About DT-Hybrid

DT-Hybrid is an R package that implements the homonymous algorithm for the prediction of interactions between small-molecules (i.e. Drug-Target Interactions).

Cite by:

  • Salvatore Alaimo, Alfredo Pulvirenti, Rosalba Giugno, and Alfredo Ferro. Drug-target interaction prediction through domain-tuned network-based inference. Bioinformatics 2013 29: 2004-2008.
  • Salvatore Alaimo, Vincenzo Bonnici, Damiano Cancemi, Alfredo Ferro, Rosalba Giugno, and Alfredo Pulvirenti. DT-Web: a web-based application for drug-target interaction and drug combination prediction through domain-tuned network-based inference. BMC systems biology, 2015 9(3), 1.

Download R 3.X.X ONLY

Package source
DTHybrid_0.99.2.tar.gz NEW
Windows Package
DTHybrid_0.99.2.zip NEW
Mac Package
DTHybrid_0.99.2.tgz NEW


Simply type R CMD INSTALL DTHybrid_0.99.2.tar.gz
From the pull-down menu, click on Packages->Install Packages from local zip file, and then select the downloaded file DTHybrid_0.99.2.zip
Note that you need to have R installed on your computer. It is freely available on http://www.r-project.org. If for some reason you should have problems installing the package, the manual "R Installation and Administration" might be helpful.

Getting started

  • Loading DT-Hybrid: library(DTHybrid) (from within R).
  • List of available help pages: help(package=DTHybrid).


  • Reference Manual [PDF] NEW
  • DT-Hybrid Paper [PDF]
  • Supporting Materials [PDF]
  • List of predictions computed for the evaluation in our paper [RData][TXT]


If you have any inquiries, please contact us at apulvirenti@dmi.unict.it.