DT-Web

DB00198 - Oseltamivir


Identification
Name Oseltamivir
Accession Number DB00198 (APRD01148)
Type small molecule
Description An acetamido cyclohexene that is a structural homolog of sialic acid and inhibits neuraminidase. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 312.4045
Groups approved
Monoisotopic Weight 312.204907394
Pharmacology
Indication Oseltamivir (Tamiflu) is for the treatment of uncomplicated acute illness due to influenza infection in patients 1 year and older who have been symptomatic for no more than 2 days. It is also used for the prophylaxis of influenza in adult patients and adolescents 13 years and older.
Mechanism of action Oseltamivir is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. The proposed mechanism of action of oseltamivir is inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
Absorption Readily absorbed from the gastrointestinal tract after oral administration with a bioavailability of 75%.
Protein binding Oseltamivir carboxylate: low (3%), Oseltamivir free base: 42%.
Biotransformation Extensively converted to oseltamivir carboxylate by esterases located predominantly in the liver. Neither oseltamivir nor oseltamivir carboxylate is a substrate for, or inhibitor of, cytochrome P450 isoforms. At least 75% of an oral dose reaches the systemic circulation as oseltamivir carboxylate.
Route of elimination Absorbed oseltamivir is primarily (>90%) eliminated by conversion to oseltamivir carboxylate. Oseltamivir carboxylate is not further metabolized and is eliminated in the urine. Oseltamivir carboxylate is eliminated entirely (>99%) by renal excretion.
Toxicity At present, there has been no experience with overdose. Single doses of up to 1000 mg of oseltamivir have been associated with nausea and/or vomiting. Mean LD (intravenous, mouse) = 100 mg/kg.
Affected organisms
  • Influenza Virus
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals. Food may improve gastric tolerance.

Targets


Neuraminidase
Name Neuraminidase
Gene Name NA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • McKimm-Breschkin J, Trivedi T, Hampson A, Hay A, Klimov A, Tashiro M, Hayden F, Zambon M: Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir. Antimicrob Agents Chemother. 2003 Jul;47(7):2264-72. - Pubmed
  • Du QS, Wang SQ, Chou KC: Analogue inhibitors by modifying oseltamivir based on the crystal neuraminidase structure for treating drug-resistant H5N1 virus. Biochem Biophys Res Commun. 2007 Oct 19;362(2):525-31. Epub 2007 Aug 13. - Pubmed
  • Wang MZ, Tai CY, Mendel DB: Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob Agents Chemother. 2002 Dec;46(12):3809-16. - Pubmed
DTHybrid score 0.1599
Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Pharmacological action yes
Actions other
References
  • Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B: Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 2006 Dec;319(3):1477-84. Epub 2006 Sep 11. - Pubmed
  • Wattanagoon Y, Stepniewska K, Lindegardh N, Pukrittayakamee S, Silachamroon U, Piyaphanee W, Singtoroj T, Hanpithakpong W, Davies G, Tarning J, Pongtavornpinyo W, Fukuda C, Singhasivanon P, Day NP, White NJ: Pharmacokinetics of high-dose oseltamivir in healthy volunteers. Antimicrob Agents Chemother. 2009 Mar;53(3):945-52. Epub 2008 Dec 22. - Pubmed
  • Zhu HJ, Markowitz JS: Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants. Drug Metab Dispos. 2009 Feb;37(2):264-7. Epub 2008 Nov 20. - Pubmed
DTHybrid score 0.7354
Sialidase-1
Name Sialidase-1
Gene Name NEU1
Pharmacological action unknown
Actions inhibitor
References
  • Chavas LM, Kato R, Suzuki N, von Itzstein M, Mann MC, Thomson RJ, Dyason JC, McKimm-Breschkin J, Fusi P, Tringali C, Venerando B, Tettamanti G, Monti E, Wakatsuki S: Complexity in influenza virus targeted drug design: interaction with human sialidases. J Med Chem. 2010 Apr 8;53(7):2998-3002. - Pubmed
DTHybrid score 0.6252
Sialidase-2
Name Sialidase-2
Gene Name NEU2
Pharmacological action unknown
Actions inhibitor
References
  • Chavas LM, Kato R, Suzuki N, von Itzstein M, Mann MC, Thomson RJ, Dyason JC, McKimm-Breschkin J, Fusi P, Tringali C, Venerando B, Tettamanti G, Monti E, Wakatsuki S: Complexity in influenza virus targeted drug design: interaction with human sialidases. J Med Chem. 2010 Apr 8;53(7):2998-3002. - Pubmed
DTHybrid score 1.0466

Transporters


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y: Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxyl ate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos. 2009 Feb;37(2):315-21. Epub 2008 Nov 24. - Pubmed
DTHybrid score 0.3326
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate
References
  • Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I: Oseltamivir (tamiflu) is a substrate of peptide transporter 1. Drug Metab Dispos. 2009 Aug;37(8):1676-81. Epub 2009 May 13. - Pubmed
DTHybrid score 0.4785
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate
References
  • Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y: Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxyl ate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos. 2009 Feb;37(2):315-21. Epub 2008 Nov 24. - Pubmed
DTHybrid score 0.3734

Predictions


Id Partner name Gene Name Score
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.2092
64 Neuraminidase NA 0.1599
2676 Neuraminidase NA 0.1599
3026 Neuraminidase NA 0.1599
3519 Neuraminidase NA 0.1599
6007 Neuraminidase NA 0.1599
1729 Solute carrier family 22 member 6 SLC22A6 0.1345
244 Angiotensin-converting enzyme ACE 0.1086
1024 Solute carrier family 22 member 11 SLC22A11 0.0824
4335 Trans-sialidase Not Available 0.0712
5481 Trans-sialidase TCTS-154 0.0712
3140 Hemagglutinin-neuraminidase HN 0.071
3609 Hemagglutinin-neuraminidase HN 0.071
1588 Multidrug resistance protein 1 ABCB1 0.0692
6143 Solute carrier family 22 member 7 SLC22A7 0.0646
587 Serum albumin ALB 0.0639
2942 Sialidase nanH 0.0605
3546 Sialidase nedA 0.0605
118 Organic cation/carnitine transporter 2 SLC22A5 0.0599
4512 Cytochrome P450 3A4 CYP3A4 0.0576
4757 Cytochrome P450 2C9 CYP2C9 0.0516
633 Penicillin-binding proteins 1A/1B pbpA 0.0507
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0506
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0484
6136 Multidrug resistance-associated protein 5 ABCC5 0.044
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.04
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0376
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0374
4924 Cytochrome P450 2C8 CYP2C8 0.0362
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0348
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0346
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0346
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0343
645 Penicillin-binding protein 1A mrcA 0.0333
5805 Penicillin-binding protein 1A ponA 0.0333
6185 Penicillin-binding protein 1A mrcA 0.0333
6799 Penicillin-binding protein 1A pbpA 0.0333
6016 Cytochrome P450 2C19 CYP2C19 0.0319
20 Prostaglandin G/H synthase 1 PTGS1 0.0316
290 Prostaglandin G/H synthase 2 PTGS2 0.0315
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0303
1 Peptidoglycan synthetase ftsI ftsI 0.0296
4155 Peptidoglycan synthetase ftsI ftsI 0.0296
862 Multidrug resistance-associated protein 1 ABCC1 0.0295
543 Penicillin-binding protein 1B mrcB 0.0288
6186 Penicillin-binding protein 1B ponB 0.0288
6822 Penicillin-binding protein 1b pbp1b 0.0288
6844 Penicillin-binding protein 1b pbp1b 0.0288
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0282
4119 Cytochrome P450 2D6 CYP2D6 0.0269
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0266
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0263
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0262
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0257
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0241
4118 Cytochrome P450 3A5 CYP3A5 0.0239
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0234
6141 Sodium/bile acid cotransporter SLC10A1 0.0224
1385 Angiotensin-converting enzyme 2 ACE2 0.0222
4200 Cytochrome P450 1A2 CYP1A2 0.0211
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0206
5626 Nucleoside diphosphate kinase B NME2 0.0206
24 Thymidylate synthase TMP1 0.0204
359 Thymidylate synthase TYMS 0.0204
2626 Thymidylate synthase thyA 0.0204
2729 Thymidylate synthase thyA 0.0204
5352 Thymidylate synthase THYA 0.0204
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.02
776 Bile salt export pump ABCB11 0.0194
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0192
6145 Solute carrier family 22 member 1 SLC22A1 0.0192
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0189
6144 Solute carrier family 22 member 2 SLC22A2 0.0187
738 Monocarboxylate transporter 1 SLC16A1 0.0178
1757 Myeloperoxidase MPO 0.0171
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0167
5294 Nucleoside diphosphate kinase A NME1 0.0165
6030 Cytochrome P450 2B6 CYP2B6 0.0165
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0164
833 Organic cation/carnitine transporter 1 SLC22A4 0.0162
6147 Solute carrier family 22 member 3 SLC22A3 0.0159
6013 Cytochrome P450 2E1 CYP2E1 0.0153
3947 Xanthine dehydrogenase/oxidase XDH 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3917 Methylenetetrahydrofolate reductase MTHFR 0.0148
6148 Multidrug resistance-associated protein 7 ABCC10 0.0144
338 DNA polymerase UL30 0.014
379 DNA polymerase UL54 0.014
697 DNA polymerase ORF28 0.014
2482 DNA polymerase 43 0.014
4104 DNA polymerase BALF5 0.014
2178 Metabotropic glutamate receptor 5 GRM5 0.0136
6107 Cytochrome P450 3A7 CYP3A7 0.0132
6020 Aldehyde oxidase AOX1 0.0131
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0129
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0127
1405 Thiopurine S-methyltransferase TPMT 0.0124
3639 Thymidine phosphorylase deoA 0.0124
3936 Thymidine phosphorylase TYMP 0.0124
3923 Cholinesterase BCHE 0.0123
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0117
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
342 P protein [Includes: DNA-directed DNA polymerase P 0.0114
612 P protein [Includes: DNA-directed DNA polymerase P 0.0114
3810 Catechol O-methyltransferase COMT 0.0113
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0112
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0112
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
6067 Penicillin binding protein 2a mecA 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
3611 Cytidine deaminase cdd 0.0106
3707 Cytidine deaminase cdd 0.0106
4211 Cytidine deaminase CDA 0.0106
6167 Organic solute transporter subunit beta OSTB 0.0102
6166 Organic solute transporter subunit alpha OSTA 0.0102
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
3685 Catabolite gene activator crp 0.0099
4655 Adenylate cyclase cyaC 0.0099
4759 Adenylate cyclase cyaB2 0.0099
6024 Cytochrome P450 1A1 CYP1A1 0.0097
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
232 Corticosteroid-binding globulin SERPINA6 0.0095
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
6137 Multidrug resistance-associated protein 6 ABCC6 0.0091
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0087
124 Histamine H2 receptor HRH2 0.0086
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0086
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0085
4760 Mll3241 protein mll3241 0.0085
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0084
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0084
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0083
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
871 Glucocorticoid receptor NR3C1 0.0081
509 Thymidine kinase TK 0.0081
570 Thymidine kinase TK 0.0081
2559 Thymidine kinase TK 0.0081
3430 Thymidine kinase tdk 0.0081
3518 Thymidine kinase TK 0.0081
5301 Thymidine kinase tdk 0.0081
5771 Thymidine kinase ORF36 0.0081
7009 Thymidine kinase ORF36 0.0081
6149 Solute carrier family 22 member 10 SLC22A10 0.008
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.008
6033 High affinity interleukin-8 receptor A CXCR1 0.0078
3587 Gastrotropin FABP6 0.0078
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0077
551 Carnitine O-acetyltransferase CRAT 0.0077
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
1198 Serum paraoxonase/arylesterase 1 PON1 0.0076
6223 Penicillin-binding protein 1C pbpC 0.0076
6168 Solute carrier family 22 member 16 SLC22A16 0.0073
3811 Cytochrome P450 19A1 CYP19A1 0.0073
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0072
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0072
1648 Elastin ELN 0.0072
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
1756 E-selectin SELE 0.0071
54 Prothrombin F2 0.0071
293 Gamma-glutamyl hydrolase GGH 0.0071
3426 Glutamine synthetase glnA 0.0071
3987 Glutamine synthetase GLUL 0.0071
438 Taste receptor type 1 member 2 TAS1R2 0.0071
318 Alpha-2A adrenergic receptor ADRA2A 0.0071
6171 Solute carrier family 28 member 3 SLC28A3 0.007
6085 Fatty acid-binding protein, intestinal FABP2 0.0069
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0069
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0067
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
2981 Phospholipase A2, membrane associated PLA2G2A 0.0066
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
867 Penicillin-binding protein 3 pbpC 0.0065
6119 Penicillin-binding protein 3 pbp3 0.0065
7154 Penicillin-binding protein 3 pbp3 0.0065
7157 Penicillin-binding protein 3 LMHCC_2184 0.0065
7162 Penicillin-binding protein 3 pbpB 0.0065
7172 Penicillin-binding protein 3 pbp3 0.0065
122 P2Y purinoceptor 12 P2RY12 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0062
3629 Endo-N-acetylneuraminidase Not Available 0.0062
6042 Prostaglandin reductase 2 PTGR2 0.0062
5416 Coat protein VP1 Not Available 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
3760 Penicillin-binding protein 5 precursor dacA 0.0061
2391 Ferrochelatase hemH 0.006
6502 Ferrochelatase DKFZp686P18130 0.006
1591 Ferrochelatase, mitochondrial FECH 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0058
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
1313 Lactoylglutathione lyase GLO1 0.0057
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0057
2324 Botulinum neurotoxin type B botB 0.0057
65 Matrix metalloproteinase-9 Not Available 0.0057
3547 Enterotoxin type B entB 0.0057
2058 P-selectin SELP 0.0056
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
632 Alpha-1B adrenergic receptor ADRA1B 0.0056
5718 Cytochrome P450 2A6 CYP2A6 0.0056
6043 Putative G-protein coupled receptor 44 GPR44 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
6106 Cytochrome P450 2C18 CYP2C18 0.0054
4252 Penicillin-binding protein 5 dacA 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0052
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0052
6493 Cytochrome c oxidase subunit 6C COX6C 0.0052
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0052
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0052
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0052
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0052
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0052
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0052
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0052
6559 Cytochrome c oxidase subunit 2 ctaC 0.0052
6669 Cytochrome c oxidase subunit 2 ctaC 0.0052
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0052
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0052
6558 Cytochrome c oxidase subunit 1 ctaD 0.0052
4217 Telomerase reverse transcriptase TERT 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
33 Cystine/glutamate transporter SLC7A11 0.005
165 FL cytokine receptor FLT3 0.005
718 Folate receptor gamma FOLR3 0.005
299 Folate receptor beta FOLR2 0.005
804 Mitochondrial folate transporter/carrier SLC25A32 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
556 Alpha-1A adrenergic receptor ADRA1A 0.005
2570 Tetanus toxin tetX 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
952 Dipeptidyl peptidase 4 DPP4 0.0048
707 72 kDa type IV collagenase MMP2 0.0048
32 Vascular endothelial growth factor receptor 1 FLT1 0.0048
136 Estrogen receptor ESR1 0.0048
2540 Choloylglycine hydrolase cbh 0.0048
6500 Phospholipase A2 PLA2G1B 0.0047
3957 Adenosine deaminase ADA 0.0047
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
228 Beta platelet-derived growth factor receptor PDGFRB 0.0046
6501 Fatty acid-binding protein, liver FABP1 0.0045
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0044
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0044
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0043
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0043
6151 Monocarboxylate transporter 10 SLC16A10 0.0043
756 Sex hormone-binding globulin SHBG 0.0042
504 Mast/stem cell growth factor receptor KIT 0.0042
2021 Thrombomodulin THBD 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0042
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
1353 DNA topoisomerase 1 TOP1 0.004
3552 DNA topoisomerase 1 topA 0.004
2320 Thymidine kinase, cytosolic TK1 0.004
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0039
1867 Major prion protein PRNP 0.0039
1898 Cytochrome P450 1B1 CYP1B1 0.0039
3809 Estrogen-related receptor gamma ESRRG 0.0039
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0039
558 Solute carrier family 12 member 1 SLC12A1 0.0039
407 Vascular endothelial growth factor receptor 2 KDR 0.0039
373 Transthyretin TTR 0.0038
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0037
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0037
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0037
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
275 Arachidonate 5-lipoxygenase ALOX5 0.0037
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0036
130 Prostacyclin synthase PTGIS 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
6218 Pannexin-1 PANX1 0.0035
6209 30S ribosomal protein S19 rpsS 0.0034
6712 30S ribosomal protein S19 rpsS 0.0034
6726 30S ribosomal protein S19 rpsS 0.0034
6207 30S ribosomal protein S14 rpsN 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0034
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
517 Alcohol dehydrogenase 1C ADH1C 0.0033
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
4226 Uridine phosphorylase 2 UPP2 0.0032
5818 Folate receptor alpha FOLR1 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0031
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0031
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.003
950 Alpha platelet-derived growth factor receptor PDGFRA 0.003
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.003
527 Prostacyclin receptor PTGIR 0.0029
4225 Uridine phosphorylase 1 UPP1 0.0029
1192 Sulfotransferase 1A1 SULT1A1 0.0029
1792 Tissue-type plasminogen activator PLAT 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0028
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
146 Androgen receptor AR 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
413 Amidophosphoribosyltransferase PPAT 0.0028
2515 Amidophosphoribosyltransferase purF 0.0028
3714 Amidophosphoribosyltransferase purF 0.0028
5126 Arginase rocF 0.0027
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0027
702 UMP-CMP kinase CMPK1 0.0027
869 Estrogen receptor beta ESR2 0.0027
1654 Interleukin-1 beta IL1B 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0025
663 Solute carrier family 12 member 4 SLC12A4 0.0024
53 Solute carrier family 12 member 5 SLC12A5 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0024
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0024
4773 Deoxycytidine kinase DCK 0.0023
432 D(4) dopamine receptor DRD4 0.0023
310 Solute carrier family 12 member 2 SLC12A2 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
489 Monocarboxylate transporter 2 SLC16A7 0.0022
638 D(3) dopamine receptor DRD3 0.0022
494 Caspase-1 CASP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0021
183 Vascular endothelial growth factor A VEGFA 0.0021
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0021
1507 Cytochrome c CYCS 0.0021
23 D(1A) dopamine receptor DRD1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
442 Envelope glycoprotein gp41 0.002
4859 Envelope glycoprotein env 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
6220 Aryl hydrocarbon receptor AHR 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
831 D(2) dopamine receptor DRD2 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
819 Penicillin-binding protein 4 dacB 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0017
365 Dihydrofolate reductase DHFR 0.0017
2381 Dihydrofolate reductase DFR1 0.0017
2833 Dihydrofolate reductase Not Available 0.0017
2931 Dihydrofolate reductase folA 0.0017
3544 Dihydrofolate reductase folA 0.0017
3682 Dihydrofolate reductase folA 0.0017
6642 Dihydrofolate reductase folA 0.0017
6756 Dihydrofolate reductase dfrA 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1184 Interferon beta IFNB1 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
2372 Bifunctional tail protein 9 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
4034 Glutaredoxin-1 GLRX 0.0013
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0013
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0013
910 Epididymal secretory glutathione peroxidase GPX5 0.0013
4036 Glutathione peroxidase 6 GPX6 0.0013
903 Glutathione S-transferase A5 GSTA5 0.0013
911 Glutathione peroxidase 3 GPX3 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
1928 Leukotriene C4 synthase LTC4S 0.0013
4029 Microsomal glutathione S-transferase 3 MGST3 0.0013
4032 Microsomal glutathione S-transferase 1 MGST1 0.0013
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0013
4040 Glutathione peroxidase 7 GPX7 0.0013
907 Glutathione peroxidase 2 GPX2 0.0013
906 Glutathione peroxidase 1 GPX1 0.0013
4035 Glutathione S-transferase Mu 5 GSTM5 0.0013
900 Glutathione S-transferase A4 GSTA4 0.0013
4042 Glutathione transferase omega-2 GSTO2 0.0013
4033 S-formylglutathione hydrolase ESD 0.0013
4038 Glutathione peroxidase 4 GPX4 0.0013
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0013
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0013
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
1243 Cathepsin D CTSD 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
3319 Hydroxyacylglutathione hydrolase HAGH 0.0011
897 Glutathione S-transferase kappa 1 GSTK1 0.0011
898 Glutathione S-transferase A3 GSTA3 0.0011
1439 Lactotransferrin LTF 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
909 Maleylacetoacetate isomerase GSTZ1 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
899 Glutathione S-transferase Mu 3 GSTM3 0.0011
905 Glutathione transferase omega-1 GSTO1 0.0011
3814 Complement C1r subcomponent C1R 0.0011
4041 Microsomal glutathione S-transferase 2 MGST2 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
2430 Chondroitinase B cslB 0.0011
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
6014 Cytochrome P450 2A13 CYP2A13 0.001
2581 Chondroitinase AC cslA 0.001
309 Antithrombin-III SERPINC1 0.001
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
2165 Glutathione S-transferase Mu 2 GSTM2 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
2207 Rhodopsin RHO 0.0009
901 Glutathione S-transferase Mu 4 GSTM4 0.0009
908 Glutathione S-transferase theta-1 GSTT1 0.0009
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0009
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0009
4031 Glutathione S-transferase A1 GSTA1 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
6031 Cytochrome P450 3A43 CYP3A43 0.0008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0008
714 Glutathione reductase, mitochondrial GSR 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0007
904 Glutathione S-transferase P GSTP1 0.0007
824 Sodium-dependent serotonin transporter SLC6A4 0.0007
3941 Amine oxidase [flavin-containing] A MAOA 0.0007
↑