DT-Web

DB01233 - Metoclopramide


Identification
Name Metoclopramide
Accession Number DB01233 (APRD00665)
Type small molecule
Description A dopamine D2 antagonist that is used as an antiemetic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 299.796
Groups approved
Monoisotopic Weight 299.14005467
Pharmacology
Indication For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Mechanism of action Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.
Absorption Rapidly and well absorbed (oral bioavailability 80±15.5%).
Protein binding 30%
Biotransformation Hepatic
Route of elimination Approximately 85% of the radioactivity of an orally administered dose appears in the urine within 72 hours.
Toxicity Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cyclosporine Metoclopramide increases serum levels of cyclosporine
Levodopa Levodopa decreases the effect of metoclopramide
Lurasidone Increases toxicity and risk of extrapyramidal effects of lurasidone by antidopaminergic effects. Concomitant therapy should be avoided.
Paliperidone Metoclopramide may increase the risk of extrapyramidal side effects of paliperidone. Concomitant therapy should be avoided.
Tacrolimus Metoclopramide may increase the concentration of Tacrolimus in the blood. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Metoclopramide therapy is initiated, discontinued or altered.
Tetrabenazine Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Venlafaxine Possible serotoninergic syndrome with this combination
Vilazodone Seek alternatives to this combination when possible. Monitor patients receiving metoclopramide with selective serotonin reuptake inhibitors for signs of extrapyramidal symptoms, neuroleptic malignant syndrome, and serotonin syndrome.
Zuclopenthixol Additive dopamine D2 receptor antagonism may cause dopaminergic imbalance in the nigrostriatal (dopamine D1 receptors) and striatopallidal (dopamine D2 receptors). Increased risk of extrapyramidal reactions and neuroleptic malignant syndrome. Concomitant therapy should be avoided.
Food Interactions
  • Food reduces availability, take 30 minutes before meals. Avoid alcohol.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • See RE, Lynch AM, Sorg BA: Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats. Neuroscience. 1996 May;72(1):99-104. - Pubmed
  • Harrold MW, Sriburi A, Matsumoto K, Miller DD, Farooqui T, Uretsky N: The interaction of ammonium, sulfonium, and sulfide analogues of metoclopramide with the dopamine D2 receptor. J Med Chem. 1993 Oct 15;36(21):3166-70. - Pubmed
  • Kishibayashi N, Karasawa A: Stimulating effects of KW-5092, a novel gastroprokinetic agent, on the gastric emptying, small intestinal propulsion and colonic propulsion in rats. Jpn J Pharmacol. 1995 Jan;67(1):45-50. - Pubmed
  • Chemnitius JM, Haselmeyer KH, Gonska BD, Kreuzer H, Zech R: Indirect parasympathomimetic activity of metoclopramide: reversible inhibition of cholinesterases from human central nervous system and blood. Pharmacol Res. 1996 Jul-Aug;34(1-2):65-72. - Pubmed
  • Dahlof CG, Hargreaves RJ: Pathophysiology and pharmacology of migraine. Is there a place for antiemetics in future treatment strategies? Cephalalgia. 1998 Nov;18(9):593-604. - Pubmed
  • Hammer D: Gastroesophageal reflux and prokinetic agents. Neonatal Netw. 2005 Mar-Apr;24(2):51-8; quiz 59-62. - Pubmed
DTHybrid score 0.3113
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Burger DM, Wiestner T, Hubler M, Binder H, Keiser M, Arnold S: Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers. J Vet Med A Physiol Pathol Clin Med. 2006 Mar;53(2):97-107. - Pubmed
  • Hammer D: Gastroesophageal reflux and prokinetic agents. Neonatal Netw. 2005 Mar-Apr;24(2):51-8; quiz 59-62. - Pubmed
DTHybrid score 0.4633
5-hydroxytryptamine 4 receptor
Name 5-hydroxytryptamine 4 receptor
Gene Name HTR4
Pharmacological action unknown
Actions agonist
References
  • Guillemot J, Compagnon P, Cartier D, Thouennon E, Bastard C, Lihrmann I, Pichon P, Thuillez C, Plouin PF, Bertherat J, Anouar Y, Kuhn JM, Yon L, Lefebvre H: Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors. Endocr Relat Cancer. 2009 Mar;16(1):281-90. Epub 2008 Oct 23. - Pubmed
DTHybrid score 0.2991

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3973
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3485
Cytochrome P450 11B2, mitochondrial
Name Cytochrome P450 11B2, mitochondrial
Gene Name CYP11B2
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3612
Cytochrome P450 17A1
Name Cytochrome P450 17A1
Gene Name CYP17A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2558

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2161
502 5-hydroxytryptamine 2A receptor HTR2A 0.1831
1588 Multidrug resistance protein 1 ABCB1 0.1528
617 Muscarinic acetylcholine receptor M2 CHRM2 0.147
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1375
4200 Cytochrome P450 1A2 CYP1A2 0.1244
6107 Cytochrome P450 3A7 CYP3A7 0.1211
4757 Cytochrome P450 2C9 CYP2C9 0.1176
320 5-hydroxytryptamine 1A receptor HTR1A 0.117
4118 Cytochrome P450 3A5 CYP3A5 0.1143
4924 Cytochrome P450 2C8 CYP2C8 0.111
737 Mineralocorticoid receptor NR3C2 0.1046
23 D(1A) dopamine receptor DRD1 0.1038
6016 Cytochrome P450 2C19 CYP2C19 0.1019
6013 Cytochrome P450 2E1 CYP2E1 0.0889
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0843
492 Histamine H1 receptor HRH1 0.0762
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0732
556 Alpha-1A adrenergic receptor ADRA1A 0.0723
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0698
5718 Cytochrome P450 2A6 CYP2A6 0.0674
590 5-hydroxytryptamine 2C receptor HTR2C 0.0672
629 Alpha-2B adrenergic receptor ADRA2B 0.0618
6030 Cytochrome P450 2B6 CYP2B6 0.0611
756 Sex hormone-binding globulin SHBG 0.0603
638 D(3) dopamine receptor DRD3 0.0589
3811 Cytochrome P450 19A1 CYP19A1 0.0573
824 Sodium-dependent serotonin transporter SLC6A4 0.0549
118 Organic cation/carnitine transporter 2 SLC22A5 0.0541
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0497
432 D(4) dopamine receptor DRD4 0.0475
436 5-hydroxytryptamine 2B receptor HTR2B 0.0469
6024 Cytochrome P450 1A1 CYP1A1 0.0427
341 5-hydroxytryptamine 3 receptor HTR3A 0.0408
318 Alpha-2A adrenergic receptor ADRA2A 0.0393
632 Alpha-1B adrenergic receptor ADRA1B 0.0384
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0375
885 5-hydroxytryptamine 1B receptor HTR1B 0.0372
163 D(1B) dopamine receptor DRD5 0.0366
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0364
269 Adrenodoxin, mitochondrial FDX1 0.0358
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0354
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0346
469 Annexin A1 ANXA1 0.0338
6145 Solute carrier family 22 member 1 SLC22A1 0.0324
3923 Cholinesterase BCHE 0.0319
2298 Cytochrome P450-cam camC 0.0318
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0318
587 Serum albumin ALB 0.0318
378 Alpha-2C adrenergic receptor ADRA2C 0.0309
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0295
146 Androgen receptor AR 0.0272
6106 Cytochrome P450 2C18 CYP2C18 0.025
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0244
713 Sodium-dependent dopamine transporter SLC6A3 0.0243
725 5-hydroxytryptamine 1D receptor HTR1D 0.0241
847 Mu-type opioid receptor OPRM1 0.0236
716 5-hydroxytryptamine 7 receptor HTR7 0.0236
260 Cytochrome P450 51 ERG11 0.0235
761 Cytochrome P450 51 ERG11 0.0235
3163 Cytochrome P450 51 cyp51 0.0235
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0233
1050 Bile salt sulfotransferase SULT2A1 0.0227
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0223
789 Alpha-1D adrenergic receptor ADRA1D 0.0222
6144 Solute carrier family 22 member 2 SLC22A2 0.0221
862 Multidrug resistance-associated protein 1 ABCC1 0.0221
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.022
871 Glucocorticoid receptor NR3C1 0.0216
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0209
232 Corticosteroid-binding globulin SERPINA6 0.02
766 Beta-2 adrenergic receptor ADRB2 0.0193
124 Histamine H2 receptor HRH2 0.0192
776 Bile salt export pump ABCB11 0.0189
465 Calmodulin CALM1 0.0189
1898 Cytochrome P450 1B1 CYP1B1 0.0184
193 Beta-1 adrenergic receptor ADRB1 0.0182
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0168
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0163
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0163
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0161
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0158
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0154
1256 5-hydroxytryptamine 6 receptor HTR6 0.0152
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0149
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0149
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0149
833 Organic cation/carnitine transporter 1 SLC22A4 0.0148
1729 Solute carrier family 22 member 6 SLC22A6 0.0141
6147 Solute carrier family 22 member 3 SLC22A3 0.0139
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0136
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0135
3876 Aromatic-L-amino-acid decarboxylase DDC 0.013
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0127
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0119
3941 Amine oxidase [flavin-containing] A MAOA 0.0114
131 Synaptic vesicular amine transporter SLC18A2 0.0113
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0111
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0111
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0108
1656 CYP2B protein CYP2B 0.0106
528 5-hydroxytryptamine 1E receptor HTR1E 0.0097
20 Prostaglandin G/H synthase 1 PTGS1 0.0096
467 Delta-type opioid receptor OPRD1 0.0092
696 Kappa-type opioid receptor OPRK1 0.0089
474 Acetylcholinesterase ACHE 0.0087
3939 Amine oxidase [flavin-containing] B MAOB 0.0083
6031 Cytochrome P450 3A43 CYP3A43 0.0079
84 Nuclear receptor 0B1 NR0B1 0.0077
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0077
7 Nitric oxide synthase, inducible NOS2 0.0077
468 Cytochrome P450 4A11 CYP4A11 0.0075
923 Glutamate receptor 3 GRIA3 0.0074
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0071
614 Progesterone receptor PGR 0.007
174 Sigma 1-type opioid receptor SIGMAR1 0.0067
6141 Sodium/bile acid cotransporter SLC10A1 0.0064
1010 Cytochrome P450 51A1 CYP51A1 0.0063
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0062
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0058
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0058
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0058
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0058
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0058
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0057
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0057
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0054
5934 Cytochrome P450 26A1 CYP26A1 0.0054
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0052
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0051
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
136 Estrogen receptor ESR1 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0051
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0049
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0049
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0048
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0048
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0048
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0046
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0046
921 Glutamate receptor 2 GRIA2 0.0045
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0045
2112 Toll-like receptor 9 TLR9 0.0044
3947 Xanthine dehydrogenase/oxidase XDH 0.0044
2129 Sucrase-isomaltase, intestinal SI 0.0043
6859 Protein S100-A4 S100A4 0.0041
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6143 Solute carrier family 22 member 7 SLC22A7 0.0038
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0038
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0038
6142 Solute carrier family 22 member 8 SLC22A8 0.0038
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
427 Substance-P receptor TACR1 0.0034
6506 Stathmin-4 STMN4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
1636 Trace amine-associated receptor 1 TAAR1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
1024 Solute carrier family 22 member 11 SLC22A11 0.0031
6432 Transporter snf 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
291 Nitric-oxide synthase, endothelial NOS3 0.0029
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0028
365 Dihydrofolate reductase DHFR 0.0028
2381 Dihydrofolate reductase DFR1 0.0028
2833 Dihydrofolate reductase Not Available 0.0028
2931 Dihydrofolate reductase folA 0.0028
3544 Dihydrofolate reductase folA 0.0028
3682 Dihydrofolate reductase folA 0.0028
6642 Dihydrofolate reductase folA 0.0028
6756 Dihydrofolate reductase dfrA 0.0028
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0027
164 Histamine H4 receptor HRH4 0.0027
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0024
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.002
4203 Histamine N-methyltransferase HNMT 0.0019
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
2164 Multidrug resistance-associated protein 4 ABCC4 0.0019
153 Dopamine beta-hydroxylase DBH 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0017
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
1629 Transcription factor AP-1 JUN 0.0016
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0016
816 Biliverdin reductase A BLVRA 0.0016
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0016
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0016
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0016
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0016
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1618 High affinity nerve growth factor receptor NTRK1 0.0015
3810 Catechol O-methyltransferase COMT 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0014
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0014
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0014
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0014
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0014
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0014
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0014
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0014
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0014
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0014
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0014
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0014
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0014
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0014
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0014
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0014
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0014
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0014
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0014
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0014
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0014
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0014
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0014
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0014
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0014
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0014
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0014
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0014
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0014
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0014
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0014
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0014
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0014
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0014
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0014
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0014
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0014
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0014
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0014
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0014
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0014
644 Heme oxygenase 2 HMOX2 0.0014
4982 Heme oxygenase 2 pbsA2 0.0014
167 L-lactate dehydrogenase C chain LDHC 0.0014
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0014
3726 D-3-phosphoglycerate dehydrogenase serA 0.0014
4291 D-3-phosphoglycerate dehydrogenase serA 0.0014
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0014
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0014
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0014
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0014
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0014
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0014
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0014
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0014
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0014
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0014
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0014
729 GDP-L-fucose synthetase TSTA3 0.0014
3463 GDP-L-fucose synthetase fcl 0.0014
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0014
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0014
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0014
34 7-dehydrocholesterol reductase DHCR7 0.0014
711 UDP-glucose 6-dehydrogenase UGDH 0.0014
3672 UDP-glucose 6-dehydrogenase hasB 0.0014
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0014
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0014
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0014
107 C-4 methylsterol oxidase SC4MOL 0.0014
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0014
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0014
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0014
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0014
206 3-keto-steroid reductase HSD17B7 0.0014
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0014
643 Peroxisomal bifunctional enzyme EHHADH 0.0014
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0014
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0014
646 Malate dehydrogenase, cytoplasmic MDH1 0.0014
4120 NADPH--cytochrome P450 reductase POR 0.0014
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0014
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0014
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0014
396 Alcohol dehydrogenase 4 ADH4 0.0014
328 Sorbitol dehydrogenase SORD 0.0014
597 Dihydropteridine reductase QDPR 0.0014
373 Transthyretin TTR 0.0014
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0014
666 NADP-dependent malic enzyme ME1 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
738 Monocarboxylate transporter 1 SLC16A1 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
857 Malate dehydrogenase, mitochondrial MDH2 0.0013
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0013
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
77 L-lactate dehydrogenase B chain LDHB 0.0013
12 Alcohol dehydrogenase class 3 ADH5 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0013
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0013
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6026 Alcohol dehydrogenase 6 ADH6 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0012
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0012
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0012
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0012
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0012
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0012
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
13 Aminomethyltransferase, mitochondrial AMT 0.0012
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0012
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0012
626 Cysteine dioxygenase type 1 CDO1 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0012
6148 Multidrug resistance-associated protein 7 ABCC10 0.0012
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
654 Flavin reductase BLVRB 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
810 Heme oxygenase 1 HMOX1 0.001
3391 Heme oxygenase 1 pbsA1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
279 Tyrosinase TYR 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
714 Glutathione reductase, mitochondrial GSR 0.001
777 Tumor necrosis factor TNF 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
517 Alcohol dehydrogenase 1C ADH1C 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
822 Aldose reductase AKR1B1 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
6020 Aldehyde oxidase AOX1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
4773 Deoxycytidine kinase DCK 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
1757 Myeloperoxidase MPO 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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