Identification | |||||||
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Name | Imipenem | ||||||
Accession Number | DB01598 | ||||||
Type | small molecule | ||||||
Description | Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem] | ||||||
Structure |
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Categories (*) | |||||||
Molecular Weight | 299.346 | ||||||
Groups | approved | ||||||
Monoisotopic Weight | 299.093976737 | ||||||
Pharmacology | |||||||
Indication | For the treatment of bacterial infections caused by susceptible bacteria. | ||||||
Mechanism of action | Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to pencillin binding proteins (PBPs). In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b. This preferential binding to PBP-2 and PBP-1b results in the direct conversion of the individual cell to a spheroblast, which leads to rapid cell lysis and death without filament formation. | ||||||
Absorption | Imipenem is not effectively absorbed from the gastrointestinal tract and therefore must be administered parenterally. | ||||||
Protein binding | 20% binds to plasma proteins | ||||||
Biotransformation | Renal. | ||||||
Route of elimination | Not Available | ||||||
Toxicity | Not Available | ||||||
Affected organisms |
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Interactions | |||||||
Drug Interactions |
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Food Interactions | Not Available |
Penicillin-binding protein 2 | |
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Name | Penicillin-binding protein 2 |
Gene Name | mrdA |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | 0.0571 |
Penicillin-binding protein 1B | |
Name | Penicillin-binding protein 1B |
Gene Name | mrcB |
Pharmacological action | yes |
Actions | inhibitor |
References | |
DTHybrid score | 0.6967 |
Penicillin-binding protein 1A | |
Name | Penicillin-binding protein 1A |
Gene Name | mrcA |
Pharmacological action | yes |
Actions | inhibitor |
References | |
DTHybrid score | 0.7023 |
Penicillin-binding protein 3 | |
Name | Penicillin-binding protein 3 |
Gene Name | pbpC |
Pharmacological action | yes |
Actions | inhibitor |
References | |
DTHybrid score | 0.6202 |
Beta-lactamase | |
Name | Beta-lactamase |
Gene Name | blaZ |
Pharmacological action | yes |
Actions | other/unknown |
References |
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DTHybrid score | 0.8172 |