DT-Web

DB00836 - Loperamide


Identification
Name Loperamide
Accession Number DB00836 (APRD00275)
Type small molecule
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 477.038
Groups approved
Monoisotopic Weight 476.223056017
Pharmacology
Indication For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Mechanism of action In vitro and animal studies show that Loperamide acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to calmodulin.
Absorption Not significantly absorbed from the gut
Protein binding 97%
Biotransformation Hepatic
Route of elimination Excretion of the unchanged loperamide and its metabolites mainly occurs through the feces.
Toxicity Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals. Increase liquid intake.

Targets


Mu-type opioid receptor
Name Mu-type opioid receptor
Gene Name OPRM1
Pharmacological action yes
Actions agonist
References
  • DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T: Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289(1):494-502. - Pubmed
  • Tan-No K, Niijima F, Nakagawasai O, Sato T, Satoh S, Tadano T: Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice. Eur J Pharm Sci. 2003 Nov;20(3):357-63. - Pubmed
  • Roge J, Baumer P, Berard H, Schwartz JC, Lecomte JM: The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. Scand J Gastroenterol. 1993 Apr;28(4):352-4. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Giagnoni G, Casiraghi L, Senini R, Revel L, Parolaro D, Sala M, Gori E: Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8. - Pubmed
  • di Bosco AM, Grieco P, Diurno MV, Campiglia P, Novellino E, Mazzoni O: Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors. Chem Biol Drug Des. 2008 Apr;71(4):328-35. Epub 2008 Feb 12. - Pubmed
DTHybrid score 1.1258
Delta-type opioid receptor
Name Delta-type opioid receptor
Gene Name OPRD1
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Giagnoni G, Casiraghi L, Senini R, Revel L, Parolaro D, Sala M, Gori E: Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8. - Pubmed
  • di Bosco AM, Grieco P, Diurno MV, Campiglia P, Novellino E, Mazzoni O: Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors. Chem Biol Drug Des. 2008 Apr;71(4):328-35. Epub 2008 Feb 12. - Pubmed
DTHybrid score 0.9531
Kappa-type opioid receptor
Name Kappa-type opioid receptor
Gene Name OPRK1
Pharmacological action yes
Actions agonist
References
  • DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T: Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289(1):494-502. - Pubmed
DTHybrid score 0.9272
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Name Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Gene Name CACNA1A
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Church J, Fletcher EJ, Abdel-Hamid K, MacDonald JF: Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol Pharmacol. 1994 Apr;45(4):747-57. - Pubmed
DTHybrid score 0.3357
Corticotropin-lipotropin
Name Corticotropin-lipotropin
Gene Name POMC
Pharmacological action unknown
Actions modulator
References
  • Nomura A, Iwasaki Y, Aoki Y, Yamamori E, Mutsuga N, Yoshida M, Asai M, Oiso Y, Saito H: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells. Neuroendocrinology. 2001 Aug;74(2):87-94. - Pubmed
  • Auernhammer CJ, Stalla GK, Lange M, Pfeiffer A, Muller OA: Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. J Clin Endocrinol Metab. 1992 Aug;75(2):552-7. - Pubmed
  • Ambrosi B, Bochicchio D, Ferrario R, Colombo P, Faglia G: Effects of the opiate agonist loperamide on pituitary-adrenal function in patients with suspected hypercortisolism. J Endocrinol Invest. 1989 Jan;12(1):31-5. - Pubmed
  • Ambrosi B, Bochicchio D, Colombo P, Ferrario R, Faglia G: Loperamide modifies but does not block the corticotropin-releasing hormone-induced ACTH response in patients with Addison's disease. Horm Metab Res Suppl. 1987;16:74-5. - Pubmed
  • Bochicchio D, Ambrosi B, Faglia G: Loperamide, an opiate analog, differently modifies the adrenocorticotropin responses to corticotropin-releasing hormone and lysine vasopressin in patients with Addison's disease. Neuroendocrinology. 1988 Dec;48(6):611-4. - Pubmed
DTHybrid score 0.385
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Daly JW, Harper J: Loperamide: novel effects on capacitative calcium influx. Cell Mol Life Sci. 2000 Jan 20;57(1):149-57. - Pubmed
  • Suzuki T, Sakai H, Ikari A, Takeguchi N: Inhibition of thromboxane A(2)-induced Cl(-) secretion by antidiarrhea drug loperamide in isolated rat colon. J Pharmacol Exp Ther. 2000 Oct;295(1):233-8. - Pubmed
  • Mellstrand T: Loperamide--an opiate receptor agonist with gastrointestinal motility effects. Scand J Gastroenterol Suppl. 1987;130:65-6. - Pubmed
  • Stoll R, Ruppin H, Domschke W: Calmodulin-mediated effects of loperamide on chloride transport by brush border membrane vesicles from human ileum. Gastroenterology. 1988 Jul;95(1):69-76. - Pubmed
  • Diener M, Knobloch SF, Rummel W: Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon. Eur J Pharmacol. 1988 Aug 2;152(3):217-25. - Pubmed
DTHybrid score 0.4589

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Baker DE: Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8. - Pubmed
  • Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. - Pubmed
DTHybrid score 0.6705
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. - Pubmed
DTHybrid score 0.3476
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. - Pubmed
DTHybrid score 0.3446
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Kim KA, Chung J, Jung DH, Park JY: Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. Epub 2004 Sep 8. - Pubmed
DTHybrid score 0.5687

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
  • Schinkel AH, Wagenaar E, Mol CA, van Deemter L: P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996 Jun 1;97(11):2517-24. - Pubmed
DTHybrid score 0.4599

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2965
1716 Tripartite motif-containing protein 13 TRIM13 0.2903
6016 Cytochrome P450 2C19 CYP2C19 0.2351
4118 Cytochrome P450 3A5 CYP3A5 0.2247
4200 Cytochrome P450 1A2 CYP1A2 0.2174
6107 Cytochrome P450 3A7 CYP3A7 0.1902
1671 Excitatory amino acid transporter 3 SLC1A1 0.1482
4137 Nociceptin receptor OPRL1 0.1394
6013 Cytochrome P450 2E1 CYP2E1 0.1273
5718 Cytochrome P450 2A6 CYP2A6 0.0904
587 Serum albumin ALB 0.0888
6024 Cytochrome P450 1A1 CYP1A1 0.0884
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0818
824 Sodium-dependent serotonin transporter SLC6A4 0.078
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0734
492 Histamine H1 receptor HRH1 0.0727
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0691
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0687
6106 Cytochrome P450 2C18 CYP2C18 0.0666
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0631
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0626
20 Prostaglandin G/H synthase 1 PTGS1 0.0621
831 D(2) dopamine receptor DRD2 0.0618
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.059
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0578
556 Alpha-1A adrenergic receptor ADRA1A 0.0571
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0559
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.055
6145 Solute carrier family 22 member 1 SLC22A1 0.0507
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0499
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0494
862 Multidrug resistance-associated protein 1 ABCC1 0.0487
502 5-hydroxytryptamine 2A receptor HTR2A 0.0484
3811 Cytochrome P450 19A1 CYP19A1 0.0465
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0461
174 Sigma 1-type opioid receptor SIGMAR1 0.0445
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0442
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0438
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0436
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0408
319 Opioid receptor, sigma 1 OPRS1 0.0402
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0399
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.039
136 Estrogen receptor ESR1 0.0388
318 Alpha-2A adrenergic receptor ADRA2A 0.0367
766 Beta-2 adrenergic receptor ADRB2 0.036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0359
1507 Cytochrome c CYCS 0.0359
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0358
590 5-hydroxytryptamine 2C receptor HTR2C 0.0357
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0353
722 Troponin I, cardiac muscle TNNI3 0.0347
341 5-hydroxytryptamine 3 receptor HTR3A 0.0339
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0335
871 Glucocorticoid receptor NR3C1 0.0335
6144 Solute carrier family 22 member 2 SLC22A2 0.033
23 D(1A) dopamine receptor DRD1 0.033
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0326
776 Bile salt export pump ABCB11 0.0325
3923 Cholinesterase BCHE 0.0324
1898 Cytochrome P450 1B1 CYP1B1 0.0323
193 Beta-1 adrenergic receptor ADRB1 0.0304
1729 Solute carrier family 22 member 6 SLC22A6 0.03
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0296
118 Organic cation/carnitine transporter 2 SLC22A5 0.0295
713 Sodium-dependent dopamine transporter SLC6A3 0.0295
320 5-hydroxytryptamine 1A receptor HTR1A 0.0295
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0294
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.029
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0288
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0288
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0274
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0271
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0269
731 HIV-1 protease HIV-1 protease 0.0263
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.026
632 Alpha-1B adrenergic receptor ADRA1B 0.0257
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0252
290 Prostaglandin G/H synthase 2 PTGS2 0.0245
2164 Multidrug resistance-associated protein 4 ABCC4 0.0239
6142 Solute carrier family 22 member 8 SLC22A8 0.0228
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0227
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0218
6147 Solute carrier family 22 member 3 SLC22A3 0.0213
638 D(3) dopamine receptor DRD3 0.0212
833 Organic cation/carnitine transporter 1 SLC22A4 0.021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0209
4120 NADPH--cytochrome P450 reductase POR 0.0208
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0207
789 Alpha-1D adrenergic receptor ADRA1D 0.0203
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0197
1291 cAMP response element-binding protein CREB1 0.0195
4210 Toll-like receptor 4 TLR4 0.0193
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0189
260 Cytochrome P450 51 ERG11 0.0189
761 Cytochrome P450 51 ERG11 0.0189
3163 Cytochrome P450 51 cyp51 0.0189
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0188
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0188
6182 Cytochrome P450 2J2 CYP2J2 0.0181
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0181
6048 Troponin C, skeletal muscle TNNC2 0.018
629 Alpha-2B adrenergic receptor ADRA2B 0.0179
3941 Amine oxidase [flavin-containing] A MAOA 0.0178
5838 Transient receptor potential cation channel subfamily V member 3 TRPV3 0.0176
2162 Transient receptor potential cation channel subfamily M member 8 TRPM8 0.0176
1944 Transient receptor potential cation channel subfamily A member 1 TRPA1 0.0176
885 5-hydroxytryptamine 1B receptor HTR1B 0.0175
468 Cytochrome P450 4A11 CYP4A11 0.0173
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0172
6143 Solute carrier family 22 member 7 SLC22A7 0.0169
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
378 Alpha-2C adrenergic receptor ADRA2C 0.0164
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0162
122 P2Y purinoceptor 12 P2RY12 0.0162
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0161
6148 Multidrug resistance-associated protein 7 ABCC10 0.016
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0159
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0154
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0145
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0145
6031 Cytochrome P450 3A43 CYP3A43 0.0145
817 DNA topoisomerase 2-alpha TOP2A 0.0144
504 Mast/stem cell growth factor receptor KIT 0.0143
146 Androgen receptor AR 0.0143
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0137
4604 Liver carboxylesterase 1 CES1 0.0137
3939 Amine oxidase [flavin-containing] B MAOB 0.0137
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0134
614 Progesterone receptor PGR 0.0133
844 Epidermal growth factor receptor EGFR 0.0133
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0132
436 5-hydroxytryptamine 2B receptor HTR2B 0.0131
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0131
725 5-hydroxytryptamine 1D receptor HTR1D 0.0131
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0127
952 Dipeptidyl peptidase 4 DPP4 0.0127
474 Acetylcholinesterase ACHE 0.0126
705 Glutamate receptor 1 GRIA1 0.0125
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
161 Tubulin beta chain TUBB 0.0122
312 Tubulin beta chain TUB2 0.0122
482 Glycine receptor subunit alpha-1 GLRA1 0.0121
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0121
380 Cytochrome P450 17A1 CYP17A1 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0118
3947 Xanthine dehydrogenase/oxidase XDH 0.0118
869 Estrogen receptor beta ESR2 0.0117
818 50S ribosomal protein L10 rplJ 0.0117
2795 Methionine aminopeptidase 2 METAP2 0.0117
6137 Multidrug resistance-associated protein 6 ABCC6 0.0116
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0115
537 ATP synthase delta chain, mitochondrial ATP5D 0.0114
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0113
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0113
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0112
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0112
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0112
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0111
94 5-hydroxytryptamine 4 receptor HTR4 0.0111
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.011
6141 Sodium/bile acid cotransporter SLC10A1 0.011
29 Tubulin beta-1 chain TUBB1 0.011
124 Histamine H2 receptor HRH2 0.0109
737 Mineralocorticoid receptor NR3C2 0.0108
6136 Multidrug resistance-associated protein 5 ABCC5 0.0107
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0107
1024 Solute carrier family 22 member 11 SLC22A11 0.0107
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0106
432 D(4) dopamine receptor DRD4 0.0106
6859 Protein S100-A4 S100A4 0.0106
2132 Protein S100-B S100B 0.0105
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0105
5682 Ribonuclease pancreatic RNASE1 0.0104
232 Corticosteroid-binding globulin SERPINA6 0.0103
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0102
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0101
756 Sex hormone-binding globulin SHBG 0.0098
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0098
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0097
811 Translocator protein TSPO 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
716 5-hydroxytryptamine 7 receptor HTR7 0.0097
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0096
70 Type-1 angiotensin II receptor AGTR1 0.0096
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0096
1656 CYP2B protein CYP2B 0.0094
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0094
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0094
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0094
407 Vascular endothelial growth factor receptor 2 KDR 0.0094
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0094
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0093
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0093
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0093
891 Dihydropteroate synthase folP 0.0093
5359 Dihydropteroate synthase folP 0.0093
7175 Dihydropteroate synthase sulI 0.0093
26 Vascular endothelial growth factor receptor 3 FLT4 0.0092
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0091
131 Synaptic vesicular amine transporter SLC18A2 0.0091
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0091
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.009
1192 Sulfotransferase 1A1 SULT1A1 0.0089
32 Vascular endothelial growth factor receptor 1 FLT1 0.0088
228 Beta platelet-derived growth factor receptor PDGFRB 0.0085
1010 Cytochrome P450 51A1 CYP51A1 0.0085
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0084
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0083
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0083
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0083
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0083
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0083
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0082
1618 High affinity nerve growth factor receptor NTRK1 0.0082
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0081
6220 Aryl hydrocarbon receptor AHR 0.0081
6085 Fatty acid-binding protein, intestinal FABP2 0.0081
373 Transthyretin TTR 0.008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
2112 Toll-like receptor 9 TLR9 0.0079
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0079
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0078
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0077
365 Dihydrofolate reductase DHFR 0.0077
2381 Dihydrofolate reductase DFR1 0.0077
2833 Dihydrofolate reductase Not Available 0.0077
2931 Dihydrofolate reductase folA 0.0077
3544 Dihydrofolate reductase folA 0.0077
3682 Dihydrofolate reductase folA 0.0077
6642 Dihydrofolate reductase folA 0.0077
6756 Dihydrofolate reductase dfrA 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
6138 Multidrug resistance protein 3 ABCB4 0.0076
1757 Myeloperoxidase MPO 0.0075
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0075
163 D(1B) dopamine receptor DRD5 0.0075
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0074
777 Tumor necrosis factor TNF 0.0074
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0074
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
6102 Arylamine N-acetyltransferase 2 NAT2 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0072
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0072
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.007
6020 Aldehyde oxidase AOX1 0.007
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
3932 Glutathione S-transferase A2 GSTA2 0.0068
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0068
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0067
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0066
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0066
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0065
738 Monocarboxylate transporter 1 SLC16A1 0.0065
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0065
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0065
2616 Ganglioside GM2 activator GM2A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
427 Substance-P receptor TACR1 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0061
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
4203 Histamine N-methyltransferase HNMT 0.006
1629 Transcription factor AP-1 JUN 0.006
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
856 Vitamin D3 receptor VDR 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
1050 Bile salt sulfotransferase SULT2A1 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
1178 Adenosine A2a receptor ADORA2A 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
6506 Stathmin-4 STMN4 0.0055
362 Melatonin receptor type 1B MTNR1B 0.0054
571 Melatonin receptor type 1A MTNR1A 0.0054
814 Ryanodine receptor 1 RYR1 0.0054
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
768 FK506-binding protein 1A FKBP1A 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0053
3830 Calreticulin CALR 0.0053
1256 5-hydroxytryptamine 6 receptor HTR6 0.0053
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
88 Retinoic acid receptor RXR-beta RXRB 0.0053
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0053
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0052
165 FL cytokine receptor FLT3 0.0052
2539 Tubulin alpha-1 chain TUBA4A 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6035 Nuclear receptor ROR-beta RORB 0.005
6034 Hydroxyindole O-methyltransferase ASMT 0.005
6036 Eosinophil peroxidase EPX 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.005
3856 Fibroblast growth factor receptor 3 FGFR3 0.005
295 Carbonic anhydrase 1 CA1 0.005
1541 Metalloproteinase mmp20 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0049
173 Toll-like receptor 7 TLR7 0.0049
1852 Microtubule-associated protein 2 MAP2 0.0048
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0048
921 Glutamate receptor 2 GRIA2 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
581 Cytochrome P450 2R1 CYP2R1 0.0048
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
683 Potassium transporter GK0582 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0046
68 Cannabinoid receptor 1 CNR1 0.0045
3086 Plasmepsin-2 Not Available 0.0045
528 5-hydroxytryptamine 1E receptor HTR1E 0.0045
6432 Transporter snf 0.0045
469 Annexin A1 ANXA1 0.0044
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0044
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0044
765 Indoleamine 2,3-dioxygenase IDO1 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
5787 Angiopoietin-1 receptor TEK 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
162 Retinoic acid receptor gamma-1 RARG 0.0043
208 DNA-directed RNA polymerase beta' chain rpoC 0.0043
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
84 Nuclear receptor 0B1 NR0B1 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
275 Arachidonate 5-lipoxygenase ALOX5 0.0042
904 Glutathione S-transferase P GSTP1 0.0041
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4122 Histone deacetylase 2 HDAC2 0.004
16 Adenosine A1 receptor ADORA1 0.004
1630 Integrin beta-2 ITGB2 0.004
1517 Beta-3 adrenergic receptor ADRB3 0.0039
239 Coagulation factor X F10 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
7 Nitric oxide synthase, inducible NOS2 0.0037
823 Fibroblast growth factor receptor 2 FGFR2 0.0037
3809 Estrogen-related receptor gamma ESRRG 0.0037
4311 tRNA TRDMT1 0.0037
4325 tRNA trmD 0.0037
4328 tRNA trmD 0.0037
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0036
1992 Vitamin D-binding protein GC 0.0036
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
518 Peroxidase/catalase T katG 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
6755 Poliovirus receptor PVR 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
780 Retinoic acid receptor RXR-gamma RXRG 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
563 Thyroid peroxidase TPO 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
5880 Thrombopoietin receptor MPL 0.0033
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
273 Apoptosis regulator Bcl-2 BCL2 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
1648 Elastin ELN 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
6146 High affinity copper uptake protein 1 SLC31A1 0.0029
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0029
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0029
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
4773 Deoxycytidine kinase DCK 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
605 Fumarate reductase flavoprotein subunit frdA 0.0027
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0027
3673 Fumarate reductase flavoprotein subunit fccA 0.0027
4912 Fumarate reductase flavoprotein subunit ifcA 0.0027
6549 Fumarate reductase flavoprotein subunit frdA 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0027
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0027
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
976 Platelet glycoprotein IX GP9 0.0027
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0027
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0026
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
49 Endothelin B receptor EDNRB 0.0026
5798 Mitogen-activated protein kinase 11 MAPK11 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
5923 Microtubule-associated protein tau MAPT 0.0025
5924 Microtubule-associated protein 4 MAP4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0024
3810 Catechol O-methyltransferase COMT 0.0024
3937 Fatty-acid amide hydrolase FAAH 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
2207 Rhodopsin RHO 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
164 Histamine H4 receptor HRH4 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
719 Retinoic acid receptor responder protein 1 RARRES1 0.0023
770 Retinoic acid-induced protein 3 GPRC5A 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
4192 DNA topoisomerase 2-beta TOP2B 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
6044 Serum paraoxonase/lactonase 3 PON3 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0021
3957 Adenosine deaminase ADA 0.0021
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0021
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0021
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0021
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0021
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
572 Integrin alpha-L ITGAL 0.002
6459 Glycodelin PAEP 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
6126 Carbonic anhydrase 7 CA7 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
569 Retinal dehydrogenase 2 ALDH1A2 0.002
267 Plasminogen activator inhibitor 1 SERPINE1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
5961 Insulin INS 0.002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.002
4217 Telomerase reverse transcriptase TERT 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
54 Prothrombin F2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
1360 Sphingomyelin phosphodiesterase SMPD1 0.0019
183 Vascular endothelial growth factor A VEGFA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6316 ADP-ribosylation factor 1 ARF1 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0018
6228 Nuclear receptor coactivator 1 NCOA1 0.0018
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
6524 Protein tonB tonB 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
444 Alcohol dehydrogenase 1B ADH1B 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
2810 Dr hemagglutinin structural subunit draA 0.0016
2981 Phospholipase A2, membrane associated PLA2G2A 0.0016
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
6218 Pannexin-1 PANX1 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
2021 Thrombomodulin THBD 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
1864 RET proto-oncogene RET 0.0012
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0012
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0012
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0012
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
6163 Copper-transporting ATPase 2 ATP7B 0.0011
6165 Copper-transporting ATPase 1 ATP7A 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2298 Cytochrome P450-cam camC 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3221 Cytochrome c4 cc4 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4984 Neuroglobin NGB 0.0006
4909 CooA protein cooA 0.0006
4910 Cytoglobin CYGB 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
5000 HemO hemO 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4961 Hemophore HasA hasA 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
4920 Peroxidase/catalase katG 0.0005
4948 Cytochrome c-553 Not Available 0.0005
4923 Cytochrome c3 DvMF_2499 0.0005
4945 Cytochrome c3 Not Available 0.0005
4949 Cytochrome c3 DVU_3171 0.0005
4968 Cytochrome c3 cytc3 0.0005
4997 Cytochrome c3 SO_2727 0.0005
5219 Cytochrome c3 cyd 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4902 Nine-heme cytochrome c Ddes_2038 0.0005
3189 High-molecular-weight cytochrome c hmcA 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
2230 Catalase CAT 0.0005
3249 Catalase katA 0.0005
3625 Catalase katA 0.0005
4539 Catalase katA 0.0005
4941 Catalase katB 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
4692 A/G-specific adenine glycosylase mutY 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
3127 Nitrite reductase nirS 0.0004
3284 Nitrite reductase nirS 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
358 Cystathionine beta-synthase CBS 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
693 Hemoglobin subunit beta HBB 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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