DT-Web

DB00453 - Clomocycline


Identification
Name Clomocycline
Accession Number DB00453 (APRD00343)
Type small molecule
Description Clomocycline is a tetracycline antibiotic.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 508.906
Groups approved
Monoisotopic Weight 508.124858115
Pharmacology
Indication For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
Mechanism of action Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


30S ribosomal protein S4
Name 30S ribosomal protein S4
Gene Name rpsD
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1
30S ribosomal protein S9
Name 30S ribosomal protein S9
Gene Name rpsI
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.079
16S rRNA
Name 16S rRNA
Gene Name Not Available
Pharmacological action no
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Toledo H, Lopez-Solis R: Tetracycline resistance in Chilean clinical isolates of Helicobacter pylori. J Antimicrob Chemother. 2010 Mar;65(3):470-3. Epub 2009 Dec 24. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
6719 30S ribosomal protein S9 rpsI 1.079
6725 30S ribosomal protein S9 rpsI 1.079
6714 30S ribosomal protein S4 rpsD 1
1024 Solute carrier family 22 member 11 SLC22A11 0.0965
6142 Solute carrier family 22 member 8 SLC22A8 0.0812
1729 Solute carrier family 22 member 6 SLC22A6 0.0742
6208 30S ribosomal protein S13 rpsM 0.0567
6706 30S ribosomal protein S13 rpsM 0.0567
6143 Solute carrier family 22 member 7 SLC22A7 0.0558
4512 Cytochrome P450 3A4 CYP3A4 0.0515
6209 30S ribosomal protein S19 rpsS 0.0511
6712 30S ribosomal protein S19 rpsS 0.0511
6726 30S ribosomal protein S19 rpsS 0.0511
6207 30S ribosomal protein S14 rpsN 0.0511
1654 Interleukin-1 beta IL1B 0.0374
494 Caspase-1 CASP1 0.0297
183 Vascular endothelial growth factor A VEGFA 0.0284
1507 Cytochrome c CYCS 0.0272
308 30S ribosomal protein S12 rpsL 0.0248
6704 30S ribosomal protein S12 rpsL 0.0248
65 Matrix metalloproteinase-9 Not Available 0.0235
2077 Caspase-3 CASP3 0.0235
275 Arachidonate 5-lipoxygenase ALOX5 0.0227
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