DT-Web: DB01183

Identification
Name	Naloxone
Accession Number	DB01183 (APRD00025)
Type	small molecule
Description	A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Antidotes Antinarcotic Agents Narcotic Antagonists Depressants Opiate Antagonists
Molecular Weight	327.3743
Groups	approved
Monoisotopic Weight	327.147058165
Pharmacology
Indication	For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
Mechanism of action	While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
Absorption	Well absorbed following intramuscular injection.
Protein binding	Plasma protein binding occurs but is relatively weak. Plasma albumin is the major binding constituent but significant binding of naloxone also occurs to plasma constituents other than albumin.
Biotransformation	Naloxone is hepatically metabolized and primarily undergoes glucuronidation to form naloxone-3-glucuronide.
Route of elimination	Urine (25%- 40% is excreted as metabolites within 6 hours)
Toxicity	LD50, IV administration, mouse = 150 ? 5 mg/kg; LD50, IV administration, rat = 109 ? 4 mg/kg;
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	yes
Actions	antagonist
References	Narita M, Suzuki M, Mizoguchi H, Narita M, Yajima Y, Sakurada S, Tseng LF, Suzuki T: Up-regulation of mu-opioid receptor-mediated G-protein activation in protein kinase Cgamma knockout mice following repeated naloxone treatment. Neurosci Lett. 2003 Feb 27;338(2):103-6. - Pubmed Freye E, Latasch L, Von Bredow G, Neruda B: [The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison] Schmerz. 1998 Feb 28;12(1):19-24. - Pubmed Neal CR Jr, Owens CE, Taylor LP, Hoversten MT, Akil H, Watson SJ Jr: Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors. J Chem Neuroanat. 2003 Jul;25(4):233-47. - Pubmed Spetea M, Toth F, Schutz J, Otvos F, Toth G, Benyhe S, Borsodi A, Schmidhammer H: Binding characteristics of [3H]14-methoxymetopon, a high affinity mu-opioid receptor agonist. Eur J Neurosci. 2003 Jul;18(2):290-5. - Pubmed Marek GJ: Behavioral evidence for mu-opioid and 5-HT2A receptor interactions. Eur J Pharmacol. 2003 Aug 1;474(1):77-83. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed Goodman AJ, Le Bourdonnec B, Dolle RE: Mu opioid receptor antagonists: recent developments. ChemMedChem. 2007 Nov;2(11):1552-70. - Pubmed van Dorp EL, Yassen A, Dahan A: Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32. - Pubmed
DTHybrid score	1.0315
Delta-type opioid receptor
Name	Delta-type opioid receptor
Gene Name	OPRD1
Pharmacological action	yes
Actions	antagonist
References	Moncada A, Cendan CM, Baeyens JM, Del Pozo E: Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice. Eur J Pharmacol. 2003 Mar 28;465(1-2):53-60. - Pubmed Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL: Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr;98(4):862-70. - Pubmed Breljak D, Boranic M, Horvat S: Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation. Int J Immunopathol Pharmacol. 2000 Jan;13(1):13-19. - Pubmed Chudapongse N, Kim SY, Kramer RE, Ho IK: Nonspecific effects of the selective kappa-opioid receptor agonist U-50,488H on dopamine uptake and release in PC12 cells. J Pharmacol Sci. 2003 Nov;93(3):372-5. - Pubmed Osman AM, Gomma M, Saad AH: A possible role for an enkephalinergic system in the internal defense mechanism of Biomphalaria alexandrina exposed to Schistosoma mansoni. J Egypt Soc Parasitol. 2003 Dec;33(3):841-61. - Pubmed Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed van Dorp EL, Yassen A, Dahan A: Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32. - Pubmed
DTHybrid score	0.8569
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	yes
Actions	antagonist
References	Peng X, Neumeyer JL: Kappa receptor bivalent ligands. Curr Top Med Chem. 2007;7(4):363-73. - Pubmed van Dorp EL, Yassen A, Dahan A: Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32. - Pubmed Helm S, Trescot AM, Colson J, Sehgal N, Silverman S: Opioid antagonists, partial agonists, and agonists/antagonists: the role of office-based detoxification. Pain Physician. 2008 Mar-Apr;11(2):225-35. - Pubmed
DTHybrid score	0.8332
cAMP response element-binding protein
Name	cAMP response element-binding protein
Gene Name	CREB1
Pharmacological action	no
Actions	other/unknown
References	Li J, Li YH, Yuan XR: Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal. Acta Pharmacol Sin. 2003 Sep;24(9):930-6. - Pubmed Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA Jr: Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003 Oct;87(1):107-18. - Pubmed Gao C, Chen LW, Tao YM, Chen J, Xu XJ, Chi ZQ: Effects of ohmefentanyl stereoisomers on phosphorylation of cAMP- response element binding protein in cultured rat hippocampal neurons. Acta Pharmacol Sin. 2003 Dec;24(12):1253-8. - Pubmed Walters CL, Cleck JN, Kuo YC, Blendy JA: Mu-opioid receptor and CREB activation are required for nicotine reward. Neuron. 2005 Jun 16;46(6):933-43. - Pubmed Hawes JJ, Narasimhaiah R, Picciotto MR: Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. J Neurochem. 2006 Feb;96(4):1160-8. Epub 2006 Jan 17. - Pubmed
DTHybrid score	0.1916
Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	no
Actions	antagonist,other/unknown
References	Farooqui M, Geng ZH, Stephenson EJ, Zaveri N, Yee D, Gupta K: Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006 Mar;5(3):611-20. - Pubmed
DTHybrid score	0.7743
Toll-like receptor 4
Name	Toll-like receptor 4
Gene Name	TLR4
Pharmacological action	unknown
Actions	inhibitor
References	Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR: (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. J Pain. 2012 May;13(5):498-506. doi: 10.1016/j.jpain.2012.02.005. Epub 2012 Apr 20. - Pubmed
DTHybrid score	0.2782

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3295
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6179

Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ: Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther. 2000 Jul;294(1):73-9. - Pubmed
DTHybrid score	0.2607
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score	0.457

Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.2607
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.457

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.2697
4757	Cytochrome P450 2C9	CYP2C9	0.2533
6241	Nuclear receptor coactivator 2	NCOA2	0.2312
4118	Cytochrome P450 3A5	CYP3A5	0.1928
6016	Cytochrome P450 2C19	CYP2C19	0.1792
6107	Cytochrome P450 3A7	CYP3A7	0.1615
4200	Cytochrome P450 1A2	CYP1A2	0.1516
6527	Lymphocyte antigen 96	LY96	0.1448
6524	Protein tonB	tonB	0.1335
6030	Cytochrome P450 2B6	CYP2B6	0.1283
1716	Tripartite motif-containing protein 13	TRIM13	0.115
869	Estrogen receptor beta	ESR2	0.098
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0939
2427	Ferrichrome-iron receptor	fhuA	0.0939
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0876
1262	Corticotropin-lipotropin	POMC	0.0859
6013	Cytochrome P450 2E1	CYP2E1	0.082
614	Progesterone receptor	PGR	0.0768
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0753
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0729
20	Prostaglandin G/H synthase 1	PTGS1	0.0718
6024	Cytochrome P450 1A1	CYP1A1	0.0695
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0677
3811	Cytochrome P450 19A1	CYP19A1	0.0656
1729	Solute carrier family 22 member 6	SLC22A6	0.0643
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0616
862	Multidrug resistance-associated protein 1	ABCC1	0.0595
5718	Cytochrome P450 2A6	CYP2A6	0.0588
6142	Solute carrier family 22 member 8	SLC22A8	0.0546
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0543
6145	Solute carrier family 22 member 1	SLC22A1	0.054
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0537
776	Bile salt export pump	ABCB11	0.0499
851	5'-AMP-activated protein kinase subunit beta-2	PRKAB2	0.0472
388	AMP deaminase 1	AMPD1	0.0471
871	Glucocorticoid receptor	NR3C1	0.0455
6141	Sodium/bile acid cotransporter	SLC10A1	0.0452
290	Prostaglandin G/H synthase 2	PTGS2	0.0451
824	Sodium-dependent serotonin transporter	SLC6A4	0.0439
6106	Cytochrome P450 2C18	CYP2C18	0.0436
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0424
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0401
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.04
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0399
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0399
297	Adenylate cyclase type 1	ADCY1	0.0399
4137	Nociceptin receptor	OPRL1	0.0389
6143	Solute carrier family 22 member 7	SLC22A7	0.0389
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0387
319	Opioid receptor, sigma 1	OPRS1	0.0381
2164	Multidrug resistance-associated protein 4	ABCC4	0.0368
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.036
174	Sigma 1-type opioid receptor	SIGMAR1	0.0355
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0353
756	Sex hormone-binding globulin	SHBG	0.0349
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0345
1024	Solute carrier family 22 member 11	SLC22A11	0.0343
492	Histamine H1 receptor	HRH1	0.0337
1898	Cytochrome P450 1B1	CYP1B1	0.0329
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0322
146	Androgen receptor	AR	0.0305
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0303
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0301
6021	Adenosine kinase	ADK	0.03
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0293
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0291
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0289
128	Adenine phosphoribosyltransferase	APRT	0.0289
465	Calmodulin	CALM1	0.0279
556	Alpha-1A adrenergic receptor	ADRA1A	0.0273
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0262
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0261
6144	Solute carrier family 22 member 2	SLC22A2	0.0252
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0252
891	Dihydropteroate synthase	folP	0.025
5359	Dihydropteroate synthase	folP	0.025
7175	Dihydropteroate synthase	sulI	0.025
831	D(2) dopamine receptor	DRD2	0.0249
4198	Fructose-1,6-bisphosphatase 1	FBP1	0.0248
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0248
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0238
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0237
731	HIV-1 protease	HIV-1 protease	0.0234
118	Organic cation/carnitine transporter 2	SLC22A5	0.0233
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0226
10	Glycogen phosphorylase, liver form	PYGL	0.0223
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.022
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0218
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0217
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0216
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0216
6085	Fatty acid-binding protein, intestinal	FABP2	0.0215
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0212
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0209
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0209
6228	Nuclear receptor coactivator 1	NCOA1	0.0204
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0203
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0202
318	Alpha-2A adrenergic receptor	ADRA2A	0.0195
244	Angiotensin-converting enzyme	ACE	0.0192
33	Cystine/glutamate transporter	SLC7A11	0.0187
3923	Cholinesterase	BCHE	0.0185
373	Transthyretin	TTR	0.0184
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0184
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0184
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0183
23	D(1A) dopamine receptor	DRD1	0.018
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0179
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0177
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0177
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
1389	Transforming growth factor beta-1	TGFB1	0.0169
632	Alpha-1B adrenergic receptor	ADRA1B	0.0168
380	Cytochrome P450 17A1	CYP17A1	0.0163
737	Mineralocorticoid receptor	NR3C2	0.0163
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0162
4604	Liver carboxylesterase 1	CES1	0.0161
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.016
904	Glutathione S-transferase P	GSTP1	0.0156
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0155
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0154
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0152
468	Cytochrome P450 4A11	CYP4A11	0.0151
2616	Ganglioside GM2 activator	GM2A	0.0151
260	Cytochrome P450 51	ERG11	0.0147
761	Cytochrome P450 51	ERG11	0.0147
3163	Cytochrome P450 51	cyp51	0.0147
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0146
844	Epidermal growth factor receptor	EGFR	0.0146
6148	Multidrug resistance-associated protein 7	ABCC10	0.0146
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0145
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0144
4120	NADPH--cytochrome P450 reductase	POR	0.0143
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
789	Alpha-1D adrenergic receptor	ADRA1D	0.014
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.014
6147	Solute carrier family 22 member 3	SLC22A3	0.0139
738	Monocarboxylate transporter 1	SLC16A1	0.0139
2528	Fatty acid metabolism regulator protein	fadR	0.0138
6740	Fatty acid metabolism regulator protein	fadR	0.0138
394	Calcineurin subunit B isoform 1	PPP3R1	0.0138
6753	Apolipoprotein M	APOM	0.0138
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0138
6742	Recoverin	RCVRN	0.0138
6743	Non-fluorescent flavoprotein	luxF	0.0138
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0138
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0138
6747	Chalcone/stilbene synthase family protein	MT1417	0.0138
6751	Gag polyprotein	gag	0.0138
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0138
6749	Polyprotein	Not Available	0.0138
193	Beta-1 adrenergic receptor	ADRB1	0.0138
6182	Cytochrome P450 2J2	CYP2J2	0.0136
6755	Poliovirus receptor	PVR	0.0136
768	FK506-binding protein 1A	FKBP1A	0.0135
766	Beta-2 adrenergic receptor	ADRB2	0.0135
6031	Cytochrome P450 3A43	CYP3A43	0.0135
833	Organic cation/carnitine transporter 1	SLC22A4	0.0133
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.0131
594	Thyroxine-binding globulin	SERPINA7	0.013
6136	Multidrug resistance-associated protein 5	ABCC5	0.0128
817	DNA topoisomerase 2-alpha	TOP2A	0.0127
70	Type-1 angiotensin II receptor	AGTR1	0.0124
3587	Gastrotropin	FABP6	0.0123
5961	Insulin	INS	0.0123
122	P2Y purinoceptor 12	P2RY12	0.0121
758	Thyroid hormone receptor alpha	THRA	0.012
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0118
3941	Amine oxidase [flavin-containing] A	MAOA	0.0117
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0117
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0116
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0115
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0115
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0113
6137	Multidrug resistance-associated protein 6	ABCC6	0.0113
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0113
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0112
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0112
6750	ADP-ribosylation factor 6	ARF6	0.0111
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0111
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0111
952	Dipeptidyl peptidase 4	DPP4	0.011
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.011
346	Thyroid hormone receptor beta-1	THRB	0.0107
2107	Microtubule-associated protein 1A	MAP1A	0.0106
2297	Genome polyprotein	Not Available	0.0106
2322	Genome polyprotein	Not Available	0.0106
2694	Genome polyprotein	Not Available	0.0106
2719	Genome polyprotein	Not Available	0.0106
2860	Genome polyprotein	Not Available	0.0106
2928	Genome polyprotein	Not Available	0.0106
3160	Genome polyprotein	Not Available	0.0106
3260	Genome polyprotein	Not Available	0.0106
4783	Genome polyprotein	Not Available	0.0106
5726	Genome polyprotein	Not Available	0.0106
5779	Genome polyprotein	Not Available	0.0106
5867	Genome polyprotein	Not Available	0.0106
6253	Genome polyprotein	Not Available	0.0106
6301	Genome polyprotein	Not Available	0.0106
6380	Genome polyprotein	Not Available	0.0106
6381	Genome polyprotein	Not Available	0.0106
6437	Genome polyprotein	Not Available	0.0106
6520	Genome polyprotein	Not Available	0.0106
6521	Genome polyprotein	Not Available	0.0106
6652	Genome polyprotein	Not Available	0.0106
6734	Genome polyprotein	Not Available	0.0106
6735	Genome polyprotein	Not Available	0.0106
6736	Genome polyprotein	Not Available	0.0106
6737	Genome polyprotein	Not Available	0.0106
6738	Genome polyprotein	Not Available	0.0106
6739	Genome polyprotein	Not Available	0.0106
6744	Genome polyprotein	Not Available	0.0106
6748	Genome polyprotein	Not Available	0.0106
6894	Genome polyprotein	Not Available	0.0106
6898	Genome polyprotein	Not Available	0.0106
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0105
1852	Microtubule-associated protein 2	MAP2	0.0104
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0104
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0103
811	Translocator protein	TSPO	0.0103
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0102
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0102
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0101
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.01
504	Mast/stem cell growth factor receptor	KIT	0.0099
6020	Aldehyde oxidase	AOX1	0.0098
6316	ADP-ribosylation factor 1	ARF1	0.0098
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
29	Tubulin beta-1 chain	TUBB1	0.0095
566	Serotransferrin	TF	0.0094
4237	50S ribosomal protein L22	rplV	0.0094
381	Prolactin receptor	PRLR	0.0093
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0093
6167	Organic solute transporter subunit beta	OSTB	0.0092
6166	Organic solute transporter subunit alpha	OSTA	0.0092
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.009
864	Gag-Pol polyprotein	gag-pol	0.009
2237	Gag-Pol polyprotein	gag-pol	0.009
2326	Gag-Pol polyprotein	gag-pol	0.009
2451	Gag-Pol polyprotein	gag-pol	0.009
2901	Gag-Pol polyprotein	gag-pol	0.009
3165	Gag-Pol polyprotein	gag-pol	0.009
3722	Gag-Pol polyprotein	gag-pol	0.009
6306	Gag-Pol polyprotein	gag-pol	0.009
6624	Gag-Pol polyprotein	gag-pol	0.009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.009
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0088
1192	Sulfotransferase 1A1	SULT1A1	0.0087
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0087
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0087
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0087
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0087
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0087
638	D(3) dopamine receptor	DRD3	0.0086
705	Glutamate receptor 1	GRIA1	0.0085
629	Alpha-2B adrenergic receptor	ADRA2B	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0085
6149	Solute carrier family 22 member 10	SLC22A10	0.0084
6102	Arylamine N-acetyltransferase 2	NAT2	0.0083
161	Tubulin beta chain	TUBB	0.0083
312	Tubulin beta chain	TUB2	0.0083
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
713	Sodium-dependent dopamine transporter	SLC6A3	0.0082
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0082
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0082
4238	50S ribosomal protein L4	rplD	0.0082
5578	50S ribosomal protein L4	rplD	0.0082
6173	50S ribosomal protein L4	rplD	0.0082
6219	50S ribosomal protein L4	rplD	0.0082
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
558	Solute carrier family 12 member 1	SLC12A1	0.0082
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0081
199	Monocarboxylate transporter 8	SLC16A2	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.008
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0079
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0079
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
1517	Beta-3 adrenergic receptor	ADRB3	0.0078
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
469	Annexin A1	ANXA1	0.0076
1618	High affinity nerve growth factor receptor	NTRK1	0.0075
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0075
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0075
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0074
378	Alpha-2C adrenergic receptor	ADRA2C	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0073
474	Acetylcholinesterase	ACHE	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
482	Glycine receptor subunit alpha-1	GLRA1	0.0072
407	Vascular endothelial growth factor receptor 2	KDR	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0071
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
6043	Putative G-protein coupled receptor 44	GPR44	0.0071
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
3932	Glutathione S-transferase A2	GSTA2	0.007
365	Dihydrofolate reductase	DHFR	0.0069
2381	Dihydrofolate reductase	DFR1	0.0069
2833	Dihydrofolate reductase	Not Available	0.0069
2931	Dihydrofolate reductase	folA	0.0069
3544	Dihydrofolate reductase	folA	0.0069
3682	Dihydrofolate reductase	folA	0.0069
6642	Dihydrofolate reductase	folA	0.0069
6756	Dihydrofolate reductase	dfrA	0.0069
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0069
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0069
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0069
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0068
24	Thymidylate synthase	TMP1	0.0068
359	Thymidylate synthase	TYMS	0.0068
2626	Thymidylate synthase	thyA	0.0068
2729	Thymidylate synthase	thyA	0.0068
5352	Thymidylate synthase	THYA	0.0068
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0068
6033	High affinity interleukin-8 receptor A	CXCR1	0.0067
26	Vascular endothelial growth factor receptor 3	FLT4	0.0067
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0067
124	Histamine H2 receptor	HRH2	0.0066
36	Insulin receptor	INSR	0.0066
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0066
183	Vascular endothelial growth factor A	VEGFA	0.0066
94	5-hydroxytryptamine 4 receptor	HTR4	0.0065
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0065
3809	Estrogen-related receptor gamma	ESRRG	0.0065
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0065
777	Tumor necrosis factor	TNF	0.0064
1050	Bile salt sulfotransferase	SULT2A1	0.0064
32	Vascular endothelial growth factor receptor 1	FLT1	0.0064
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0064
3939	Amine oxidase [flavin-containing] B	MAOB	0.0064
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0064
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0064
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0064
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0063
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0063
1010	Cytochrome P450 51A1	CYP51A1	0.0062
3810	Catechol O-methyltransferase	COMT	0.0062
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0061
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0061
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0061
88	Retinoic acid receptor RXR-beta	RXRB	0.0061
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0061
185	Vasopressin V1a receptor	AVPR1A	0.006
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0058
716	5-hydroxytryptamine 7 receptor	HTR7	0.0058
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0057
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0057
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6138	Multidrug resistance protein 3	ABCB4	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0056
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0056
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0055
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0055
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0054
1656	CYP2B protein	CYP2B	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
1649	Small inducible cytokine A2	CCL2	0.0054
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
6014	Cytochrome P450 2A13	CYP2A13	0.0053
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0052
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
2539	Tubulin alpha-1 chain	TUBA4A	0.0051
162	Retinoic acid receptor gamma-1	RARG	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
273	Apoptosis regulator Bcl-2	BCL2	0.005
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.005
5787	Angiopoietin-1 receptor	TEK	0.005
5300	Antigen peptide transporter 1	TAP1	0.005
6151	Monocarboxylate transporter 10	SLC16A10	0.005
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1541	Metalloproteinase	mmp20	0.0049
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0049
284	DNA-directed RNA polymerase beta chain	rpoB	0.0049
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
432	D(4) dopamine receptor	DRD4	0.0049
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0048
814	Ryanodine receptor 1	RYR1	0.0048
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
4122	Histone deacetylase 2	HDAC2	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
6677	Myelin P2 protein	PMP2	0.0047
6103	Arylamine N-acetyltransferase 1	NAT1	0.0047
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0047
5934	Cytochrome P450 26A1	CYP26A1	0.0047
459	Retinoic acid receptor RXR-alpha	RXRA	0.0047
683	Potassium transporter	GK0582	0.0047
68	Cannabinoid receptor 1	CNR1	0.0045
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0045
6220	Aryl hydrocarbon receptor	AHR	0.0045
1630	Integrin beta-2	ITGB2	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
976	Platelet glycoprotein IX	GP9	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
1629	Transcription factor AP-1	JUN	0.0044
3947	Xanthine dehydrogenase/oxidase	XDH	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0043
856	Vitamin D3 receptor	VDR	0.0043
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0043
780	Retinoic acid receptor RXR-gamma	RXRG	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
992	Protein tyrosine kinase 2 beta	PTK2B	0.0042
275	Arachidonate 5-lipoxygenase	ALOX5	0.0041
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0041
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0041
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0041
2021	Thrombomodulin	THBD	0.0041
427	Substance-P receptor	TACR1	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.004
4203	Histamine N-methyltransferase	HNMT	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
1178	Adenosine A2a receptor	ADORA2A	0.0039
239	Coagulation factor X	F10	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
3856	Fibroblast growth factor receptor 3	FGFR3	0.0038
1757	Myeloperoxidase	MPO	0.0038
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0037
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0037
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0037
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0037
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
6218	Pannexin-1	PANX1	0.0037
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0037
6044	Serum paraoxonase/lactonase 3	PON3	0.0036
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0036
165	FL cytokine receptor	FLT3	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0036
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0035
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
2112	Toll-like receptor 9	TLR9	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0034
295	Carbonic anhydrase 1	CA1	0.0034
1992	Vitamin D-binding protein	GC	0.0034
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
489	Monocarboxylate transporter 2	SLC16A7	0.0034
357	Carbonic anhydrase 2	CA2	0.0034
572	Integrin alpha-L	ITGAL	0.0034
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0033
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0033
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0033
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0033
6432	Transporter	snf	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
6459	Glycodelin	PAEP	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
6501	Fatty acid-binding protein, liver	FABP1	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
571	Melatonin receptor type 1A	MTNR1A	0.0033
362	Melatonin receptor type 1B	MTNR1B	0.0033
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
1867	Major prion protein	PRNP	0.0032
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0032
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0032
163	D(1B) dopamine receptor	DRD5	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4217	Telomerase reverse transcriptase	TERT	0.0031
6174	50S ribosomal protein L32	rpmF	0.0031
16	Adenosine A1 receptor	ADORA1	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1648	Elastin	ELN	0.0031
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0031
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2207	Rhodopsin	RHO	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
208	DNA-directed RNA polymerase beta' chain	rpoC	0.003
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.003
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0029
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0029
1792	Tissue-type plasminogen activator	PLAT	0.0029
663	Solute carrier family 12 member 4	SLC12A4	0.0029
53	Solute carrier family 12 member 5	SLC12A5	0.0029
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
751	Potassium channel subfamily K member 6	KCNK6	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
921	Glutamate receptor 2	GRIA2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
310	Solute carrier family 12 member 2	SLC12A2	0.0027
4311	tRNA	TRDMT1	0.0026
4325	tRNA	trmD	0.0026
4328	tRNA	trmD	0.0026
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0026
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0026
172	Potassium channel subfamily K member 1	KCNK1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
3830	Calreticulin	CALR	0.0025
5923	Microtubule-associated protein tau	MAPT	0.0025
5924	Microtubule-associated protein 4	MAP4	0.0025
823	Fibroblast growth factor receptor 2	FGFR2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
6042	Prostaglandin reductase 2	PTGR2	0.0025
518	Peroxidase/catalase T	katG	0.0025
7	Nitric oxide synthase, inducible	NOS2	0.0025
2320	Thymidine kinase, cytosolic	TK1	0.0025
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0025
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0025
5818	Folate receptor alpha	FOLR1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6035	Nuclear receptor ROR-beta	RORB	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0024
6036	Eosinophil peroxidase	EPX	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
4192	DNA topoisomerase 2-beta	TOP2B	0.0022
4773	Deoxycytidine kinase	DCK	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
293	Gamma-glutamyl hydrolase	GGH	0.0021
4226	Uridine phosphorylase 2	UPP2	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
936	Ephrin type-A receptor 2	EPHA2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3937	Fatty-acid amide hydrolase	FAAH	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
4225	Uridine phosphorylase 1	UPP1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
1313	Lactoylglutathione lyase	GLO1	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
1650	Heme carrier protein 1	SLC46A1	0.0019
54	Prothrombin	F2	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0019
634	Squalene monooxygenase	SQLE	0.0019
7196	Squalene monooxygenase	ERG1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
413	Amidophosphoribosyltransferase	PPAT	0.0018
2515	Amidophosphoribosyltransferase	purF	0.0018
3714	Amidophosphoribosyltransferase	purF	0.0018
2808	Chloramphenicol acetyltransferase 3	cat3	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0018
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0018
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0017
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
2391	Ferrochelatase	hemH	0.0017
6502	Ferrochelatase	DKFZp686P18130	0.0017
1591	Ferrochelatase, mitochondrial	FECH	0.0017
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0017
3957	Adenosine deaminase	ADA	0.0017
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
1864	RET proto-oncogene	RET	0.0017
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0017
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0017
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
2810	Dr hemagglutinin structural subunit	draA	0.0016
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0016
6146	High affinity copper uptake protein 1	SLC31A1	0.0016
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
3233	Bile acid receptor	NR1H4	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
3639	Thymidine phosphorylase	deoA	0.0015
3936	Thymidine phosphorylase	TYMP	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
1275	Estrogen sulfotransferase	SULT1E1	0.0014
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
164	Histamine H4 receptor	HRH4	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
517	Alcohol dehydrogenase 1C	ADH1C	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0012
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0012
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0012
6859	Protein S100-A4	S100A4	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
268	Adenosine A2b receptor	ADORA2B	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0011
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
569	Retinal dehydrogenase 2	ALDH1A2	0.001
267	Plasminogen activator inhibitor 1	SERPINE1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
6221	Steroid hormone receptor ERR1	ESRRA	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2298	Cytochrome P450-cam	camC	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3221	Cytochrome c4	cc4	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
1830	5'-nucleotidase	NT5E	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4916	Cyanoglobin	glbN	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
5000	HemO	hemO	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4984	Neuroglobin	NGB	0.0006
4961	Hemophore HasA	hasA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4909	CooA protein	cooA	0.0006
4910	Cytoglobin	CYGB	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4972	P450cin	cinA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
4920	Peroxidase/catalase	katG	0.0005
4948	Cytochrome c-553	Not Available	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4923	Cytochrome c3	DvMF_2499	0.0005
4945	Cytochrome c3	Not Available	0.0005
4949	Cytochrome c3	DVU_3171	0.0005
4968	Cytochrome c3	cytc3	0.0005
4997	Cytochrome c3	SO_2727	0.0005
5219	Cytochrome c3	cyd	0.0005
4902	Nine-heme cytochrome c	Ddes_2038	0.0005
3189	High-molecular-weight cytochrome c	hmcA	0.0005
4990	PpcA	ppcA	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
4037	Hypothetical protein	GPX1	0.0005
4297	Hypothetical protein	SP_1951	0.0005
4521	Hypothetical protein	BC_2969	0.0005
4540	Hypothetical protein	TM_1070	0.0005
4555	Hypothetical protein	MT1739	0.0005
4569	Hypothetical protein	mshD	0.0005
4578	Hypothetical protein	PA3270	0.0005
4747	Hypothetical protein	PA3967	0.0005
5177	Hypothetical protein	TM_0096	0.0005
5194	Hypothetical protein	PA1204	0.0005
5240	Hypothetical protein	Rv2991	0.0005
5370	Hypothetical protein	TM_1158	0.0005
5710	Hypothetical protein	Tb927.5.1360	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
4386	Hemoglobin-like protein HbN	glbN	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
1507	Cytochrome c	CYCS	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01183 - Naloxone

Targets

Enzymes

Transporters

Carriers

Predictions