DT-Web

DB00950 - Fexofenadine


Identification
Name Fexofenadine
Accession Number DB00950 (APRD00349)
Type small molecule
Description Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 501.6564
Groups approved
Monoisotopic Weight 501.287908741
Pharmacology
Indication For management of Seasonal allergic rhinitis
Mechanism of action Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
Absorption 33%
Protein binding 60%-70%
Biotransformation Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.
Route of elimination Not Available
Toxicity Side effects include dizziness, drowsiness, and dry mouth.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cisapride Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Fexofenadine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide Trimethobenzamide and Fexofenadine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Fexofenadine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Fexofenadine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions
  • Take without regard to meals.
  • Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly decrease serum levels of this product.

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Amon U, Amon S, Gibbs BF: In vitro studies with fexofenadine, a new nonsedating histamine H1 receptor antagonist, on isolated human basophils. Inflamm Res. 2000 Apr;49 Suppl 1:S13-4. - Pubmed
  • Abbas MN, Abdel Fattah AA, Zahran E: A novel membrane sensor for histamine H1-receptor antagonist - fexofenadine
  • Grzelewska-Rzymowska I, Kroczynska-Bednarek J, Pietrzkowicz M: [Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction] Pol Merkur Lekarski. 2003 Jan;14(79):43-6. - Pubmed
  • Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K: Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004 Aug;44(8):890-900. - Pubmed
  • Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. - Pubmed
  • Devillier P, Roche N, Faisy C: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clin Pharmacokinet. 2008;47(4):217-30. - Pubmed
  • Dhanya NB, Thasleem Z, Rai R, Srinivas CR: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):361-3. - Pubmed
  • Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. - Pubmed
  • Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. - Pubmed
DTHybrid score 0.5225

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3572

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
  • Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. - Pubmed
  • Petri N, Tannergren C, Rungstad D, Lennernas H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004 Aug;21(8):1398-404. - Pubmed
DTHybrid score 0.3906
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. - Pubmed
DTHybrid score 0.2482
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score 0.2728
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions Not Available
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score 0.3442
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions Not Available
References
  • Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. Epub 2005 Jul 13. - Pubmed
DTHybrid score 0.2594

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2941
4757 Cytochrome P450 2C9 CYP2C9 0.171
4924 Cytochrome P450 2C8 CYP2C8 0.1562
6016 Cytochrome P450 2C19 CYP2C19 0.1486
4118 Cytochrome P450 3A5 CYP3A5 0.1361
4200 Cytochrome P450 1A2 CYP1A2 0.1334
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1232
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1161
587 Serum albumin ALB 0.0965
6107 Cytochrome P450 3A7 CYP3A7 0.0946
6030 Cytochrome P450 2B6 CYP2B6 0.0937
6142 Solute carrier family 22 member 8 SLC22A8 0.0919
862 Multidrug resistance-associated protein 1 ABCC1 0.0817
1729 Solute carrier family 22 member 6 SLC22A6 0.0769
6145 Solute carrier family 22 member 1 SLC22A1 0.0726
776 Bile salt export pump ABCB11 0.0681
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0669
6024 Cytochrome P450 1A1 CYP1A1 0.0638
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.061
6141 Sodium/bile acid cotransporter SLC10A1 0.0588
2164 Multidrug resistance-associated protein 4 ABCC4 0.0588
6013 Cytochrome P450 2E1 CYP2E1 0.0584
556 Alpha-1A adrenergic receptor ADRA1A 0.058
738 Monocarboxylate transporter 1 SLC16A1 0.0578
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0573
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0555
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0551
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0513
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0513
3587 Gastrotropin FABP6 0.0481
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0468
502 5-hydroxytryptamine 2A receptor HTR2A 0.0463
824 Sodium-dependent serotonin transporter SLC6A4 0.0447
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0445
6143 Solute carrier family 22 member 7 SLC22A7 0.0443
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.044
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0429
5718 Cytochrome P450 2A6 CYP2A6 0.0423
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0421
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0415
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0413
831 D(2) dopamine receptor DRD2 0.0412
118 Organic cation/carnitine transporter 2 SLC22A5 0.0406
1024 Solute carrier family 22 member 11 SLC22A11 0.0403
320 5-hydroxytryptamine 1A receptor HTR1A 0.0385
318 Alpha-2A adrenergic receptor ADRA2A 0.0381
70 Type-1 angiotensin II receptor AGTR1 0.036
20 Prostaglandin G/H synthase 1 PTGS1 0.0359
713 Sodium-dependent dopamine transporter SLC6A3 0.0345
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0339
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0335
6144 Solute carrier family 22 member 2 SLC22A2 0.0335
6167 Organic solute transporter subunit beta OSTB 0.0318
6166 Organic solute transporter subunit alpha OSTA 0.0318
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0317
33 Cystine/glutamate transporter SLC7A11 0.0308
590 5-hydroxytryptamine 2C receptor HTR2C 0.0307
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0299
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0294
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0291
833 Organic cation/carnitine transporter 1 SLC22A4 0.0288
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0283
1898 Cytochrome P450 1B1 CYP1B1 0.0277
193 Beta-1 adrenergic receptor ADRB1 0.0273
758 Thyroid hormone receptor alpha THRA 0.0272
23 D(1A) dopamine receptor DRD1 0.0267
136 Estrogen receptor ESR1 0.0265
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0265
766 Beta-2 adrenergic receptor ADRB2 0.0262
6148 Multidrug resistance-associated protein 7 ABCC10 0.0258
594 Thyroxine-binding globulin SERPINA7 0.0251
632 Alpha-1B adrenergic receptor ADRA1B 0.0249
346 Thyroid hormone receptor beta-1 THRB 0.0244
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0242
6136 Multidrug resistance-associated protein 5 ABCC5 0.024
731 HIV-1 protease HIV-1 protease 0.0238
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0222
6106 Cytochrome P450 2C18 CYP2C18 0.0208
871 Glucocorticoid receptor NR3C1 0.0205
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0203
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0196
638 D(3) dopamine receptor DRD3 0.0195
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.019
6599 HTH-type transcriptional regulator ttgR ttgR 0.0189
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0186
373 Transthyretin TTR 0.0186
1341 Histamine H3 receptor HRH3 0.0184
3811 Cytochrome P450 19A1 CYP19A1 0.0182
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0181
244 Angiotensin-converting enzyme ACE 0.0179
847 Mu-type opioid receptor OPRM1 0.0179
885 5-hydroxytryptamine 1B receptor HTR1B 0.0178
29 Tubulin beta-1 chain TUBB1 0.0176
725 5-hydroxytryptamine 1D receptor HTR1D 0.0175
341 5-hydroxytryptamine 3 receptor HTR3A 0.0173
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0173
672 Prostaglandin F2-alpha receptor PTGFR 0.0171
3923 Cholinesterase BCHE 0.0171
4604 Liver carboxylesterase 1 CES1 0.0171
432 D(4) dopamine receptor DRD4 0.017
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0168
516 Neurotensin receptor type 2 NTSR2 0.0168
6147 Solute carrier family 22 member 3 SLC22A3 0.0166
629 Alpha-2B adrenergic receptor ADRA2B 0.0164
696 Kappa-type opioid receptor OPRK1 0.0163
290 Prostaglandin G/H synthase 2 PTGS2 0.016
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0158
468 Cytochrome P450 4A11 CYP4A11 0.0158
789 Alpha-1D adrenergic receptor ADRA1D 0.0157
3941 Amine oxidase [flavin-containing] A MAOA 0.0155
467 Delta-type opioid receptor OPRD1 0.0155
378 Alpha-2C adrenergic receptor ADRA2C 0.0152
6151 Monocarboxylate transporter 10 SLC16A10 0.0151
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0149
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0145
6149 Solute carrier family 22 member 10 SLC22A10 0.0144
869 Estrogen receptor beta ESR2 0.0143
756 Sex hormone-binding globulin SHBG 0.0143
199 Monocarboxylate transporter 8 SLC16A2 0.0142
465 Calmodulin CALM1 0.0142
6182 Cytochrome P450 2J2 CYP2J2 0.0136
904 Glutathione S-transferase P GSTP1 0.0135
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0129
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0129
124 Histamine H2 receptor HRH2 0.0127
436 5-hydroxytryptamine 2B receptor HTR2B 0.0124
1656 CYP2B protein CYP2B 0.0123
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0123
716 5-hydroxytryptamine 7 receptor HTR7 0.0123
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0122
500 Monocarboxylate transporter 4 SLC16A3 0.0118
2539 Tubulin alpha-1 chain TUBA4A 0.0116
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0115
6031 Cytochrome P450 3A43 CYP3A43 0.0114
380 Cytochrome P450 17A1 CYP17A1 0.0114
273 Apoptosis regulator Bcl-2 BCL2 0.011
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.011
737 Mineralocorticoid receptor NR3C2 0.0109
952 Dipeptidyl peptidase 4 DPP4 0.0108
6085 Fatty acid-binding protein, intestinal FABP2 0.0108
275 Arachidonate 5-lipoxygenase ALOX5 0.0107
146 Androgen receptor AR 0.0105
489 Monocarboxylate transporter 2 SLC16A7 0.0101
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0101
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0099
5650 NimA-related protein DR_0842 0.0098
817 DNA topoisomerase 2-alpha TOP2A 0.0098
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0096
1275 Estrogen sulfotransferase SULT1E1 0.0095
6220 Aryl hydrocarbon receptor AHR 0.0094
26 Vascular endothelial growth factor receptor 3 FLT4 0.0094
1852 Microtubule-associated protein 2 MAP2 0.0094
1792 Tissue-type plasminogen activator PLAT 0.0094
474 Acetylcholinesterase ACHE 0.0092
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0091
1256 5-hydroxytryptamine 6 receptor HTR6 0.0091
860 Nicotinamide N-methyltransferase NNMT 0.0091
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0091
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0091
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0091
699 Nicotinic acid receptor 1 GPR109A 0.0091
928 Nicotinic acid receptor 2 GPR109B 0.0091
32 Vascular endothelial growth factor receptor 1 FLT1 0.009
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0089
511 5-hydroxytryptamine 1F receptor HTR1F 0.0088
163 D(1B) dopamine receptor DRD5 0.0087
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0085
5923 Microtubule-associated protein tau MAPT 0.0085
5924 Microtubule-associated protein 4 MAP4 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0083
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0081
3939 Amine oxidase [flavin-containing] B MAOB 0.0081
5880 Thrombopoietin receptor MPL 0.0081
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.008
407 Vascular endothelial growth factor receptor 2 KDR 0.008
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0079
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0078
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0077
504 Mast/stem cell growth factor receptor KIT 0.0076
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0075
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0074
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0074
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0072
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
6137 Multidrug resistance-associated protein 6 ABCC6 0.0071
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0069
284 DNA-directed RNA polymerase beta chain rpoB 0.0068
5773 DNA-directed RNA polymerase beta chain rpoB 0.0068
844 Epidermal growth factor receptor EGFR 0.0068
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0068
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0067
1353 DNA topoisomerase 1 TOP1 0.0067
3552 DNA topoisomerase 1 topA 0.0067
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0067
528 5-hydroxytryptamine 1E receptor HTR1E 0.0067
3810 Catechol O-methyltransferase COMT 0.0066
260 Cytochrome P450 51 ERG11 0.0065
761 Cytochrome P450 51 ERG11 0.0065
3163 Cytochrome P450 51 cyp51 0.0065
1517 Beta-3 adrenergic receptor ADRB3 0.0064
4238 50S ribosomal protein L4 rplD 0.0064
5578 50S ribosomal protein L4 rplD 0.0064
6173 50S ribosomal protein L4 rplD 0.0064
6219 50S ribosomal protein L4 rplD 0.0064
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0064
161 Tubulin beta chain TUBB 0.0063
312 Tubulin beta chain TUB2 0.0063
1192 Sulfotransferase 1A1 SULT1A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
131 Synaptic vesicular amine transporter SLC18A2 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
232 Corticosteroid-binding globulin SERPINA6 0.0062
1630 Integrin beta-2 ITGB2 0.0061
365 Dihydrofolate reductase DHFR 0.0061
2381 Dihydrofolate reductase DFR1 0.0061
2833 Dihydrofolate reductase Not Available 0.0061
2931 Dihydrofolate reductase folA 0.0061
3544 Dihydrofolate reductase folA 0.0061
3682 Dihydrofolate reductase folA 0.0061
6642 Dihydrofolate reductase folA 0.0061
6756 Dihydrofolate reductase dfrA 0.0061
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0061
4237 50S ribosomal protein L22 rplV 0.0059
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0058
4120 NADPH--cytochrome P450 reductase POR 0.0058
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0057
228 Beta platelet-derived growth factor receptor PDGFRB 0.0056
469 Annexin A1 ANXA1 0.0056
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0056
3809 Estrogen-related receptor gamma ESRRG 0.0056
2391 Ferrochelatase hemH 0.0056
6502 Ferrochelatase DKFZp686P18130 0.0056
1591 Ferrochelatase, mitochondrial FECH 0.0056
5818 Folate receptor alpha FOLR1 0.0056
2112 Toll-like receptor 9 TLR9 0.0055
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0055
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0055
2021 Thrombomodulin THBD 0.0055
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0054
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0054
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0054
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0053
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0053
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
527 Prostacyclin receptor PTGIR 0.0052
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0051
614 Progesterone receptor PGR 0.0051
24 Thymidylate synthase TMP1 0.0051
359 Thymidylate synthase TYMS 0.0051
2626 Thymidylate synthase thyA 0.0051
2729 Thymidylate synthase thyA 0.0051
5352 Thymidylate synthase THYA 0.0051
3947 Xanthine dehydrogenase/oxidase XDH 0.0051
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.005
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
6044 Serum paraoxonase/lactonase 3 PON3 0.005
3856 Fibroblast growth factor receptor 3 FGFR3 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
6837 Serine/threonine-protein kinase 17B STK17B 0.0049
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0049
4203 Histamine N-methyltransferase HNMT 0.0049
293 Gamma-glutamyl hydrolase GGH 0.0048
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0048
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
2599 Tyrosine-protein kinase HCK HCK 0.0048
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0048
563 Thyroid peroxidase TPO 0.0048
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0047
4122 Histone deacetylase 2 HDAC2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
572 Integrin alpha-L ITGAL 0.0046
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0046
3014 Ribonuclease UK114 HRSP12 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
768 FK506-binding protein 1A FKBP1A 0.0046
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0046
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0045
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0045
164 Histamine H4 receptor HRH4 0.0044
2540 Choloylglycine hydrolase cbh 0.0044
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0044
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0044
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0044
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0044
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0043
122 P2Y purinoceptor 12 P2RY12 0.0043
1650 Heme carrier protein 1 SLC46A1 0.0043
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0043
1048 Protein S100-A13 S100A13 0.0043
6432 Transporter snf 0.0043
2226 Protein S100-A12 S100A12 0.0043
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0042
1525 Heparin-binding growth factor 2 FGF2 0.0042
1291 cAMP response element-binding protein CREB1 0.0041
6501 Fatty acid-binding protein, liver FABP1 0.0041
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0041
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
4210 Toll-like receptor 4 TLR4 0.0041
1760 Aminopeptidase N ANPEP 0.0041
6843 Aminopeptidase N pepN 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.004
2132 Protein S100-B S100B 0.004
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
1010 Cytochrome P450 51A1 CYP51A1 0.004
2958 Probable tautomerase ydcE pptA 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0039
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
117 Sterol O-acyltransferase 1 SOAT1 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
751 Potassium channel subfamily K member 6 KCNK6 0.0039
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
777 Tumor necrosis factor TNF 0.0037
976 Platelet glycoprotein IX GP9 0.0036
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0036
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0036
172 Potassium channel subfamily K member 1 KCNK1 0.0035
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0035
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
3917 Methylenetetrahydrofolate reductase MTHFR 0.0035
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0035
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0035
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
6500 Phospholipase A2 PLA2G1B 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0034
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0034
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0033
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6020 Aldehyde oxidase AOX1 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0033
6168 Solute carrier family 22 member 16 SLC22A16 0.0033
1178 Adenosine A2a receptor ADORA2A 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
517 Alcohol dehydrogenase 1C ADH1C 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
1629 Transcription factor AP-1 JUN 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.003
4102 Proteasome subunit beta type 5 PSMB5 0.003
4101 Proteasome subunit beta type 1 PSMB1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0029
6645 D-amino-acid oxidase DAO 0.0029
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
683 Potassium transporter GK0582 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
6014 Cytochrome P450 2A13 CYP2A13 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
760 Fibroblast growth factor 1 FGF1 0.0026
1618 High affinity nerve growth factor receptor NTRK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
1757 Myeloperoxidase MPO 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0025
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
5934 Cytochrome P450 26A1 CYP26A1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
165 FL cytokine receptor FLT3 0.0023
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
84 Nuclear receptor 0B1 NR0B1 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
144 Hemoglobin subunit alpha HBA1 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.002
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6218 Pannexin-1 PANX1 0.0019
4773 Deoxycytidine kinase DCK 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
6043 Putative G-protein coupled receptor 44 GPR44 0.0016
6102 Arylamine N-acetyltransferase 2 NAT2 0.0016
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0016
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0015
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0015
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0015
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
4311 tRNA TRDMT1 0.0014
4325 tRNA trmD 0.0014
4328 tRNA trmD 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
3404 Exotoxin A eta 0.0013
3957 Adenosine deaminase ADA 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
694 Matrix protein 2 M 0.0012
295 Carbonic anhydrase 1 CA1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
6459 Glycodelin PAEP 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
427 Substance-P receptor TACR1 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
106 Cannabinoid receptor 2 CNR2 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
811 Translocator protein TSPO 0.001
183 Vascular endothelial growth factor A VEGFA 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2149 Angiogenin ANG 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
518 Peroxidase/catalase T katG 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1864 RET proto-oncogene RET 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
54 Prothrombin F2 0.0009
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
5579 Carboxypeptidase B CPB1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
2207 Rhodopsin RHO 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1992 Vitamin D-binding protein GC 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
5682 Ribonuclease pancreatic RNASE1 0.0006
822 Aldose reductase AKR1B1 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
153 Dopamine beta-hydroxylase DBH 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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