DT-Web

DB02691 - N-Cholylglycine


Identification
Name N-Cholylglycine
Accession Number DB02691 (EXPT01558)
Type small molecule
Description The glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 465.6227
Groups experimental
Monoisotopic Weight 465.309038113
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Gastrotropin
Name Gastrotropin
Gene Name FABP6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2569

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.2945
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.3663
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.3065

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1255
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0956
4512 Cytochrome P450 3A4 CYP3A4 0.0871
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0762
4924 Cytochrome P450 2C8 CYP2C8 0.0742
6142 Solute carrier family 22 member 8 SLC22A8 0.0728
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0705
6141 Sodium/bile acid cotransporter SLC10A1 0.0691
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0648
776 Bile salt export pump ABCB11 0.0608
4757 Cytochrome P450 2C9 CYP2C9 0.0597
587 Serum albumin ALB 0.0586
862 Multidrug resistance-associated protein 1 ABCC1 0.0574
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0563
2164 Multidrug resistance-associated protein 4 ABCC4 0.0541
1729 Solute carrier family 22 member 6 SLC22A6 0.0537
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.053
4118 Cytochrome P450 3A5 CYP3A5 0.0525
6016 Cytochrome P450 2C19 CYP2C19 0.0502
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0498
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.049
6145 Solute carrier family 22 member 1 SLC22A1 0.0401
33 Cystine/glutamate transporter SLC7A11 0.0387
4119 Cytochrome P450 2D6 CYP2D6 0.0379
6167 Organic solute transporter subunit beta OSTB 0.036
6166 Organic solute transporter subunit alpha OSTA 0.0359
6107 Cytochrome P450 3A7 CYP3A7 0.0359
6143 Solute carrier family 22 member 7 SLC22A7 0.0354
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0349
4200 Cytochrome P450 1A2 CYP1A2 0.0348
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0335
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0335
70 Type-1 angiotensin II receptor AGTR1 0.0324
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0315
6030 Cytochrome P450 2B6 CYP2B6 0.0295
6148 Multidrug resistance-associated protein 7 ABCC10 0.0281
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0277
738 Monocarboxylate transporter 1 SLC16A1 0.0261
2391 Ferrochelatase hemH 0.026
6502 Ferrochelatase DKFZp686P18130 0.026
1591 Ferrochelatase, mitochondrial FECH 0.026
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.026
758 Thyroid hormone receptor alpha THRA 0.0257
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0249
1024 Solute carrier family 22 member 11 SLC22A11 0.0241
594 Thyroxine-binding globulin SERPINA7 0.0234
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0232
346 Thyroid hormone receptor beta-1 THRB 0.023
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0227
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0227
6493 Cytochrome c oxidase subunit 6C COX6C 0.0227
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0227
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0227
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0227
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0227
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0227
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0226
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0226
6559 Cytochrome c oxidase subunit 2 ctaC 0.0226
6669 Cytochrome c oxidase subunit 2 ctaC 0.0226
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0226
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0226
6558 Cytochrome c oxidase subunit 1 ctaD 0.0226
6024 Cytochrome P450 1A1 CYP1A1 0.0226
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0212
2540 Choloylglycine hydrolase cbh 0.0208
6501 Fatty acid-binding protein, liver FABP1 0.0197
4604 Liver carboxylesterase 1 CES1 0.0192
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0178
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0173
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0172
3809 Estrogen-related receptor gamma ESRRG 0.0172
6500 Phospholipase A2 PLA2G1B 0.0159
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0158
29 Tubulin beta-1 chain TUBB1 0.0151
373 Transthyretin TTR 0.0149
20 Prostaglandin G/H synthase 1 PTGS1 0.0147
136 Estrogen receptor ESR1 0.0144
731 HIV-1 protease HIV-1 protease 0.0136
517 Alcohol dehydrogenase 1C ADH1C 0.0135
199 Monocarboxylate transporter 8 SLC16A2 0.0132
118 Organic cation/carnitine transporter 2 SLC22A5 0.0124
1898 Cytochrome P450 1B1 CYP1B1 0.012
904 Glutathione S-transferase P GSTP1 0.0116
833 Organic cation/carnitine transporter 1 SLC22A4 0.0112
6013 Cytochrome P450 2E1 CYP2E1 0.0108
244 Angiotensin-converting enzyme ACE 0.0108
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0103
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0101
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.01
6136 Multidrug resistance-associated protein 5 ABCC5 0.01
2539 Tubulin alpha-1 chain TUBA4A 0.0099
756 Sex hormone-binding globulin SHBG 0.0098
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
6151 Monocarboxylate transporter 10 SLC16A10 0.0095
6144 Solute carrier family 22 member 2 SLC22A2 0.0095
492 Histamine H1 receptor HRH1 0.0094
871 Glucocorticoid receptor NR3C1 0.0088
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0087
5718 Cytochrome P450 2A6 CYP2A6 0.0086
869 Estrogen receptor beta ESR2 0.0086
3811 Cytochrome P450 19A1 CYP19A1 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
5880 Thrombopoietin receptor MPL 0.0081
468 Cytochrome P450 4A11 CYP4A11 0.0078
273 Apoptosis regulator Bcl-2 BCL2 0.0076
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0076
737 Mineralocorticoid receptor NR3C2 0.0076
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0075
5923 Microtubule-associated protein tau MAPT 0.0074
5924 Microtubule-associated protein 4 MAP4 0.0074
1852 Microtubule-associated protein 2 MAP2 0.0068
511 5-hydroxytryptamine 1F receptor HTR1F 0.0067
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
146 Androgen receptor AR 0.0064
6149 Solute carrier family 22 member 10 SLC22A10 0.0063
290 Prostaglandin G/H synthase 2 PTGS2 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0059
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0059
6031 Cytochrome P450 3A43 CYP3A43 0.0056
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
3941 Amine oxidase [flavin-containing] A MAOA 0.0054
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0053
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
5818 Folate receptor alpha FOLR1 0.0052
6220 Aryl hydrocarbon receptor AHR 0.0052
380 Cytochrome P450 17A1 CYP17A1 0.0051
275 Arachidonate 5-lipoxygenase ALOX5 0.0051
6085 Fatty acid-binding protein, intestinal FABP2 0.0051
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0049
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0049
1630 Integrin beta-2 ITGB2 0.0049
725 5-hydroxytryptamine 1D receptor HTR1D 0.0048
885 5-hydroxytryptamine 1B receptor HTR1B 0.0048
6147 Solute carrier family 22 member 3 SLC22A3 0.0047
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
284 DNA-directed RNA polymerase beta chain rpoB 0.0045
5773 DNA-directed RNA polymerase beta chain rpoB 0.0045
293 Gamma-glutamyl hydrolase GGH 0.0045
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0044
320 5-hydroxytryptamine 1A receptor HTR1A 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
469 Annexin A1 ANXA1 0.0042
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
1650 Heme carrier protein 1 SLC46A1 0.004
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.004
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
6044 Serum paraoxonase/lactonase 3 PON3 0.0039
563 Thyroid peroxidase TPO 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
3810 Catechol O-methyltransferase COMT 0.0038
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0037
572 Integrin alpha-L ITGAL 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0036
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0036
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
952 Dipeptidyl peptidase 4 DPP4 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
3923 Cholinesterase BCHE 0.0034
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
3917 Methylenetetrahydrofolate reductase MTHFR 0.0033
1291 cAMP response element-binding protein CREB1 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
6020 Aldehyde oxidase AOX1 0.0031
117 Sterol O-acyltransferase 1 SOAT1 0.003
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
6106 Cytochrome P450 2C18 CYP2C18 0.003
24 Thymidylate synthase TMP1 0.003
359 Thymidylate synthase TYMS 0.003
2626 Thymidylate synthase thyA 0.003
2729 Thymidylate synthase thyA 0.003
5352 Thymidylate synthase THYA 0.003
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
365 Dihydrofolate reductase DHFR 0.0029
2381 Dihydrofolate reductase DFR1 0.0029
2833 Dihydrofolate reductase Not Available 0.0029
2931 Dihydrofolate reductase folA 0.0029
3544 Dihydrofolate reductase folA 0.0029
3682 Dihydrofolate reductase folA 0.0029
6642 Dihydrofolate reductase folA 0.0029
6756 Dihydrofolate reductase dfrA 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0028
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0028
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0028
172 Potassium channel subfamily K member 1 KCNK1 0.0028
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
976 Platelet glycoprotein IX GP9 0.0023
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0019
2021 Thrombomodulin THBD 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
1353 DNA topoisomerase 1 TOP1 0.0018
3552 DNA topoisomerase 1 topA 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
1757 Myeloperoxidase MPO 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0016
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0016
3947 Xanthine dehydrogenase/oxidase XDH 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0016
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
5934 Cytochrome P450 26A1 CYP26A1 0.0015
6218 Pannexin-1 PANX1 0.0015
1010 Cytochrome P450 51A1 CYP51A1 0.0015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0015
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0015
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
6042 Prostaglandin reductase 2 PTGR2 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0013
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0013
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0013
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0013
6043 Putative G-protein coupled receptor 44 GPR44 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0012
260 Cytochrome P450 51 ERG11 0.0012
761 Cytochrome P450 51 ERG11 0.0012
3163 Cytochrome P450 51 cyp51 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
1313 Lactoylglutathione lyase GLO1 0.0011
824 Sodium-dependent serotonin transporter SLC6A4 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
7 Nitric oxide synthase, inducible NOS2 0.0008
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