DT-Web

DB01411 - Pranlukast


Identification
Name Pranlukast
Accession Number DB01411
Type small molecule
Description Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 481.5026
Groups approved
Monoisotopic Weight 481.175004249
Pharmacology
Indication Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
Mechanism of action Pranlukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Pranlukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cysteinyl leukotriene receptor 1
Name Cysteinyl leukotriene receptor 1
Gene Name CYSLTR1
Pharmacological action yes
Actions antagonist
References
  • Yoo SH, Park SH, Song JS, Kang KH, Park CS, Yoo JH, Choi BW, Hahn MH: Clinical effects of pranlukast, an oral leukotriene receptor antagonist, in mild-to-moderate asthma: a 4 week randomized multicentre controlled trial. Respirology. 2001 Mar;6(1):15-21. - Pubmed
  • Ogasawara H, Ishii S, Yokomizo T, Kakinuma T, Komine M, Tamaki K, Shimizu T, Izumi T: Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem. 2002 May 24;277(21):18763-8. Epub 2002 Feb 19. - Pubmed
  • Ishinaga H, Takeuchi K, Kishioka C, Suzuki S, Basbaum C, Majima Y: Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. Pharmacology. 2005 Feb;73(2):89-96. Epub 2004 Oct 5. - Pubmed
  • Shirasaki H, Kanaizumi E, Seki N, Kikuchi M, Watanabe K, Konno N, Himi T: Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa. Acta Otolaryngol. 2006 Sep;126(9):948-51. - Pubmed
  • Ding Q, Wei EQ, Zhang YJ, Zhang WP, Chen Z: Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice. Acta Pharmacol Sin. 2006 Dec;27(12):1526-36. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7645
Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action unknown
Actions other/unknown
References
  • Tomari S, Matsuse H, Machida I, Kondo Y, Kawano T, Obase Y, Fukushima C, Shimoda T, Kohno S: Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics. Clin Exp Allergy. 2003 Jun;33(6):795-801. - Pubmed
  • Ichiyama T, Hasegawa S, Umeda M, Terai K, Matsubara T, Furukawa S: Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. Clin Exp Allergy. 2003 Jun;33(6):802-7. - Pubmed
  • Ichiyama T, Kajimoto M, Hasegawa M, Hashimoto K, Matsubara T, Furukawa S: Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages. Clin Exp Allergy. 2007 Apr;37(4):608-14. - Pubmed
DTHybrid score 0.9859
Interleukin-5
Name Interleukin-5
Gene Name IL5
Pharmacological action unknown
Actions antagonist
References
  • Hojo M, Suzuki M, Maghni K, Hamid Q, Powell WS, Martin JG: Role of cysteinyl leukotrienes in CD4(+) T cell-driven late allergic airway responses. J Pharmacol Exp Ther. 2000 May;293(2):410-6. - Pubmed
  • Nabe T, Yamashita K, Miura M, Kawai T, Kohno S: Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. Clin Exp Allergy. 2002 Apr;32(4):633-40. - Pubmed
  • Nogimura M, Nagata M, Sutani A, Saito K, Sakamoto Y: [Study on the effect of cysteinyl leukotriene antagonist, pranlukast hydrate, on adhesive interaction between eosinophils and pulmonary endothelial cells] Nihon Kokyuki Gakkai Zasshi. 2002 Dec;40(12):919-24. - Pubmed
  • Fukushima C, Matsuse H, Hishikawa Y, Kondo Y, Machida I, Saeki S, Kawano T, Tomari S, Obase Y, Shimoda T, Koji T, Kohno S: Pranlukast, a leukotriene receptor antagonist, inhibits interleukin-5 production via a mechanism distinct from leukotriene receptor antagonism. Int Arch Allergy Immunol. 2005 Feb;136(2):165-72. Epub 2005 Jan 12. - Pubmed
  • Matsuse H, Kondo Y, Machida I, Kawano T, Saeki S, Tomari S, Obase Y, Fukushima C, Mizuta Y, Kohno S: Effects of anti-inflammatory therapies on recurrent and low-grade respiratory syncytial virus infections in a murine model of asthma. Ann Allergy Asthma Immunol. 2006 Jul;97(1):55-60. - Pubmed
DTHybrid score 0.6027
Eosinophil cationic protein
Name Eosinophil cationic protein
Gene Name RNASE3
Pharmacological action unknown
Actions other/unknown
References
  • Horiguchi T, Tachikawa S, Kasahara J, Doi M, Shiga M: Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma. Arzneimittelforschung. 1999 Jan;49(1):35-7. - Pubmed
  • Ishioka S, Hozawa S, Haruta Y, Hiyama K, Maeda A, Yamakido M: Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic protein levels in patients with asthma. Hiroshima J Med Sci. 1999 Dec;48(4):105-10. - Pubmed
  • Obase Y, Shimoda T, Tomari S, Mitsuta K, Fukushima C, Kawano T, Matsuse H, Kohno S: Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. Ann Allergy Asthma Immunol. 2001 Jul;87(1):74-9. - Pubmed
  • Kanazawa H, Yoshikawa T, Hirata K, Yoshikawa J: Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients. Chest. 2004 May;125(5):1700-5. - Pubmed
DTHybrid score 0.5819
Nuclear factor NF-kappa-B p105 subunit
Name Nuclear factor NF-kappa-B p105 subunit
Gene Name NFKB1
Pharmacological action unknown
Actions other/unknown
References
  • Tomari S, Matsuse H, Machida I, Kondo Y, Kawano T, Obase Y, Fukushima C, Shimoda T, Kohno S: Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics. Clin Exp Allergy. 2003 Jun;33(6):795-801. - Pubmed
  • Ichiyama T, Hasegawa S, Umeda M, Terai K, Matsubara T, Furukawa S: Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. Clin Exp Allergy. 2003 Jun;33(6):802-7. - Pubmed
DTHybrid score 0.6692
Mucin-2
Name Mucin-2
Gene Name MUC2
Pharmacological action unknown
Actions other/unknown
References
  • Ishinaga H, Takeuchi K, Kishioka C, Suzuki S, Basbaum C, Majima Y: Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. Pharmacology. 2005 Feb;73(2):89-96. Epub 2004 Oct 5. - Pubmed
  • Bai CH, Song SY, Kim YD: The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. Auris Nasus Larynx. 2007 Jun;34(2):203-6. Epub 2007 Jan 12. - Pubmed
DTHybrid score 0.602

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions Not Available
References
  • -
  • Nakade S, Yamauchi A, Komaba J, Ohno T, Kitagawa J, Honda N, Hasegawa C, Yoneda K, Kodama Y, Yasuda K, Azuma J, Miyata Y: Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers. Drug Metab Pharmacokinet. 2008;23(6):428-33. - Pubmed
DTHybrid score 0.4844
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.428

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Horikawa M, Kato Y, Tyson CA, Sugiyama Y: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet. 2002;17(1):23-33. - Pubmed
DTHybrid score 0.332

Predictions


Id Partner name Gene Name Score
2390 Nonsecretory ribonuclease RNASE2 0.1806
6016 Cytochrome P450 2C19 CYP2C19 0.1694
20 Prostaglandin G/H synthase 1 PTGS1 0.1561
4200 Cytochrome P450 1A2 CYP1A2 0.1511
4924 Cytochrome P450 2C8 CYP2C8 0.1469
1588 Multidrug resistance protein 1 ABCB1 0.139
4119 Cytochrome P450 2D6 CYP2D6 0.1327
4118 Cytochrome P450 3A5 CYP3A5 0.1264
5682 Ribonuclease pancreatic RNASE1 0.1088
6013 Cytochrome P450 2E1 CYP2E1 0.1058
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0879
6024 Cytochrome P450 1A1 CYP1A1 0.0815
290 Prostaglandin G/H synthase 2 PTGS2 0.0782
6030 Cytochrome P450 2B6 CYP2B6 0.0703
6107 Cytochrome P450 3A7 CYP3A7 0.069
111 Cysteinyl leukotriene receptor 2 CYSLTR2 0.0672
1448 fMet-Leu-Phe receptor FPR1 0.0671
325 Prostaglandin D2 receptor PTGDR 0.067
7 Nitric oxide synthase, inducible NOS2 0.0668
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0662
5718 Cytochrome P450 2A6 CYP2A6 0.0536
823 Fibroblast growth factor receptor 2 FGFR2 0.0513
587 Serum albumin ALB 0.0452
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0451
862 Multidrug resistance-associated protein 1 ABCC1 0.0439
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0413
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0369
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0339
776 Bile salt export pump ABCB11 0.0333
275 Arachidonate 5-lipoxygenase ALOX5 0.0331
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0327
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0322
2164 Multidrug resistance-associated protein 4 ABCC4 0.031
1729 Solute carrier family 22 member 6 SLC22A6 0.0298
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0288
1820 Beta-nerve growth factor NGF 0.0274
3090 Chitosanase csn 0.0265
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0265
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.026
136 Estrogen receptor ESR1 0.0259
70 Type-1 angiotensin II receptor AGTR1 0.0247
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0241
1253 Interferon gamma IFNG 0.023
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0223
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0219
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0219
3811 Cytochrome P450 19A1 CYP19A1 0.0218
492 Histamine H1 receptor HRH1 0.0217
2782 Complement C1s subcomponent C1S 0.0213
6106 Cytochrome P450 2C18 CYP2C18 0.0209
6145 Solute carrier family 22 member 1 SLC22A1 0.0203
766 Beta-2 adrenergic receptor ADRB2 0.0203
118 Organic cation/carnitine transporter 2 SLC22A5 0.0202
6144 Solute carrier family 22 member 2 SLC22A2 0.0199
3815 Complement C1q subcomponent subunit A C1QA 0.0197
3816 Complement C1q subcomponent subunit B C1QB 0.0197
1898 Cytochrome P450 1B1 CYP1B1 0.0196
3817 Complement C1q subcomponent subunit C C1QC 0.0196
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0194
6142 Solute carrier family 22 member 8 SLC22A8 0.0194
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0194
3814 Complement C1r subcomponent C1R 0.0194
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0194
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0194
2112 Toll-like receptor 9 TLR9 0.0192
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0192
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0186
1517 Beta-3 adrenergic receptor ADRB3 0.0181
731 HIV-1 protease HIV-1 protease 0.018
817 DNA topoisomerase 2-alpha TOP2A 0.0173
193 Beta-1 adrenergic receptor ADRB1 0.0172
871 Glucocorticoid receptor NR3C1 0.0172
65 Matrix metalloproteinase-9 Not Available 0.0171
824 Sodium-dependent serotonin transporter SLC6A4 0.0163
3932 Glutathione S-transferase A2 GSTA2 0.0163
6148 Multidrug resistance-associated protein 7 ABCC10 0.0161
1789 Lymphotoxin-alpha LTA 0.0156
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0154
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0151
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0151
6143 Solute carrier family 22 member 7 SLC22A7 0.015
6141 Sodium/bile acid cotransporter SLC10A1 0.0142
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.014
614 Progesterone receptor PGR 0.014
502 5-hydroxytryptamine 2A receptor HTR2A 0.0139
6137 Multidrug resistance-associated protein 6 ABCC6 0.0137
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0132
477 DNA topoisomerase 4 subunit A parC 0.0132
886 DNA topoisomerase 4 subunit A parC 0.0132
6226 DNA topoisomerase 4 subunit A parC 0.0132
404 DNA gyrase subunit A gyrA 0.013
6224 DNA gyrase subunit A gyrA 0.013
1024 Solute carrier family 22 member 11 SLC22A11 0.0129
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0129
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0129
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0125
556 Alpha-1A adrenergic receptor ADRA1A 0.0123
260 Cytochrome P450 51 ERG11 0.0117
761 Cytochrome P450 51 ERG11 0.0117
3163 Cytochrome P450 51 cyp51 0.0117
847 Mu-type opioid receptor OPRM1 0.0117
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0117
891 Dihydropteroate synthase folP 0.0116
5359 Dihydropteroate synthase folP 0.0116
7175 Dihydropteroate synthase sulI 0.0116
831 D(2) dopamine receptor DRD2 0.0115
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0114
341 5-hydroxytryptamine 3 receptor HTR3A 0.0111
122 P2Y purinoceptor 12 P2RY12 0.011
318 Alpha-2A adrenergic receptor ADRA2A 0.0109
2443 Azurin azu 0.0108
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0108
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0106
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0105
322 Vasopressin V2 receptor AVPR2 0.0104
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0104
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0103
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0101
467 Delta-type opioid receptor OPRD1 0.0101
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0101
320 5-hydroxytryptamine 1A receptor HTR1A 0.0098
6147 Solute carrier family 22 member 3 SLC22A3 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0096
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0096
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0096
5060 Intron-associated endonuclease 1 ITEVIR 0.0096
5590 N utilization substance protein B homolog nusB 0.0096
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0096
2300 Lysozyme E 0.0095
3633 Lysozyme R 0.0095
5597 Lysozyme 17 0.0095
5591 Complement component C8 gamma chain C8G 0.0095
5582 Regulator of transcription; stringent starvation protein A sspA 0.0095
2838 Ribose-5-phosphate isomerase A rpiA 0.0095
2952 Ribose-5-phosphate isomerase A rpiA 0.0095
5595 Ribose-5-phosphate isomerase A rpiA 0.0095
5593 Transferase Not Available 0.0095
4695 UPF0124 protein yfiH yfiH 0.0095
4375 Glutamine synthetase 1 glnA1 0.0095
5588 Cell division protein FtsY TM_0570 0.0095
5575 Short tail fiber protein 12 0.0095
5600 Pyruvate decarboxylase pdc 0.0095
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0095
5587 Iron(III)-binding periplasmic protein fbpA 0.0095
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0095
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0095
5581 Beta-fructosidase bfrA 0.0095
5580 Hexon protein PII 0.0095
5574 Invasin YPTB1668 0.0095
6136 Multidrug resistance-associated protein 5 ABCC5 0.0095
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0094
590 5-hydroxytryptamine 2C receptor HTR2C 0.0093
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0093
4992 Cytochrome c peroxidase Not Available 0.0092
6031 Cytochrome P450 3A43 CYP3A43 0.0091
713 Sodium-dependent dopamine transporter SLC6A3 0.009
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.009
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.009
4604 Liver carboxylesterase 1 CES1 0.0089
632 Alpha-1B adrenergic receptor ADRA1B 0.0089
24 Thymidylate synthase TMP1 0.0088
359 Thymidylate synthase TYMS 0.0088
2626 Thymidylate synthase thyA 0.0088
2729 Thymidylate synthase thyA 0.0088
5352 Thymidylate synthase THYA 0.0088
696 Kappa-type opioid receptor OPRK1 0.0088
146 Androgen receptor AR 0.0087
833 Organic cation/carnitine transporter 1 SLC22A4 0.0086
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0084
3132 Tryptophan synthase alpha chain trpA 0.0084
6568 Tryptophan synthase alpha chain trpA 0.0084
5328 Prostaglandin F synthase Tb11.02.2310 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0083
3729 Citrate synthase gltA 0.0083
4575 Citrate synthase cit 0.0083
4580 Citrate synthase gltA 0.0083
5006 RNASE4 protein RNASE4 0.0083
4533 Glyoxalase family protein BC_1747 0.0083
2555 Pol polyprotein pol 0.0083
3242 Pol polyprotein gag-pol 0.0083
3471 Pol polyprotein gag-pro-pol 0.0083
5256 Pol polyprotein pol 0.0083
6469 Pol polyprotein gag-pol 0.0083
6565 Pol polyprotein Not Available 0.0083
23 D(1A) dopamine receptor DRD1 0.0083
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0083
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0083
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0083
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0079
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0079
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0078
29 Tubulin beta-1 chain TUBB1 0.0078
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0078
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0078
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0077
2521 Cell division protein ftsZ ftsZ 0.0077
3301 Cell division protein ftsZ ftsZ 0.0077
2603 Beta-lactamase II blm 0.0077
2149 Angiogenin ANG 0.0077
3583 6-phosphogluconolactonase pgl 0.0077
738 Monocarboxylate transporter 1 SLC16A1 0.0077
161 Tubulin beta chain TUBB 0.0076
312 Tubulin beta chain TUB2 0.0076
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0076
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0076
2808 Chloramphenicol acetyltransferase 3 cat3 0.0075
3923 Cholinesterase BCHE 0.0074
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0074
857 Malate dehydrogenase, mitochondrial MDH2 0.0073
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0073
3486 Fumarate hydratase class II fumC 0.0073
2942 Sialidase nanH 0.0072
3546 Sialidase nedA 0.0072
4116 Dihydropteroate synthetase Not Available 0.0072
2286 Isocitrate dehydrogenase [NADP] icd 0.0072
2302 Isocitrate dehydrogenase [NADP] icd 0.0072
2771 Isocitrate dehydrogenase [NADP] icd 0.0072
3947 Xanthine dehydrogenase/oxidase XDH 0.0071
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.007
407 Vascular endothelial growth factor receptor 2 KDR 0.0069
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0069
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0069
49 Endothelin B receptor EDNRB 0.0069
1757 Myeloperoxidase MPO 0.0069
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0069
332 Beta-lactamase blaZ 0.0069
2478 Beta-lactamase ampC 0.0069
2613 Beta-lactamase ampC 0.0069
2635 Beta-lactamase ampC 0.0069
2700 Beta-lactamase penP 0.0069
5445 Beta-lactamase blaB 0.0069
6019 Beta-lactamase SHV-7 0.0069
6701 Beta-lactamase cphA 0.0069
2697 Uridine-cytidine kinase 2 UCK2 0.0069
2452 Tryptophanyl-tRNA synthetase trpS 0.0068
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
1629 Transcription factor AP-1 JUN 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0066
811 Translocator protein TSPO 0.0066
908 Glutathione S-transferase theta-1 GSTT1 0.0066
504 Mast/stem cell growth factor receptor KIT 0.0065
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0065
789 Alpha-1D adrenergic receptor ADRA1D 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0065
357 Carbonic anhydrase 2 CA2 0.0064
5579 Carboxypeptidase B CPB1 0.0064
411 Glycine N-methyltransferase GNMT 0.0064
3941 Amine oxidase [flavin-containing] A MAOA 0.0063
295 Carbonic anhydrase 1 CA1 0.0063
3384 Macrophage migration inhibitory factor MIF 0.0063
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0063
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0063
133 Dihydropterate synthase sulI 0.0063
3270 Elongation factor G fusA 0.0062
904 Glutathione S-transferase P GSTP1 0.0062
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0062
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0061
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0061
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.006
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.006
128 Adenine phosphoribosyltransferase APRT 0.006
629 Alpha-2B adrenergic receptor ADRA2B 0.006
737 Mineralocorticoid receptor NR3C2 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
6182 Cytochrome P450 2J2 CYP2J2 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0059
3810 Catechol O-methyltransferase COMT 0.0058
465 Calmodulin CALM1 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
6146 High affinity copper uptake protein 1 SLC31A1 0.0058
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0057
26 Vascular endothelial growth factor receptor 3 FLT4 0.0056
885 5-hydroxytryptamine 1B receptor HTR1B 0.0056
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0056
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0056
3939 Amine oxidase [flavin-containing] B MAOB 0.0056
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0055
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0054
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0054
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0054
228 Beta platelet-derived growth factor receptor PDGFRB 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0054
4120 NADPH--cytochrome P450 reductase POR 0.0054
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0053
6220 Aryl hydrocarbon receptor AHR 0.0053
896 Glutathione S-transferase Mu 1 GSTM1 0.0053
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0053
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0052
6085 Fatty acid-binding protein, intestinal FABP2 0.0052
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0052
638 D(3) dopamine receptor DRD3 0.0051
1852 Microtubule-associated protein 2 MAP2 0.0051
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0051
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.005
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.005
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.005
6163 Copper-transporting ATPase 2 ATP7B 0.005
6165 Copper-transporting ATPase 1 ATP7A 0.005
952 Dipeptidyl peptidase 4 DPP4 0.005
365 Dihydrofolate reductase DHFR 0.0049
2381 Dihydrofolate reductase DFR1 0.0049
2833 Dihydrofolate reductase Not Available 0.0049
2931 Dihydrofolate reductase folA 0.0049
3544 Dihydrofolate reductase folA 0.0049
3682 Dihydrofolate reductase folA 0.0049
6642 Dihydrofolate reductase folA 0.0049
6756 Dihydrofolate reductase dfrA 0.0049
822 Aldose reductase AKR1B1 0.0049
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0048
725 5-hydroxytryptamine 1D receptor HTR1D 0.0048
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0048
5626 Nucleoside diphosphate kinase B NME2 0.0048
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0048
378 Alpha-2C adrenergic receptor ADRA2C 0.0048
869 Estrogen receptor beta ESR2 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0046
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0046
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0046
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0046
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0046
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
5923 Microtubule-associated protein tau MAPT 0.0045
5924 Microtubule-associated protein 4 MAP4 0.0045
474 Acetylcholinesterase ACHE 0.0045
130 Prostacyclin synthase PTGIS 0.0044
6043 Putative G-protein coupled receptor 44 GPR44 0.0044
273 Apoptosis regulator Bcl-2 BCL2 0.0044
756 Sex hormone-binding globulin SHBG 0.0043
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0043
165 FL cytokine receptor FLT3 0.0042
461 Glycine receptor subunit alpha-3 GLRA3 0.0042
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0042
284 DNA-directed RNA polymerase beta chain rpoB 0.0042
5773 DNA-directed RNA polymerase beta chain rpoB 0.0042
432 D(4) dopamine receptor DRD4 0.0042
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0042
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0042
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0041
856 Vitamin D3 receptor VDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
427 Substance-P receptor TACR1 0.004
2539 Tubulin alpha-1 chain TUBA4A 0.004
6020 Aldehyde oxidase AOX1 0.004
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.004
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.004
950 Alpha platelet-derived growth factor receptor PDGFRA 0.004
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.004
814 Ryanodine receptor 1 RYR1 0.0039
1541 Metalloproteinase mmp20 0.0039
5294 Nucleoside diphosphate kinase A NME1 0.0039
2449 Tubulin alpha-3 chain TUBA1A 0.0039
716 5-hydroxytryptamine 7 receptor HTR7 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
33 Cystine/glutamate transporter SLC7A11 0.0039
380 Cytochrome P450 17A1 CYP17A1 0.0039
1275 Estrogen sulfotransferase SULT1E1 0.0038
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0038
131 Synaptic vesicular amine transporter SLC18A2 0.0037
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0037
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0037
6149 Solute carrier family 22 member 10 SLC22A10 0.0037
54 Prothrombin F2 0.0037
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
4122 Histone deacetylase 2 HDAC2 0.0036
844 Epidermal growth factor receptor EGFR 0.0036
1656 CYP2B protein CYP2B 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
6014 Cytochrome P450 2A13 CYP2A13 0.0036
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
939 50S ribosomal protein L3 rplC 0.0035
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0034
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0034
4192 DNA topoisomerase 2-beta TOP2B 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0034
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0033
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
1569 G1/S-specific cyclin-D1 CCND1 0.0032
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
921 Glutamate receptor 2 GRIA2 0.0031
1630 Integrin beta-2 ITGB2 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
1760 Aminopeptidase N ANPEP 0.0031
6843 Aminopeptidase N pepN 0.0031
88 Retinoic acid receptor RXR-beta RXRB 0.003
705 Glutamate receptor 1 GRIA1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
124 Histamine H2 receptor HRH2 0.003
4773 Deoxycytidine kinase DCK 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
6211 Tubulin epsilon chain TUBE1 0.0029
6210 Tubulin delta chain TUBD1 0.0029
6212 Tubulin gamma-1 chain TUBG1 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0029
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0029
1010 Cytochrome P450 51A1 CYP51A1 0.0028
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
1353 DNA topoisomerase 1 TOP1 0.0027
3552 DNA topoisomerase 1 topA 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0027
163 D(1B) dopamine receptor DRD5 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
2981 Phospholipase A2, membrane associated PLA2G2A 0.0026
1714 Mitogen-activated protein kinase 3 MAPK3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0026
373 Transthyretin TTR 0.0026
6167 Organic solute transporter subunit beta OSTB 0.0026
6166 Organic solute transporter subunit alpha OSTA 0.0026
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0026
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0026
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0025
84 Nuclear receptor 0B1 NR0B1 0.0025
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
6044 Serum paraoxonase/lactonase 3 PON3 0.0025
1192 Sulfotransferase 1A1 SULT1A1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
1648 Elastin ELN 0.0024
489 Monocarboxylate transporter 2 SLC16A7 0.0024
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3809 Estrogen-related receptor gamma ESRRG 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0023
572 Integrin alpha-L ITGAL 0.0023
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
528 5-hydroxytryptamine 1E receptor HTR1E 0.0022
16 Adenosine A1 receptor ADORA1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
1050 Bile salt sulfotransferase SULT2A1 0.0022
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
1176 Mitogen-activated protein kinase 1 MAPK1 0.0021
2599 Tyrosine-protein kinase HCK HCK 0.0021
1178 Adenosine A2a receptor ADORA2A 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
469 Annexin A1 ANXA1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
6218 Pannexin-1 PANX1 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
3587 Gastrotropin FABP6 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0018
518 Peroxidase/catalase T katG 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
164 Histamine H4 receptor HRH4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
1618 High affinity nerve growth factor receptor NTRK1 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0018
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
239 Coagulation factor X F10 0.0018
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
1313 Lactoylglutathione lyase GLO1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
563 Thyroid peroxidase TPO 0.0016
702 UMP-CMP kinase CMPK1 0.0016
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
6042 Prostaglandin reductase 2 PTGR2 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
634 Squalene monooxygenase SQLE 0.0015
7196 Squalene monooxygenase ERG1 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0014
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
517 Alcohol dehydrogenase 1C ADH1C 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
2417 Chloramphenicol acetyltransferase cat 0.0013
3278 Chloramphenicol acetyltransferase cat 0.0013
3808 Dihydropteroate synthase 2 folP2 0.0013
3601 Dihydropteroate synthase 1 folP1 0.0013
3807 Dihydropteroate synthase 1 folP1 0.0013
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1992 Vitamin D-binding protein GC 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
319 Opioid receptor, sigma 1 OPRS1 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
5818 Folate receptor alpha FOLR1 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
976 Platelet glycoprotein IX GP9 0.0011
4103 Proteasome subunit beta type 2 PSMB2 0.0011
4101 Proteasome subunit beta type 1 PSMB1 0.0011
4102 Proteasome subunit beta type 5 PSMB5 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
1374 Natriuretic peptides B NPPB 0.0011
1827 Gap junction alpha-1 protein GJA1 0.0011
1908 Vascular cell adhesion protein 1 VCAM1 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
4217 Telomerase reverse transcriptase TERT 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.001
174 Sigma 1-type opioid receptor SIGMAR1 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
3086 Plasmepsin-2 Not Available 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
292 Activin receptor type-1 ACVR1 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
3404 Exotoxin A eta 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
1864 RET proto-oncogene RET 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
1867 Major prion protein PRNP 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
6432 Transporter snf 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0008
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0008
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0008
2091 Endoplasmin HSP90B1 0.0008
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0008
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0008
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2298 Cytochrome P450-cam camC 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
125 DNA polymerase beta POLB 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3221 Cytochrome c4 cc4 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3957 Adenosine deaminase ADA 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
1507 Cytochrome c CYCS 0.0005
2207 Rhodopsin RHO 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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