DT-Web

DB01370 - Aluminium


Identification
Name Aluminium
Accession Number DB01370
Type small molecule
Description A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 26.9815386
Groups approved
Monoisotopic Weight 26.981538441
Pharmacology
Indication Not Available
Mechanism of action Aluminum Acetate is an astringent. An astrignent is a chemical that tends to shrink or constrict body tissues, usually locally after topical medicinal application. The shrinkage or constriction is through osmotic flow of water (or other fluids) away from the area where the astringent was applied. Astringent medicines cause shrinkage of mucous membranes or exposed tissues and are often used internally to check discharge of blood serum or mucous secretions. This can happen with a sore throat, hemorrhages, diarrhea, or with peptic ulcers. Externally applied astringents, which cause mild coagulation of skin proteins, dry, harden, and protect the skin. Acne sufferers are often advised to use astringents if they have oily skin. Astringents also help heal stretch marks and other scars. Mild astringent solutions are used in the relief of such minor skin irritations as those resulting from superficial cuts, allergies, insect bites, or fungal infections such as athlete's foot.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir The antiacid decreases the absorption of amprenavir
Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Chloroquine The antiacid decreases the absorption of chloroquine
Ciprofloxacin Formation of non-absorbable complexes
Clindamycin The aluminium salt decreases the absorption of lincosamides
Clodronate Formation of non-absorbable complexes
Dapsone Formation of non-absorbable complexes
Deferasirox Possible physicochemical interaction
Delavirdine The antiacid decreases the effect of delavirdine
Demeclocycline Formation of non-absorbable complexes
Doxycycline Formation of non-absorbable complexes
Etidronic acid Formation of non-absorbable complexes
Fosamprenavir The antiacid decreases the absorption of amprenavir
Gatifloxacin Formation of non-absorbable complexes
Gemifloxacin Formation of non-absorbable complexes
Grepafloxacin Formation of non-absorbable complexes
Ibandronate Formation of non absorbable complexes
Indinavir The antacid decreases the absorption of indinavir
Itraconazole Aluminum-containing antacids may decrease the effect of itraconazole.
Ketoconazole Aluminum-containing antacids may decrease the effect of ketoconazole.
Levofloxacin Formation of non-absorbable complexes
Lincomycin The aluminium salt decreases the absorption of lincosamides
Minocycline Formation of non-absorbable complexes
Moxifloxacin Formation of non-absorbable complexes
Norfloxacin Formation of non-absorbable complexes
Ofloxacin Formation of non-absorbable complexes
Penciclovir The multivalent agent decreases the effect of penicillamine
Polystyrene sulfonate Risk of alkalosis in renal impairment
Tetracycline Formation of non-absorbable complexes
Trovafloxacin Aluminum may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the aluminum containing agent to minimize the interaction.
Food Interactions Not Available

Targets


Serotransferrin
Name Serotransferrin
Gene Name TF
Pharmacological action unknown
Actions Not Available
References
  • Nolte E, Beck E, Winklhofer C, Steinhausen C: Compartmental model for aluminium biokinetics. Hum Exp Toxicol. 2001 Feb;20(2):111-7. - Pubmed
  • Nagaoka MH, Maitani T: Binding affinity of aluminium to human serum transferrin and effects of carbohydrate chain modification as studied by HPLC/high-resolution ICP-MS--speciation of aluminium in human serum. J Inorg Biochem. 2005 Sep;99(9):1887-94. - Pubmed
  • Mizutani K, Mikami B, Aibara S, Hirose M: Structure of aluminium-bound ovotransferrin at 2.15 Angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1636-42. Epub 2005 Nov 19. - Pubmed
  • Beardmore J, Rugg G, Exley C: A systems biology approach to the blood-aluminium problem: The application and testing of a computational model. J Inorg Biochem. 2007 Sep;101(9):1187-91. Epub 2007 Jun 12. - Pubmed
DTHybrid score 0.6475
Sodium/potassium-transporting ATPase alpha-1 chain
Name Sodium/potassium-transporting ATPase alpha-1 chain
Gene Name ATP1A1
Pharmacological action unknown
Actions binder
References
  • Menz RI, Walker JE, Leslie AG: Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis. Cell. 2001 Aug 10;106(3):331-41. - Pubmed
  • Silva VS, Goncalves PP: The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50. - Pubmed
  • Amador FC, Santos MS, Oliveira CR: Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals. Neurotox Res. 2001 Jul;3(3):223-33. - Pubmed
  • Kohila T, Parkkonen E, Tahti H: Evaluation of the effects of aluminium, ethanol and their combination on rat brain synaptosomal integral proteins in vitro and after 90-day oral exposure. Arch Toxicol. 2004 May;78(5):276-82. - Pubmed
  • Kohila T, Tahti H: Effects of aluminium and lead on ATPase activity of knockout +/- mouse cerebral synaptosomes in vitro. Altern Lab Anim. 2004 Oct;32(4):361-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8778

Predictions


Id Partner name Gene Name Score
443 Ferritin heavy chain FTH1 0.1124
587 Serum albumin ALB 0.0941
95 Ferritin light chain FTL 0.088
5142 Protein-tyrosine-phosphatase PPI 0.0744
6315 V-type proton ATPase subunit B, brain isoform ATP6V1B2 0.0659
1654 Interleukin-1 beta IL1B 0.062
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0608
693 Hemoglobin subunit beta HBB 0.0604
144 Hemoglobin subunit alpha HBA1 0.0582
798 Osteocalcin BGLAP 0.0535
558 Solute carrier family 12 member 1 SLC12A1 0.0385
295 Carbonic anhydrase 1 CA1 0.0298
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.028
357 Carbonic anhydrase 2 CA2 0.0223
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0221
592 Carbonic anhydrase 4 CA4 0.0214
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0187
3932 Glutathione S-transferase A2 GSTA2 0.017
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0156
1405 Thiopurine S-methyltransferase TPMT 0.0148
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0143
466 Solute carrier family 12 member 3 SLC12A3 0.0124
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0124
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0123
1588 Multidrug resistance protein 1 ABCB1 0.0123
3426 Glutamine synthetase glnA 0.0121
3987 Glutamine synthetase GLUL 0.0121
4205 Carbonic anhydrase 9 CA9 0.0118
3007 Carbonic anhydrase 12 CA12 0.0118
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0108
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0103
6142 Solute carrier family 22 member 8 SLC22A8 0.0102
1729 Solute carrier family 22 member 6 SLC22A6 0.0098
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0093
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0087
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0081
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.008
4512 Cytochrome P450 3A4 CYP3A4 0.0076
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0073
6167 Organic solute transporter subunit beta OSTB 0.0066
6166 Organic solute transporter subunit alpha OSTA 0.0066
6024 Cytochrome P450 1A1 CYP1A1 0.0065
465 Calmodulin CALM1 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0054
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
776 Bile salt export pump ABCB11 0.0041
4119 Cytochrome P450 2D6 CYP2D6 0.0037
↑