DT-Web

DB02857 - Guanosine


Identification
Name Guanosine
Accession Number DB02857 (EXPT01622)
Type small molecule
Description Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a ?-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate). [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 283.2407
Groups experimental
Monoisotopic Weight 283.091668551
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA polymerase
Name DNA polymerase
Gene Name 43
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4381
Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name PNP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.892
Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name TTHA1435
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.892

Predictions


Id Partner name Gene Name Score
2870 Purine nucleoside phosphorylase punA 1.892
2945 Purine nucleoside phosphorylase punA 1.892
4659 Purine nucleoside phosphorylase TM_1596 1.892
338 DNA polymerase UL30 1.4381
379 DNA polymerase UL54 1.4381
697 DNA polymerase ORF28 1.4381
4104 DNA polymerase BALF5 1.4381
5421 Uridine phosphorylase, putative PFE0660c 0.0777
3300 Xanthine phosphoribosyltransferase xpt 0.065
3681 Xanthine phosphoribosyltransferase gpt 0.065
2516 GMP reductase 1 GMPR 0.0544
2361 Response regulator pleD pleD 0.0544
2257 Uridine phosphorylase udp 0.0489
5132 Uridine phosphorylase udp 0.0489
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0474
4106 Guanylate kinase GUK1 0.0474
4516 Guanylate kinase gmk 0.0474
413 Amidophosphoribosyltransferase PPAT 0.0473
2515 Amidophosphoribosyltransferase purF 0.0473
3714 Amidophosphoribosyltransferase purF 0.0473
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0437
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0384
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0362
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0311
1673 GTP cyclohydrolase I GCH1 0.0311
3302 GTP cyclohydrolase I folE 0.0311
2837 Xanthosine phosphorylase xapA 0.0273
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0273
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0238
1729 Solute carrier family 22 member 6 SLC22A6 0.0139
6111 DNA polymerase epsilon subunit 4 POLE4 0.0087
6112 DNA polymerase epsilon subunit 3 POLE3 0.0087
6110 DNA polymerase epsilon subunit 2 POLE2 0.0087
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0087
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0087
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0086
603 DNA polymerase alpha catalytic subunit POLA1 0.0065
6171 Solute carrier family 28 member 3 SLC28A3 0.0059
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0059
4773 Deoxycytidine kinase DCK 0.0052
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0033
6144 Solute carrier family 22 member 2 SLC22A2 0.0033
6145 Solute carrier family 22 member 1 SLC22A1 0.0033
↑