DT-Web

DB01274 - Arformoterol


Identification
Name Arformoterol
Accession Number DB01274
Type small molecule
Description Arformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema. The use of arformoterol is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long acting beta agonists for the treatment of asthma.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 344.4049
Groups approved
Monoisotopic Weight 344.173607266
Pharmacology
Indication A bronchodilator used for the long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Mechanism of action While it is recognized that ?2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and ?1-receptors are the predominant receptors in the heart, data indicate that there are also ?2-receptors in the human heart comprising 10% to 50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective ?2-agonists may have cardiac effects. The pharmacologic effects of ?2-adrenoceptor agonist drugs, including arformoterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3′,5′-adenosine monophosphate (cyclic AMP). Increased intracellular cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of proinflammatory mediators from cells, especially from mast cells. In vitro tests show that arformoterol is an inhibitor of the release of mast cell mediators, such as histamine and leukotrienes, from the human lung. Arformoterol also inhibits histamine-induced plasma albumin extravasation in anesthetized guinea pigs and inhibits allergen-induced eosinophil influx in dogs with airway hyper-response.
Absorption Not Available
Protein binding The binding of arformoterol to human plasma proteins in vitro was 52-65% at concentrations of 0.25, 0.5 and 1.0 ng/mL of radiolabeled arformoterol.
Biotransformation Arformoterol was almost entirely metabolized following oral administration of 35 mcg of radiolabeled arformoterol in eight healthy subjects. Direct conjugation of arformoterol with glucuronic acid was the major metabolic pathway. O-Desmethylation is a secondary route catalyzed by the CYP enzymes CYP2D6 and CYP2C19.
Route of elimination After administration of a single oral dose of radiolabeled arformoterol to eight healthy male subjects, 63% of the total radioactive dose was recovered in urine and 11% in feces within 48 hours. Direct glucuronidation of arformoterol is mediated by several UGT enzymes and is the primary elimination route.
Toxicity A death was reported in dogs after a single oral dose of 5 mg/kg (approximately 4500 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis). As with all inhaled sympathomimetic medications, cardiac arrest and even death may be associated with an overdose.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions agonist
References
  • Arformoterol: (R,R)-eformoterol, (R,R)-formoterol, arformoterol tartrate, eformoterol-sepracor, formoterol-sepracor, R,R-eformoterol, R,R-formoterol. Drugs R D. 2004;5(1):25-7. - Pubmed
  • Op't Holt TB: Inhaled beta agonists. Respir Care. 2007 Jul;52(7):820-32. - Pubmed
  • Matera MG, Cazzola M: ultra-long-acting beta2-adrenoceptor agonists: an emerging therapeutic option for asthma and COPD? Drugs. 2007;67(4):503-15. - Pubmed
  • Cazzola M, Hanania NA, Matera MG: Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4(2):155-62. - Pubmed
  • Cazzola M, Matera MG, Lotvall J: Ultra long-acting beta 2-agonists in development for asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2005 Jul;14(7):775-83. - Pubmed
  • Kharidia J, Fogarty CM, Laforce CF, Maier G, Hsu R, Dunnington KM, Curry L, Baumgartner RA, Hanrahan JP: A pharmacokinetic/pharmacodynamic study comparing arformoterol tartrate inhalation solution and racemic formoterol dry powder inhaler in subjects with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008 Aug;21(4):657-62. Epub 2008 Apr 7. - Pubmed
  • Baumgartner RA, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Hanrahan JP: Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial. Clin Ther. 2007 Feb;29(2):261-78. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4947

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR: A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. Epub 2007 Jul 12. - Pubmed
  • Zhang M, Fawcett JP, Kennedy JM, Shaw JP: Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol. 2000 Feb;49(2):152-7. - Pubmed
DTHybrid score 0.4096
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR: A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. Epub 2007 Jul 12. - Pubmed
  • Zhang M, Fawcett JP, Kennedy JM, Shaw JP: Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol. 2000 Feb;49(2):152-7. - Pubmed
DTHybrid score 0.3277
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR: A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. Epub 2007 Jul 12. - Pubmed
  • Zhang M, Fawcett JP, Kennedy JM, Shaw JP: Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol. 2000 Feb;49(2):152-7. - Pubmed
DTHybrid score 0.2817
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR: A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. Epub 2007 Jul 12. - Pubmed
  • Zhang M, Fawcett JP, Kennedy JM, Shaw JP: Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol. 2000 Feb;49(2):152-7. - Pubmed
DTHybrid score 0.3684

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2892
193 Beta-1 adrenergic receptor ADRB1 0.2418
4200 Cytochrome P450 1A2 CYP1A2 0.1835
4924 Cytochrome P450 2C8 CYP2C8 0.1667
1588 Multidrug resistance protein 1 ABCB1 0.1401
6030 Cytochrome P450 2B6 CYP2B6 0.1233
6013 Cytochrome P450 2E1 CYP2E1 0.1173
4118 Cytochrome P450 3A5 CYP3A5 0.1091
6107 Cytochrome P450 3A7 CYP3A7 0.0839
6024 Cytochrome P450 1A1 CYP1A1 0.0815
20 Prostaglandin G/H synthase 1 PTGS1 0.0676
1517 Beta-3 adrenergic receptor ADRB3 0.0669
556 Alpha-1A adrenergic receptor ADRA1A 0.0555
492 Histamine H1 receptor HRH1 0.051
587 Serum albumin ALB 0.05
824 Sodium-dependent serotonin transporter SLC6A4 0.0492
6106 Cytochrome P450 2C18 CYP2C18 0.0477
320 5-hydroxytryptamine 1A receptor HTR1A 0.0437
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0432
6144 Solute carrier family 22 member 2 SLC22A2 0.0419
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0415
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0401
318 Alpha-2A adrenergic receptor ADRA2A 0.035
3923 Cholinesterase BCHE 0.0343
6145 Solute carrier family 22 member 1 SLC22A1 0.0342
713 Sodium-dependent dopamine transporter SLC6A3 0.0335
502 5-hydroxytryptamine 2A receptor HTR2A 0.0319
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0302
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0301
831 D(2) dopamine receptor DRD2 0.0299
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0297
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.029
290 Prostaglandin G/H synthase 2 PTGS2 0.029
1729 Solute carrier family 22 member 6 SLC22A6 0.0282
632 Alpha-1B adrenergic receptor ADRA1B 0.0272
3811 Cytochrome P450 19A1 CYP19A1 0.0271
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0269
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0264
3941 Amine oxidase [flavin-containing] A MAOA 0.0262
118 Organic cation/carnitine transporter 2 SLC22A5 0.0258
885 5-hydroxytryptamine 1B receptor HTR1B 0.0251
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0251
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0249
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0249
590 5-hydroxytryptamine 2C receptor HTR2C 0.0243
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0219
2300 Lysozyme E 0.0215
3633 Lysozyme R 0.0215
5597 Lysozyme 17 0.0215
1898 Cytochrome P450 1B1 CYP1B1 0.0214
862 Multidrug resistance-associated protein 1 ABCC1 0.0211
341 5-hydroxytryptamine 3 receptor HTR3A 0.0205
629 Alpha-2B adrenergic receptor ADRA2B 0.0204
3939 Amine oxidase [flavin-containing] B MAOB 0.02
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0199
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0197
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0196
6147 Solute carrier family 22 member 3 SLC22A3 0.0185
23 D(1A) dopamine receptor DRD1 0.0185
891 Dihydropteroate synthase folP 0.0183
5359 Dihydropteroate synthase folP 0.0183
7175 Dihydropteroate synthase sulI 0.0183
731 HIV-1 protease HIV-1 protease 0.0174
847 Mu-type opioid receptor OPRM1 0.0173
465 Calmodulin CALM1 0.0172
3810 Catechol O-methyltransferase COMT 0.0171
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0171
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.017
260 Cytochrome P450 51 ERG11 0.017
761 Cytochrome P450 51 ERG11 0.017
3163 Cytochrome P450 51 cyp51 0.017
378 Alpha-2C adrenergic receptor ADRA2C 0.0169
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0167
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0163
776 Bile salt export pump ABCB11 0.0163
468 Cytochrome P450 4A11 CYP4A11 0.0156
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0155
6014 Cytochrome P450 2A13 CYP2A13 0.0155
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0154
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0153
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0152
789 Alpha-1D adrenergic receptor ADRA1D 0.0149
467 Delta-type opioid receptor OPRD1 0.0148
696 Kappa-type opioid receptor OPRK1 0.0148
136 Estrogen receptor ESR1 0.0147
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0146
2164 Multidrug resistance-associated protein 4 ABCC4 0.0141
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0139
6142 Solute carrier family 22 member 8 SLC22A8 0.0138
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0138
6031 Cytochrome P450 3A43 CYP3A43 0.0137
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0136
6143 Solute carrier family 22 member 7 SLC22A7 0.0134
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0133
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0133
638 D(3) dopamine receptor DRD3 0.0128
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0127
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0126
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0123
122 P2Y purinoceptor 12 P2RY12 0.012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0118
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0114
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0114
833 Organic cation/carnitine transporter 1 SLC22A4 0.0114
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0114
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0111
436 5-hydroxytryptamine 2B receptor HTR2B 0.0111
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.011
131 Synaptic vesicular amine transporter SLC18A2 0.0109
777 Tumor necrosis factor TNF 0.0108
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0106
432 D(4) dopamine receptor DRD4 0.0104
817 DNA topoisomerase 2-alpha TOP2A 0.0104
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0097
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0096
146 Androgen receptor AR 0.0096
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0096
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0096
70 Type-1 angiotensin II receptor AGTR1 0.0096
124 Histamine H2 receptor HRH2 0.0094
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0093
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0092
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0092
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0092
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0091
725 5-hydroxytryptamine 1D receptor HTR1D 0.0089
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0088
6182 Cytochrome P450 2J2 CYP2J2 0.0087
6136 Multidrug resistance-associated protein 5 ABCC5 0.0087
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0087
716 5-hydroxytryptamine 7 receptor HTR7 0.0086
380 Cytochrome P450 17A1 CYP17A1 0.0086
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0084
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0084
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0083
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0083
94 5-hydroxytryptamine 4 receptor HTR4 0.0083
482 Glycine receptor subunit alpha-1 GLRA1 0.0081
1820 Beta-nerve growth factor NGF 0.0081
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0081
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.008
1024 Solute carrier family 22 member 11 SLC22A11 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0078
828 Phenylalanine-4-hydroxylase PAH 0.0077
3109 Phenylalanine-4-hydroxylase phhA 0.0077
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0077
183 Vascular endothelial growth factor A VEGFA 0.0074
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0074
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0074
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0073
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0071
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0071
49 Endothelin B receptor EDNRB 0.007
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.007
844 Epidermal growth factor receptor EGFR 0.007
198 Sodium channel protein type 10 subunit alpha SCN10A 0.007
528 5-hydroxytryptamine 1E receptor HTR1E 0.0069
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0068
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0068
871 Glucocorticoid receptor NR3C1 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
2230 Catalase CAT 0.0066
3249 Catalase katA 0.0066
3625 Catalase katA 0.0066
4539 Catalase katA 0.0066
4941 Catalase katB 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
295 Carbonic anhydrase 1 CA1 0.0065
518 Peroxidase/catalase T katG 0.0065
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0065
592 Carbonic anhydrase 4 CA4 0.0065
474 Acetylcholinesterase ACHE 0.0064
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
133 Dihydropterate synthase sulI 0.0063
163 D(1B) dopamine receptor DRD5 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0062
365 Dihydrofolate reductase DHFR 0.0061
2381 Dihydrofolate reductase DFR1 0.0061
2833 Dihydrofolate reductase Not Available 0.0061
2931 Dihydrofolate reductase folA 0.0061
3544 Dihydrofolate reductase folA 0.0061
3682 Dihydrofolate reductase folA 0.0061
6642 Dihydrofolate reductase folA 0.0061
6756 Dihydrofolate reductase dfrA 0.0061
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0061
563 Thyroid peroxidase TPO 0.0061
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.006
1256 5-hydroxytryptamine 6 receptor HTR6 0.006
4604 Liver carboxylesterase 1 CES1 0.006
921 Glutamate receptor 2 GRIA2 0.0059
4238 50S ribosomal protein L4 rplD 0.0059
5578 50S ribosomal protein L4 rplD 0.0059
6173 50S ribosomal protein L4 rplD 0.0059
6219 50S ribosomal protein L4 rplD 0.0059
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0058
362 Melatonin receptor type 1B MTNR1B 0.0058
571 Melatonin receptor type 1A MTNR1A 0.0058
1010 Cytochrome P450 51A1 CYP51A1 0.0058
811 Translocator protein TSPO 0.0057
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0056
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0056
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0056
275 Arachidonate 5-lipoxygenase ALOX5 0.0056
373 Transthyretin TTR 0.0056
6220 Aryl hydrocarbon receptor AHR 0.0056
106 Cannabinoid receptor 2 CNR2 0.0055
4237 50S ribosomal protein L22 rplV 0.0054
6174 50S ribosomal protein L32 rpmF 0.0054
1275 Estrogen sulfotransferase SULT1E1 0.0054
6137 Multidrug resistance-associated protein 6 ABCC6 0.0054
1656 CYP2B protein CYP2B 0.0054
504 Mast/stem cell growth factor receptor KIT 0.0053
1757 Myeloperoxidase MPO 0.0053
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0053
161 Tubulin beta chain TUBB 0.0052
312 Tubulin beta chain TUB2 0.0052
6141 Sodium/bile acid cotransporter SLC10A1 0.0052
444 Alcohol dehydrogenase 1B ADH1B 0.0052
68 Cannabinoid receptor 1 CNR1 0.0052
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0051
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0051
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0051
6432 Transporter snf 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.005
705 Glutamate receptor 1 GRIA1 0.005
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0049
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0049
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
407 Vascular endothelial growth factor receptor 2 KDR 0.0049
869 Estrogen receptor beta ESR2 0.0048
4120 NADPH--cytochrome P450 reductase POR 0.0048
1192 Sulfotransferase 1A1 SULT1A1 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0048
357 Carbonic anhydrase 2 CA2 0.0048
614 Progesterone receptor PGR 0.0047
6126 Carbonic anhydrase 7 CA7 0.0047
3947 Xanthine dehydrogenase/oxidase XDH 0.0047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0047
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
738 Monocarboxylate transporter 1 SLC16A1 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0044
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0044
232 Corticosteroid-binding globulin SERPINA6 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0044
84 Nuclear receptor 0B1 NR0B1 0.0043
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0043
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
427 Substance-P receptor TACR1 0.0043
1374 Natriuretic peptides B NPPB 0.0043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0043
1827 Gap junction alpha-1 protein GJA1 0.0042
1908 Vascular cell adhesion protein 1 VCAM1 0.0042
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0041
4203 Histamine N-methyltransferase HNMT 0.004
1176 Mitogen-activated protein kinase 1 MAPK1 0.004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.004
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
511 5-hydroxytryptamine 1F receptor HTR1F 0.0039
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
3932 Glutathione S-transferase A2 GSTA2 0.0038
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0038
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0037
130 Prostacyclin synthase PTGIS 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
228 Beta platelet-derived growth factor receptor PDGFRB 0.0036
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0035
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
54 Prothrombin F2 0.0034
6085 Fatty acid-binding protein, intestinal FABP2 0.0034
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0034
174 Sigma 1-type opioid receptor SIGMAR1 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
6506 Stathmin-4 STMN4 0.0033
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0033
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
164 Histamine H4 receptor HRH4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
1050 Bile salt sulfotransferase SULT2A1 0.0033
823 Fibroblast growth factor receptor 2 FGFR2 0.0032
3639 Thymidine phosphorylase deoA 0.0032
3936 Thymidine phosphorylase TYMP 0.0032
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0032
756 Sex hormone-binding globulin SHBG 0.0032
2298 Cytochrome P450-cam camC 0.0032
1618 High affinity nerve growth factor receptor NTRK1 0.0032
7 Nitric oxide synthase, inducible NOS2 0.0032
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0032
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0031
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0031
950 Alpha platelet-derived growth factor receptor PDGFRA 0.003
88 Retinoic acid receptor RXR-beta RXRB 0.003
153 Dopamine beta-hydroxylase DBH 0.003
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.003
634 Squalene monooxygenase SQLE 0.003
7196 Squalene monooxygenase ERG1 0.003
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0029
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0029
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0029
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0029
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0029
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0029
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0029
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0029
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
208 DNA-directed RNA polymerase beta' chain rpoC 0.0028
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0028
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0028
3917 Methylenetetrahydrofolate reductase MTHFR 0.0028
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0028
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
5934 Cytochrome P450 26A1 CYP26A1 0.0028
1932 Apolipoprotein E APOE 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
1178 Adenosine A2a receptor ADORA2A 0.0027
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0027
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0027
952 Dipeptidyl peptidase 4 DPP4 0.0026
1629 Transcription factor AP-1 JUN 0.0026
2320 Thymidine kinase, cytosolic TK1 0.0026
4226 Uridine phosphorylase 2 UPP2 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
85 Growth hormone receptor GHR 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0025
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0025
1541 Metalloproteinase mmp20 0.0025
581 Cytochrome P450 2R1 CYP2R1 0.0025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0025
4122 Histone deacetylase 2 HDAC2 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
4225 Uridine phosphorylase 1 UPP1 0.0024
6146 High affinity copper uptake protein 1 SLC31A1 0.0024
4311 tRNA TRDMT1 0.0024
4325 tRNA trmD 0.0024
4328 tRNA trmD 0.0024
2981 Phospholipase A2, membrane associated PLA2G2A 0.0024
1196 Complement decay-accelerating factor CD55 0.0023
239 Coagulation factor X F10 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
1992 Vitamin D-binding protein GC 0.0023
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0023
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0023
1268 Neuropeptide S receptor NPSR1 0.0023
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
319 Opioid receptor, sigma 1 OPRS1 0.0023
1039 Histone deacetylase 9 HDAC9 0.0023
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0023
719 Retinoic acid receptor responder protein 1 RARRES1 0.0023
770 Retinoic acid-induced protein 3 GPRC5A 0.0023
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
413 Amidophosphoribosyltransferase PPAT 0.0022
2515 Amidophosphoribosyltransferase purF 0.0022
3714 Amidophosphoribosyltransferase purF 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
469 Annexin A1 ANXA1 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
976 Platelet glycoprotein IX GP9 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
1630 Integrin beta-2 ITGB2 0.0022
4103 Proteasome subunit beta type 2 PSMB2 0.0022
4102 Proteasome subunit beta type 5 PSMB5 0.0022
4101 Proteasome subunit beta type 1 PSMB1 0.0022
5300 Antigen peptide transporter 1 TAP1 0.0021
6073 Potassium channel subfamily K member 9 KCNK9 0.0021
6072 Potassium channel subfamily K member 3 KCNK3 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
2808 Chloramphenicol acetyltransferase 3 cat3 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
569 Retinal dehydrogenase 2 ALDH1A2 0.002
1502 Peroxisome proliferator-activated receptor delta PPARD 0.002
477 DNA topoisomerase 4 subunit A parC 0.002
886 DNA topoisomerase 4 subunit A parC 0.002
6226 DNA topoisomerase 4 subunit A parC 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
404 DNA gyrase subunit A gyrA 0.0019
6224 DNA gyrase subunit A gyrA 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
3808 Dihydropteroate synthase 2 folP2 0.0019
3601 Dihydropteroate synthase 1 folP1 0.0019
3807 Dihydropteroate synthase 1 folP1 0.0019
16 Adenosine A1 receptor ADORA1 0.0019
2417 Chloramphenicol acetyltransferase cat 0.0018
3278 Chloramphenicol acetyltransferase cat 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
2810 Dr hemagglutinin structural subunit draA 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0018
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
6044 Serum paraoxonase/lactonase 3 PON3 0.0018
1341 Histamine H3 receptor HRH3 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
856 Vitamin D3 receptor VDR 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
165 FL cytokine receptor FLT3 0.0017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0016
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
572 Integrin alpha-L ITGAL 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6149 Solute carrier family 22 member 10 SLC22A10 0.0016
1864 RET proto-oncogene RET 0.0016
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0016
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0016
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0016
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0016
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0016
2207 Rhodopsin RHO 0.0016
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
1648 Elastin ELN 0.0015
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0014
4773 Deoxycytidine kinase DCK 0.0014
3086 Plasmepsin-2 Not Available 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
798 Osteocalcin BGLAP 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
3404 Exotoxin A eta 0.0013
6020 Aldehyde oxidase AOX1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
273 Apoptosis regulator Bcl-2 BCL2 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
820 Glycine receptor subunit alpha-2 GLRA2 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
814 Ryanodine receptor 1 RYR1 0.0013
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
2021 Thrombomodulin THBD 0.0012
369 Coagulation factor VII F7 0.0012
33 Cystine/glutamate transporter SLC7A11 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
267 Plasminogen activator inhibitor 1 SERPINE1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
6218 Pannexin-1 PANX1 0.001
6221 Steroid hormone receptor ERR1 ESRRA 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
144 Hemoglobin subunit alpha HBA1 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
6043 Putative G-protein coupled receptor 44 GPR44 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
3957 Adenosine deaminase ADA 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0006
3221 Cytochrome c4 cc4 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1507 Cytochrome c CYCS 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
760 Fibroblast growth factor 1 FGF1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
908 Glutathione S-transferase theta-1 GSTT1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑