DT-Web: DB01189

Identification
Name	Desflurane
Accession Number	DB01189 (APRD00907)
Type	small molecule
Description	Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Anesthetics, Inhalation Neuroprotective Agents
Molecular Weight	168.0378
Groups	approved
Monoisotopic Weight	168.000983916
Pharmacology
Indication	For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Mechanism of action	Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.
Absorption	Rapidly absorbed into the circulation via the lungs following inhalation.
Protein binding	Not Available
Biotransformation	Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).
Route of elimination	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Seo K, Seino H, Yoshikawa H, Petrenko AB, Baba H, Fujiwara N, Someya G, Kawano Y, Maeda T, Matsuda M, Kanematsu T, Hirata M: Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane. Neurosci Lett. 2010 Mar 12;472(1):1-4. Epub 2010 Jan 25. - Pubmed
DTHybrid score	0.4956
Glycine receptor subunit alpha-1
Name	Glycine receptor subunit alpha-1
Gene Name	GLRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Grasshoff C, Antkowiak B: Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats. Br J Anaesth. 2006 Nov;97(5):687-94. Epub 2006 Sep 13. - Pubmed
DTHybrid score	0.5945
Glutamate receptor 1
Name	Glutamate receptor 1
Gene Name	GRIA1
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Dildy-Mayfield JE, Eger EI 2nd, Harris RA: Anesthetics produce subunit-selective actions on glutamate receptors. J Pharmacol Exp Ther. 1996 Mar;276(3):1058-65. - Pubmed
DTHybrid score	0.6349
Potassium voltage-gated channel subfamily A member 1
Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Pharmacological action	yes
Actions	inducer
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Matchett GA, Allard MW, Martin RD, Zhang JH: Neuroprotective effect of volatile anesthetic agents: molecular mechanisms. Neurol Res. 2009 Mar;31(2):128-34. - Pubmed
DTHybrid score	0.5525
Calcium-transporting ATPase type 2C member 1
Name	Calcium-transporting ATPase type 2C member 1
Gene Name	ATP2C1
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6312
ATP synthase delta chain, mitochondrial
Name	ATP synthase delta chain, mitochondrial
Gene Name	ATP5D
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kosk-Kosicka D, Roszczynska G: Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics. Anesthesiology. 1993 Oct;79(4):774-80. - Pubmed
DTHybrid score	0.5988
NADH-ubiquinone oxidoreductase chain 1
Name	NADH-ubiquinone oxidoreductase chain 1
Gene Name	MT-ND1
Pharmacological action	unknown
Actions	unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.5406

Id	Partner name	Gene Name	Score
6013	Cytochrome P450 2E1	CYP2E1	0.2349
6030	Cytochrome P450 2B6	CYP2B6	0.1654
4512	Cytochrome P450 3A4	CYP3A4	0.1561
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.1153
5718	Cytochrome P450 2A6	CYP2A6	0.1123
4757	Cytochrome P450 2C9	CYP2C9	0.1035
465	Calmodulin	CALM1	0.0878
4119	Cytochrome P450 2D6	CYP2D6	0.073
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0702
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0697
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0652
4200	Cytochrome P450 1A2	CYP1A2	0.0646
4118	Cytochrome P450 3A5	CYP3A5	0.0536
820	Glycine receptor subunit alpha-2	GLRA2	0.0487
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0485
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0477
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0476
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0473
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0472
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0472
1268	Neuropeptide S receptor	NPSR1	0.0472
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0459
1108	Calpastatin	CAST	0.0448
1089	Cartilage oligomeric matrix protein	COMP	0.0448
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0445
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0445
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0441
6016	Cytochrome P450 2C19	CYP2C19	0.0414
461	Glycine receptor subunit alpha-3	GLRA3	0.0372
1588	Multidrug resistance protein 1	ABCB1	0.0371
6073	Potassium channel subfamily K member 9	KCNK9	0.0365
6072	Potassium channel subfamily K member 3	KCNK3	0.0365
5469	Head decoration protein	shp	0.035
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0344
62	Glycine receptor subunit beta	GLRB	0.0341
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0334
4924	Cytochrome P450 2C8	CYP2C8	0.0333
1181	Alpha-1-acid glycoprotein 1	ORM1	0.033
921	Glutamate receptor 2	GRIA2	0.0327
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0326
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0323
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0323
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0302
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.03
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0288
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0282
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0281
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.028
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0278
6048	Troponin C, skeletal muscle	TNNC2	0.0276
2132	Protein S100-B	S100B	0.0274
20	Prostaglandin G/H synthase 1	PTGS1	0.0265
2207	Rhodopsin	RHO	0.0255
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0254
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.025
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0246
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0246
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0245
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0245
1729	Solute carrier family 22 member 6	SLC22A6	0.0239
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0228
6151	Monocarboxylate transporter 10	SLC16A10	0.0217
811	Translocator protein	TSPO	0.0215
891	Dihydropteroate synthase	folP	0.0207
5359	Dihydropteroate synthase	folP	0.0207
7175	Dihydropteroate synthase	sulI	0.0207
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0206
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0191
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0188
290	Prostaglandin G/H synthase 2	PTGS2	0.018
6024	Cytochrome P450 1A1	CYP1A1	0.0173
6107	Cytochrome P450 3A7	CYP3A7	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0154
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.014
6142	Solute carrier family 22 member 8	SLC22A8	0.0139
3426	Glutamine synthetase	glnA	0.0125
3987	Glutamine synthetase	GLUL	0.0125
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0124
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0122
1024	Solute carrier family 22 member 11	SLC22A11	0.0121
251	Alcohol dehydrogenase 1A	ADH1A	0.0112
556	Alpha-1A adrenergic receptor	ADRA1A	0.0111
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0109
468	Cytochrome P450 4A11	CYP4A11	0.0108
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0108
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0107
23	D(1A) dopamine receptor	DRD1	0.0106
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0102
444	Alcohol dehydrogenase 1B	ADH1B	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
566	Serotransferrin	TF	0.0094
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0094
6145	Solute carrier family 22 member 1	SLC22A1	0.0089
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0087
6143	Solute carrier family 22 member 7	SLC22A7	0.0086
517	Alcohol dehydrogenase 1C	ADH1C	0.0085
2164	Multidrug resistance-associated protein 4	ABCC4	0.0083
318	Alpha-2A adrenergic receptor	ADRA2A	0.0082
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0082
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0082
862	Multidrug resistance-associated protein 1	ABCC1	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0077
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0076
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0075
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0074
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0074
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
831	D(2) dopamine receptor	DRD2	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
824	Sodium-dependent serotonin transporter	SLC6A4	0.0071
645	Penicillin-binding protein 1A	mrcA	0.0071
5805	Penicillin-binding protein 1A	ponA	0.0071
6185	Penicillin-binding protein 1A	mrcA	0.0071
6799	Penicillin-binding protein 1A	pbpA	0.0071
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0071
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0071
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0071
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
36	Insulin receptor	INSR	0.0066
6106	Cytochrome P450 2C18	CYP2C18	0.0064
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0064
1618	High affinity nerve growth factor receptor	NTRK1	0.0064
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0063
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0062
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0061
172	Potassium channel subfamily K member 1	KCNK1	0.0061
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0061
756	Sex hormone-binding globulin	SHBG	0.006
738	Monocarboxylate transporter 1	SLC16A1	0.0059
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0058
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0058
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0057
3175	Glutamate--cysteine ligase	gshA	0.0056
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0054
696	Kappa-type opioid receptor	OPRK1	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
183	Vascular endothelial growth factor A	VEGFA	0.0052
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0051
6589	Delta-hemolysin	hld	0.0051
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0051
6586	Protein S100-G	S100G	0.0051
6591	ATP synthase C chain	atpH	0.0051
6587	Rubredoxin	rub	0.0051
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0051
6588	Methionyl-tRNA formyltransferase	fmt	0.005
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.005
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.005
6593	Immunoglobulin G-binding protein G	spg	0.005
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.005
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.005
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0049
4056	N-arachidonyl glycine receptor	GPR18	0.0049
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0049
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0049
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0049
6085	Fatty acid-binding protein, intestinal	FABP2	0.0049
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0049
4057	Glycine N-acyltransferase	GLYAT	0.0049
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0049
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0049
1466	Glycyl-tRNA synthetase	GARS	0.0049
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0049
6020	Aldehyde oxidase	AOX1	0.0049
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0048
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
3811	Cytochrome P450 19A1	CYP19A1	0.0048
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
3382	Glycolipid transfer protein	GLTP	0.0046
789	Alpha-1D adrenergic receptor	ADRA1D	0.0046
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0045
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0045
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0045
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0045
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0044
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0044
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0044
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0044
6279	Beta-2-microglobulin	B2M	0.0044
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0044
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0044
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0044
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0044
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0044
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0044
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0044
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0044
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0044
6559	Cytochrome c oxidase subunit 2	ctaC	0.0044
6669	Cytochrome c oxidase subunit 2	ctaC	0.0044
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0044
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0044
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0044
6558	Cytochrome c oxidase subunit 1	ctaD	0.0044
373	Transthyretin	TTR	0.0044
467	Delta-type opioid receptor	OPRD1	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0043
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0042
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0042
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0042
844	Epidermal growth factor receptor	EGFR	0.0041
118	Organic cation/carnitine transporter 2	SLC22A5	0.0041
492	Histamine H1 receptor	HRH1	0.0041
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0041
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0041
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0041
632	Alpha-1B adrenergic receptor	ADRA1B	0.0041
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0041
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0041
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0041
404	DNA gyrase subunit A	gyrA	0.004
6224	DNA gyrase subunit A	gyrA	0.004
477	DNA topoisomerase 4 subunit A	parC	0.004
886	DNA topoisomerase 4 subunit A	parC	0.004
6226	DNA topoisomerase 4 subunit A	parC	0.004
558	Solute carrier family 12 member 1	SLC12A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.004
4161	Furin	FURIN	0.004
309	Antithrombin-III	SERPINC1	0.004
629	Alpha-2B adrenergic receptor	ADRA2B	0.004
4604	Liver carboxylesterase 1	CES1	0.0039
6141	Sodium/bile acid cotransporter	SLC10A1	0.0039
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0039
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0039
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0039
922	Glutamate receptor 4	GRIA4	0.0039
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0038
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0038
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0037
3884	SHMT2 protein	SHMT2	0.0037
3901	SHMT2 protein	SHMT2	0.0037
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0037
3879	Serine hydroxymethyltransferase 2	Not Available	0.0037
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0037
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0037
411	Glycine N-methyltransferase	GNMT	0.0036
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
70	Type-1 angiotensin II receptor	AGTR1	0.0036
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0036
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0036
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0036
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0036
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0036
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0036
4027	Glutamate receptor delta-1 subunit	GRID1	0.0036
4018	Glutamate receptor delta-2 subunit	GRID2	0.0036
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0036
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
664	Glutamate decarboxylase 2	GAD2	0.0036
3890	Glutamate decarboxylase 2	GAD2	0.0036
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0036
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0036
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0036
1912	Excitatory amino acid transporter 1	SLC1A3	0.0036
4016	Excitatory amino acid transporter 5	SLC1A7	0.0036
4019	Excitatory amino acid transporter 4	SLC1A6	0.0036
1047	Excitatory amino acid transporter 2	SLC1A2	0.0036
927	Metabotropic glutamate receptor 8	GRM8	0.0036
925	Metabotropic glutamate receptor 4	GRM4	0.0036
926	Metabotropic glutamate receptor 7	GRM7	0.0036
4020	Glutamyl aminopeptidase	ENPEP	0.0036
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0036
4026	Aspartyl aminopeptidase	DNPEP	0.0036
4017	5-oxoprolinase	OPLAH	0.0036
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0034
6102	Arylamine N-acetyltransferase 2	NAT2	0.0034
1898	Cytochrome P450 1B1	CYP1B1	0.0034
383	Glycine amidinotransferase, mitochondrial	GATM	0.0034
6352	Reaction center protein H chain	puhA	0.0033
6456	Reaction center protein H chain	puhA	0.0033
6682	Reaction center protein H chain	puhA	0.0033
6353	Reaction center protein L chain	pufL	0.0033
6454	Reaction center protein L chain	pufL	0.0033
6683	Reaction center protein L chain	pufL	0.0033
6354	Reaction center protein M chain	pufM	0.0033
6455	Reaction center protein M chain	pufM	0.0033
6684	Reaction center protein M chain	pufM	0.0033
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
33	Cystine/glutamate transporter	SLC7A11	0.0033
349	Serine--pyruvate aminotransferase	AGXT	0.0033
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0032
594	Thyroxine-binding globulin	SERPINA7	0.0032
6677	Myelin P2 protein	PMP2	0.0032
136	Estrogen receptor	ESR1	0.0032
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0031
357	Carbonic anhydrase 2	CA2	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.003
5	Glutaminase liver isoform, mitochondrial	GLS2	0.003
917	Glutaminase kidney isoform, mitochondrial	GLS	0.003
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.003
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.003
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.003
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.003
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.003
5261	Phosphoribosylformylglycinamidine synthase	purL	0.003
592	Carbonic anhydrase 4	CA4	0.003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.003
758	Thyroid hormone receptor alpha	THRA	0.003
459	Retinoic acid receptor RXR-alpha	RXRA	0.003
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.003
665	Phosphoserine aminotransferase	PSAT1	0.003
4652	Phosphoserine aminotransferase	serC	0.003
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.003
420	Glutamate decarboxylase 1	GAD1	0.003
3900	Glutamate decarboxylase 1	GAD1	0.003
923	Glutamate receptor 3	GRIA3	0.003
3027	Streptavidin	Not Available	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3932	Glutathione S-transferase A2	GSTA2	0.0029
625	Glutamate carboxypeptidase 2	FOLH1	0.0029
146	Androgen receptor	AR	0.0029
3937	Fatty-acid amide hydrolase	FAAH	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1671	Excitatory amino acid transporter 3	SLC1A1	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0027
3877	Growth-inhibiting protein 18	GIG18	0.0027
916	Metabotropic glutamate receptor 1	GRM1	0.0027
380	Cytochrome P450 17A1	CYP17A1	0.0027
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0027
346	Thyroid hormone receptor beta-1	THRB	0.0027
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0027
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0027
5682	Ribonuclease pancreatic	RNASE1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
122	P2Y purinoceptor 12	P2RY12	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
763	Tyrosine aminotransferase	TAT	0.0026
5493	Tyrosine aminotransferase	Not Available	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0026
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0026
4252	Penicillin-binding protein 5	dacA	0.0025
6043	Putative G-protein coupled receptor 44	GPR44	0.0025
847	Mu-type opioid receptor	OPRM1	0.0025
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0025
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0025
776	Bile salt export pump	ABCB11	0.0025
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0024
1867	Major prion protein	PRNP	0.0024
3923	Cholinesterase	BCHE	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6231	Pepsin A	PGA3	0.0024
633	Penicillin-binding proteins 1A/1B	pbpA	0.0024
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6144	Solute carrier family 22 member 2	SLC22A2	0.0023
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0023
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0023
1525	Heparin-binding growth factor 2	FGF2	0.0022
6103	Arylamine N-acetyltransferase 1	NAT1	0.0022
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0022
707	72 kDa type IV collagenase	MMP2	0.0021
4210	Toll-like receptor 4	TLR4	0.0021
6209	30S ribosomal protein S19	rpsS	0.0021
6712	30S ribosomal protein S19	rpsS	0.0021
6726	30S ribosomal protein S19	rpsS	0.0021
6207	30S ribosomal protein S14	rpsN	0.0021
1050	Bile salt sulfotransferase	SULT2A1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.002
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
768	FK506-binding protein 1A	FKBP1A	0.002
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.002
822	Aldose reductase	AKR1B1	0.002
1992	Vitamin D-binding protein	GC	0.002
869	Estrogen receptor beta	ESR2	0.0019
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0019
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0019
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0019
1517	Beta-3 adrenergic receptor	ADRB3	0.0019
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
65	Matrix metalloproteinase-9	Not Available	0.0018
6136	Multidrug resistance-associated protein 5	ABCC5	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0018
5934	Cytochrome P450 26A1	CYP26A1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1714	Mitogen-activated protein kinase 3	MAPK3	0.0017
1291	cAMP response element-binding protein	CREB1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
780	Retinoic acid receptor RXR-gamma	RXRG	0.0017
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
244	Angiotensin-converting enzyme	ACE	0.0016
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
88	Retinoic acid receptor RXR-beta	RXRB	0.0016
162	Retinoic acid receptor gamma-1	RARG	0.0015
614	Progesterone receptor	PGR	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0015
6147	Solute carrier family 22 member 3	SLC22A3	0.0015
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0015
871	Glucocorticoid receptor	NR3C1	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0013
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0013
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0013
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0013
597	Dihydropteridine reductase	QDPR	0.0013
328	Sorbitol dehydrogenase	SORD	0.0013
1656	CYP2B protein	CYP2B	0.0013
396	Alcohol dehydrogenase 4	ADH4	0.0013
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
6459	Glycodelin	PAEP	0.0013
6432	Transporter	snf	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0012
666	NADP-dependent malic enzyme	ME1	0.0012
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0012
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0012
857	Malate dehydrogenase, mitochondrial	MDH2	0.0012
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0012
77	L-lactate dehydrogenase B chain	LDHB	0.0012
12	Alcohol dehydrogenase class 3	ADH5	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0012
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0012
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0012
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0012
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0012
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0011
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
473	L-lactate dehydrogenase A chain	LDHA	0.0011
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0011
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0011
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0011
24	Thymidylate synthase	TMP1	0.0011
359	Thymidylate synthase	TYMS	0.0011
2626	Thymidylate synthase	thyA	0.0011
2729	Thymidylate synthase	thyA	0.0011
5352	Thymidylate synthase	THYA	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
365	Dihydrofolate reductase	DHFR	0.0011
2381	Dihydrofolate reductase	DFR1	0.0011
2833	Dihydrofolate reductase	Not Available	0.0011
2931	Dihydrofolate reductase	folA	0.0011
3544	Dihydrofolate reductase	folA	0.0011
3682	Dihydrofolate reductase	folA	0.0011
6642	Dihydrofolate reductase	folA	0.0011
6756	Dihydrofolate reductase	dfrA	0.0011
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0011
13	Aminomethyltransferase, mitochondrial	AMT	0.0011
611	Retinal dehydrogenase 1	ALDH1A1	0.0011
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0011
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0011
810	Heme oxygenase 1	HMOX1	0.0011
3391	Heme oxygenase 1	pbsA1	0.0011
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.001
279	Tyrosinase	TYR	0.001
6137	Multidrug resistance-associated protein 6	ABCC6	0.001
2021	Thrombomodulin	THBD	0.001
904	Glutathione S-transferase P	GSTP1	0.001
654	Flavin reductase	BLVRB	0.001
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0009
1353	DNA topoisomerase 1	TOP1	0.0009
3552	DNA topoisomerase 1	topA	0.0009
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1864	RET proto-oncogene	RET	0.0009
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0009
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0009
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0009
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0009
714	Glutathione reductase, mitochondrial	GSR	0.0009
378	Alpha-2C adrenergic receptor	ADRA2C	0.0008
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
6148	Multidrug resistance-associated protein 7	ABCC10	0.0008
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0008
6218	Pannexin-1	PANX1	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
731	HIV-1 protease	HIV-1 protease	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
6042	Prostaglandin reductase 2	PTGR2	0.0007
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0007
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0007
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0007
3947	Xanthine dehydrogenase/oxidase	XDH	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
1792	Tissue-type plasminogen activator	PLAT	0.0007
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0007
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0007
273	Apoptosis regulator Bcl-2	BCL2	0.0007
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0007
6014	Cytochrome P450 2A13	CYP2A13	0.0007
504	Mast/stem cell growth factor receptor	KIT	0.0006
293	Gamma-glutamyl hydrolase	GGH	0.0006
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0006
275	Arachidonate 5-lipoxygenase	ALOX5	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
1650	Heme carrier protein 1	SLC46A1	0.0006
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
193	Beta-1 adrenergic receptor	ADRB1	0.0005
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0004
833	Organic cation/carnitine transporter 1	SLC22A4	0.0004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0004
3941	Amine oxidase [flavin-containing] A	MAOA	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
716	5-hydroxytryptamine 7 receptor	HTR7	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
163	D(1B) dopamine receptor	DRD5	0.0004
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
432	D(4) dopamine receptor	DRD4	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0003
638	D(3) dopamine receptor	DRD3	0.0003
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0003
4943	Cytochrome c6	petJ	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
5000	HemO	hemO	0.0003
4916	Cyanoglobin	glbN	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4984	Neuroglobin	NGB	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4961	Hemophore HasA	hasA	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4910	Cytoglobin	CYGB	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4909	CooA protein	cooA	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4952	Catalase/peroxidase	katA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
4920	Peroxidase/catalase	katG	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4948	Cytochrome c-553	Not Available	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
4990	PpcA	ppcA	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
518	Peroxidase/catalase T	katG	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
605	Fumarate reductase flavoprotein subunit	frdA	0.0002
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0002
3673	Fumarate reductase flavoprotein subunit	fccA	0.0002
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0002
6549	Fumarate reductase flavoprotein subunit	frdA	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
260	Cytochrome P450 51	ERG11	0.0002
761	Cytochrome P450 51	ERG11	0.0002
3163	Cytochrome P450 51	cyp51	0.0002
358	Cystathionine beta-synthase	CBS	0.0001
1507	Cytochrome c	CYCS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
2298	Cytochrome P450-cam	camC	0.0001
76	Nitric-oxide synthase, brain	NOS1	0.0001
7	Nitric oxide synthase, inducible	NOS2	0.0001
291	Nitric-oxide synthase, endothelial	NOS3	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01189 - Desflurane

Targets

Carriers

Predictions