DT-Web: DB00480

Identification

Name

Lenalidomide

Accession Number

DB00480 (APRD01303)

Type

small molecule

Description

Lenalidomide (initially known as CC-5013 and marketed as Revlimid(R) by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. [Wikipedia] FDA approved on December 27, 2005.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

259.2606

Groups

approved

Monoisotopic Weight

259.095691297

Pharmacology

Indication

Lenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.

Mechanism of action

The mechanism of action of lenalidomide remains to be fully characterized, however it has been demonstrated that lenalidomide inhibits the expression of cyclooxygenase-2 (COX-2), but not COX-1, in vitro. In vivo it induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity

Absorption

Rapidly absorbed following oral administration, with maximum plasma concentrations occurring between 0.625 and 1.5 hours post-dose. Co-administration with food does not alter the extent of absorption (AUC) but does reduce the maximal plasma concentration (C_max) by 36%. The pharmacokinetic disposition of lenalidomide is linear. Accumulation does not occur following multiple doses.

Protein binding

30% protein bound.

Biotransformation

Lenalidomide undergoes limited metabolism. Unchanged lenalidomide is the predominant circulating component in humans. Two identified metabolites are hydroxy-lenalidomide and N-acetyl-lenalidomide; each constitutes less than 5% of parent levels in circulation. The cytochrome P450 enzyme system is not involved with the metabolism of lenalidomide.

Route of elimination

Elimination is primarily renal. When a single oral dose of 25 mg is given healthy subjects, 90% and 4% of the dose is eliminated in urine and feces, respectively. Hydroxy-lenalidomide and N-acetyl-lenalidomide represent 4.59% and 1.83% of the excreted dose, respectively.

Toxicity

The most frequently reported adverse events were related to blood and lymphatic system disorders, skin and subcutaneous tissue disorders, gastrointestinal disorders, and general disorders and administrative site conditions.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Food Interactions

When given with a fatty meal, the extent of absorption is reduced.

Protein cereblon
Name	Protein cereblon
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	Zhu YX, Kortuem KM, Stewart AK: Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7. doi: 10.3109/10428194.2012.728597. Epub 2012 Sep 28. - Pubmed
DTHybrid score	Not Available
Tumor necrosis factor ligand superfamily member 11
Name	Tumor necrosis factor ligand superfamily member 11
Gene Name	TNFSF11
Pharmacological action	yes
Actions	inhibitor
References	Akobeng AK, Stokkers PC: Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351. - Pubmed Melchert M, List A: The thalidomide saga. Int J Biochem Cell Biol. 2007;39(7-8):1489-99. Epub 2007 Jan 30. - Pubmed
DTHybrid score	1.8038
Cadherin-5
Name	Cadherin-5
Gene Name	CDH5
Pharmacological action	unknown
Actions	antagonist
References	Lu L, Payvandi F, Wu L, Zhang LH, Hariri RJ, Man HW, Chen RS, Muller GW, Hughes CC, Stirling DI, Schafer PH, Bartlett JB: The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. Epub 2008 Sep 4. - Pubmed
DTHybrid score	0.9461
Vascular endothelial growth factor
Name	Vascular endothelial growth factor
Gene Name	VEGF
Pharmacological action	unknown
Actions	inhibitor
References	Lu L, Payvandi F, Wu L, Zhang LH, Hariri RJ, Man HW, Chen RS, Muller GW, Hughes CC, Stirling DI, Schafer PH, Bartlett JB: The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. Epub 2008 Sep 4. - Pubmed
DTHybrid score	0.9463
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	unknown
Actions	negative modulator
References	Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI: Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell Immunol. 2004 Aug;230(2):81-8. - Pubmed Zeldis JB, Schafer PH, Bennett BL, Mercurio F, Stirling DI: Potential new therapeutics for Waldenstrom's macroglobulinemia. Semin Oncol. 2003 Apr;30(2):275-81. - Pubmed
DTHybrid score	0.6315

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	FDA label -
DTHybrid score	0.4023

Id	Partner name	Gene Name	Score
20	Prostaglandin G/H synthase 1	PTGS1	0.1744
4512	Cytochrome P450 3A4	CYP3A4	0.092
4757	Cytochrome P450 2C9	CYP2C9	0.0691
4924	Cytochrome P450 2C8	CYP2C8	0.0464
4200	Cytochrome P450 1A2	CYP1A2	0.0462
587	Serum albumin	ALB	0.0428
4119	Cytochrome P450 2D6	CYP2D6	0.0411
1729	Solute carrier family 22 member 6	SLC22A6	0.0402
6016	Cytochrome P450 2C19	CYP2C19	0.0401
4118	Cytochrome P450 3A5	CYP3A5	0.0399
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0312
6107	Cytochrome P450 3A7	CYP3A7	0.0245
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0225
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0223
6024	Cytochrome P450 1A1	CYP1A1	0.0212
6013	Cytochrome P450 2E1	CYP2E1	0.021
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0207
6030	Cytochrome P450 2B6	CYP2B6	0.0206
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0199
275	Arachidonate 5-lipoxygenase	ALOX5	0.0196
1757	Myeloperoxidase	MPO	0.0195
6142	Solute carrier family 22 member 8	SLC22A8	0.0193
3923	Cholinesterase	BCHE	0.0186
1159	Interleukin-6	IL6	0.0185
862	Multidrug resistance-associated protein 1	ABCC1	0.0184
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0179
2164	Multidrug resistance-associated protein 4	ABCC4	0.0162
1024	Solute carrier family 22 member 11	SLC22A11	0.014
1181	Alpha-1-acid glycoprotein 1	ORM1	0.014
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0139
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
871	Glucocorticoid receptor	NR3C1	0.0132
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0131
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0129
6143	Solute carrier family 22 member 7	SLC22A7	0.0126
777	Tumor necrosis factor	TNF	0.0125
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
3312	Fatty acid-binding protein, brain	FABP7	0.0113
373	Transthyretin	TTR	0.0113
5718	Cytochrome P450 2A6	CYP2A6	0.0112
556	Alpha-1A adrenergic receptor	ADRA1A	0.0108
6145	Solute carrier family 22 member 1	SLC22A1	0.0106
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0105
6220	Aryl hydrocarbon receptor	AHR	0.0098
1439	Lactotransferrin	LTF	0.0095
6144	Solute carrier family 22 member 2	SLC22A2	0.0094
193	Beta-1 adrenergic receptor	ADRB1	0.0093
824	Sodium-dependent serotonin transporter	SLC6A4	0.0092
776	Bile salt export pump	ABCB11	0.0091
146	Androgen receptor	AR	0.009
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.009
3811	Cytochrome P450 19A1	CYP19A1	0.0088
831	D(2) dopamine receptor	DRD2	0.0087
1898	Cytochrome P450 1B1	CYP1B1	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
6106	Cytochrome P450 2C18	CYP2C18	0.0086
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0086
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0086
185	Vasopressin V1a receptor	AVPR1A	0.0085
3947	Xanthine dehydrogenase/oxidase	XDH	0.0085
322	Vasopressin V2 receptor	AVPR2	0.0084
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0081
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0081
492	Histamine H1 receptor	HRH1	0.0081
614	Progesterone receptor	PGR	0.0081
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0078
703	NADPH azoreductase	azr	0.0076
817	DNA topoisomerase 2-alpha	TOP2A	0.0075
6137	Multidrug resistance-associated protein 6	ABCC6	0.0075
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0074
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0072
136	Estrogen receptor	ESR1	0.0072
737	Mineralocorticoid receptor	NR3C2	0.0072
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0071
1192	Sulfotransferase 1A1	SULT1A1	0.007
766	Beta-2 adrenergic receptor	ADRB2	0.007
723	Cytosolic phospholipase A2	PLA2G4A	0.007
850	Vasopressin V1b receptor	AVPR1B	0.007
6141	Sodium/bile acid cotransporter	SLC10A1	0.0068
661	ADP/ATP translocase 1	SLC25A4	0.0067
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0065
1656	CYP2B protein	CYP2B	0.0065
738	Monocarboxylate transporter 1	SLC16A1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0061
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0061
4604	Liver carboxylesterase 1	CES1	0.0061
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.006
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0059
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0059
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0058
632	Alpha-1B adrenergic receptor	ADRA1B	0.0058
118	Organic cation/carnitine transporter 2	SLC22A5	0.0055
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0055
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0054
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
6148	Multidrug resistance-associated protein 7	ABCC10	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
6182	Cytochrome P450 2J2	CYP2J2	0.0052
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0052
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0051
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0051
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0051
320	5-hydroxytryptamine 1A receptor	HTR1A	0.005
232	Corticosteroid-binding globulin	SERPINA6	0.005
789	Alpha-1D adrenergic receptor	ADRA1D	0.005
844	Epidermal growth factor receptor	EGFR	0.005
731	HIV-1 protease	HIV-1 protease	0.005
1353	DNA topoisomerase 1	TOP1	0.005
3552	DNA topoisomerase 1	topA	0.005
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0049
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0049
828	Phenylalanine-4-hydroxylase	PAH	0.0049
3109	Phenylalanine-4-hydroxylase	phhA	0.0049
23	D(1A) dopamine receptor	DRD1	0.0048
847	Mu-type opioid receptor	OPRM1	0.0048
1648	Elastin	ELN	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
465	Calmodulin	CALM1	0.0046
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0046
6043	Putative G-protein coupled receptor 44	GPR44	0.0046
318	Alpha-2A adrenergic receptor	ADRA2A	0.0045
124	Histamine H2 receptor	HRH2	0.0044
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0044
4120	NADPH--cytochrome P450 reductase	POR	0.0043
467	Delta-type opioid receptor	OPRD1	0.0043
291	Nitric-oxide synthase, endothelial	NOS3	0.0043
260	Cytochrome P450 51	ERG11	0.0043
761	Cytochrome P450 51	ERG11	0.0043
3163	Cytochrome P450 51	cyp51	0.0043
869	Estrogen receptor beta	ESR2	0.0042
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.004
436	5-hydroxytryptamine 2B receptor	HTR2B	0.004
6147	Solute carrier family 22 member 3	SLC22A3	0.004
696	Kappa-type opioid receptor	OPRK1	0.004
474	Acetylcholinesterase	ACHE	0.004
161	Tubulin beta chain	TUBB	0.0039
312	Tubulin beta chain	TUB2	0.0039
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0038
6136	Multidrug resistance-associated protein 5	ABCC5	0.0038
6149	Solute carrier family 22 member 10	SLC22A10	0.0038
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0038
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0038
130	Prostacyclin synthase	PTGIS	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
489	Monocarboxylate transporter 2	SLC16A7	0.0037
952	Dipeptidyl peptidase 4	DPP4	0.0037
504	Mast/stem cell growth factor receptor	KIT	0.0036
6102	Arylamine N-acetyltransferase 2	NAT2	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0036
1714	Mitogen-activated protein kinase 3	MAPK3	0.0036
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0036
477	DNA topoisomerase 4 subunit A	parC	0.0035
886	DNA topoisomerase 4 subunit A	parC	0.0035
6226	DNA topoisomerase 4 subunit A	parC	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
823	Fibroblast growth factor receptor 2	FGFR2	0.0035
404	DNA gyrase subunit A	gyrA	0.0035
6224	DNA gyrase subunit A	gyrA	0.0035
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0034
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0034
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0034
904	Glutathione S-transferase P	GSTP1	0.0034
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0034
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0034
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0033
3941	Amine oxidase [flavin-containing] A	MAOA	0.0033
6500	Phospholipase A2	PLA2G1B	0.0033
759	Free fatty acid receptor 1	FFAR1	0.0032
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0032
6033	High affinity interleukin-8 receptor A	CXCR1	0.0032
3939	Amine oxidase [flavin-containing] B	MAOB	0.0032
908	Glutathione S-transferase theta-1	GSTT1	0.0032
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0032
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0032
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0032
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0032
833	Organic cation/carnitine transporter 1	SLC22A4	0.0031
2499	Tubulin beta-2C chain	TUBB2C	0.0031
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0031
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0031
468	Cytochrome P450 4A11	CYP4A11	0.0031
638	D(3) dopamine receptor	DRD3	0.0031
459	Retinoic acid receptor RXR-alpha	RXRA	0.0031
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.003
756	Sex hormone-binding globulin	SHBG	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
590	5-hydroxytryptamine 2C receptor	HTR2C	0.003
6085	Fatty acid-binding protein, intestinal	FABP2	0.0029
26	Vascular endothelial growth factor receptor 3	FLT4	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
380	Cytochrome P450 17A1	CYP17A1	0.0029
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0029
1650	Heme carrier protein 1	SLC46A1	0.0029
683	Potassium transporter	GK0582	0.0029
70	Type-1 angiotensin II receptor	AGTR1	0.0029
629	Alpha-2B adrenergic receptor	ADRA2B	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
32	Vascular endothelial growth factor receptor 1	FLT1	0.0028
1053	BC269730_2	FADS1	0.0028
1395	Sodium/calcium exchanger 1	SLC8A1	0.0028
6138	Multidrug resistance protein 3	ABCB4	0.0028
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0027
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0027
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0026
818	50S ribosomal protein L10	rplJ	0.0026
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0026
407	Vascular endothelial growth factor receptor 2	KDR	0.0026
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0026
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
1852	Microtubule-associated protein 2	MAP2	0.0026
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0026
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0026
29	Tubulin beta-1 chain	TUBB1	0.0025
3601	Dihydropteroate synthase 1	folP1	0.0025
3807	Dihydropteroate synthase 1	folP1	0.0025
3808	Dihydropteroate synthase 2	folP2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
273	Apoptosis regulator Bcl-2	BCL2	0.0025
310	Solute carrier family 12 member 2	SLC12A2	0.0024
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0024
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
2236	Casein kinase II subunit alpha	CSNK2A1	0.0024
4192	DNA topoisomerase 2-beta	TOP2B	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0023
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
713	Sodium-dependent dopamine transporter	SLC6A3	0.0023
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0023
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0023
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0022
2021	Thrombomodulin	THBD	0.0022
716	5-hydroxytryptamine 7 receptor	HTR7	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
378	Alpha-2C adrenergic receptor	ADRA2C	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
24	Thymidylate synthase	TMP1	0.0021
359	Thymidylate synthase	TYMS	0.0021
2626	Thymidylate synthase	thyA	0.0021
2729	Thymidylate synthase	thyA	0.0021
5352	Thymidylate synthase	THYA	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
3814	Complement C1r subcomponent	C1R	0.0021
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.002
822	Aldose reductase	AKR1B1	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
1275	Estrogen sulfotransferase	SULT1E1	0.0019
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0019
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0019
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0019
1050	Bile salt sulfotransferase	SULT2A1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
239	Coagulation factor X	F10	0.0019
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0018
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0018
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0018
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0018
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0018
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0018
605	Fumarate reductase flavoprotein subunit	frdA	0.0018
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0018
3673	Fumarate reductase flavoprotein subunit	fccA	0.0018
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0018
6549	Fumarate reductase flavoprotein subunit	frdA	0.0018
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0017
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
2539	Tubulin alpha-1 chain	TUBA4A	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6042	Prostaglandin reductase 2	PTGR2	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
2599	Tyrosine-protein kinase HCK	HCK	0.0016
6163	Copper-transporting ATPase 2	ATP7B	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
6165	Copper-transporting ATPase 1	ATP7A	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0015
6755	Poliovirus receptor	PVR	0.0015
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6146	High affinity copper uptake protein 1	SLC31A1	0.0015
1517	Beta-3 adrenergic receptor	ADRB3	0.0015
1792	Tissue-type plasminogen activator	PLAT	0.0015
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0015
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0015
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
165	FL cytokine receptor	FLT3	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
1178	Adenosine A2a receptor	ADORA2A	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
1629	Transcription factor AP-1	JUN	0.0014
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0013
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0013
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0013
896	Glutathione S-transferase Mu 1	GSTM1	0.0013
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0013
6167	Organic solute transporter subunit beta	OSTB	0.0013
6166	Organic solute transporter subunit alpha	OSTA	0.0013
1010	Cytochrome P450 51A1	CYP51A1	0.0013
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0013
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0013
6432	Transporter	snf	0.0013
365	Dihydrofolate reductase	DHFR	0.0013
2381	Dihydrofolate reductase	DFR1	0.0013
2833	Dihydrofolate reductase	Not Available	0.0013
2931	Dihydrofolate reductase	folA	0.0013
3544	Dihydrofolate reductase	folA	0.0013
3682	Dihydrofolate reductase	folA	0.0013
6642	Dihydrofolate reductase	folA	0.0013
6756	Dihydrofolate reductase	dfrA	0.0013
4773	Deoxycytidine kinase	DCK	0.0012
1313	Lactoylglutathione lyase	GLO1	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0012
694	Matrix protein 2	M	0.0012
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0012
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0012
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0012
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0012
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0012
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0012
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0012
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0012
6859	Protein S100-A4	S100A4	0.0012
432	D(4) dopamine receptor	DRD4	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0011
469	Annexin A1	ANXA1	0.0011
5923	Microtubule-associated protein tau	MAPT	0.0011
5924	Microtubule-associated protein 4	MAP4	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
131	Synaptic vesicular amine transporter	SLC18A2	0.0011
427	Substance-P receptor	TACR1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.001
106	Cannabinoid receptor 2	CNR2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
811	Translocator protein	TSPO	0.001
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.001
890	Niemann-Pick C1-like protein 1	NPC1L1	0.001
68	Cannabinoid receptor 1	CNR1	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
3957	Adenosine deaminase	ADA	0.0009
936	Ephrin type-A receptor 2	EPHA2	0.0009
3611	Cytidine deaminase	cdd	0.0009
3707	Cytidine deaminase	cdd	0.0009
4211	Cytidine deaminase	CDA	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
3809	Estrogen-related receptor gamma	ESRRG	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
1760	Aminopeptidase N	ANPEP	0.0009
6843	Aminopeptidase N	pepN	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
7	Nitric oxide synthase, inducible	NOS2	0.0009
54	Prothrombin	F2	0.0009
3932	Glutathione S-transferase A2	GSTA2	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
117	Sterol O-acyltransferase 1	SOAT1	0.0008
5787	Angiopoietin-1 receptor	TEK	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0008
3810	Catechol O-methyltransferase	COMT	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
3221	Cytochrome c4	cc4	0.0007
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0007
163	D(1B) dopamine receptor	DRD5	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
1630	Integrin beta-2	ITGB2	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
976	Platelet glycoprotein IX	GP9	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
4217	Telomerase reverse transcriptase	TERT	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0006
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0006
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0005
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0005
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0005
6044	Serum paraoxonase/lactonase 3	PON3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
2207	Rhodopsin	RHO	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
572	Integrin alpha-L	ITGAL	0.0005
183	Vascular endothelial growth factor A	VEGFA	0.0005
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
16	Adenosine A1 receptor	ADORA1	0.0005
2320	Thymidine kinase, cytosolic	TK1	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0005
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
4943	Cytochrome c6	petJ	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4984	Neuroglobin	NGB	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4961	Hemophore HasA	hasA	0.0005
4910	Cytoglobin	CYGB	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4916	Cyanoglobin	glbN	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
5000	HemO	hemO	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4909	CooA protein	cooA	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4972	P450cin	cinA	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4952	Catalase/peroxidase	katA	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
4122	Histone deacetylase 2	HDAC2	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
5934	Cytochrome P450 26A1	CYP26A1	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
6218	Pannexin-1	PANX1	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
751	Potassium channel subfamily K member 6	KCNK6	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
172	Potassium channel subfamily K member 1	KCNK1	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
84	Nuclear receptor 0B1	NR0B1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
4920	Peroxidase/catalase	katG	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
4923	Cytochrome c3	DvMF_2499	0.0004
4945	Cytochrome c3	Not Available	0.0004
4949	Cytochrome c3	DVU_3171	0.0004
4968	Cytochrome c3	cytc3	0.0004
4997	Cytochrome c3	SO_2727	0.0004
5219	Cytochrome c3	cyd	0.0004
4948	Cytochrome c-553	Not Available	0.0004
2119	Cytochrome b5	CYB5A	0.0004
3189	High-molecular-weight cytochrome c	hmcA	0.0004
4902	Nine-heme cytochrome c	Ddes_2038	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4990	PpcA	ppcA	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
6014	Cytochrome P450 2A13	CYP2A13	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
284	DNA-directed RNA polymerase beta chain	rpoB	0.0003
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
295	Carbonic anhydrase 1	CA1	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
518	Peroxidase/catalase T	katG	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0003
3127	Nitrite reductase	nirS	0.0003
3284	Nitrite reductase	nirS	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
164	Histamine H4 receptor	HRH4	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
1507	Cytochrome c	CYCS	0.0002
6021	Adenosine kinase	ADK	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0002
6020	Aldehyde oxidase	AOX1	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0002
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0002
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0002
517	Alcohol dehydrogenase 1C	ADH1C	0.0002
2298	Cytochrome P450-cam	camC	0.0002
921	Glutamate receptor 2	GRIA2	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00480 - Lenalidomide

Targets

Transporters

Predictions