):314-20. - Pubmed
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. - Pubmed
DTHybrid score 0.381
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. - Pubmed
DTHybrid score 0.562

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. Epub 2011 Mar 2. - Pubmed
DTHybrid score 0.5645
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. Epub 2011 Mar 2. - Pubmed
  • de Waart DR, Vlaming ML, Kunne C, Schinkel AH, Oude Elferink RP: Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. doi: 10.1124/dmd.108.026146. Epub 2009 May 14. - Pubmed
DTHybrid score 0.3989
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. Epub 2011 Mar 2. - Pubmed
DTHybrid score 0.4039
ATP-binding cassette sub-family G member 5
Name ATP-binding cassette sub-family G member 5
Gene Name Not Available
Actions substrate
References
  • Couture P, Lamarche B: Ezetimibe and bile acid sequestrants: impact on lipoprotein metabolism and beyond. Curr Opin Lipidol. 2013 Jun;24(3):227-32. doi: 10.1097/MOL.0b013e3283613a55. - Pubmed
DTHybrid score Not Available
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions substrate
References
  • de Waart DR, Vlaming ML, Kunne C, Schinkel AH, Oude Elferink RP: Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. doi: 10.1124/dmd.108.026146. Epub 2009 May 14. - Pubmed
DTHybrid score 0.2665
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • de Waart DR, Vlaming ML, Kunne C, Schinkel AH, Oude Elferink RP: Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. doi: 10.1124/dmd.108.026146. Epub 2009 May 14. - Pubmed
DTHybrid score 0.4506
ATP-binding cassette sub-family G member 8
Name ATP-binding cassette sub-family G member 8
Gene Name Not Available
Actions substrate
References
  • Couture P, Lamarche B: Ezetimibe and bile acid sequestrants: impact on lipoprotein metabolism and beyond. Curr Opin Lipidol. 2013 Jun;24(3):227-32. doi: 10.1097/MOL.0b013e3283613a55. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
6843 Aminopeptidase N pepN 0.6689
5993 B2 bradykinin receptor BDKRB2 0.3927
4757 Cytochrome P450 2C9 CYP2C9 0.2482
4924 Cytochrome P450 2C8 CYP2C8 0.239
4200 Cytochrome P450 1A2 CYP1A2 0.2375
4118 Cytochrome P450 3A5 CYP3A5 0.2051
6016 Cytochrome P450 2C19 CYP2C19 0.1924
4119 Cytochrome P450 2D6 CYP2D6 0.1795
259 Microsomal triglyceride transfer protein large subunit MTTP 0.168
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1474
862 Multidrug resistance-associated protein 1 ABCC1 0.1414
6107 Cytochrome P450 3A7 CYP3A7 0.1365
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1334
6030 Cytochrome P450 2B6 CYP2B6 0.1313
587 Serum albumin ALB 0.1271
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1139
2164 Multidrug resistance-associated protein 4 ABCC4 0.1114
1729 Solute carrier family 22 member 6 SLC22A6 0.1068
20 Prostaglandin G/H synthase 1 PTGS1 0.0927
6013 Cytochrome P450 2E1 CYP2E1 0.082
6024 Cytochrome P450 1A1 CYP1A1 0.0818
776 Bile salt export pump ABCB11 0.0783
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0757
5718 Cytochrome P450 2A6 CYP2A6 0.0685
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0683
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0683
290 Prostaglandin G/H synthase 2 PTGS2 0.067
6142 Solute carrier family 22 member 8 SLC22A8 0.064
70 Type-1 angiotensin II receptor AGTR1 0.0626
238 Peroxisome proliferator-activated receptor gamma PPARG 0.06
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0544
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0542
6145 Solute carrier family 22 member 1 SLC22A1 0.0536
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0511
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0508
6141 Sodium/bile acid cotransporter SLC10A1 0.0495
6148 Multidrug resistance-associated protein 7 ABCC10 0.0492
1898 Cytochrome P450 1B1 CYP1B1 0.0468
6137 Multidrug resistance-associated protein 6 ABCC6 0.0451
6143 Solute carrier family 22 member 7 SLC22A7 0.0449
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0439
817 DNA topoisomerase 2-alpha TOP2A 0.0433
1024 Solute carrier family 22 member 11 SLC22A11 0.0425
6144 Solute carrier family 22 member 2 SLC22A2 0.0421
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0397
4604 Liver carboxylesterase 1 CES1 0.0385
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0384
5880 Thrombopoietin receptor MPL 0.0384
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0376
6136 Multidrug resistance-associated protein 5 ABCC5 0.0367
118 Organic cation/carnitine transporter 2 SLC22A5 0.036
136 Estrogen receptor ESR1 0.0359
847 Mu-type opioid receptor OPRM1 0.0353
467 Delta-type opioid receptor OPRD1 0.0346
3811 Cytochrome P450 19A1 CYP19A1 0.034
696 Kappa-type opioid receptor OPRK1 0.0327
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0318
6106 Cytochrome P450 2C18 CYP2C18 0.0313
26 Vascular endothelial growth factor receptor 3 FLT4 0.0311
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0308
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0307
504 Mast/stem cell growth factor receptor KIT 0.0302
32 Vascular endothelial growth factor receptor 1 FLT1 0.0297
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0293
492 Histamine H1 receptor HRH1 0.0287
871 Glucocorticoid receptor NR3C1 0.0286
731 HIV-1 protease HIV-1 protease 0.0282
6147 Solute carrier family 22 member 3 SLC22A3 0.0279
6026 Alcohol dehydrogenase 6 ADH6 0.0266
407 Vascular endothelial growth factor receptor 2 KDR 0.0264
1353 DNA topoisomerase 1 TOP1 0.0256
3552 DNA topoisomerase 1 topA 0.0256
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0255
24 Thymidylate synthase TMP1 0.0255
359 Thymidylate synthase TYMS 0.0255
2626 Thymidylate synthase thyA 0.0255
2729 Thymidylate synthase thyA 0.0255
5352 Thymidylate synthase THYA 0.0255
556 Alpha-1A adrenergic receptor ADRA1A 0.0253
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.025
824 Sodium-dependent serotonin transporter SLC6A4 0.0248
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.024
844 Epidermal growth factor receptor EGFR 0.0239
738 Monocarboxylate transporter 1 SLC16A1 0.0236
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0236
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0229
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0227
468 Cytochrome P450 4A11 CYP4A11 0.0225
228 Beta platelet-derived growth factor receptor PDGFRB 0.0223
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0217
3923 Cholinesterase BCHE 0.021
502 5-hydroxytryptamine 2A receptor HTR2A 0.0207
908 Glutathione S-transferase theta-1 GSTT1 0.0206
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0202
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.02
3587 Gastrotropin FABP6 0.0198
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0198
3810 Catechol O-methyltransferase COMT 0.0196
766 Beta-2 adrenergic receptor ADRB2 0.0194
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0193
6085 Fatty acid-binding protein, intestinal FABP2 0.0191
146 Androgen receptor AR 0.019
1630 Integrin beta-2 ITGB2 0.0189
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0188
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0188
833 Organic cation/carnitine transporter 1 SLC22A4 0.0187
904 Glutathione S-transferase P GSTP1 0.0183
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0182
2539 Tubulin alpha-1 chain TUBA4A 0.0181
51 Muscarinic acetylcholine receptor M3 CHRM3 0.018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0179
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0179
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0178
275 Arachidonate 5-lipoxygenase ALOX5 0.0176
632 Alpha-1B adrenergic receptor ADRA1B 0.0176
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0174
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0173
29 Tubulin beta-1 chain TUBB1 0.0173
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0173
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0173
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0172
3233 Bile acid receptor NR1H4 0.0171
33 Cystine/glutamate transporter SLC7A11 0.0171
3947 Xanthine dehydrogenase/oxidase XDH 0.017
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0169
1650 Heme carrier protein 1 SLC46A1 0.0168
477 DNA topoisomerase 4 subunit A parC 0.0167
886 DNA topoisomerase 4 subunit A parC 0.0167
6226 DNA topoisomerase 4 subunit A parC 0.0167
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0167
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0167
6220 Aryl hydrocarbon receptor AHR 0.0167
614 Progesterone receptor PGR 0.0166
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0165
404 DNA gyrase subunit A gyrA 0.0165
6224 DNA gyrase subunit A gyrA 0.0165
789 Alpha-1D adrenergic receptor ADRA1D 0.0164
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0164
161 Tubulin beta chain TUBB 0.0164
312 Tubulin beta chain TUB2 0.0164
320 5-hydroxytryptamine 1A receptor HTR1A 0.0164
6167 Organic solute transporter subunit beta OSTB 0.0164
6166 Organic solute transporter subunit alpha OSTA 0.0164
831 D(2) dopamine receptor DRD2 0.0162
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0162
6102 Arylamine N-acetyltransferase 2 NAT2 0.016
4120 NADPH--cytochrome P450 reductase POR 0.0158
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0157
1629 Transcription factor AP-1 JUN 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6044 Serum paraoxonase/lactonase 3 PON3 0.0153
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0151
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.015
590 5-hydroxytryptamine 2C receptor HTR2C 0.015
3917 Methylenetetrahydrofolate reductase MTHFR 0.0149
260 Cytochrome P450 51 ERG11 0.0149
761 Cytochrome P450 51 ERG11 0.0149
3163 Cytochrome P450 51 cyp51 0.0149
3809 Estrogen-related receptor gamma ESRRG 0.0147
6031 Cytochrome P450 3A43 CYP3A43 0.0147
273 Apoptosis regulator Bcl-2 BCL2 0.0145
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
952 Dipeptidyl peptidase 4 DPP4 0.0143
572 Integrin alpha-L ITGAL 0.0142
4122 Histone deacetylase 2 HDAC2 0.014
4773 Deoxycytidine kinase DCK 0.0139
293 Gamma-glutamyl hydrolase GGH 0.0138
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0137
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0136
6138 Multidrug resistance protein 3 ABCB4 0.0136
373 Transthyretin TTR 0.0133
869 Estrogen receptor beta ESR2 0.0133
723 Cytosolic phospholipase A2 PLA2G4A 0.0133
811 Translocator protein TSPO 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.013
322 Vasopressin V2 receptor AVPR2 0.0128
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0127
193 Beta-1 adrenergic receptor ADRB1 0.0127
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0126
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0126
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0126
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0126
318 Alpha-2A adrenergic receptor ADRA2A 0.0125
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0125
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0124
459 Retinoic acid receptor RXR-alpha RXRA 0.0123
4192 DNA topoisomerase 2-beta TOP2B 0.0123
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0123
319 Opioid receptor, sigma 1 OPRS1 0.0123
885 5-hydroxytryptamine 1B receptor HTR1B 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
725 5-hydroxytryptamine 1D receptor HTR1D 0.012
896 Glutathione S-transferase Mu 1 GSTM1 0.0118
4148 Serine/threonine-protein kinase mTOR MTOR 0.0118
758 Thyroid hormone receptor alpha THRA 0.0117
6163 Copper-transporting ATPase 2 ATP7B 0.0117
6165 Copper-transporting ATPase 1 ATP7A 0.0117
267 Plasminogen activator inhibitor 1 SERPINE1 0.0117
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0116
6146 High affinity copper uptake protein 1 SLC31A1 0.0115
3856 Fibroblast growth factor receptor 3 FGFR3 0.0115
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0115
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0114
165 FL cytokine receptor FLT3 0.0114
6599 HTH-type transcriptional regulator ttgR ttgR 0.0113
6149 Solute carrier family 22 member 10 SLC22A10 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
756 Sex hormone-binding globulin SHBG 0.011
6182 Cytochrome P450 2J2 CYP2J2 0.011
2021 Thrombomodulin THBD 0.011
1757 Myeloperoxidase MPO 0.0109
6043 Putative G-protein coupled receptor 44 GPR44 0.0109
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0109
2443 Azurin azu 0.0108
1192 Sulfotransferase 1A1 SULT1A1 0.0107
6221 Steroid hormone receptor ERR1 ESRRA 0.0107
5626 Nucleoside diphosphate kinase B NME2 0.0105
23 D(1A) dopamine receptor DRD1 0.0104
346 Thyroid hormone receptor beta-1 THRB 0.0104
3941 Amine oxidase [flavin-containing] A MAOA 0.0101
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.01
1852 Microtubule-associated protein 2 MAP2 0.01
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0098
2981 Phospholipase A2, membrane associated PLA2G2A 0.0097
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0096
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0096
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0095
284 DNA-directed RNA polymerase beta chain rpoB 0.0095
5773 DNA-directed RNA polymerase beta chain rpoB 0.0095
341 5-hydroxytryptamine 3 receptor HTR3A 0.0095
465 Calmodulin CALM1 0.0094
299 Folate receptor beta FOLR2 0.0093
718 Folate receptor gamma FOLR3 0.0092
804 Mitochondrial folate transporter/carrier SLC25A32 0.0092
232 Corticosteroid-binding globulin SERPINA6 0.0091
274 Muscarinic acetylcholine receptor M5 CHRM5 0.009
5787 Angiopoietin-1 receptor TEK 0.009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0089
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0088
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0088
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0088
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0086
6042 Prostaglandin reductase 2 PTGR2 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
5294 Nucleoside diphosphate kinase A NME1 0.0085
713 Sodium-dependent dopamine transporter SLC6A3 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0084
594 Thyroxine-binding globulin SERPINA7 0.0083
1313 Lactoylglutathione lyase GLO1 0.0083
342 P protein [Includes: DNA-directed DNA polymerase P 0.0083
612 P protein [Includes: DNA-directed DNA polymerase P 0.0083
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0083
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0082
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0082
702 UMP-CMP kinase CMPK1 0.0082
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
5923 Microtubule-associated protein tau MAPT 0.0081
5924 Microtubule-associated protein 4 MAP4 0.0081
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0081
737 Mineralocorticoid receptor NR3C2 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
777 Tumor necrosis factor TNF 0.0078
511 5-hydroxytryptamine 1F receptor HTR1F 0.0078
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0077
6168 Solute carrier family 22 member 16 SLC22A16 0.0076
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0076
1792 Tissue-type plasminogen activator PLAT 0.0076
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
2298 Cytochrome P450-cam camC 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
629 Alpha-2B adrenergic receptor ADRA2B 0.0074
2449 Tubulin alpha-3 chain TUBA1A 0.0074
474 Acetylcholinesterase ACHE 0.0073
6020 Aldehyde oxidase AOX1 0.0072
54 Prothrombin F2 0.0072
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0072
122 P2Y purinoceptor 12 P2RY12 0.0072
638 D(3) dopamine receptor DRD3 0.0071
68 Cannabinoid receptor 1 CNR1 0.0071
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0071
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0071
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0071
768 FK506-binding protein 1A FKBP1A 0.007
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0069
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0069
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0068
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0068
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0068
244 Angiotensin-converting enzyme ACE 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
1039 Histone deacetylase 9 HDAC9 0.0067
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
4217 Telomerase reverse transcriptase TERT 0.0066
5818 Folate receptor alpha FOLR1 0.0066
2808 Chloramphenicol acetyltransferase 3 cat3 0.0066
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0066
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
378 Alpha-2C adrenergic receptor ADRA2C 0.0063
3270 Elongation factor G fusA 0.0062
124 Histamine H2 receptor HRH2 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
760 Fibroblast growth factor 1 FGF1 0.0062
936 Ephrin type-A receptor 2 EPHA2 0.0062
380 Cytochrome P450 17A1 CYP17A1 0.0061
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0059
4226 Uridine phosphorylase 2 UPP2 0.0059
1618 High affinity nerve growth factor receptor NTRK1 0.0059
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0059
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0059
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0058
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0058
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0058
469 Annexin A1 ANXA1 0.0058
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0058
489 Monocarboxylate transporter 2 SLC16A7 0.0057
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0057
365 Dihydrofolate reductase DHFR 0.0057
2381 Dihydrofolate reductase DFR1 0.0057
2833 Dihydrofolate reductase Not Available 0.0057
2931 Dihydrofolate reductase folA 0.0057
3544 Dihydrofolate reductase folA 0.0057
3682 Dihydrofolate reductase folA 0.0057
6642 Dihydrofolate reductase folA 0.0057
6756 Dihydrofolate reductase dfrA 0.0057
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0057
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
823 Fibroblast growth factor receptor 2 FGFR2 0.0056
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0055
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0055
4225 Uridine phosphorylase 1 UPP1 0.0055
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0054
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0053
2320 Thymidine kinase, cytosolic TK1 0.0052
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0052
7 Nitric oxide synthase, inducible NOS2 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
2391 Ferrochelatase hemH 0.0051
6502 Ferrochelatase DKFZp686P18130 0.0051
1591 Ferrochelatase, mitochondrial FECH 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0051
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0051
413 Amidophosphoribosyltransferase PPAT 0.0051
2515 Amidophosphoribosyltransferase purF 0.0051
3714 Amidophosphoribosyltransferase purF 0.0051
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
2599 Tyrosine-protein kinase HCK HCK 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.005
5798 Mitogen-activated protein kinase 11 MAPK11 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0049
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0049
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0049
6218 Pannexin-1 PANX1 0.0049
199 Monocarboxylate transporter 8 SLC16A2 0.0048
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0048
131 Synaptic vesicular amine transporter SLC18A2 0.0048
1525 Heparin-binding growth factor 2 FGF2 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
3939 Amine oxidase [flavin-containing] B MAOB 0.0047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0047
239 Coagulation factor X F10 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0047
683 Potassium transporter GK0582 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
2232 Interleukin-5 IL5 0.0045
1593 Mucin-2 MUC2 0.0045
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0045
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0045
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0045
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0045
6493 Cytochrome c oxidase subunit 6C COX6C 0.0045
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0045
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0045
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0045
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0045
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0045
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0045
6559 Cytochrome c oxidase subunit 2 ctaC 0.0045
6669 Cytochrome c oxidase subunit 2 ctaC 0.0045
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0045
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0045
6558 Cytochrome c oxidase subunit 1 ctaD 0.0045
563 Thyroid peroxidase TPO 0.0044
3932 Glutathione S-transferase A2 GSTA2 0.0044
6837 Serine/threonine-protein kinase 17B STK17B 0.0044
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0043
432 D(4) dopamine receptor DRD4 0.0043
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
3639 Thymidine phosphorylase deoA 0.0042
3936 Thymidine phosphorylase TYMP 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
1656 CYP2B protein CYP2B 0.0041
2540 Choloylglycine hydrolase cbh 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
6501 Fatty acid-binding protein, liver FABP1 0.0038
357 Carbonic anhydrase 2 CA2 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0038
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0037
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
6211 Tubulin epsilon chain TUBE1 0.0037
6210 Tubulin delta chain TUBD1 0.0037
6212 Tubulin gamma-1 chain TUBG1 0.0037
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
751 Potassium channel subfamily K member 6 KCNK6 0.0034
76 Nitric-oxide synthase, brain NOS1 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0034
291 Nitric-oxide synthase, endothelial NOS3 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
484 Tyrosine-protein kinase ABL2 ABL2 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6014 Cytochrome P450 2A13 CYP2A13 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
1275 Estrogen sulfotransferase SULT1E1 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
6151 Monocarboxylate transporter 10 SLC16A10 0.0033
6500 Phospholipase A2 PLA2G1B 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0032
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0032
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0032
172 Potassium channel subfamily K member 1 KCNK1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
921 Glutamate receptor 2 GRIA2 0.0031
517 Alcohol dehydrogenase 1C ADH1C 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
4041 Microsomal glutathione S-transferase 2 MGST2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
295 Carbonic anhydrase 1 CA1 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0029
3937 Fatty-acid amide hydrolase FAAH 0.0028
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
2216 Fibroblast growth factor receptor 4 FGFR4 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
1063 Signal transducer and activator of transcription 5B STAT5B 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1010 Cytochrome P450 51A1 CYP51A1 0.0027
5300 Antigen peptide transporter 1 TAP1 0.0026
1178 Adenosine A2a receptor ADORA2A 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
427 Substance-P receptor TACR1 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
4034 Glutaredoxin-1 GLRX 0.0024
1928 Leukotriene C4 synthase LTC4S 0.0024
907 Glutathione peroxidase 2 GPX2 0.0024
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0024
4037 Hypothetical protein GPX1 0.0024
4297 Hypothetical protein SP_1951 0.0024
4521 Hypothetical protein BC_2969 0.0024
4540 Hypothetical protein TM_1070 0.0024
4555 Hypothetical protein MT1739 0.0024
4569 Hypothetical protein mshD 0.0024
4578 Hypothetical protein PA3270 0.0024
4747 Hypothetical protein PA3967 0.0024
5177 Hypothetical protein TM_0096 0.0024
5194 Hypothetical protein PA1204 0.0024
5240 Hypothetical protein Rv2991 0.0024
5370 Hypothetical protein TM_1158 0.0024
5710 Hypothetical protein Tb927.5.1360 0.0024
4029 Microsomal glutathione S-transferase 3 MGST3 0.0024
4032 Microsomal glutathione S-transferase 1 MGST1 0.0024
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0024
4040 Glutathione peroxidase 7 GPX7 0.0024
910 Epididymal secretory glutathione peroxidase GPX5 0.0024
903 Glutathione S-transferase A5 GSTA5 0.0024
4038 Glutathione peroxidase 4 GPX4 0.0024
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0024
906 Glutathione peroxidase 1 GPX1 0.0024
4033 S-formylglutathione hydrolase ESD 0.0024
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0024
4035 Glutathione S-transferase Mu 5 GSTM5 0.0024
4036 Glutathione peroxidase 6 GPX6 0.0024
900 Glutathione S-transferase A4 GSTA4 0.0024
911 Glutathione peroxidase 3 GPX3 0.0024
4042 Glutathione transferase omega-2 GSTO2 0.0024
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0024
528 5-hydroxytryptamine 1E receptor HTR1E 0.0024
4031 Glutathione S-transferase A1 GSTA1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
3319 Hydroxyacylglutathione hydrolase HAGH 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
898 Glutathione S-transferase A3 GSTA3 0.0022
897 Glutathione S-transferase kappa 1 GSTK1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
909 Maleylacetoacetate isomerase GSTZ1 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
905 Glutathione transferase omega-1 GSTO1 0.0021
899 Glutathione S-transferase Mu 3 GSTM3 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
1864 RET proto-oncogene RET 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6432 Transporter snf 0.002
4203 Histamine N-methyltransferase HNMT 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2165 Glutathione S-transferase Mu 2 GSTM2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
207 Glutathione synthetase GSS 0.0019
5269 Glutathione synthetase gshB 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
2112 Toll-like receptor 9 TLR9 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
901 Glutathione S-transferase Mu 4 GSTM4 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
16 Adenosine A1 receptor ADORA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6174 50S ribosomal protein L32 rpmF 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
714 Glutathione reductase, mitochondrial GSR 0.0016
173 Toll-like receptor 7 TLR7 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6755 Poliovirus receptor PVR 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
1295 Fatty acid synthase FASN 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
3957 Adenosine deaminase ADA 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
6859 Protein S100-A4 S100A4 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
4311 tRNA TRDMT1 0.0011
4325 tRNA trmD 0.0011
4328 tRNA trmD 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
976 Platelet glycoprotein IX GP9 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
6021 Adenosine kinase ADK 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
164 Histamine H4 receptor HRH4 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6677 Myelin P2 protein PMP2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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