Partner ID 1405
Name Thiopurine S-methyltransferase
Synonyms 3200
Gene name TPMT
General function Secondary metabolites biosynthesis, transport and catabolism
Specific function Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine
Gene sequence + ...

ATGGATGGTACAAGAACTTCACTTGACATTGAAGAGTACTCGGATACTGAGGTACAGAAAAACCAAGTACTAACTCTGGAAGAATGGCAAGACAAGTGGGTGAACGGCAAGACTGCTTTTCATCAGGAACAAGGACATCAGCTATTAAAGAAGCATTTAGATACTTTCCTTAAAGGCAAGAGTGGACTGAGGGTATTTTTTCCTCTTTGCGGAAAAGCGGTTGAGATGAAATGGTTTGCAGACCGGGGACACAGTGTAGTTGGTGTGGAAATCAGTGAACTTGGGATACAAGAATTTTTTACAGAGCAGAATCTTTCTTACTCAGAAGAACCAATCACCGAAATTCCTGGAACCAAAGTATTTAAGAGTTCTTCGGGGAACATTTCATTGTACTGTTGCAGTATTTTTGATCTTCCCAGGACAAATATTGGCAAATTTGACATGATTTGGGATAGAGGAGCATTAGTTGCCATTAATCCAGGTGATCGCAAATGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAA

Protein sequence + ...

MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK

GO Classification
component
cytoplasm
cell
intracellular
function
S-methyltransferase activity
thiopurine S-methyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
process
physiological process
metabolism
See more information at   →   www.drugbank.ca
Id Name
DB01250 Olsalazine
Id Name
DB00041 Aldesleukin
DB00070 Hyaluronidase
DB00091 Cyclosporine
DB00127 Spermine
DB00137 Xanthophyll
DB00139 Succinic acid
DB00140 Riboflavin
DB00143 Glutathione
DB00157 NADH
DB00158 Folic Acid
DB00163 Vitamin E
DB00168 Aspartame
DB00170 Menadione
DB00175 Pravastatin
DB00177 Valsartan
DB00181 Baclofen
DB00197 Troglitazone
DB00198 Oseltamivir
DB00203 Sildenafil
DB00214 Torasemide
DB00228 Enflurane
DB00229 Cefotiam
DB00232 Methyclothiazide
DB00242 Cladribine
DB00252 Phenytoin
DB00254 Doxycycline
DB00267 Cefmenoxime
DB00273 Topiramate
DB00274 Cefmetazole
DB00279 Liothyronine
DB00286 Conjugated Estrogens
DB00300 Tenofovir
DB00303 Ertapenem
DB00310 Chlorthalidone
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00316 Acetaminophen
DB00317 Gefitinib
DB00319 Piperacillin
DB00321 Amitriptyline
DB00328 Indomethacin
DB00334 Olanzapine
DB00336 Nitrofurazone
DB00339 Pyrazinamide
DB00345 Aminohippurate
DB00352 Thioguanine
DB00356 Chlorzoxazone
DB00364 Sucralfate
DB00365 Grepafloxacin
DB00369 Cidofovir
DB00381 Amlodipine
DB00390 Digoxin
DB00398 Sorafenib
DB00412 Rosiglitazone
DB00415 Ampicillin
DB00423 Methocarbamol
DB00426 Famciclovir
DB00430 Cefpiramide
DB00432 Trifluridine
DB00436 Bendroflumethiazide
DB00437 Allopurinol
DB00438 Ceftazidime
DB00441 Gemcitabine
DB00446 Chloramphenicol
DB00451 Levothyroxine
DB00454 Meperidine
DB00456 Cefalotin
DB00459 Acitretin
DB00469 Tenoxicam
DB00472 Fluoxetine
DB00477 Chlorpromazine
DB00481 Raloxifene
DB00482 Celecoxib
DB00484 Brimonidine
DB00493 Cefotaxime
DB00495 Zidovudine
DB00500 Tolmetin
DB00501 Cimetidine
DB00511 Acetyldigitoxin
DB00512 Vancomycin
DB00513 Aminocaproic Acid
DB00515 Cisplatin
DB00520 Caspofungin
DB00524 Metolazone
DB00526 Oxaliplatin
DB00529 Foscarnet
DB00530 Erlotinib
DB00533 Rofecoxib
DB00534 Chlormerodrin
DB00536 Guanidine
DB00540 Nortriptyline
DB00544 Fluorouracil
DB00554 Piroxicam
DB00562 Benzthiazide
DB00563 Methotrexate
DB00567 Cephalexin
DB00573 Fenoprofen
DB00576 Sulfamethizole
DB00577 Valaciclovir
DB00578 Carbenicillin
DB00583 L-Carnitine
DB00584 Enalapril
DB00586 Diclofenac
DB00595 Oxytetracycline
DB00605 Sulindac
DB00606 Cyclothiazide
DB00607 Nafcillin
DB00608 Chloroquine
DB00619 Imatinib
DB00624 Testosterone
DB00635 Prednisone
DB00636 Clofibrate
DB00640 Adenosine
DB00642 Pemetrexed
DB00649 Stavudine
DB00650 Leucovorin
DB00655 Estrone
DB00661 Verapamil
DB00672 Chlorpropamide
DB00678 Losartan
DB00682 Warfarin
DB00688 Mycophenolate mofetil
DB00693 Fluorescein
DB00694 Daunorubicin
DB00695 Furosemide
DB00703 Methazolamide
DB00709 Lamivudine
DB00712 Flurbiprofen
DB00717 Norethindrone
DB00718 Adefovir Dipivoxil
DB00731 Nateglinide
DB00743 Gadobenate Dimeglumine
DB00746 Deferoxamine
DB00749 Etodolac
DB00753 Isoflurane
DB00759 Tetracycline
DB00761 Potassium Chloride
DB00762 Irinotecan
DB00770 Alprostadil
DB00774 Hydroflumethiazide
DB00776 Oxcarbazepine
DB00779 Nalidixic Acid
DB00783 Estradiol
DB00787 Acyclovir
DB00788 Naproxen
DB00798 Gentamicin
DB00802 Alfentanil
DB00811 Ribavirin
DB00812 Phenylbutazone
DB00814 Meloxicam
DB00815 Sodium lauryl sulfate
DB00818 Propofol
DB00819 Acetazolamide
DB00821 Carprofen
DB00827 Cinoxacin
DB00829 Diazepam
DB00831 Trifluoperazine
DB00856 Chlorphenesin
DB00861 Diflunisal
DB00863 Ranitidine
DB00864 Tacrolimus
DB00869 Dorzolamide
DB00880 Chlorothiazide
DB00887 Bumetanide
DB00900 Didanosine
DB00903 Ethacrynic acid
DB00908 Quinidine
DB00909 Zonisamide
DB00912 Repaglinide
DB00917 Dinoprostone
DB00927 Famotidine
DB00931 Methacycline
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00943 Zalcitabine
DB00945 Acetylsalicylic acid
DB00946 Phenprocoumon
DB00948 Mezlocillin
DB00958 Carboplatin
DB00962 Zaleplon
DB00975 Dipyridamole
DB00987 Cytarabine
DB00993 Azathioprine
DB00995 Auranofin
DB00997 Doxorubicin
DB00999 Hydrochlorothiazide
DB01003 Cromoglicic acid
DB01004 Ganciclovir
DB01008 Busulfan
DB01009 Ketoprofen
DB01015 Sulfamethoxazole
DB01016 Glyburide
DB01017 Minocycline
DB01021 Trichlormethiazide
DB01031 Ethinamate
DB01032 Probenecid
DB01033 Mercaptopurine
DB01044 Gatifloxacin
DB01045 Rifampin
DB01050 Ibuprofen
DB01051 Novobiocin
DB01053 Penicillin G
DB01056 Tocainide
DB01059 Norfloxacin
DB01060 Amoxicillin
DB01065 Melatonin
DB01068 Clonazepam
DB01073 Fludarabine
DB01076 Atorvastatin
DB01078 Deslanoside
DB01082 Streptomycin
DB01092 Ouabain
DB01098 Rosuvastatin
DB01110 Miconazole
DB01119 Diazoxide
DB01120 Gliclazide
DB01124 Tolbutamide
DB01136 Carvedilol
DB01137 Levofloxacin
DB01138 Sulfinpyrazone
DB01140 Cefadroxil
DB01144 Dichlorphenamide
DB01147 Cloxacillin
DB01158 Bretylium
DB01159 Halothane
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01168 Procarbazine
DB01183 Naloxone
DB01189 Desflurane
DB01194 Brinzolamide
DB01197 Captopril
DB01212 Ceftriaxone
DB01232 Saquinavir
DB01236 Sevoflurane
DB01237 Bromodiphenhydramine
DB01242 Clomipramine
DB01244 Bepridil
DB01250 Olsalazine
DB01268 Sunitinib
DB01294 Bismuth Subsalicylate
DB01296 Glucosamine
DB01307 Insulin Detemir
DB01320 Fosphenytoin
DB01324 Polythiazide
DB01325 Quinethazone
DB01326 Cefamandole
DB01327 Cefazolin
DB01328 Cefonicid
DB01329 Cefoperazone
DB01330 Cefotetan
DB01331 Cefoxitin
DB01332 Ceftizoxime
DB01333 Cefradine
DB01345 Potassium
DB01370 Aluminium
DB01378 Magnesium
DB01396 Digitoxin
DB01397 Magnesium salicylate
DB01413 Cefepime
DB01414 Cefacetrile
DB01415 Ceftibuten
DB01416 Cefpodoxime
DB01418 Acenocoumarol
DB01424 Aminophenazone
DB01430 Almitrine
DB01435 Antipyrine
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB01583 Liotrix
DB01586 Ursodeoxycholic acid
DB01587 Ketazolam
DB01597 Cilastatin
DB01598 Imipenem
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01650 trans-2-hydroxycinnamic acid
DB01671 4-(Hydroxymercury)Benzoic Acid
DB01685 4-[5-Pyridin-4-Yl-1h-[1,2,4]Triazol-3-Yl]-Pyridine-2-Carbonitrile
DB01748 N-Benzyl-4-Sulfamoyl-Benzamide
DB01784 4-Flourobenzenesulfonamide
DB01834 (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
DB01915 S-Hydroxycysteine
DB01942 Formic Acid
DB01964 AL5424
DB02069 N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide
DB02087 3,5-Difluorobenzenesulfonamide
DB02165 Zinc Trihydroxide
DB02212 Pyrophosphate 2-
DB02220 Al7089a
DB02221 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide
DB02266 Flufenamic Acid
DB02292 6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate
DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
DB02315 Cyclic Guanosine Monophosphate
DB02429 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide
DB02458 Glutathione S-(2,4 Dinitrobenzene)
DB02479 (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
DB02486 2-Hydroxyethyl Disulfide
DB02527 Cyclic Adenosine Monophosphate
DB02535 Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide
DB02602 AL7182
DB02610 N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide
DB02659 Cholic Acid
DB02679 Cyanamide
DB02745 Uridine
DB02861 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide
DB02866 Dansylamide
DB02894 Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester
DB02925 Piretanide
DB02943 N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine
DB02986 N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide
DB03003 Glutathione Sulfonic Acid
DB03014 Heme
DB03039 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide
DB03147 Flavin-Adenine Dinucleotide
DB03153 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol
DB03193 Stearic acid
DB03221 AL7099A
DB03262 Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
DB03270 2,6-Difluorobenzenesulfonamide
DB03294 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide
DB03314 Fluorotryptophane
DB03328 dioxothiomolybdenum(VI) ion
DB03333 (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester
DB03385 4-Methylimidazole
DB03526 AL5927
DB03553 Glutaric Acid
DB03585 Oxyphenbutazone
DB03594 1,2,4-Triazole
DB03596 N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide
DB03598 Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
DB03600 Decanoic Acid
DB03602 S-Benzyl-Glutathione
DB03674 Methyl Mercury Ion
DB03697 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide
DB03783 Phenacetin
DB03793 Benzoic Acid
DB03796 Palmitic Acid
DB03841 Y-700
DB03844 N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide
DB03877 AL4623
DB03902 Oxalic Acid
DB03904 Urea
DB03950 (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
DB03975 Mercuribenzoic Acid
DB04002 4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide
DB04081 (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide
DB04089 AL5300
DB04132 S-Hexylglutathione
DB04133 Degraded Cephaloridine
DB04180 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide
DB04187 (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
DB04203 3-Mercuri-4-Aminobenzenesulfonamide
DB04224 Oleic Acid
DB04348 Taurocholic Acid
DB04356 9-Deazaguanine
DB04371 AL6528
DB04394 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide
DB04485 Deoxythymidine
DB04519 Caprylic acid
DB04549 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide
DB04557 Arachidonic Acid
DB04570 Latamoxef
DB04574 Estropipate
DB04600 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
DB04601 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
DB04711 Iodipamide
DB04763 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM
DB04827 Ethyl carbamate
DB04855 Dronedarone
DB05294 Vandetanib
DB05521 Telaprevir
DB05812 Abiraterone
DB06151 Acetylcysteine
DB06201 Rufinamide
DB06209 Prasugrel
DB06335 Saxagliptin
DB06705 Gadofosveset trisodium
DB06710 Methyltestosterone
DB06716 Fospropofol
DB06891 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE
DB06954 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate
DB07048 N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide
DB07050 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
DB07363 THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)
DB07402 AZAPROPAZONE
DB07467 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide
DB07476 N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE
DB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07596 (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate
DB07632 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
DB07710 PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE
DB07742 N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE
DB07992 3-SULFOOXY-1H-INDOLE
DB08046 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide
DB08083 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide
DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE
DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID
DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE
DB08165 indane-5-sulfonamide
DB08202 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE
DB08231 MYRISTIC ACID
DB08298 (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
DB08301 N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE
DB08329 SULTHIAME
DB08416 (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE
DB08418 (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate
DB08645 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
DB08659 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
DB08735 4-HYDROXY-3-[(1S,3R)-3-HYDROXY-1-PHENYLBUTYL]-2H-CHROMEN-2-ONE
DB08736 4-HYDROXY-3-[(1S,3S)-3-HYDROXY-1-PHENYLBUTYL]-2H-CHROMEN-2-ONE
DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
DB08782 4-(2-AMINOETHYL)BENZENESULFONAMIDE
DB08820 Ivacaftor
DB08828 Vismodegib
DB08837 Tetraethylammonium
DB08846 Ellagic Acid
DB08860 Pitavastatin
DB08881 Vemurafenib
DB08884 Gadoxetate
DB08893 Mirabegron
DB08899 Enzalutamide
DB08907 Canagliflozin
DB08912 Dabrafenib