DT-Web

DB00139 - Succinic acid


Identification
Name Succinic acid
Accession Number DB00139 (NUTR00054)
Type small molecule
Description A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 118.088
Groups approved
Monoisotopic Weight 118.02660868
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral rat LD50: 2260 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Name Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Gene Name SDHC
Pharmacological action unknown
Actions Not Available
References
  • Bayley JP, van Minderhout I, Weiss MM, Jansen JC, Oomen PH, Menko FH, Pasini B, Ferrando B, Wong N, Alpert LC, Williams R, Blair E, Devilee P, Taschner PE: Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet. 2006 Jan 11;7:1. - Pubmed
  • Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N: Mitochondrial regulation of insulin production in rat pancreatic islets. Diabetologia. 2005 Aug;48(8):1549-59. Epub 2005 Jun 29. - Pubmed
  • Bayley JP, Devilee P, Taschner PE: The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. BMC Med Genet. 2005 Nov 16;6:39. - Pubmed
  • Szeto SS, Reinke SN, Sykes BD, Lemire BD: Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate. J Biol Chem. 2007 Sep 14;282(37):27518-26. Epub 2007 Jul 18. - Pubmed
  • Kubo Y, Takagi H, Nakamori S: Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. J Biosci Bioeng. 2000;90(6):619-24. - Pubmed
DTHybrid score 0.8844
Succinate receptor 1
Name Succinate receptor 1
Gene Name SUCNR1
Pharmacological action unknown
Actions Not Available
References
  • Macaulay IC, Tijssen MR, Thijssen-Timmer DC, Gusnanto A, Steward M, Burns P, Langford CF, Ellis PD, Dudbridge F, Zwaginga JJ, Watkins NA, van der Schoot CE, Ouwehand WH: Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood. 2007 Apr 15;109(8):3260-9. Epub 2006 Dec 27. - Pubmed
DTHybrid score 1.0097
Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial
Name Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial
Gene Name OXCT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.012
Trimethyllysine dioxygenase, mitochondrial
Name Trimethyllysine dioxygenase, mitochondrial
Gene Name TMLHE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.925
Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial
Name Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial
Gene Name SUCLA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0102
Mitochondrial dicarboxylate carrier
Name Mitochondrial dicarboxylate carrier
Gene Name SLC25A10
Pharmacological action unknown
Actions Not Available
References
  • Ventura FV, Ruiter J, Ijlst L, de Almeida IT, Wanders RJ: Differential inhibitory effect of long-chain acyl-CoA esters on succinate and glutamate transport into rat liver mitochondria and its possible implications for long-chain fatty acid oxidation defects. Mol Genet Metab. 2005 Nov;86(3):344-52. Epub 2005 Sep 19. - Pubmed
  • Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H: Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. J Biol Chem. 2005 Sep 16;280(37):32434-41. Epub 2005 Jul 15. - Pubmed
DTHybrid score 1.0099
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene Name SDHA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Maklashina E, Iverson TM, Sher Y, Kotlyar V, Andrell J, Mirza O, Hudson JM, Armstrong FA, Rothery RA, Weiner JH, Cecchini G: Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain. J Biol Chem. 2006 Apr 21;281(16):11357-65. Epub 2006 Feb 15. - Pubmed
  • Takeo S, Kokaze A, Ng CS, Mizuchi D, Watanabe JI, Tanabe K, Kojima S, Kita K: Succinate dehydrogenase in Plasmodium falciparum mitochondria: molecular characterization of the SDHA and SDHB genes for the catalytic subunits, the flavoprotein (Fp) and iron-sulfur (Ip) subunits. Mol Biochem Parasitol. 2000 Apr 15;107(2):191-205. - Pubmed
  • Ackrell BA: Cytopathies involving mitochondrial complex II. Mol Aspects Med. 2002 Oct;23(5):369-84. - Pubmed
DTHybrid score 1.2981
Oxidoreductase
Name Oxidoreductase
Gene Name HSD17B6
Pharmacological action unknown
Actions Not Available
References
  • Goel HC, Gupta D, Gupta S, Garg AP, Bala M: Protection of mitochondrial system by Hippophae rhamnoides L. against radiation-induced oxidative damage in mice. J Pharm Pharmacol. 2005 Jan;57(1):135-43. - Pubmed
  • Gupta D, Arora R, Garg AP, Bala M, Goel HC: Modification of radiation damage to mitochondrial system in vivo by Podophyllum hexandrum: mechanistic aspects. Mol Cell Biochem. 2004 Nov;266(1-2):65-77. - Pubmed
  • Dudkina NV, Eubel H, Keegstra W, Boekema EJ, Braun HP: Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3225-9. Epub 2005 Feb 15. - Pubmed
  • Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY, Anderson VE, Berry EA: 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72. Epub 2005 Dec 21. - Pubmed
  • Bayley JP, van Minderhout I, Weiss MM, Jansen JC, Oomen PH, Menko FH, Pasini B, Ferrando B, Wong N, Alpert LC, Williams R, Blair E, Devilee P, Taschner PE: Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet. 2006 Jan 11;7:1. - Pubmed
DTHybrid score 1.0097
Solute carrier family 13 member 3
Name Solute carrier family 13 member 3
Gene Name SLC13A3
Pharmacological action unknown
Actions Not Available
References
  • Oshiro N, Pajor AM: Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1159-68. Epub 2005 Jun 8. - Pubmed
  • Wolff NA, Burckhardt BC, Burckhardt G, Oellerich M, Armstrong VW: Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. Nephrol Dial Transplant. 2007 Sep;22(9):2497-503. Epub 2007 May 25. - Pubmed
  • Hagos Y, Steffgen J, Rizwan AN, Langheit D, Knoll A, Burckhardt G, Burckhardt BC: Functional roles of cationic amino acid residues in the sodium-dicarboxylate cotransporter 3 (NaDC-3) from winter flounder. Am J Physiol Renal Physiol. 2006 Dec;291(6):F1224-31. Epub 2006 May 30. - Pubmed
  • Yodoya E, Wada M, Shimada A, Katsukawa H, Okada N, Yamamoto A, Ganapathy V, Fujita T: Functional and molecular identification of sodium-coupled dicarboxylate transporters in rat primary cultured cerebrocortical astrocytes and neurons. J Neurochem. 2006 Apr;97(1):162-73. Epub 2006 Mar 8. - Pubmed
  • Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G: Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. Am J Physiol Renal Physiol. 2005 Apr;288(4):F792-9. Epub 2004 Nov 23. - Pubmed
DTHybrid score 1.0096
Solute carrier family 13 member 2
Name Solute carrier family 13 member 2
Gene Name SLC13A2
Pharmacological action unknown
Actions Not Available
References
  • Takahashi R, Ishihara H, Tamura A, Yamaguchi S, Yamada T, Takei D, Katagiri H, Endou H, Oka Y: Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets. Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E308-16. Epub 2005 Sep 27. - Pubmed
  • Hagos Y, Steffgen J, Rizwan AN, Langheit D, Knoll A, Burckhardt G, Burckhardt BC: Functional roles of cationic amino acid residues in the sodium-dicarboxylate cotransporter 3 (NaDC-3) from winter flounder. Am J Physiol Renal Physiol. 2006 Dec;291(6):F1224-31. Epub 2006 May 30. - Pubmed
  • Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G: Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. Am J Physiol Renal Physiol. 2005 Apr;288(4):F792-9. Epub 2004 Nov 23. - Pubmed
  • Hall JA, Pajor AM: Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug;187(15):5189-94. - Pubmed
DTHybrid score 1.0098
Solute carrier family 13 member 1
Name Solute carrier family 13 member 1
Gene Name SLC13A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Lee A, Beck L, Markovich D: The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. Genomics. 2000 Dec 15;70(3):354-63. - Pubmed
DTHybrid score 1.0096
Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial
Name Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial
Gene Name SUCLG2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0101
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Name Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Gene Name SDHD
Pharmacological action unknown
Actions Not Available
References
  • Brink I, Schaefer O, Walz M, Neumann HP: Fluorine-18 DOPA PET imaging of paraganglioma syndrome. Clin Nucl Med. 2006 Jan;31(1):39-41. - Pubmed
  • Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z: Crystal structure of mitochondrial respiratory membrane protein complex II. Cell. 2005 Jul 1;121(7):1043-57. - Pubmed
  • Bayley JP, Devilee P, Taschner PE: The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. BMC Med Genet. 2005 Nov 16;6:39. - Pubmed
  • Lehtonen HJ, Makinen MJ, Kiuru M, Laiho P, Herva R, van Minderhout I, Hogendoorn PC, Cornelisse C, Devilee P, Launonen V, Aaltonen LA: Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability. Int J Cancer. 2007 Sep 15;121(6):1386-9. - Pubmed
  • Bayley JP, van Minderhout I, Weiss MM, Jansen JC, Oomen PH, Menko FH, Pasini B, Ferrando B, Wong N, Alpert LC, Williams R, Blair E, Devilee P, Taschner PE: Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet. 2006 Jan 11;7:1. - Pubmed
DTHybrid score 0.9221
Prolyl 4-hydroxylase subunit alpha-2
Name Prolyl 4-hydroxylase subunit alpha-2
Gene Name P4HA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9041
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Gene Name PLOD3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9252
Gamma-butyrobetaine dioxygenase
Name Gamma-butyrobetaine dioxygenase
Gene Name BBOX1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Yoshisue K, Yamamoto Y, Yoshida K, Saeki M, Minami Y, Esumi Y, Kawaguchi Y: Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium)propionate dihydrate (MET-88), a novel cardioprotective agent, in rats. Drug Metab Dispos. 2000 Jun;28(6):687-94. - Pubmed
DTHybrid score 0.9249
Prolyl 4-hydroxylase subunit alpha-1
Name Prolyl 4-hydroxylase subunit alpha-1
Gene Name P4HA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9609
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Name Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene Name SDHB
Pharmacological action unknown
Actions Not Available
References
  • Arikawa Y, Kuroyanagi T, Shimosaka M, Muratsubaki H, Enomoto K, Kodaira R, Okazaki M: Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. J Biosci Bioeng. 1999;87(1):28-36. - Pubmed
  • Bayley JP, Devilee P, Taschner PE: The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. BMC Med Genet. 2005 Nov 16;6:39. - Pubmed
  • Lehtonen HJ, Makinen MJ, Kiuru M, Laiho P, Herva R, van Minderhout I, Hogendoorn PC, Cornelisse C, Devilee P, Launonen V, Aaltonen LA: Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability. Int J Cancer. 2007 Sep 15;121(6):1386-9. - Pubmed
  • Bayley JP, van Minderhout I, Weiss MM, Jansen JC, Oomen PH, Menko FH, Pasini B, Ferrando B, Wong N, Alpert LC, Williams R, Blair E, Devilee P, Taschner PE: Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet. 2006 Jan 11;7:1. - Pubmed
  • Szeto SS, Reinke SN, Sykes BD, Lemire BD: Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate. J Biol Chem. 2007 Sep 14;282(37):27518-26. Epub 2007 Jul 18. - Pubmed
DTHybrid score 0.8837
Succinate semialdehyde dehydrogenase, mitochondrial
Name Succinate semialdehyde dehydrogenase, mitochondrial
Gene Name ALDH5A1
Pharmacological action unknown
Actions inhibitor
References
  • Yogeeswari P, Sriram D, Vaigundaragavendran J: The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Curr Drug Metab. 2005 Apr;6(2):127-39. - Pubmed
  • Popov VN, Eprintsev AT, Fedorin DN, Fomenko OIu, Igamberdiev AU: [Role of transamination in the mobilization of respiratory substrates in germinating seeds of castor oil plants] Prikl Biokhim Mikrobiol. 2007 May-Jun;43(3):376-81. - Pubmed
  • Wang C, Zhang HB, Wang LH, Zhang LH: Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. Mol Microbiol. 2006 Oct;62(1):45-56. Epub 2006 Aug 30. - Pubmed
  • Ahn SJ, Yang CH, Cooksey DA: Pseudomonas putida 06909 genes expressed during colonization on mycelial surfaces and phenotypic characterization of mutants. J Appl Microbiol. 2007 Jul;103(1):120-32. - Pubmed
  • Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R: Final steps in the catabolism of nicotine. FEBS J. 2006 Apr;273(7):1528-36. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7938
Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
Name Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
Gene Name SUCLG1
Pharmacological action unknown
Actions Not Available
References
  • Ostergaard E, Christensen E, Kristensen E, Mogensen B, Duno M, Shoubridge EA, Wibrand F: Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion. Am J Hum Genet. 2007 Aug;81(2):383-7. Epub 2007 Jun 4. - Pubmed
DTHybrid score 1.0097
Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
Name Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
Gene Name OXCT1
Pharmacological action unknown
Actions Not Available
References
  • Coros AM, Swenson L, Wolodko WT, Fraser ME: Structure of the CoA transferase from pig heart to 1.7 A resolution. Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1717-25. Epub 2004 Sep 23. - Pubmed
DTHybrid score 1.1795
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Gene Name PLOD1
Pharmacological action unknown
Actions Not Available
References
  • Cudic M, Patel DA, Lauer-Fields JL, Brew K, Fields GB: Development of a convenient peptide-based assay for lysyl hydroxylase. Biopolymers. 2007 Jul 3;. - Pubmed
DTHybrid score 0.9253
Aspartyl/asparaginyl beta-hydroxylase
Name Aspartyl/asparaginyl beta-hydroxylase
Gene Name ASPH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8953
Prolyl 3-hydroxylase 1
Name Prolyl 3-hydroxylase 1
Gene Name LEPRE1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9349
Prolyl 3-hydroxylase 2
Name Prolyl 3-hydroxylase 2
Gene Name LEPREL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.935
Prolyl 3-hydroxylase 3
Name Prolyl 3-hydroxylase 3
Gene Name LEPREL2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9346

Transporters


Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score 0.4613

Predictions


Id Partner name Gene Name Score
4725 Oxidoreductase Not Available 1.0097
5124 Oxidoreductase Not Available 1.0097
6563 Sensor protein TM_1359 0.3996
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.2025
3935 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 PLOD2 0.2024
3948 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 ALKBH2 0.2015
3962 Egl nine homolog 3 EGLN3 0.2015
3956 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 0.2015
3946 Hypothetical protein DKFZp686H15154 OGFOD2 0.2014
3954 Egl nine homolog 2 EGLN2 0.2014
3966 Putative HIF-prolyl hydroxylase PH-4 P4HTM 0.2014
189 Solute carrier family 23 member 1 SLC23A1 0.2014
3953 2-oxoglutarate and iron-dependent oxygenase domain containing 1 OGFOD1 0.2014
3958 Jumonji/ARID domain-containing protein 1D KDM5D 0.2012
6890 Hypothetical membrane spanning protein TT_C0153 0.1617
6886 Thiol:disulfide interchange protein dsbA dsbA 0.1616
6888 NrfC protein nrfC 0.1615
6889 Thiosulfate reductase TT_C0155 0.1614
3943 Peptidyl-glycine alpha-amidating monooxygenase PAM 0.1422
3960 Egl nine homolog 1 EGLN1 0.1417
6887 Disulfide bond formation protein B dsbB 0.141
6389 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial ETFDH 0.1407
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.1315
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.1315
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.1315
4090 Chromosome 14 open reading frame 149 C14orf149 0.1314
4082 Proline oxidase, mitochondrial PRODH 0.1314
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.1314
797 Sodium-dependent proline transporter SLC6A7 0.1314
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.1314
153 Dopamine beta-hydroxylase DBH 0.1276
126 D-lactate dehydrogenase dld 0.1214
3545 D-lactate dehydrogenase Not Available 0.1214
4510 D-lactate dehydrogenase ldhA 0.1214
2485 Hyaluronate lyase SP_0314 0.1161
3172 Hyaluronate lyase hylB 0.1161
6847 Lactase-phlorizin hydrolase LCT 0.1111
2245 Xylose isomerase xylA 0.111
2253 Xylose isomerase xylA 0.111
2260 Xylose isomerase xylA 0.111
2431 Xylose isomerase xylA 0.111
558 Solute carrier family 12 member 1 SLC12A1 0.1081
6353 Reaction center protein L chain pufL 0.1073
6454 Reaction center protein L chain pufL 0.1073
6683 Reaction center protein L chain pufL 0.1073
6352 Reaction center protein H chain puhA 0.1073
6456 Reaction center protein H chain puhA 0.1073
6682 Reaction center protein H chain puhA 0.1073
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.1073
6354 Reaction center protein M chain pufM 0.1073
6455 Reaction center protein M chain pufM 0.1073
6684 Reaction center protein M chain pufM 0.1073
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.1052
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.1022
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.1022
4604 Liver carboxylesterase 1 CES1 0.1012
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.1011
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.1001
1483 Membrane copper amine oxidase AOC3 0.0982
6359 Cytochrome b-c1 complex subunit 8 UQCRQ 0.093
6358 Cytochrome b-c1 complex subunit 6, mitochondrial UQCRH 0.093
6357 Cytochrome b-c1 complex subunit 2, mitochondrial UQCRC2 0.0928
6363 Cytochrome b-c1 complex subunit 9 UQCR10 0.0909
6362 Cytochrome b-c1 complex subunit 7 UQCRB 0.0908
6356 Cytochrome c1, heme protein, mitochondrial CYC1 0.0907
6360 Cytochrome b-c1 complex subunit Rieske, mitochondrial UQCRFS1 0.0907
1227 Cytochrome b MT-CYB 0.0907
6386 Cytochrome b petB 0.0907
6937 Cytochrome b MT-CYB 0.0907
1495 Ubiquinol-cytochrome-c reductase complex core protein 1, mitochondrial UQCRC1 0.0906
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0895
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0883
237 Histo-blood group ABO system transferase ABO 0.0841
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0796
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0782
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0782
1729 Solute carrier family 22 member 6 SLC22A6 0.0768
6151 Monocarboxylate transporter 10 SLC16A10 0.0751
1024 Solute carrier family 22 member 11 SLC22A11 0.0581
4512 Cytochrome P450 3A4 CYP3A4 0.0527
6143 Solute carrier family 22 member 7 SLC22A7 0.0474
2632 Adenylosuccinate synthetase purA 0.0396
3323 Adenylosuccinate synthetase purA 0.0396
3975 Adenylosuccinate synthetase ADSS 0.0396
4598 Adenylosuccinate synthetase Adss 0.0396
6817 Adenylosuccinate synthetase purA 0.0396
533 Aminoacylase-1 ACY1 0.0395
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0395
209 Aspartoacylase ASPA 0.0395
3979 Aspartoacylase-2 ACY3 0.0395
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0395
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0395
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0395
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0395
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0395
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0395
3977 ASRGL1 protein ASRGL1 0.0306
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0272
1671 Excitatory amino acid transporter 3 SLC1A1 0.0264
3877 Growth-inhibiting protein 18 GIG18 0.0251
118 Organic cation/carnitine transporter 2 SLC22A5 0.0241
740 Argininosuccinate synthase ASS1 0.0231
865 Argininosuccinate synthase ASS1 0.0231
2680 Argininosuccinate synthase argG 0.0231
3194 Argininosuccinate synthase argG 0.0231
426 Aspartate aminotransferase, mitochondrial GOT2 0.0227
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0224
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0221
587 Serum albumin ALB 0.02
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0195
2164 Multidrug resistance-associated protein 4 ABCC4 0.0194
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0185
4757 Cytochrome P450 2C9 CYP2C9 0.0176
1039 Histone deacetylase 9 HDAC9 0.0172
20 Prostaglandin G/H synthase 1 PTGS1 0.017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.017
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0159
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0155
738 Monocarboxylate transporter 1 SLC16A1 0.015
5682 Ribonuclease pancreatic RNASE1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0149
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0146
4924 Cytochrome P450 2C8 CYP2C8 0.0143
6145 Solute carrier family 22 member 1 SLC22A1 0.0142
1588 Multidrug resistance protein 1 ABCB1 0.0138
6016 Cytochrome P450 2C19 CYP2C19 0.0138
6144 Solute carrier family 22 member 2 SLC22A2 0.0137
290 Prostaglandin G/H synthase 2 PTGS2 0.0132
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0121
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0115
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
4200 Cytochrome P450 1A2 CYP1A2 0.0111
4118 Cytochrome P450 3A5 CYP3A5 0.0108
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0104
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0103
159 Penicillin-binding protein 2B penA 0.0102
6121 Penicillin-binding protein 2B penA 0.0102
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
833 Organic cation/carnitine transporter 1 SLC22A4 0.01
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.01
338 DNA polymerase UL30 0.01
379 DNA polymerase UL54 0.01
697 DNA polymerase ORF28 0.01
2482 DNA polymerase 43 0.01
4104 DNA polymerase BALF5 0.01
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0096
6020 Aldehyde oxidase AOX1 0.0096
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
6136 Multidrug resistance-associated protein 5 ABCC5 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0092
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0089
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0088
6030 Cytochrome P450 2B6 CYP2B6 0.0088
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0087
6141 Sodium/bile acid cotransporter SLC10A1 0.0087
543 Penicillin-binding protein 1B mrcB 0.0086
6186 Penicillin-binding protein 1B ponB 0.0086
6822 Penicillin-binding protein 1b pbp1b 0.0086
6844 Penicillin-binding protein 1b pbp1b 0.0086
124 Histamine H2 receptor HRH2 0.0086
645 Penicillin-binding protein 1A mrcA 0.0084
5805 Penicillin-binding protein 1A ponA 0.0084
6185 Penicillin-binding protein 1A mrcA 0.0084
6799 Penicillin-binding protein 1A pbpA 0.0084
862 Multidrug resistance-associated protein 1 ABCC1 0.0082
6106 Cytochrome P450 2C18 CYP2C18 0.0082
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0081
6147 Solute carrier family 22 member 3 SLC22A3 0.0079
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0075
776 Bile salt export pump ABCB11 0.0074
438 Taste receptor type 1 member 2 TAS1R2 0.0071
5718 Cytochrome P450 2A6 CYP2A6 0.007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0069
5626 Nucleoside diphosphate kinase B NME2 0.0067
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
5294 Nucleoside diphosphate kinase A NME1 0.0055
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
6167 Organic solute transporter subunit beta OSTB 0.005
6166 Organic solute transporter subunit alpha OSTA 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
6024 Cytochrome P450 1A1 CYP1A1 0.0047
1405 Thiopurine S-methyltransferase TPMT 0.0047
6148 Multidrug resistance-associated protein 7 ABCC10 0.0046
633 Penicillin-binding proteins 1A/1B pbpA 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
3811 Cytochrome P450 19A1 CYP19A1 0.0044
6149 Solute carrier family 22 member 10 SLC22A10 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0042
612 P protein [Includes: DNA-directed DNA polymerase P 0.0042
756 Sex hormone-binding globulin SHBG 0.0042
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0039
1867 Major prion protein PRNP 0.0039
5482 Sialidase-2 NEU2 0.0039
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0039
3685 Catabolite gene activator crp 0.0038
4655 Adenylate cyclase cyaC 0.0038
4759 Adenylate cyclase cyaB2 0.0038
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
4119 Cytochrome P450 2D6 CYP2D6 0.0037
130 Prostacyclin synthase PTGIS 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0035
115 Penicillin-binding protein 2 mrdA 0.0035
6069 Penicillin-binding protein 2 mrdA 0.0035
6118 Penicillin-binding protein 2 penA 0.0035
6187 Penicillin-binding protein 2 pbpA 0.0035
6686 Penicillin-binding protein 2 pbp2 0.0035
6939 Penicillin-binding protein 2 mrdA 0.0035
7163 Penicillin-binding protein 2 pbpA 0.0035
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
6209 30S ribosomal protein S19 rpsS 0.0034
6712 30S ribosomal protein S19 rpsS 0.0034
6726 30S ribosomal protein S19 rpsS 0.0034
6207 30S ribosomal protein S14 rpsN 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
4760 Mll3241 protein mll3241 0.0032
1 Peptidoglycan synthetase ftsI ftsI 0.0032
4155 Peptidoglycan synthetase ftsI ftsI 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0029
6033 High affinity interleukin-8 receptor A CXCR1 0.0029
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0029
527 Prostacyclin receptor PTGIR 0.0029
1198 Serum paraoxonase/arylesterase 1 PON1 0.0029
6223 Penicillin-binding protein 1C pbpC 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
146 Androgen receptor AR 0.0028
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0028
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0028
816 Biliverdin reductase A BLVRA 0.0028
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
373 Transthyretin TTR 0.0028
5126 Arginase rocF 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0026
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0026
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0026
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0026
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0026
1654 Interleukin-1 beta IL1B 0.0026
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0026
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0026
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0026
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0026
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0026
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0026
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0026
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0026
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0026
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0026
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0026
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0026
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0026
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0026
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0026
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0026
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0026
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0026
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0026
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0026
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0026
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0026
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0026
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0026
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0026
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0026
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0026
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0026
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0026
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0026
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0026
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0026
107 C-4 methylsterol oxidase SC4MOL 0.0026
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0026
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0026
34 7-dehydrocholesterol reductase DHCR7 0.0026
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0026
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0026
729 GDP-L-fucose synthetase TSTA3 0.0026
3463 GDP-L-fucose synthetase fcl 0.0026
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0026
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0026
167 L-lactate dehydrogenase C chain LDHC 0.0026
206 3-keto-steroid reductase HSD17B7 0.0026
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0026
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0026
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0026
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0026
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0026
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0026
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0026
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0026
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0026
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0026
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0026
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0026
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0026
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0026
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0026
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0026
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0026
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0026
711 UDP-glucose 6-dehydrogenase UGDH 0.0026
3672 UDP-glucose 6-dehydrogenase hasB 0.0026
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0026
3726 D-3-phosphoglycerate dehydrogenase serA 0.0026
4291 D-3-phosphoglycerate dehydrogenase serA 0.0026
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0026
643 Peroxisomal bifunctional enzyme EHHADH 0.0026
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0026
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0026
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0026
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0025
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0025
1757 Myeloperoxidase MPO 0.0025
244 Angiotensin-converting enzyme ACE 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
663 Solute carrier family 12 member 4 SLC12A4 0.0024
53 Solute carrier family 12 member 5 SLC12A5 0.0024
275 Arachidonate 5-lipoxygenase ALOX5 0.0024
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
597 Dihydropteridine reductase QDPR 0.0023
328 Sorbitol dehydrogenase SORD 0.0023
396 Alcohol dehydrogenase 4 ADH4 0.0023
626 Cysteine dioxygenase type 1 CDO1 0.0023
310 Solute carrier family 12 member 2 SLC12A2 0.0023
857 Malate dehydrogenase, mitochondrial MDH2 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0022
666 NADP-dependent malic enzyme ME1 0.0022
1898 Cytochrome P450 1B1 CYP1B1 0.0022
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0022
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0022
494 Caspase-1 CASP1 0.0022
6026 Alcohol dehydrogenase 6 ADH6 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0021
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0021
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0021
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
77 L-lactate dehydrogenase B chain LDHB 0.0021
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0021
627 11-cis retinol dehydrogenase RDH5 0.0021
12 Alcohol dehydrogenase class 3 ADH5 0.0021
183 Vascular endothelial growth factor A VEGFA 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0021
136 Estrogen receptor ESR1 0.0021
1507 Cytochrome c CYCS 0.0021
3587 Gastrotropin FABP6 0.002
6107 Cytochrome P450 3A7 CYP3A7 0.002
11 NAD(P) transhydrogenase, mitochondrial NNT 0.002
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.002
13 Aminomethyltransferase, mitochondrial AMT 0.002
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.002
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
473 L-lactate dehydrogenase A chain LDHA 0.002
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0019
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
3760 Penicillin-binding protein 5 precursor dacA 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0018
279 Tyrosinase TYR 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0018
365 Dihydrofolate reductase DHFR 0.0018
2381 Dihydrofolate reductase DFR1 0.0018
2833 Dihydrofolate reductase Not Available 0.0018
2931 Dihydrofolate reductase folA 0.0018
3544 Dihydrofolate reductase folA 0.0018
3682 Dihydrofolate reductase folA 0.0018
6642 Dihydrofolate reductase folA 0.0018
6756 Dihydrofolate reductase dfrA 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0017
819 Penicillin-binding protein 4 dacB 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
654 Flavin reductase BLVRB 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0016
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0016
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
6137 Multidrug resistance-associated protein 6 ABCC6 0.0016
810 Heme oxygenase 1 HMOX1 0.0016
3391 Heme oxygenase 1 pbsA1 0.0016
2021 Thrombomodulin THBD 0.0016
6013 Cytochrome P450 2E1 CYP2E1 0.0016
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0016
380 Cytochrome P450 17A1 CYP17A1 0.0015
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
714 Glutathione reductase, mitochondrial GSR 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
468 Cytochrome P450 4A11 CYP4A11 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0013
6218 Pannexin-1 PANX1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0012
822 Aldose reductase AKR1B1 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
5818 Folate receptor alpha FOLR1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0011
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
465 Calmodulin CALM1 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.001
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.001
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
1313 Lactoylglutathione lyase GLO1 0.0009
1650 Heme carrier protein 1 SLC46A1 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
6501 Fatty acid-binding protein, liver FABP1 0.0008
6031 Cytochrome P450 3A43 CYP3A43 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
3917 Methylenetetrahydrofolate reductase MTHFR 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0007
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
3941 Amine oxidase [flavin-containing] A MAOA 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
869 Estrogen receptor beta ESR2 0.0006
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