DT-Web

DB00799 - Tazarotene


Identification
Name Tazarotene
Accession Number DB00799 (APRD01246)
Type small molecule
Description Tazarotene (marketed as Tazorac(R), Avage(R) and Zorac(R)) is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 351.462
Groups approved
Monoisotopic Weight 351.129299611
Pharmacology
Indication Used to treat psoriasis, acne and sun damaged skin (photodamage).
Mechanism of action Although the exact mechanism of tazarotene action is not known, studies have shown that the active form of the drug (tazarotenic acid) binds to all three members of the retinoic acid receptor (RAR) family: RARa, RARb, and RARg, but shows relative selectivity for RARb, and RARg and may modify gene expression. It also has affinity for RXR receptors.
Absorption Minimal systemic absorption of tazarotene occurs due to its rapid metabolism in the skin to the active metabolite, tazarotenic acid, which can be systemically absorbed and further metabolized. Gender had no influence on the systemic bioavailability of tazarotenic acid.
Protein binding The active form of the drug, tazarotenic acid, is highly bound to plasma proteins (>99%).
Biotransformation Undergoes esterase hydrolysis in skin to form its active metabolite, tazarotenic acid. Tazarotenic acid is further metabolized in skin and, after systemic absorption, hepatically metabolized to sulfoxides, sulfones, and other polar products for elimination.
Route of elimination Tazarotene and tazarotenic acid were metabolized to sulfoxides, sulfones and other polar metabolites which were eliminated through urinary and fecal pathways.
Toxicity Excessive topical use may lead to marked redness, peeling, or discomfort. Oral ingestion of the drug may affect liver function causing hypertriglyceridemia. Other symptoms may include conjunctival irritation, hair loss, headache, edema, fatigue, dermatitis, nausea, and visual disturbances. Oral administration of this material to rats and rabbits at doses of 0.20 mg/kg/day (rabbits) and 0.25 mg/kg/day (rats) resulted in developmental toxicity. A no effect level of 0.05 mg/kg/day was established. Similar teratogenic effects have been reported for other retinoid compounds.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Retinoic acid receptor alpha
Name Retinoic acid receptor alpha
Gene Name RARA
Pharmacological action yes
Actions agonist
References
  • Baumann L, Vujevich J, Halem M, Martin LK, Kerdel F, Lazarus M, Pacheco H, Black L, Bryde J: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging. Cutis. 2005 Jul;76(1):69-73. - Pubmed
  • Chandraratna RA: Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996 Oct;135 Suppl 49:18-25. - Pubmed
  • Yen A, Fenning R, Chandraratna R, Walker P, Varvayanis S: A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation. Mol Pharmacol. 2004 Dec;66(6):1727-37. Epub 2004 Sep 21. - Pubmed
  • Meder W, Wendland M, Busmann A, Kutzleb C, Spodsberg N, John H, Richter R, Schleuder D, Meyer M, Forssmann WG: Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Lett. 2003 Dec 18;555(3):495-9. - Pubmed
  • Wang Q, Lee D, Sysounthone V, Chandraratna RAS, Christakos S, Korah R, Wieder R: 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects. Breast Cancer Res Treat. 2001 May;67(2):157-68. - Pubmed
  • Nagpal S, Chandraratna RA: Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31. - Pubmed
DTHybrid score 0.8932
Retinoic acid receptor RXR-beta
Name Retinoic acid receptor RXR-beta
Gene Name RXRB
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nagpal S, Chandraratna RA: Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31. - Pubmed
DTHybrid score 0.7092
Retinoic acid receptor gamma-1
Name Retinoic acid receptor gamma-1
Gene Name RARG
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Arechalde A, Saurat JH: Management of psoriasis: the position of retinoid drugs. BioDrugs. 2000 May;13(5):327-33. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2867
Retinoic acid receptor beta
Name Retinoic acid receptor beta
Gene Name RARB
Pharmacological action yes
Actions agonist
References
  • Jones PH, Burnett RD, Fainaru I, Nadolny P, Walker P, Yu Z, Tang-Liu D, Ganesan TS, Talbot DC, Harris AL, Rustin GJ: A phase 1 study of tazarotene in adults with advanced cancer. Br J Cancer. 2003 Sep 1;89(5):808-15. - Pubmed
  • Orlandi A, Bianchi L, Costanzo A, Campione E, Giusto Spagnoli L, Chimenti S: Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene. J Invest Dermatol. 2004 Apr;122(4):1037-41. - Pubmed
  • Chandraratna RA: Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996 Oct;135 Suppl 49:18-25. - Pubmed
  • Arechalde A, Saurat JH: Management of psoriasis: the position of retinoid drugs. BioDrugs. 2000 May;13(5):327-33. - Pubmed
DTHybrid score 0.8971

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1991

Predictions


Id Partner name Gene Name Score
780 Retinoic acid receptor RXR-gamma RXRG 0.3373
459 Retinoic acid receptor RXR-alpha RXRA 0.29
564 Cellular retinoic acid-binding protein 1 CRABP1 0.1537
6283 Oxysterols receptor LXR-alpha NR1H3 0.1452
5934 Cytochrome P450 26A1 CYP26A1 0.1409
4757 Cytochrome P450 2C9 CYP2C9 0.0953
331 Retinol-binding protein I, cellular RBP1 0.0828
4512 Cytochrome P450 3A4 CYP3A4 0.0807
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0792
1588 Multidrug resistance protein 1 ABCB1 0.0632
4200 Cytochrome P450 1A2 CYP1A2 0.0578
587 Serum albumin ALB 0.0509
6241 Nuclear receptor coactivator 2 NCOA2 0.0507
3811 Cytochrome P450 19A1 CYP19A1 0.048
6016 Cytochrome P450 2C19 CYP2C19 0.0478
4119 Cytochrome P450 2D6 CYP2D6 0.0427
4118 Cytochrome P450 3A5 CYP3A5 0.0369
6030 Cytochrome P450 2B6 CYP2B6 0.0353
6107 Cytochrome P450 3A7 CYP3A7 0.0289
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
6106 Cytochrome P450 2C18 CYP2C18 0.0229
5718 Cytochrome P450 2A6 CYP2A6 0.0228
6013 Cytochrome P450 2E1 CYP2E1 0.0228
6024 Cytochrome P450 1A1 CYP1A1 0.0225
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.021
20 Prostaglandin G/H synthase 1 PTGS1 0.0208
719 Retinoic acid receptor responder protein 1 RARRES1 0.0174
770 Retinoic acid-induced protein 3 GPRC5A 0.0174
6228 Nuclear receptor coactivator 1 NCOA1 0.0172
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0156
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0152
84 Nuclear receptor 0B1 NR0B1 0.0148
569 Retinal dehydrogenase 2 ALDH1A2 0.014
611 Retinal dehydrogenase 1 ALDH1A1 0.0135
468 Cytochrome P450 4A11 CYP4A11 0.0132
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0118
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0116
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0113
290 Prostaglandin G/H synthase 2 PTGS2 0.0105
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0095
1729 Solute carrier family 22 member 6 SLC22A6 0.0089
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0082
1898 Cytochrome P450 1B1 CYP1B1 0.0079
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0079
862 Multidrug resistance-associated protein 1 ABCC1 0.0079
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0075
2164 Multidrug resistance-associated protein 4 ABCC4 0.0072
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0067
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0064
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
776 Bile salt export pump ABCB11 0.006
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0057
136 Estrogen receptor ESR1 0.0057
6142 Solute carrier family 22 member 8 SLC22A8 0.0057
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0053
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0051
696 Kappa-type opioid receptor OPRK1 0.005
871 Glucocorticoid receptor NR3C1 0.005
6143 Solute carrier family 22 member 7 SLC22A7 0.0049
492 Histamine H1 receptor HRH1 0.0048
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0048
467 Delta-type opioid receptor OPRD1 0.0048
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0048
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0047
6182 Cytochrome P450 2J2 CYP2J2 0.0047
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0045
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0044
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0044
847 Mu-type opioid receptor OPRM1 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0043
1024 Solute carrier family 22 member 11 SLC22A11 0.0042
6141 Sodium/bile acid cotransporter SLC10A1 0.0042
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0042
824 Sodium-dependent serotonin transporter SLC6A4 0.0041
146 Androgen receptor AR 0.0041
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.004
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0039
6102 Arylamine N-acetyltransferase 2 NAT2 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0037
70 Type-1 angiotensin II receptor AGTR1 0.0037
502 5-hydroxytryptamine 2A receptor HTR2A 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0035
1541 Metalloproteinase mmp20 0.0035
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0034
504 Mast/stem cell growth factor receptor KIT 0.0034
365 Dihydrofolate reductase DHFR 0.0034
2381 Dihydrofolate reductase DFR1 0.0034
2833 Dihydrofolate reductase Not Available 0.0034
2931 Dihydrofolate reductase folA 0.0034
3544 Dihydrofolate reductase folA 0.0034
3682 Dihydrofolate reductase folA 0.0034
6642 Dihydrofolate reductase folA 0.0034
6756 Dihydrofolate reductase dfrA 0.0034
811 Translocator protein TSPO 0.0034
5880 Thrombopoietin receptor MPL 0.0033
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0033
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0033
844 Epidermal growth factor receptor EGFR 0.0032
6144 Solute carrier family 22 member 2 SLC22A2 0.0031
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0031
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0031
831 D(2) dopamine receptor DRD2 0.0031
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.003
891 Dihydropteroate synthase folP 0.003
5359 Dihydropteroate synthase folP 0.003
7175 Dihydropteroate synthase sulI 0.003
465 Calmodulin CALM1 0.003
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.003
6145 Solute carrier family 22 member 1 SLC22A1 0.003
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.003
29 Tubulin beta-1 chain TUBB1 0.003
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.003
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0029
3941 Amine oxidase [flavin-containing] A MAOA 0.0029
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0028
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0028
6085 Fatty acid-binding protein, intestinal FABP2 0.0027
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0027
869 Estrogen receptor beta ESR2 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
118 Organic cation/carnitine transporter 2 SLC22A5 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0025
737 Mineralocorticoid receptor NR3C2 0.0025
6147 Solute carrier family 22 member 3 SLC22A3 0.0025
4116 Dihydropteroate synthetase Not Available 0.0025
952 Dipeptidyl peptidase 4 DPP4 0.0025
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
122 P2Y purinoceptor 12 P2RY12 0.0023
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0023
731 HIV-1 protease HIV-1 protease 0.0023
260 Cytochrome P450 51 ERG11 0.0023
761 Cytochrome P450 51 ERG11 0.0023
3163 Cytochrome P450 51 cyp51 0.0023
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0023
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0023
1050 Bile salt sulfotransferase SULT2A1 0.0022
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0022
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0022
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0022
94 5-hydroxytryptamine 4 receptor HTR4 0.0022
3086 Plasmepsin-2 Not Available 0.0022
1648 Elastin ELN 0.0022
24 Thymidylate synthase TMP1 0.0022
359 Thymidylate synthase TYMS 0.0022
2626 Thymidylate synthase thyA 0.0022
2729 Thymidylate synthase thyA 0.0022
5352 Thymidylate synthase THYA 0.0022
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0021
4120 NADPH--cytochrome P450 reductase POR 0.0021
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
208 DNA-directed RNA polymerase beta' chain rpoC 0.0021
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0021
833 Organic cation/carnitine transporter 1 SLC22A4 0.0021
6148 Multidrug resistance-associated protein 7 ABCC10 0.002
1010 Cytochrome P450 51A1 CYP51A1 0.002
407 Vascular endothelial growth factor receptor 2 KDR 0.002
614 Progesterone receptor PGR 0.002
373 Transthyretin TTR 0.002
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
4203 Histamine N-methyltransferase HNMT 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.002
26 Vascular endothelial growth factor receptor 3 FLT4 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0019
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0019
32 Vascular endothelial growth factor receptor 1 FLT1 0.0019
4604 Liver carboxylesterase 1 CES1 0.0019
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0019
590 5-hydroxytryptamine 2C receptor HTR2C 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0018
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0018
341 5-hydroxytryptamine 3 receptor HTR3A 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
3856 Fibroblast growth factor receptor 3 FGFR3 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
6103 Arylamine N-acetyltransferase 1 NAT1 0.0018
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0017
738 Monocarboxylate transporter 1 SLC16A1 0.0017
3939 Amine oxidase [flavin-containing] B MAOB 0.0017
766 Beta-2 adrenergic receptor ADRB2 0.0016
518 Peroxidase/catalase T katG 0.0016
469 Annexin A1 ANXA1 0.0016
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0016
756 Sex hormone-binding globulin SHBG 0.0016
23 D(1A) dopamine receptor DRD1 0.0016
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0016
427 Substance-P receptor TACR1 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
1757 Myeloperoxidase MPO 0.0015
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0015
6174 50S ribosomal protein L32 rpmF 0.0015
1629 Transcription factor AP-1 JUN 0.0015
4238 50S ribosomal protein L4 rplD 0.0015
5578 50S ribosomal protein L4 rplD 0.0015
6173 50S ribosomal protein L4 rplD 0.0015
6219 50S ribosomal protein L4 rplD 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0015
6020 Aldehyde oxidase AOX1 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
199 Monocarboxylate transporter 8 SLC16A2 0.0014
777 Tumor necrosis factor TNF 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0014
6138 Multidrug resistance protein 3 ABCB4 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
1178 Adenosine A2a receptor ADORA2A 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0013
634 Squalene monooxygenase SQLE 0.0013
7196 Squalene monooxygenase ERG1 0.0013
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
556 Alpha-1A adrenergic receptor ADRA1A 0.0013
713 Sodium-dependent dopamine transporter SLC6A3 0.0013
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
2808 Chloramphenicol acetyltransferase 3 cat3 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
1192 Sulfotransferase 1A1 SULT1A1 0.0013
632 Alpha-1B adrenergic receptor ADRA1B 0.0012
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0012
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0012
165 FL cytokine receptor FLT3 0.0012
5787 Angiopoietin-1 receptor TEK 0.0012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0012
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.0011
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0011
885 5-hydroxytryptamine 1B receptor HTR1B 0.0011
638 D(3) dopamine receptor DRD3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0011
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0011
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0011
581 Cytochrome P450 2R1 CYP2R1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
161 Tubulin beta chain TUBB 0.0011
312 Tubulin beta chain TUB2 0.0011
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0011
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0011
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0011
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0011
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.001
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.001
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.001
1992 Vitamin D-binding protein GC 0.001
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.001
319 Opioid receptor, sigma 1 OPRS1 0.001
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
1483 Membrane copper amine oxidase AOC3 0.001
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.001
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
1618 High affinity nerve growth factor receptor NTRK1 0.001
6014 Cytochrome P450 2A13 CYP2A13 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
1630 Integrin beta-2 ITGB2 0.001
976 Platelet glycoprotein IX GP9 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
436 5-hydroxytryptamine 2B receptor HTR2B 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0009
4217 Telomerase reverse transcriptase TERT 0.0009
814 Ryanodine receptor 1 RYR1 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
239 Coagulation factor X F10 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0009
6677 Myelin P2 protein PMP2 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6048 Troponin C, skeletal muscle TNNC2 0.0008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0008
268 Adenosine A2b receptor ADORA2B 0.0008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
6044 Serum paraoxonase/lactonase 3 PON3 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
2021 Thrombomodulin THBD 0.0008
856 Vitamin D3 receptor VDR 0.0008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0008
572 Integrin alpha-L ITGAL 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0007
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0007
2207 Rhodopsin RHO 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0007
5798 Mitogen-activated protein kinase 11 MAPK11 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
2320 Thymidine kinase, cytosolic TK1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
1852 Microtubule-associated protein 2 MAP2 0.0007
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
789 Alpha-1D adrenergic receptor ADRA1D 0.0007
4192 DNA topoisomerase 2-beta TOP2B 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
6218 Pannexin-1 PANX1 0.0006
751 Potassium channel subfamily K member 6 KCNK6 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
908 Glutathione S-transferase theta-1 GSTT1 0.0006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
3917 Methylenetetrahydrofolate reductase MTHFR 0.0006
193 Beta-1 adrenergic receptor ADRB1 0.0006
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
6220 Aryl hydrocarbon receptor AHR 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0005
3957 Adenosine deaminase ADA 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0005
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0005
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
284 DNA-directed RNA polymerase beta chain rpoB 0.0005
5773 DNA-directed RNA polymerase beta chain rpoB 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
817 DNA topoisomerase 2-alpha TOP2A 0.0005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0005
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0005
295 Carbonic anhydrase 1 CA1 0.0005
320 5-hydroxytryptamine 1A receptor HTR1A 0.0005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0005
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
124 Histamine H2 receptor HRH2 0.0004
7 Nitric oxide synthase, inducible NOS2 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0004
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0004
2981 Phospholipase A2, membrane associated PLA2G2A 0.0004
164 Histamine H4 receptor HRH4 0.0004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0003
1256 5-hydroxytryptamine 6 receptor HTR6 0.0003
716 5-hydroxytryptamine 7 receptor HTR7 0.0003
432 D(4) dopamine receptor DRD4 0.0002
4954 Soluble cytochrome b558 Not Available 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4943 Cytochrome c6 petJ 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4961 Hemophore HasA hasA 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
5000 HemO hemO 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
4984 Neuroglobin NGB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4935 Cytochrome c-554 cycA1 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4910 Cytoglobin CYGB 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
378 Alpha-2C adrenergic receptor ADRA2C 0.0002
629 Alpha-2B adrenergic receptor ADRA2B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
3221 Cytochrome c4 cc4 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
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