DT-Web: DB00856

Identification

Name

Chlorphenesin

Accession Number

DB00856 (APRD00867)

Type

small molecule

Description

A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Muscle Relaxants, Central

Molecular Weight

202.635

Groups

approved

Monoisotopic Weight

202.039671925

Pharmacology

Indication

Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.

Mechanism of action

The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.

Absorption

Rapid and complete.

Protein binding

Not Available

Biotransformation

Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.

Route of elimination

Not Available

Toxicity

Symptoms of a chlorphenesin overdose include drowsiness and nausea.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Triprolidine	The CNS depressants, Triprolidine and Chlorphenesin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Food Interactions

Not Available

CYP2B protein
Name	CYP2B protein
Gene Name	CYP2B
Actions	inducer
References	Jarukamjorn K, Sakuma T, Nemoto N: Discriminating activation of CYP2B9 expression in male C57BL/6 mouse liver by beta-estradiol. Biochem Biophys Res Commun. 2000 Dec 9;279(1):288-92. - Pubmed Nims RW, Lubet RA, Fox SD, Jones CR, Thomas PE, Reddy AB, Kocarek TA: Comparative pharmacodynamics of CYP2B induction by DDT, DDE, and DDD in male rat liver and cultured rat hepatocytes. J Toxicol Environ Health A. 1998 Mar 27;53(6):455-77. - Pubmed
DTHybrid score	0.2586
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inducer
References	Holloway AC, Stys KA, Foster WG: DDE-induced changes in aromatase activity in endometrial stromal cells in culture. Endocrine. 2005 Jun;27(1):45-50. - Pubmed Younglai EV, Holloway AC, Lim GE, Foster WG: Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity. Hum Reprod. 2004 May;19(5):1089-93. Epub 2004 Apr 7. - Pubmed
DTHybrid score	0.3675
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inducer
References	Medina-Diaz IM, Arteaga-Illan G, de Leon MB, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G: Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane. Drug Metab Dispos. 2007 Jan;35(1):95-102. Epub 2006 Oct 11. - Pubmed Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brosen K: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):202-6. Epub 2007 Jul 14. - Pubmed
DTHybrid score	0.3893
Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	inhibitor
References	Springer RH, Dimmitt MK, Novinson T, O'Brien DE, Robins RK, Simon LN, Miller JP: Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo(1,5-alpha)pyrimidines. J Med Chem. 1976 Feb;19(2):291-6. - Pubmed
DTHybrid score	0.443
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Actions	inhibitor
References	Fernandez P, Guillen MI, Gomar F, Aller E, Molina P, Alcaraz MJ: A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in osteoarthritis. Biochem Pharmacol. 2004 Aug 1;68(3):417-21. - Pubmed
DTHybrid score	0.4174
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Actions	inducer
References	Westlake GE, Bunyan PJ, Stanley PI, Walker CH: The effects of 1,1-di(p-chlorophenyl)-2-chloroethylene on plasma enzymes and blood constituents in the Japanese quail. Chem Biol Interact. 1979 May;25(2-3):197-210. - Pubmed
DTHybrid score	0.6115

Id	Partner name	Gene Name	Score
20	Prostaglandin G/H synthase 1	PTGS1	0.1912
1588	Multidrug resistance protein 1	ABCB1	0.1316
4757	Cytochrome P450 2C9	CYP2C9	0.1269
4200	Cytochrome P450 1A2	CYP1A2	0.1253
4119	Cytochrome P450 2D6	CYP2D6	0.1108
474	Acetylcholinesterase	ACHE	0.1004
6016	Cytochrome P450 2C19	CYP2C19	0.093
4118	Cytochrome P450 3A5	CYP3A5	0.0804
6030	Cytochrome P450 2B6	CYP2B6	0.0792
146	Androgen receptor	AR	0.0755
103	Muscarinic acetylcholine receptor M1	CHRM1	0.071
4924	Cytochrome P450 2C8	CYP2C8	0.0679
6013	Cytochrome P450 2E1	CYP2E1	0.064
587	Serum albumin	ALB	0.0592
492	Histamine H1 receptor	HRH1	0.0573
6107	Cytochrome P450 3A7	CYP3A7	0.0521
824	Sodium-dependent serotonin transporter	SLC6A4	0.0437
136	Estrogen receptor	ESR1	0.0422
6020	Aldehyde oxidase	AOX1	0.0417
1898	Cytochrome P450 1B1	CYP1B1	0.041
1729	Solute carrier family 22 member 6	SLC22A6	0.0408
6142	Solute carrier family 22 member 8	SLC22A8	0.0407
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0355
713	Sodium-dependent dopamine transporter	SLC6A3	0.0353
6024	Cytochrome P450 1A1	CYP1A1	0.0351
5718	Cytochrome P450 2A6	CYP2A6	0.035
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0335
1757	Myeloperoxidase	MPO	0.0322
556	Alpha-1A adrenergic receptor	ADRA1A	0.0321
871	Glucocorticoid receptor	NR3C1	0.0314
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.031
756	Sex hormone-binding globulin	SHBG	0.0303
766	Beta-2 adrenergic receptor	ADRB2	0.0303
275	Arachidonate 5-lipoxygenase	ALOX5	0.0288
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0285
260	Cytochrome P450 51	ERG11	0.0283
761	Cytochrome P450 51	ERG11	0.0283
3163	Cytochrome P450 51	cyp51	0.0283
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0282
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0278
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0267
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0256
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0245
614	Progesterone receptor	PGR	0.0241
3941	Amine oxidase [flavin-containing] A	MAOA	0.0237
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0236
6143	Solute carrier family 22 member 7	SLC22A7	0.0232
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0226
3823	Cytokine receptor common gamma chain	IL2RG	0.0223
3939	Amine oxidase [flavin-containing] B	MAOB	0.0218
318	Alpha-2A adrenergic receptor	ADRA2A	0.0217
563	Thyroid peroxidase	TPO	0.0213
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0212
2164	Multidrug resistance-associated protein 4	ABCC4	0.021
4116	Dihydropteroate synthetase	Not Available	0.0209
831	D(2) dopamine receptor	DRD2	0.0205
226	Gonadotropin-releasing hormone receptor	GNRHR	0.02
724	Interleukin-2 receptor alpha chain	IL2RA	0.0195
717	Interleukin-2 receptor subunit beta	IL2RB	0.0194
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0194
6145	Solute carrier family 22 member 1	SLC22A1	0.0193
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0193
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
896	Glutathione S-transferase Mu 1	GSTM1	0.0191
3076	Antigen 85-C	fbpC	0.0187
1159	Interleukin-6	IL6	0.0185
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0183
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0182
862	Multidrug resistance-associated protein 1	ABCC1	0.0177
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0176
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0174
6144	Solute carrier family 22 member 2	SLC22A2	0.0174
1405	Thiopurine S-methyltransferase	TPMT	0.0172
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0171
632	Alpha-1B adrenergic receptor	ADRA1B	0.0167
63	Malate dehydrogenase	mdh	0.0165
2329	Malate dehydrogenase	mdh	0.0165
3445	Malate dehydrogenase	mdh	0.0165
4420	Malate dehydrogenase	mdh	0.0165
4438	Malate dehydrogenase	mdh	0.0165
723	Cytosolic phospholipase A2	PLA2G4A	0.0162
232	Corticosteroid-binding globulin	SERPINA6	0.0162
833	Organic cation/carnitine transporter 1	SLC22A4	0.0162
776	Bile salt export pump	ABCB11	0.0159
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0156
327	Glutathione reductase	gor	0.0156
5110	Glutathione reductase	GR2	0.0156
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0154
6106	Cytochrome P450 2C18	CYP2C18	0.015
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
1024	Solute carrier family 22 member 11	SLC22A11	0.0145
465	Calmodulin	CALM1	0.0141
3454	Esterase	estA	0.0141
847	Mu-type opioid receptor	OPRM1	0.014
6137	Multidrug resistance-associated protein 6	ABCC6	0.014
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0139
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
373	Transthyretin	TTR	0.0131
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0126
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0125
468	Cytochrome P450 4A11	CYP4A11	0.0125
6136	Multidrug resistance-associated protein 5	ABCC5	0.0125
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
6044	Serum paraoxonase/lactonase 3	PON3	0.0121
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0121
777	Tumor necrosis factor	TNF	0.0121
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0121
3932	Glutathione S-transferase A2	GSTA2	0.012
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0118
6220	Aryl hydrocarbon receptor	AHR	0.0116
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0115
737	Mineralocorticoid receptor	NR3C2	0.0114
908	Glutathione S-transferase theta-1	GSTT1	0.0114
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
3312	Fatty acid-binding protein, brain	FABP7	0.0113
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0111
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
904	Glutathione S-transferase P	GSTP1	0.0108
6163	Copper-transporting ATPase 2	ATP7B	0.0108
6165	Copper-transporting ATPase 1	ATP7A	0.0108
638	D(3) dopamine receptor	DRD3	0.0108
4031	Glutathione S-transferase A1	GSTA1	0.0108
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0108
6146	High affinity copper uptake protein 1	SLC31A1	0.0107
244	Angiotensin-converting enzyme	ACE	0.0106
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0106
6148	Multidrug resistance-associated protein 7	ABCC10	0.0103
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0102
869	Estrogen receptor beta	ESR2	0.0102
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.01
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.01
1439	Lactotransferrin	LTF	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
118	Organic cation/carnitine transporter 2	SLC22A5	0.0099
124	Histamine H2 receptor	HRH2	0.0098
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0097
185	Vasopressin V1a receptor	AVPR1A	0.0096
4604	Liver carboxylesterase 1	CES1	0.0096
817	DNA topoisomerase 2-alpha	TOP2A	0.0094
322	Vasopressin V2 receptor	AVPR2	0.0094
23	D(1A) dopamine receptor	DRD1	0.0094
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0093
629	Alpha-2B adrenergic receptor	ADRA2B	0.0092
6859	Protein S100-A4	S100A4	0.0091
144	Hemoglobin subunit alpha	HBA1	0.0091
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.009
380	Cytochrome P450 17A1	CYP17A1	0.0089
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0088
1178	Adenosine A2a receptor	ADORA2A	0.0088
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0088
467	Delta-type opioid receptor	OPRD1	0.0088
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0087
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0087
6168	Solute carrier family 22 member 16	SLC22A16	0.0087
731	HIV-1 protease	HIV-1 protease	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
6147	Solute carrier family 22 member 3	SLC22A3	0.0081
3957	Adenosine deaminase	ADA	0.0081
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.008
4120	NADPH--cytochrome P450 reductase	POR	0.0079
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0078
449	Ornithine decarboxylase	ODC1	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
85	Growth hormone receptor	GHR	0.0077
703	NADPH azoreductase	azr	0.0076
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0075
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0073
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0073
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0073
459	Retinoic acid receptor RXR-alpha	RXRA	0.0072
6043	Putative G-protein coupled receptor 44	GPR44	0.0072
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0071
1649	Small inducible cytokine A2	CCL2	0.007
850	Vasopressin V1b receptor	AVPR1B	0.007
291	Nitric-oxide synthase, endothelial	NOS3	0.0069
6031	Cytochrome P450 3A43	CYP3A43	0.0069
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0069
6171	Solute carrier family 28 member 3	SLC28A3	0.0068
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0068
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0066
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0066
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0066
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0066
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0066
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0064
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0062
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0062
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0061
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.006
1010	Cytochrome P450 51A1	CYP51A1	0.006
29	Tubulin beta-1 chain	TUBB1	0.006
3814	Complement C1r subcomponent	C1R	0.006
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
4192	DNA topoisomerase 2-beta	TOP2B	0.0059
2782	Complement C1s subcomponent	C1S	0.0059
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0058
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0058
193	Beta-1 adrenergic receptor	ADRB1	0.0058
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0057
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0057
131	Synaptic vesicular amine transporter	SLC18A2	0.0056
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0056
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0056
1648	Elastin	ELN	0.0056
780	Retinoic acid receptor RXR-gamma	RXRG	0.0056
696	Kappa-type opioid receptor	OPRK1	0.0055
3815	Complement C1q subcomponent subunit A	C1QA	0.0055
3817	Complement C1q subcomponent subunit C	C1QC	0.0055
3816	Complement C1q subcomponent subunit B	C1QB	0.0055
1374	Natriuretic peptides B	NPPB	0.0055
1827	Gap junction alpha-1 protein	GJA1	0.0055
1908	Vascular cell adhesion protein 1	VCAM1	0.0055
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0055
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0055
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0055
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0055
3809	Estrogen-related receptor gamma	ESRRG	0.0054
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0054
551	Carnitine O-acetyltransferase	CRAT	0.0054
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0054
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0053
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0053
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0053
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0052
6141	Sodium/bile acid cotransporter	SLC10A1	0.0052
828	Phenylalanine-4-hydroxylase	PAH	0.0052
3109	Phenylalanine-4-hydroxylase	phhA	0.0052
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0052
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0051
844	Epidermal growth factor receptor	EGFR	0.0051
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0051
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0051
88	Retinoic acid receptor RXR-beta	RXRB	0.005
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.005
400	Coagulation factor IX	F9	0.005
5461	Coagulation factor IX	F9	0.005
564	Cellular retinoic acid-binding protein 1	CRABP1	0.005
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.005
6102	Arylamine N-acetyltransferase 2	NAT2	0.005
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.005
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.005
5934	Cytochrome P450 26A1	CYP26A1	0.0049
634	Squalene monooxygenase	SQLE	0.0048
7196	Squalene monooxygenase	ERG1	0.0048
738	Monocarboxylate transporter 1	SLC16A1	0.0048
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0048
183	Vascular endothelial growth factor A	VEGFA	0.0048
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0047
789	Alpha-1D adrenergic receptor	ADRA1D	0.0047
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0047
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0046
604	Vitamin K-dependent protein Z	PROZ	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
7	Nitric oxide synthase, inducible	NOS2	0.0046
130	Prostacyclin synthase	PTGIS	0.0044
229	Retinoic acid receptor beta	RARB	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0042
730	Retinoic acid receptor alpha	RARA	0.0042
422	Vitamin K-dependent protein C	PROC	0.0042
1245	Vitamin K-dependent protein S	PROS1	0.0042
378	Alpha-2C adrenergic receptor	ADRA2C	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
162	Retinoic acid receptor gamma-1	RARG	0.0041
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0041
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
725	5-hydroxytryptamine 1D receptor	HTR1D	0.004
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.004
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.004
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0039
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
273	Apoptosis regulator Bcl-2	BCL2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1852	Microtubule-associated protein 2	MAP2	0.0039
1192	Sulfotransferase 1A1	SULT1A1	0.0039
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0038
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0037
6014	Cytochrome P450 2A13	CYP2A13	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0037
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0037
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0037
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0037
6182	Cytochrome P450 2J2	CYP2J2	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
4787	Envelope glycoprotein gp160	env	0.0036
4820	Envelope glycoprotein gp160	env	0.0036
5727	Envelope glycoprotein gp160	env	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0035
856	Vitamin D3 receptor	VDR	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
239	Coagulation factor X	F10	0.0035
798	Osteocalcin	BGLAP	0.0035
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0035
6131	Carbonic anhydrase 14	CA14	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6500	Phospholipase A2	PLA2G1B	0.0035
811	Translocator protein	TSPO	0.0035
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0034
3830	Calreticulin	CALR	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0034
1714	Mitogen-activated protein kinase 3	MAPK3	0.0033
76	Nitric-oxide synthase, brain	NOS1	0.0033
814	Ryanodine receptor 1	RYR1	0.0033
759	Free fatty acid receptor 1	FFAR1	0.0032
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0032
6033	High affinity interleukin-8 receptor A	CXCR1	0.0032
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0032
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0032
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0032
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0032
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0032
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0032
489	Monocarboxylate transporter 2	SLC16A7	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0032
823	Fibroblast growth factor receptor 2	FGFR2	0.0032
369	Coagulation factor VII	F7	0.0032
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0032
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0032
6035	Nuclear receptor ROR-beta	RORB	0.0032
6034	Hydroxyindole O-methyltransferase	ASMT	0.0032
6036	Eosinophil peroxidase	EPX	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0031
432	D(4) dopamine receptor	DRD4	0.0031
5923	Microtubule-associated protein tau	MAPT	0.0031
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0031
5924	Microtubule-associated protein 4	MAP4	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
3810	Catechol O-methyltransferase	COMT	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3437	Eosinophil lysophospholipase	CLC	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
54	Prothrombin	F2	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
3601	Dihydropteroate synthase 1	folP1	0.003
3807	Dihydropteroate synthase 1	folP1	0.003
3808	Dihydropteroate synthase 2	folP2	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.003
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.003
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0029
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0029
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0029
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0028
2236	Casein kinase II subunit alpha	CSNK2A1	0.0028
6149	Solute carrier family 22 member 10	SLC22A10	0.0028
1053	BC269730_2	FADS1	0.0028
1395	Sodium/calcium exchanger 1	SLC8A1	0.0028
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
765	Indoleamine 2,3-dioxygenase	IDO1	0.0027
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0027
295	Carbonic anhydrase 1	CA1	0.0027
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0026
2207	Rhodopsin	RHO	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
267	Plasminogen activator inhibitor 1	SERPINE1	0.0026
1650	Heme carrier protein 1	SLC46A1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0025
469	Annexin A1	ANXA1	0.0025
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0025
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0025
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0025
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0025
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0025
310	Solute carrier family 12 member 2	SLC12A2	0.0024
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0024
84	Nuclear receptor 0B1	NR0B1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6221	Steroid hormone receptor ERR1	ESRRA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0024
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0024
6167	Organic solute transporter subunit beta	OSTB	0.0024
6166	Organic solute transporter subunit alpha	OSTA	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
822	Aldose reductase	AKR1B1	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
605	Fumarate reductase flavoprotein subunit	frdA	0.0022
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0022
3673	Fumarate reductase flavoprotein subunit	fccA	0.0022
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0022
6549	Fumarate reductase flavoprotein subunit	frdA	0.0022
504	Mast/stem cell growth factor receptor	KIT	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0022
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0022
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0022
4785	Ig gamma-1 chain C region	IGHG1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
163	D(1B) dopamine receptor	DRD5	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0021
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
2268	Cholesterol oxidase	choB	0.002
2822	Cholesterol oxidase	choA	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
1275	Estrogen sulfotransferase	SULT1E1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0017
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0017
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0017
3927	Choline transporter-like protein 3	SLC44A3	0.0017
861	Choline kinase alpha	CHKA	0.0017
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0017
769	High-affinity choline transporter 1	SLC5A7	0.0017
700	Choline dehydrogenase, mitochondrial	CHDH	0.0017
1686	Choline transporter-like protein 1	SLC44A1	0.0017
3926	Choline transporter-like protein 2	SLC44A2	0.0017
3925	Choline transporter-like protein 4	SLC44A4	0.0017
576	Choline O-acetyltransferase	CHAT	0.0017
3922	Phospholipase D2	PLD2	0.0017
3924	Phospholipase D1	PLD1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0017
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0017
6085	Fatty acid-binding protein, intestinal	FABP2	0.0017
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
2021	Thrombomodulin	THBD	0.0016
597	Dihydropteridine reductase	QDPR	0.0016
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
173	Toll-like receptor 7	TLR7	0.0016
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0015
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0015
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
427	Substance-P receptor	TACR1	0.0015
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0015
1629	Transcription factor AP-1	JUN	0.0015
3102	Flavohemoprotein	hmp	0.0015
4969	Flavohemoprotein	hmp	0.0015
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
365	Dihydrofolate reductase	DHFR	0.0015
2381	Dihydrofolate reductase	DFR1	0.0015
2833	Dihydrofolate reductase	Not Available	0.0015
2931	Dihydrofolate reductase	folA	0.0015
3544	Dihydrofolate reductase	folA	0.0015
3682	Dihydrofolate reductase	folA	0.0015
6642	Dihydrofolate reductase	folA	0.0015
6756	Dihydrofolate reductase	dfrA	0.0015
1541	Metalloproteinase	mmp20	0.0014
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0014
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0013
4122	Histone deacetylase 2	HDAC2	0.0013
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
4486	Phenol 2-hydroxylase component B	pheA2	0.0013
4439	Ferredoxin reductase	bphA4	0.0013
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0013
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0013
5117	Dihydrolipoyl dehydrogenase	lpd	0.0013
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
473	L-lactate dehydrogenase A chain	LDHA	0.0013
4608	Putative cytochrome P450	SCO1207	0.0013
4963	Putative cytochrome P450	SCO2884	0.0013
6254	Putative cytochrome P450	SCO6998	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4498	Ornithine cyclodeaminase	PP3533	0.0012
16	Adenosine A1 receptor	ADORA1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
6042	Prostaglandin reductase 2	PTGR2	0.0012
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0012
5122	Mersacidin decarboxylase	mrsD	0.0012
526	Thioredoxin reductase	trxB	0.0012
3767	Thioredoxin reductase	trxB	0.0012
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0012
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0012
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0012
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0012
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0012
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0012
5115	FkbI	fkbI	0.0012
3133	UDP-galactopyranose mutase	glf	0.0012
5099	UDP-galactopyranose mutase	glf	0.0012
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0012
5095	Putidaredoxin reductase	camA	0.0012
5083	Cryptochrome DASH	cry	0.0012
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0012
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5081	L-aspartate oxidase	nadB	0.0012
5111	Phenylacetone monooxygenase	pamO	0.0012
1410	Oxidoreductase	HSD17B6	0.0012
4725	Oxidoreductase	Not Available	0.0012
5124	Oxidoreductase	Not Available	0.0012
5109	Outer membrane protein p64k or PM-6	m-6	0.0012
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
5449	Hypothetical gliding protein	mglB	0.0012
5443	UPF0189 protein ymdB	ymdB	0.0012
5440	UPF0067 protein yebR	yebR	0.0012
4705	Manganese catalase	Not Available	0.0012
5439	33 kDa chaperonin	hslO	0.0012
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0012
2720	Copper-containing nitrite reductase	nirK	0.0012
5448	Ribonuclease Z	rnz	0.0012
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0012
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0012
5454	Internalin-A	inlA	0.0012
332	Beta-lactamase	blaZ	0.0012
2478	Beta-lactamase	ampC	0.0012
2613	Beta-lactamase	ampC	0.0012
2635	Beta-lactamase	ampC	0.0012
2700	Beta-lactamase	penP	0.0012
5445	Beta-lactamase	blaB	0.0012
6019	Beta-lactamase	SHV-7	0.0012
6701	Beta-lactamase	cphA	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0011
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0011
921	Glutamate receptor 2	GRIA2	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4440	NADH peroxidase	npr	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0011
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0011
5072	N,N-dimethylglycine oxidase	dmg	0.0011
5073	Ferredoxin--NADP reductase	petH	0.0011
5076	Ferredoxin--NADP reductase	fpr	0.0011
5119	Ferredoxin--NADP reductase	petH	0.0011
5121	Ferredoxin--NADP reductase	fpr	0.0011
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0011
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0011
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0011
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0011
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0011
2526	NADPH-ferredoxin reductase fprA	fprA	0.0011
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0011
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0011
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0011
2470	Pyruvate oxidase	pox5	0.0011
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0011
5450	Prolyl endopeptidase Pep	pep	0.0011
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.001
3356	Diaminopimelate decarboxylase	lysA	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4771	Dissimilatory copper-containing nitrite reductase	nir	0.001
3274	Hydroxylamine reductase	hcp	0.001
4804	Hydroxylamine reductase	hcp	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2714	Chorismate mutase	aroH	0.001
4611	Chorismate mutase	aroG	0.001
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
126	D-lactate dehydrogenase	dld	0.001
3545	D-lactate dehydrogenase	Not Available	0.001
4510	D-lactate dehydrogenase	ldhA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
518	Peroxidase/catalase T	katG	0.001
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.001
2893	Glycine oxidase	thiO	0.001
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.001
3399	Limonene-1,2-epoxide hydrolase	limA	0.001
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.001
1313	Lactoylglutathione lyase	GLO1	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0009
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0009
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0009
2567	Thymidylate synthase thyX	thyX	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
5180	L(+)-mandelate dehydrogenase	mdlB	0.0009
3086	Plasmepsin-2	Not Available	0.0009
2823	Trypanothione reductase	TPR	0.0009
577	Argininosuccinate lyase	ASL	0.0009
3500	Putative family 31 glucosidase yicI	yicI	0.0009
4878	Glycoprotein hormones alpha chain	CGA	0.0009
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0009
165	FL cytokine receptor	FLT3	0.0009
1072	Granzyme B	GZMB	0.0009
4889	Ig epsilon chain C region	IGHE	0.0009
4877	Beta-mannanase	man	0.0009
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0009
4189	Alpha-galactosidase A	GLA	0.0009
4850	Beta-2-glycoprotein 1	APOH	0.0009
4880	Membrane cofactor protein	CD46	0.0009
4856	CD209 antigen	CD209	0.0009
1354	Beta-glucuronidase	GUSB	0.0009
757	Fusion glycoprotein F0	F	0.0009
4875	Fusion glycoprotein F0	F	0.0009
4869	Major capsid protein	A430L	0.0009
4852	Reticulon-4 receptor	RTN4R	0.0009
4845	ADAM 33	ADAM33	0.0009
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0009
442	Envelope glycoprotein	gp41	0.0009
4859	Envelope glycoprotein	env	0.0009
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0009
4721	Beta-1,4-mannanase	manA	0.0009
3352	Structural polyprotein	Not Available	0.0009
3628	Structural polyprotein	Not Available	0.0009
4892	Structural polyprotein	Not Available	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
2769	P-hydroxybenzoate hydroxylase	pobA	0.0009
2809	P-hydroxybenzoate hydroxylase	pobA	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
1615	Chymase	CMA1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
2298	Cytochrome P450-cam	camC	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2380	Monomeric sarcosine oxidase	soxA	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
251	Alcohol dehydrogenase 1A	ADH1A	0.0008
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
6645	D-amino-acid oxidase	DAO	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4861	Interleukin-6 receptor alpha chain	IL6R	0.0008
793	T-cell surface antigen CD2	CD2	0.0008
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0008
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0008
3837	Cytokine receptor common beta chain	CSF2RB	0.0008
6432	Transporter	snf	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0007
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
4890	Hemagglutinin	HA	0.0007
6566	Hemagglutinin	Not Available	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
1379	Interleukin-12 subunit beta	IL12B	0.0007
810	Heme oxygenase 1	HMOX1	0.0007
3391	Heme oxygenase 1	pbsA1	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
6858	Inactive carboxylesterase 4	CES1P1	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1184	Interferon beta	IFNB1	0.0007
816	Biliverdin reductase A	BLVRA	0.0007
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0007
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0007
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0007
164	Histamine H4 receptor	HRH4	0.0007
125	DNA polymerase beta	POLB	0.0007
1618	High affinity nerve growth factor receptor	NTRK1	0.0007
4311	tRNA	TRDMT1	0.0007
4325	tRNA	trmD	0.0007
4328	tRNA	trmD	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
517	Alcohol dehydrogenase 1C	ADH1C	0.0006
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
554	Low-density lipoprotein receptor	LDLR	0.0006
852	Heparin cofactor 2	SERPIND1	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0006
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0006
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0006
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0006
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0006
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0006
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0006
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0006
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0006
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0006
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0006
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0006
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0006
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0006
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0006
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0006
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0006
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0006
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0006
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0006
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0006
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0006
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0006
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0006
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0006
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0006
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0006
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0006
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0006
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0006
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0006
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0006
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0006
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0006
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0006
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0006
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0006
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0006
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0006
729	GDP-L-fucose synthetase	TSTA3	0.0006
3463	GDP-L-fucose synthetase	fcl	0.0006
167	L-lactate dehydrogenase C chain	LDHC	0.0006
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0006
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0006
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0006
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0006
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0006
206	3-keto-steroid reductase	HSD17B7	0.0006
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0006
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0006
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0006
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0006
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0006
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0006
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0006
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0006
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0006
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0006
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0006
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0006
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0006
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0006
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0006
34	7-dehydrocholesterol reductase	DHCR7	0.0006
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0006
711	UDP-glucose 6-dehydrogenase	UGDH	0.0006
3672	UDP-glucose 6-dehydrogenase	hasB	0.0006
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0006
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0006
107	C-4 methylsterol oxidase	SC4MOL	0.0006
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0006
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0006
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0006
643	Peroxisomal bifunctional enzyme	EHHADH	0.0006
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
1859	Prostatic acid phosphatase	ACPP	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
3444	Cyanovirin-N	Not Available	0.0006
3140	Hemagglutinin-neuraminidase	HN	0.0006
3609	Hemagglutinin-neuraminidase	HN	0.0006
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0006
595	Fibrinogen alpha chain	FGA	0.0006
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0006
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0006
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0006
328	Sorbitol dehydrogenase	SORD	0.0006
396	Alcohol dehydrogenase 4	ADH4	0.0006
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4984	Neuroglobin	NGB	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
3116	Bacterioferritin	bfr	0.0006
4906	Bacterioferritin	bfr	0.0006
4965	Bacterioferritin	bfr	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
5000	HemO	hemO	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4972	P450cin	cinA	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4952	Catalase/peroxidase	katA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0006
666	NADP-dependent malic enzyme	ME1	0.0006
857	Malate dehydrogenase, mitochondrial	MDH2	0.0005
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0005
4666	Fucose-binding lectin PA-IIL	lecB	0.0005
4210	Toll-like receptor 4	TLR4	0.0005
2372	Bifunctional tail protein	9	0.0005
77	L-lactate dehydrogenase B chain	LDHB	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
12	Alcohol dehydrogenase class 3	ADH5	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
958	Insulin-like growth factor 1 receptor	IGF1R	0.0005
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0005
6026	Alcohol dehydrogenase 6	ADH6	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0005
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0005
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0005
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0005
626	Cysteine dioxygenase type 1	CDO1	0.0005
627	11-cis retinol dehydrogenase	RDH5	0.0005
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0005
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0005
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0005
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0005
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
13	Aminomethyltransferase, mitochondrial	AMT	0.0005
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
64	Neuraminidase	NA	0.0005
641	Neuraminidase	NA	0.0005
2676	Neuraminidase	NA	0.0005
3026	Neuraminidase	NA	0.0005
3519	Neuraminidase	NA	0.0005
6007	Neuraminidase	NA	0.0005
1243	Cathepsin D	CTSD	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0005
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0005
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0005
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0005
309	Antithrombin-III	SERPINC1	0.0005
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
279	Tyrosinase	TYR	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
654	Flavin reductase	BLVRB	0.0004
4920	Peroxidase/catalase	katG	0.0004
2430	Chondroitinase B	cslB	0.0004
6307	Ig gamma-2 chain C region	IGHG2	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
4923	Cytochrome c3	DvMF_2499	0.0004
4945	Cytochrome c3	Not Available	0.0004
4949	Cytochrome c3	DVU_3171	0.0004
4968	Cytochrome c3	cytc3	0.0004
4997	Cytochrome c3	SO_2727	0.0004
5219	Cytochrome c3	cyd	0.0004
4948	Cytochrome c-553	Not Available	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
3189	High-molecular-weight cytochrome c	hmcA	0.0004
4902	Nine-heme cytochrome c	Ddes_2038	0.0004
4990	PpcA	ppcA	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
319	Opioid receptor, sigma 1	OPRS1	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
2581	Chondroitinase AC	cslA	0.0004
6847	Lactase-phlorizin hydrolase	LCT	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
976	Platelet glycoprotein IX	GP9	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
4386	Hemoglobin-like protein HbN	glbN	0.0004
174	Sigma 1-type opioid receptor	SIGMAR1	0.0004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
3127	Nitrite reductase	nirS	0.0003
3284	Nitrite reductase	nirS	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
3221	Cytochrome c4	cc4	0.0003
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1507	Cytochrome c	CYCS	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
751	Potassium channel subfamily K member 6	KCNK6	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
172	Potassium channel subfamily K member 1	KCNK1	0.0002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00856 - Chlorphenesin

Enzymes

Predictions