DT-Web

DB04743 - Nimesulide


Identification
Name Nimesulide
Accession Number DB04743
Type small molecule
Description Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 308.31
Groups withdrawn
Monoisotopic Weight 308.046692194
Pharmacology
Indication For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Mechanism of action The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Absorption Rapidly absorbed following oral administration.
Protein binding >97.5%
Biotransformation Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).
Route of elimination Renal (50%), fecal (29%)
Toxicity Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Rainsford KD: Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin. 2006 Jun;22(6):1161-70. - Pubmed
DTHybrid score 0.4333
Group IIE secretory phospholipase A2
Name Group IIE secretory phospholipase A2
Gene Name PLA2G2E
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1644
Lactotransferrin
Name Lactotransferrin
Gene Name LTF
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3661

Predictions


Id Partner name Gene Name Score
20 Prostaglandin G/H synthase 1 PTGS1 0.1708
3057 L-arabinose-binding periplasmic protein araF 0.136
6500 Phospholipase A2 PLA2G1B 0.1093
2981 Phospholipase A2, membrane associated PLA2G2A 0.0626
1729 Solute carrier family 22 member 6 SLC22A6 0.0503
6269 S-phase kinase-associated protein 1 SKP1 0.0488
587 Serum albumin ALB 0.0448
4757 Cytochrome P450 2C9 CYP2C9 0.0422
2537 Aromatic-amino-acid aminotransferase tyrB 0.0417
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0416
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0401
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0401
3677 Penicillin-insensitive murein endopeptidase precursor mepA 0.0401
2249 Aspartate aminotransferase aspC 0.0387
2671 Aspartate aminotransferase aspC 0.0387
5490 Aspartate aminotransferase Not Available 0.0387
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0369
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0369
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0369
275 Arachidonate 5-lipoxygenase ALOX5 0.0364
1757 Myeloperoxidase MPO 0.0351
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0331
4512 Cytochrome P450 3A4 CYP3A4 0.0202
4200 Cytochrome P450 1A2 CYP1A2 0.0189
1159 Interleukin-6 IL6 0.0185
4924 Cytochrome P450 2C8 CYP2C8 0.0181
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0152
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
6142 Solute carrier family 22 member 8 SLC22A8 0.0133
1588 Multidrug resistance protein 1 ABCB1 0.012
6016 Cytochrome P450 2C19 CYP2C19 0.0118
3923 Cholinesterase BCHE 0.0118
2164 Multidrug resistance-associated protein 4 ABCC4 0.0117
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0117
6013 Cytochrome P450 2E1 CYP2E1 0.0115
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0112
1024 Solute carrier family 22 member 11 SLC22A11 0.0109
777 Tumor necrosis factor TNF 0.0098
6220 Aryl hydrocarbon receptor AHR 0.0094
373 Transthyretin TTR 0.009
3116 Bacterioferritin bfr 0.0087
4906 Bacterioferritin bfr 0.0087
4965 Bacterioferritin bfr 0.0087
3238 Multidrug resistance protein mexA mexA 0.0087
3173 Enolase eno 0.0087
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0087
3709 Glycerol uptake facilitator protein glpF 0.0087
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0087
3393 TGF-beta receptor type-2 TGFBR2 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
2852 DNA mismatch repair protein mutL mutL 0.0076
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0071
6459 Glycodelin PAEP 0.007
850 Vasopressin V1b receptor AVPR1B 0.007
3221 Cytochrome c4 cc4 0.0069
6143 Solute carrier family 22 member 7 SLC22A7 0.0067
3947 Xanthine dehydrogenase/oxidase XDH 0.0067
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0067
3191 Histidinol dehydrogenase hisD 0.0067
146 Androgen receptor AR 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
4311 tRNA TRDMT1 0.0062
4325 tRNA trmD 0.0062
4328 tRNA trmD 0.0062
4692 A/G-specific adenine glycosylase mutY 0.0061
185 Vasopressin V1a receptor AVPR1A 0.0061
740 Argininosuccinate synthase ASS1 0.0061
865 Argininosuccinate synthase ASS1 0.0061
2680 Argininosuccinate synthase argG 0.0061
3194 Argininosuccinate synthase argG 0.0061
2802 Endoglucanase G celCCG 0.0061
6012 Tryptophan 2,3-dioxygenase TDO2 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
723 Cytosolic phospholipase A2 PLA2G4A 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
904 Glutathione S-transferase P GSTP1 0.006
322 Vasopressin V2 receptor AVPR2 0.006
6316 ADP-ribosylation factor 1 ARF1 0.0059
6024 Cytochrome P450 1A1 CYP1A1 0.0059
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0056
4878 Glycoprotein hormones alpha chain CGA 0.0054
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0054
1072 Granzyme B GZMB 0.0054
4877 Beta-mannanase man 0.0054
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0054
4850 Beta-2-glycoprotein 1 APOH 0.0054
757 Fusion glycoprotein F0 F 0.0054
4875 Fusion glycoprotein F0 F 0.0054
4880 Membrane cofactor protein CD46 0.0054
4856 CD209 antigen CD209 0.0054
442 Envelope glycoprotein gp41 0.0054
4859 Envelope glycoprotein env 0.0054
4889 Ig epsilon chain C region IGHE 0.0054
4189 Alpha-galactosidase A GLA 0.0054
4869 Major capsid protein A430L 0.0054
3352 Structural polyprotein Not Available 0.0054
3628 Structural polyprotein Not Available 0.0054
4892 Structural polyprotein Not Available 0.0054
4852 Reticulon-4 receptor RTN4R 0.0054
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0054
1354 Beta-glucuronidase GUSB 0.0054
4845 ADAM 33 ADAM33 0.0054
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0054
4721 Beta-1,4-mannanase manA 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0052
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0052
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
3814 Complement C1r subcomponent C1R 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
1184 Interferon beta IFNB1 0.0047
6858 Inactive carboxylesterase 4 CES1P1 0.0047
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0047
1379 Interleukin-12 subunit beta IL12B 0.0047
793 T-cell surface antigen CD2 CD2 0.0047
4861 Interleukin-6 receptor alpha chain IL6R 0.0047
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0047
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0047
4890 Hemagglutinin HA 0.0047
6566 Hemagglutinin Not Available 0.0047
3837 Cytokine receptor common beta chain CSF2RB 0.0047
1648 Elastin ELN 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
4119 Cytochrome P450 2D6 CYP2D6 0.0046
1656 CYP2B protein CYP2B 0.0045
737 Mineralocorticoid receptor NR3C2 0.0044
3444 Cyanovirin-N Not Available 0.0044
1859 Prostatic acid phosphatase ACPP 0.0044
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0044
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0044
3140 Hemagglutinin-neuraminidase HN 0.0044
3609 Hemagglutinin-neuraminidase HN 0.0044
2297 Genome polyprotein Not Available 0.0044
2322 Genome polyprotein Not Available 0.0044
2694 Genome polyprotein Not Available 0.0044
2719 Genome polyprotein Not Available 0.0044
2860 Genome polyprotein Not Available 0.0044
2928 Genome polyprotein Not Available 0.0044
3160 Genome polyprotein Not Available 0.0044
3260 Genome polyprotein Not Available 0.0044
4783 Genome polyprotein Not Available 0.0044
5726 Genome polyprotein Not Available 0.0044
5779 Genome polyprotein Not Available 0.0044
5867 Genome polyprotein Not Available 0.0044
6253 Genome polyprotein Not Available 0.0044
6301 Genome polyprotein Not Available 0.0044
6380 Genome polyprotein Not Available 0.0044
6381 Genome polyprotein Not Available 0.0044
6437 Genome polyprotein Not Available 0.0044
6520 Genome polyprotein Not Available 0.0044
6521 Genome polyprotein Not Available 0.0044
6652 Genome polyprotein Not Available 0.0044
6734 Genome polyprotein Not Available 0.0044
6735 Genome polyprotein Not Available 0.0044
6736 Genome polyprotein Not Available 0.0044
6737 Genome polyprotein Not Available 0.0044
6738 Genome polyprotein Not Available 0.0044
6739 Genome polyprotein Not Available 0.0044
6744 Genome polyprotein Not Available 0.0044
6748 Genome polyprotein Not Available 0.0044
6894 Genome polyprotein Not Available 0.0044
6898 Genome polyprotein Not Available 0.0044
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0043
6043 Putative G-protein coupled receptor 44 GPR44 0.0042
4666 Fucose-binding lectin PA-IIL lecB 0.0041
2372 Bifunctional tail protein 9 0.0041
4787 Envelope glycoprotein gp160 env 0.0041
4820 Envelope glycoprotein gp160 env 0.0041
5727 Envelope glycoprotein gp160 env 0.0041
738 Monocarboxylate transporter 1 SLC16A1 0.0041
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0041
4118 Cytochrome P450 3A5 CYP3A5 0.004
614 Progesterone receptor PGR 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0039
554 Low-density lipoprotein receptor LDLR 0.0039
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
852 Heparin cofactor 2 SERPIND1 0.0039
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0038
3480 Mannan endo-1,4-beta-mannosidase manA 0.0038
64 Neuraminidase NA 0.0038
641 Neuraminidase NA 0.0038
2676 Neuraminidase NA 0.0038
3026 Neuraminidase NA 0.0038
3519 Neuraminidase NA 0.0038
6007 Neuraminidase NA 0.0038
130 Prostacyclin synthase PTGIS 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
6106 Cytochrome P450 2C18 CYP2C18 0.0036
1243 Cathepsin D CTSD 0.0036
595 Fibrinogen alpha chain FGA 0.0036
2430 Chondroitinase B cslB 0.0035
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0035
958 Insulin-like growth factor 1 receptor IGF1R 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0035
6307 Ig gamma-2 chain C region IGHG2 0.0034
2581 Chondroitinase AC cslA 0.0034
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
871 Glucocorticoid receptor NR3C1 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
6847 Lactase-phlorizin hydrolase LCT 0.0033
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
6033 High affinity interleukin-8 receptor A CXCR1 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
4604 Liver carboxylesterase 1 CES1 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
2207 Rhodopsin RHO 0.0031
6137 Multidrug resistance-associated protein 6 ABCC6 0.003
489 Monocarboxylate transporter 2 SLC16A7 0.003
3811 Cytochrome P450 19A1 CYP19A1 0.003
309 Antithrombin-III SERPINC1 0.003
76 Nitric-oxide synthase, brain NOS1 0.0029
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0029
1714 Mitogen-activated protein kinase 3 MAPK3 0.0028
4785 Ig gamma-1 chain C region IGHG1 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
862 Multidrug resistance-associated protein 1 ABCC1 0.0027
823 Fibroblast growth factor receptor 2 FGFR2 0.0027
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
1650 Heme carrier protein 1 SLC46A1 0.0026
6141 Sodium/bile acid cotransporter SLC10A1 0.0026
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
952 Dipeptidyl peptidase 4 DPP4 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
6030 Cytochrome P450 2B6 CYP2B6 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
2782 Complement C1s subcomponent C1S 0.0022
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0022
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
1898 Cytochrome P450 1B1 CYP1B1 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
822 Aldose reductase AKR1B1 0.002
1181 Alpha-1-acid glycoprotein 1 ORM1 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0019
2021 Thrombomodulin THBD 0.0016
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
4192 DNA topoisomerase 2-beta TOP2B 0.0014
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
6148 Multidrug resistance-associated protein 7 ABCC10 0.0011
6085 Fatty acid-binding protein, intestinal FABP2 0.0011
817 DNA topoisomerase 2-alpha TOP2A 0.001
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
1313 Lactoylglutathione lyase GLO1 0.0009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
6144 Solute carrier family 22 member 2 SLC22A2 0.0007
4943 Cytochrome c6 petJ 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4984 Neuroglobin NGB 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4961 Hemophore HasA hasA 0.0005
4910 Cytoglobin CYGB 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4916 Cyanoglobin glbN 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
5000 HemO hemO 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4909 CooA protein cooA 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4972 P450cin cinA 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4952 Catalase/peroxidase katA 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
4920 Peroxidase/catalase katG 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4948 Cytochrome c-553 Not Available 0.0004
2119 Cytochrome b5 CYB5A 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4990 PpcA ppcA 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
518 Peroxidase/catalase T katG 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
605 Fumarate reductase flavoprotein subunit frdA 0.0003
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0003
3673 Fumarate reductase flavoprotein subunit fccA 0.0003
4912 Fumarate reductase flavoprotein subunit ifcA 0.0003
6549 Fumarate reductase flavoprotein subunit frdA 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0003
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
7 Nitric oxide synthase, inducible NOS2 0.0002
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