DT-Web

DB01017 - Minocycline


Identification
Name Minocycline
Accession Number DB01017 (APRD00547)
Type small molecule
Description A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 457.4764
Groups approved
Monoisotopic Weight 457.184900233
Pharmacology
Indication For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Mechanism of action Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Absorption Rapidly absorbed from the gastrointestinal tract and absorption is not significantly impaired by ingestion of food or milk. Oral bioavailability is 100%.
Protein binding 55% to 76%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Minocycline has been observed to cause a dark discoloration of the thyroid in experimental animals (rats, minipigs, dogs and monkeys). In the rat, chronic treatment with minocycline has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production. Minocycline has also been found to produce thyroid hyperplasia in rats and dogs. LD50=2380 mg/kg (rat, oral), LD50=3600 mg/kg (mouse, oral)
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The tetracycline, minocycline, may increase the anticoagulant effect of acenocoumarol.
Acitretin Increased risk of intracranial hypertension.
Aluminium Formation of non-absorbable complexes
Amoxicillin Possible antagonism of action
Ampicillin Possible antagonism of action
Anisindione The tetracycline, minocycline, may increase the anticoagulant effect of anisindione.
Attapulgite Formation of non-absorbable complexes
Azlocillin Possible antagonism of action
Aztreonam Possible antagonism of action
Bacampicillin Possible antagonism of action
Bexarotene Tetracycline derivatives like minocycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Bismuth Subsalicylate Formation of non-absorbable complexes
Calcium Formation of non-absorbable complexes
Calcium Acetate Calcium salts such as calcium acetate may decrease the serum concentration of tetracycline derivatives such as minocycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Calcium Chloride Calcium salts such as calcium chloride may decrease the serum concentration of tetracycline derivatives such as minocycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Carbenicillin Possible antagonism of action
Clavulanate Possible antagonism of action
Cloxacillin Possible antagonism of action
Colesevelam Bile acid sequestrants such as colesevelam may decrease the absorption of Tetracycline Derivatives. Monitor for decreased therapeutic effects of tetracycline derivatives if coadministered with a bile acid sequestrant. If these agents are used concomitantly, separate doses 2 or more hours to minimize the interaction. The manufacturer of colesevelam suggests that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclacillin Possible antagonism of action
Dicloxacillin Possible antagonism of action
Dicumarol The tetracycline, minocycline, may increase the anticoagulant effect of dicumarol.
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Etretinate Increased risk of intracranial hypertension
Flucloxacillin Possible antagonism of action
Hetacillin Possible antagonism of action
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Isotretinoin Increased risk of intracranial hypertension
Magnesium Formation of non-absorbable complexes
Magnesium oxide Formation of non-absorbable complexes
Magnesium salicylate Formation of non-absorbable complexes
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methicillin Acyl-Serine Possible antagonism of action
Methoxyflurane The tetracycline, minocycline, may increase the renal toxicity of methoxyflurane.
Mezlocillin Possible antagonism of action
Nafcillin Possible antagonism of action
Oxacillin Possible antagonism of action
Penicillin G Possible antagonism of action
Penicillin V Possible antagonism of action
Piperacillin Possible antagonism of action
Pivampicillin Possible antagonism of action
Pivmecillinam Possible antagonism of action
Tazobactam Possible antagonism of action
Ticarcillin Minocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Minocycline.
Tretinoin Minocycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Trisalicylate-choline Formation of non-absorbable complexes
Warfarin The tetracycline, minocycline, may increase the anticoagulant effect of warfarin.
Zinc Formation of non-absorbable complexes
Food Interactions
  • Take with food.
  • Calcium and iron needs increased with long term use.
  • Do not take Aluminum or magnesium antacids or supplements while on this medication.

Targets


30S ribosomal protein S9
Name 30S ribosomal protein S9
Gene Name rpsI
Pharmacological action yes
Actions inhibitor
References
  • Zhanel GG, Homenuik K, Nichol K, Noreddin A, Vercaigne L, Embil J, Gin A, Karlowsky JA, Hoban DJ: The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. - Pubmed
DTHybrid score 1.2175
30S ribosomal protein S4
Name 30S ribosomal protein S4
Gene Name rpsD
Pharmacological action yes
Actions inhibitor
References
  • Zhanel GG, Homenuik K, Nichol K, Noreddin A, Vercaigne L, Embil J, Gin A, Karlowsky JA, Hoban DJ: The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. - Pubmed
DTHybrid score 1.147
16S rRNA
Name 16S rRNA
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
Interleukin-1 beta
Name Interleukin-1 beta
Gene Name IL1B
Pharmacological action unknown
Actions modulator
References
  • Sadowski T, Steinmeyer J: Minocycline inhibits the production of inducible nitric oxide synthase in articular chondrocytes. J Rheumatol. 2001 Feb;28(2):336-40. - Pubmed
  • Oringer RJ, Al-Shammari KF, Aldredge WA, Iacono VJ, Eber RM, Wang HL, Berwald B, Nejat R, Giannobile WV: Effect of locally delivered minocycline microspheres on markers of bone resorption. J Periodontol. 2002 Aug;73(8):835-42. - Pubmed
  • Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB: A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14014-9. - Pubmed
  • Steinmeyer J, Daufeldt S, Taiwo YO: Pharmacological effect of tetracyclines on proteoglycanases from interleukin-1-treated articular cartilage. Biochem Pharmacol. 1998 Jan 1;55(1):93-100. - Pubmed
DTHybrid score 1.2264
Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action unknown
Actions inhibitor
References
  • Song Y, Wei EQ, Zhang WP, Zhang L, Liu JR, Chen Z: Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation. Neuroreport. 2004 Oct 5;15(14):2181-4. - Pubmed
  • Song Y, Wei EQ, Zhang WP, Ge QF, Liu JR, Wang ML, Huang XJ, Hu X, Chen Z: Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation. Brain Res. 2006 Apr 26;1085(1):57-67. Epub 2006 Mar 30. - Pubmed
  • Chu LS, Fang SH, Zhou Y, Yu GL, Wang ML, Zhang WP, Wei EQ: Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats. Acta Pharmacol Sin. 2007 Jun;28(6):763-72. - Pubmed
DTHybrid score 0.3663
Matrix metalloproteinase-9
Name Matrix metalloproteinase-9
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW: Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain. 2002 Jun;125(Pt 6):1297-308. - Pubmed
  • Sutton TA, Kelly KJ, Mang HE, Plotkin Z, Sandoval RM, Dagher PC: Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury. Am J Physiol Renal Physiol. 2005 Jan;288(1):F91-7. Epub 2004 Sep 7. - Pubmed
  • Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J: Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice. J Cereb Blood Flow Metab. 2005 Apr;25(4):460-7. - Pubmed
  • Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL: Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab. 2006 Sep;26(9):1157-64. Epub 2006 Jan 4. - Pubmed
  • Machado LS, Kozak A, Ergul A, Hess DC, Borlongan CV, Fagan SC: Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci. 2006 Jul 17;7:56. - Pubmed
DTHybrid score 1.0766
Vascular endothelial growth factor A
Name Vascular endothelial growth factor A
Gene Name VEGFA
Pharmacological action unknown
Actions inhibitor
References
  • Sasamura H, Takahashi A, Miyao N, Yanase M, Masumori N, Kitamura H, Itoh N, Tsukamoto T: Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma. Br J Cancer. 2002 Mar 4;86(5):768-73. - Pubmed
  • Yao JS, Chen Y, Zhai W, Xu K, Young WL, Yang GY: Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases. Circ Res. 2004 Aug 20;95(4):364-71. Epub 2004 Jul 15. - Pubmed
  • Rocchetti R, Talevi S, Margiotta C, Calza R, Corallini A, Possati L: Antiangiogenic drugs for chemotherapy of bladder tumours. Chemotherapy. 2005 Oct;51(6):291-9. Epub 2005 Oct 13. - Pubmed
DTHybrid score 0.5737
Caspase-1
Name Caspase-1
Gene Name CASP1
Pharmacological action unknown
Actions negative modulator
References
  • Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000 Jul;6(7):797-801. - Pubmed
  • Sanchez Mejia RO, Ona VO, Li M, Friedlander RM: Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery. 2001 Jun;48(6):1393-9; discussion 1399-401. - Pubmed
  • Vincent JA, Mohr S: Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes. 2007 Jan;56(1):224-30. - Pubmed
  • Kim HS, Suh YH: Minocycline and neurodegenerative diseases. Behav Brain Res. 2009 Jan 23;196(2):168-79. Epub 2008 Oct 11. - Pubmed
DTHybrid score 1.49
Caspase-3
Name Caspase-3
Gene Name CASP3
Pharmacological action unknown
Actions negative modulator
References
  • Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000 Jul;6(7):797-801. - Pubmed
  • Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM: Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002 Jul;52(1):54-61. - Pubmed
  • Dommergues MA, Plaisant F, Verney C, Gressens P: Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience. 2003;121(3):619-28. - Pubmed
  • Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC, Oh YJ, Markelonis GJ, Oh TH: Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma. 2003 Oct;20(10):1017-27. - Pubmed
  • Baptiste DC, Hartwick AT, Jollimore CA, Baldridge WH, Seigel GM, Kelly ME: An investigation of the neuroprotective effects of tetracycline derivatives in experimental models of retinal cell death. Mol Pharmacol. 2004 Nov;66(5):1113-22. Epub 2004 Aug 10. - Pubmed
  • Kim HS, Suh YH: Minocycline and neurodegenerative diseases. Behav Brain Res. 2009 Jan 23;196(2):168-79. Epub 2008 Oct 11. - Pubmed
DTHybrid score 1.8423
Cytochrome c
Name Cytochrome c
Gene Name CYCS
Pharmacological action unknown
Actions negative modulator
References
  • Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM: Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 2002 May 2;417(6884):74-8. - Pubmed
  • Matsuki S, Iuchi Y, Ikeda Y, Sasagawa I, Tomita Y, Fujii J: Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline. Biochem Biophys Res Commun. 2003 Dec 19;312(3):843-9. - Pubmed
  • Chu HC, Lin YL, Sytwu HK, Lin SH, Liao CL, Chao YC: Effects of minocycline on Fas-mediated fulminant hepatitis in mice. Br J Pharmacol. 2005 Jan;144(2):275-82. - Pubmed
  • Heo K, Cho YJ, Cho KJ, Kim HW, Kim HJ, Shin HY, Lee BI, Kim GW: Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Neurosci Lett. 2006 May 8;398(3):195-200. Epub 2006 Feb 15. - Pubmed
  • Mansson R, Hansson MJ, Morota S, Uchino H, Ekdahl CT, Elmer E: Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline. Neurobiol Dis. 2007 Jan;25(1):198-205. Epub 2006 Oct 24. - Pubmed
  • Kim HS, Suh YH: Minocycline and neurodegenerative diseases. Behav Brain Res. 2009 Jan 23;196(2):168-79. Epub 2008 Oct 11. - Pubmed
DTHybrid score 0.9718

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.5851
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.5138
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.4498
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.3627

Predictions


Id Partner name Gene Name Score
6719 30S ribosomal protein S9 rpsI 1.2175
6725 30S ribosomal protein S9 rpsI 1.2175
6714 30S ribosomal protein S4 rpsD 1.147
20 Prostaglandin G/H synthase 1 PTGS1 0.2007
4512 Cytochrome P450 3A4 CYP3A4 0.1404
5377 Placenta growth factor PGF 0.1355
587 Serum albumin ALB 0.129
290 Prostaglandin G/H synthase 2 PTGS2 0.1175
4757 Cytochrome P450 2C9 CYP2C9 0.1001
5142 Protein-tyrosine-phosphatase PPI 0.084
465 Calmodulin CALM1 0.0756
6315 V-type proton ATPase subunit B, brain isoform ATP6V1B2 0.0737
1588 Multidrug resistance protein 1 ABCB1 0.0729
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0692
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0691
6209 30S ribosomal protein S19 rpsS 0.069
6712 30S ribosomal protein S19 rpsS 0.069
6726 30S ribosomal protein S19 rpsS 0.069
6207 30S ribosomal protein S14 rpsN 0.069
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0663
6016 Cytochrome P450 2C19 CYP2C19 0.0643
2164 Multidrug resistance-associated protein 4 ABCC4 0.0639
566 Serotransferrin TF 0.062
798 Osteocalcin BGLAP 0.061
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0571
118 Organic cation/carnitine transporter 2 SLC22A5 0.0571
6208 30S ribosomal protein S13 rpsM 0.0567
6706 30S ribosomal protein S13 rpsM 0.0567
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0545
4924 Cytochrome P450 2C8 CYP2C8 0.0542
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0502
862 Multidrug resistance-associated protein 1 ABCC1 0.0501
4200 Cytochrome P450 1A2 CYP1A2 0.0496
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0495
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0478
6182 Cytochrome P450 2J2 CYP2J2 0.0472
1334 Tissue factor pathway inhibitor TFPI 0.0471
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0432
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0417
1719 Heparanase HPSE 0.0414
6144 Solute carrier family 22 member 2 SLC22A2 0.0406
6145 Solute carrier family 22 member 1 SLC22A1 0.0379
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0376
2058 P-selectin SELP 0.0373
308 30S ribosomal protein S12 rpsL 0.037
6704 30S ribosomal protein S12 rpsL 0.037
738 Monocarboxylate transporter 1 SLC16A1 0.0355
1757 Myeloperoxidase MPO 0.0335
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0322
4118 Cytochrome P450 3A5 CYP3A5 0.0315
6136 Multidrug resistance-associated protein 5 ABCC5 0.0306
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
309 Antithrombin-III SERPINC1 0.0304
3221 Cytochrome c4 cc4 0.0302
633 Penicillin-binding proteins 1A/1B pbpA 0.0301
703 NADPH azoreductase azr 0.0295
6013 Cytochrome P450 2E1 CYP2E1 0.0295
707 72 kDa type IV collagenase MMP2 0.0295
4119 Cytochrome P450 2D6 CYP2D6 0.0291
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0286
338 DNA polymerase UL30 0.0285
379 DNA polymerase UL54 0.0285
697 DNA polymerase ORF28 0.0285
2482 DNA polymerase 43 0.0285
4104 DNA polymerase BALF5 0.0285
776 Bile salt export pump ABCB11 0.0283
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0282
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0276
6141 Sodium/bile acid cotransporter SLC10A1 0.0276
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.027
5353 Glutamate decarboxylase alpha gadA 0.027
3090 Chitosanase csn 0.0267
645 Penicillin-binding protein 1A mrcA 0.0267
5805 Penicillin-binding protein 1A ponA 0.0267
6185 Penicillin-binding protein 1A mrcA 0.0267
6799 Penicillin-binding protein 1A pbpA 0.0267
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0267
833 Organic cation/carnitine transporter 1 SLC22A4 0.0262
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0258
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0251
438 Taste receptor type 1 member 2 TAS1R2 0.0248
543 Penicillin-binding protein 1B mrcB 0.0246
6186 Penicillin-binding protein 1B ponB 0.0246
6822 Penicillin-binding protein 1b pbp1b 0.0246
6844 Penicillin-binding protein 1b pbp1b 0.0246
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0246
244 Angiotensin-converting enzyme ACE 0.0245
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0241
6024 Cytochrome P450 1A1 CYP1A1 0.0231
1253 Interferon gamma IFNG 0.023
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0227
3947 Xanthine dehydrogenase/oxidase XDH 0.0227
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0226
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0224
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0223
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0212
6149 Solute carrier family 22 member 10 SLC22A10 0.021
1867 Major prion protein PRNP 0.0208
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
777 Tumor necrosis factor TNF 0.0203
6107 Cytochrome P450 3A7 CYP3A7 0.0203
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
3923 Cholinesterase BCHE 0.0201
6020 Aldehyde oxidase AOX1 0.02
4411 DNA protection during starvation protein dps 0.0197
5423 UPF0010 protein HI1317 HI_1317 0.0197
3780 Lipoprotein nlpI precursor nlpI 0.0197
5424 Endonuclease VIII-like 1 NEIL1 0.0197
2016 Dipeptidase 1 DPEP1 0.0197
558 Solute carrier family 12 member 1 SLC12A1 0.0196
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0193
5718 Cytochrome P450 2A6 CYP2A6 0.0193
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0184
5787 Angiopoietin-1 receptor TEK 0.0182
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0182
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
3164 Biotin synthase bioB 0.0173
4923 Cytochrome c3 DvMF_2499 0.0172
4945 Cytochrome c3 Not Available 0.0172
4949 Cytochrome c3 DVU_3171 0.0172
4968 Cytochrome c3 cytc3 0.0172
4997 Cytochrome c3 SO_2727 0.0172
5219 Cytochrome c3 cyd 0.0172
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0172
4948 Cytochrome c-553 Not Available 0.0172
4902 Nine-heme cytochrome c Ddes_2038 0.0172
3189 High-molecular-weight cytochrome c hmcA 0.0172
5036 Small inducible cytokine A8 CCL8 0.017
5012 Ig lambda chain V-II region MGC Not Available 0.017
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.017
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
357 Carbonic anhydrase 2 CA2 0.017
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
115 Penicillin-binding protein 2 mrdA 0.0166
6069 Penicillin-binding protein 2 mrdA 0.0166
6118 Penicillin-binding protein 2 penA 0.0166
6187 Penicillin-binding protein 2 pbpA 0.0166
6686 Penicillin-binding protein 2 pbp2 0.0166
6939 Penicillin-binding protein 2 mrdA 0.0166
7163 Penicillin-binding protein 2 pbpA 0.0166
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
1650 Heme carrier protein 1 SLC46A1 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
3583 6-phosphogluconolactonase pgl 0.0159
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0158
4386 Hemoglobin-like protein HbN glbN 0.0156
6147 Solute carrier family 22 member 3 SLC22A3 0.0155
1 Peptidoglycan synthetase ftsI ftsI 0.0155
4155 Peptidoglycan synthetase ftsI ftsI 0.0155
6033 High affinity interleukin-8 receptor A CXCR1 0.0154
527 Prostacyclin receptor PTGIR 0.0152
3259 Autolysin lytA 0.0151
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.015
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3152 Cytochrome c'' cycA 0.0148
5023 Glycoside hydrolase Not Available 0.0148
5024 Glycoside hydrolase Not Available 0.0148
672 Prostaglandin F2-alpha receptor PTGFR 0.0148
5221 Cytochrome c3, 13 kDa Not Available 0.0148
5220 Split-Soret cytochrome c Ddes_2150 0.0148
3700 Cytochrome c-552 precursor nrfA 0.0148
4771 Dissimilatory copper-containing nitrite reductase nir 0.0148
5006 RNASE4 protein RNASE4 0.0148
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0146
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0145
844 Epidermal growth factor receptor EGFR 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0143
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
3817 Complement C1q subcomponent subunit C C1QC 0.0138
3816 Complement C1q subcomponent subunit B C1QB 0.0138
6148 Multidrug resistance-associated protein 7 ABCC10 0.0138
3815 Complement C1q subcomponent subunit A C1QA 0.0138
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0136
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0136
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0136
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0136
3814 Complement C1r subcomponent C1R 0.0136
2149 Angiogenin ANG 0.0136
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0135
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0133
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.013
6167 Organic solute transporter subunit beta OSTB 0.013
6166 Organic solute transporter subunit alpha OSTA 0.013
3127 Nitrite reductase nirS 0.0129
3284 Nitrite reductase nirS 0.0129
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
2320 Thymidine kinase, cytosolic TK1 0.0126
6106 Cytochrome P450 2C18 CYP2C18 0.0125
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0124
130 Prostacyclin synthase PTGIS 0.0124
3030 Salivary alpha-amylase AMY1A 0.0123
1374 Natriuretic peptides B NPPB 0.0122
1827 Gap junction alpha-1 protein GJA1 0.0121
1908 Vascular cell adhesion protein 1 VCAM1 0.0121
124 Histamine H2 receptor HRH2 0.0121
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
6030 Cytochrome P450 2B6 CYP2B6 0.0119
2723 Cholera enterotoxin subunit B ctxB 0.0118
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0118
6374 Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 0.0116
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0115
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0112
2430 Chondroitinase B cslB 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
4760 Mll3241 protein mll3241 0.0109
373 Transthyretin TTR 0.0109
3426 Glutamine synthetase glnA 0.0104
3987 Glutamine synthetase GLUL 0.0104
6126 Carbonic anhydrase 7 CA7 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
2981 Phospholipase A2, membrane associated PLA2G2A 0.0101
4217 Telomerase reverse transcriptase TERT 0.0101
3917 Methylenetetrahydrofolate reductase MTHFR 0.0101
3760 Penicillin-binding protein 5 precursor dacA 0.01
33 Cystine/glutamate transporter SLC7A11 0.01
4513 Pancreatic alpha-amylase AMY2A 0.0098
1405 Thiopurine S-methyltransferase TPMT 0.0097
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
997 Protein kinase C beta type PRKCB 0.0094
4604 Liver carboxylesterase 1 CES1 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
819 Penicillin-binding protein 4 dacB 0.009
6031 Cytochrome P450 3A43 CYP3A43 0.0089
24 Thymidylate synthase TMP1 0.0089
359 Thymidylate synthase TYMS 0.0089
2626 Thymidylate synthase thyA 0.0089
2729 Thymidylate synthase thyA 0.0089
5352 Thymidylate synthase THYA 0.0089
1970 Protein kinase C alpha type PRKCA 0.0088
6201 Matrix metalloproteinase-27 MMP27 0.0087
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0087
6200 Matrix metalloproteinase-26 MMP26 0.0087
6197 Matrix metalloproteinase-23 MMP23A 0.0087
6199 Matrix metalloproteinase-25 MMP25 0.0087
6198 Matrix metalloproteinase-24 MMP24 0.0087
6192 Matrix metalloproteinase-15 MMP15 0.0087
6191 Matrix metalloproteinase-14 MMP14 0.0087
6196 Matrix metalloproteinase-21 MMP21 0.0087
6194 Matrix metalloproteinase-19 MMP19 0.0087
6193 Matrix metalloproteinase-17 MMP17 0.0087
6202 Matrix metalloproteinase-28 MMP28 0.0087
4122 Histone deacetylase 2 HDAC2 0.0087
2970 Matrix metalloproteinase-16 MMP16 0.0085
3811 Cytochrome P450 19A1 CYP19A1 0.0085
6195 Matrix metalloproteinase-20 MMP20 0.0084
6188 Stromelysin-2 MMP10 0.0084
6190 Stromelysin-3 MMP11 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6137 Multidrug resistance-associated protein 6 ABCC6 0.0083
3932 Glutathione S-transferase A2 GSTA2 0.0082
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0081
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0081
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0081
16 Adenosine A1 receptor ADORA1 0.008
1898 Cytochrome P450 1B1 CYP1B1 0.008
1178 Adenosine A2a receptor ADORA2A 0.0078
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0078
6189 Matrilysin MMP7 0.0078
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
86 SEC14-like protein 4 SEC14L4 0.0075
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0075
375 SEC14-like protein 3 SEC14L3 0.0075
4076 Diacylglycerol kinase alpha DGKA 0.0075
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
810 Heme oxygenase 1 HMOX1 0.0074
3391 Heme oxygenase 1 pbsA1 0.0074
1167 Interstitial collagenase MMP1 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0072
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0072
293 Gamma-glutamyl hydrolase GGH 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0071
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.007
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
756 Sex hormone-binding globulin SHBG 0.0068
6218 Pannexin-1 PANX1 0.0068
708 Alpha-tocopherol transfer protein TTPA 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0065
283 SEC14-like protein 2 SEC14L2 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
4773 Deoxycytidine kinase DCK 0.0064
905 Glutathione transferase omega-1 GSTO1 0.0063
899 Glutathione S-transferase Mu 3 GSTM3 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
1330 Collagenase 3 MMP13 0.0062
2154 Neutrophil collagenase MMP8 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0061
5818 Folate receptor alpha FOLR1 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0061
6042 Prostaglandin reductase 2 PTGR2 0.006
2203 Macrophage metalloelastase MMP12 0.006
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.006
146 Androgen receptor AR 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0058
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0058
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0057
1926 Stromelysin-1 MMP3 0.0057
193 Beta-1 adrenergic receptor ADRB1 0.0057
766 Beta-2 adrenergic receptor ADRB2 0.0056
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
818 50S ribosomal protein L10 rplJ 0.0053
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0053
4238 50S ribosomal protein L4 rplD 0.0052
5578 50S ribosomal protein L4 rplD 0.0052
6173 50S ribosomal protein L4 rplD 0.0052
6219 50S ribosomal protein L4 rplD 0.0052
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
556 Alpha-1A adrenergic receptor ADRA1A 0.005
4905 Cytochrome c2 Not Available 0.0049
4939 Cytochrome c2 cycA 0.0049
4964 Cytochrome c2 cycA 0.0049
4979 Cytochrome c2 cycA 0.0049
6673 Cytochrome c2 cycA 0.0049
4934 Cytochrome c-551 nirM 0.0049
5218 Cytochrome c-551 nirM 0.0049
4916 Cyanoglobin glbN 0.0049
4936 Cytochrome c2 iso-2 Not Available 0.0049
4943 Cytochrome c6 petJ 0.0049
4998 Hemoglobin-like protein yjbI yjbI 0.0049
4981 Iron-starvation protein PigA pigA 0.0049
4994 Hemoglobin-like protein HbO glbO 0.0049
4947 Bacterial hemoglobin vhb 0.0049
4915 Cytochrome c-550 psbV 0.0049
4959 Cytochrome c-550 psbV 0.0049
5216 Cytochrome c-550 psbV 0.0049
4925 Cytochrome c-type protein SHP shp 0.0049
4975 Cytochrome c-556 RPA3973 0.0049
4942 Diheme cytochrome c napB napB 0.0049
3116 Bacterioferritin bfr 0.0049
4906 Bacterioferritin bfr 0.0049
4965 Bacterioferritin bfr 0.0049
4999 Cytochrome P450 165B3 CYP165B3 0.0049
4984 Neuroglobin NGB 0.0049
4935 Cytochrome c-554 cycA1 0.0049
4954 Soluble cytochrome b558 Not Available 0.0049
4907 Cytochrome c-L moxG 0.0049
6865 Cytochrome c-L moxG 0.0049
4909 CooA protein cooA 0.0049
4937 Cytochrome oxidase subunit II rcoxA 0.0049
4961 Hemophore HasA hasA 0.0049
4910 Cytoglobin CYGB 0.0049
4904 Cytochrome c family protein GSU1996 0.0049
5000 HemO hemO 0.0049
4971 Nonaheme cytochrome c hmcA 0.0049
644 Heme oxygenase 2 HMOX2 0.0049
4982 Heme oxygenase 2 pbsA2 0.0049
4931 Cytochrome P450 167A1 CYP167A1 0.0049
4989 Cytochrome c551 peroxidase ccp 0.0049
5222 Cytochrome c551 peroxidase ccpA 0.0049
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0049
4976 Apocytochrome f petA 0.0049
6407 Apocytochrome f petA 0.0049
4903 Methyl-accepting chemotaxis protein Tar4 0.0049
4922 Cytochrome c, putative SO_4144 0.0049
4764 Cytochrome P450 165C4 CYP165C4 0.0049
4972 P450cin cinA 0.0049
4960 Putative cytochrome P450-family protein SCO7417 0.0049
4926 Heme-based aerotactic transducer hemAT hemAT 0.0049
4952 Catalase/peroxidase katA 0.0049
4993 Hydroxylamine oxidoreductase hao1 0.0049
3093 Catalase HPII katE 0.0049
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
4237 50S ribosomal protein L22 rplV 0.0047
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0047
1313 Lactoylglutathione lyase GLO1 0.0046
136 Estrogen receptor ESR1 0.0046
1039 Histone deacetylase 9 HDAC9 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0044
489 Monocarboxylate transporter 2 SLC16A7 0.0044
3587 Gastrotropin FABP6 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0041
408 Riboflavin kinase RFK 0.0041
4920 Peroxidase/catalase katG 0.004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.004
4990 PpcA ppcA 0.004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.004
2119 Cytochrome b5 CYB5A 0.004
904 Glutathione S-transferase P GSTP1 0.004
4037 Hypothetical protein GPX1 0.0039
4297 Hypothetical protein SP_1951 0.0039
4521 Hypothetical protein BC_2969 0.0039
4540 Hypothetical protein TM_1070 0.0039
4555 Hypothetical protein MT1739 0.0039
4569 Hypothetical protein mshD 0.0039
4578 Hypothetical protein PA3270 0.0039
4747 Hypothetical protein PA3967 0.0039
5177 Hypothetical protein TM_0096 0.0039
5194 Hypothetical protein PA1204 0.0039
5240 Hypothetical protein Rv2991 0.0039
5370 Hypothetical protein TM_1158 0.0039
5710 Hypothetical protein Tb927.5.1360 0.0039
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
3570 Cytochrome P450 152A1 cypC 0.0039
4289 Cytochrome P450 TT_P0059 0.0039
6262 Cytochrome P450 staP 0.0039
4992 Cytochrome c peroxidase Not Available 0.0039
4988 Sulfite oxidase, mitochondrial SUOX 0.0039
3375 Acidic cytochrome c3 Not Available 0.0039
4813 Heme oxygenase hmuO 0.0039
5769 Heme oxygenase Not Available 0.0039
4385 Cytochrome c' Not Available 0.0039
4967 Cytochrome c' cycA 0.0039
5038 Cytochrome c' Not Available 0.0039
5223 Cytochrome c' cycP 0.0039
2915 Sensor protein fixL fixL 0.0039
4944 Sensor protein fixL fixL 0.0039
3941 Amine oxidase [flavin-containing] A MAOA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0038
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
3670 Soluble cytochrome b562 precursor cybC 0.0036
3411 Cytochrome P450 121 cyp121 0.0036
2230 Catalase CAT 0.0035
3249 Catalase katA 0.0035
3625 Catalase katA 0.0035
4539 Catalase katA 0.0035
4941 Catalase katB 0.0035
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
2617 Nitric oxide synthase oxygenase nos 0.0035
2701 Nitric oxide synthase oxygenase nos 0.0035
3291 Cytochrome c-552 cycA 0.0035
4927 Cytochrome c-552 nrfA 0.0035
4938 Cytochrome c-552 cycA 0.0035
4953 Cytochrome c-552 nrfA 0.0035
5217 Cytochrome c-552 cycM 0.0035
492 Histamine H1 receptor HRH1 0.0035
3102 Flavohemoprotein hmp 0.0035
4969 Flavohemoprotein hmp 0.0035
594 Thyroxine-binding globulin SERPINA7 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0033
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
605 Fumarate reductase flavoprotein subunit frdA 0.0031
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0031
3673 Fumarate reductase flavoprotein subunit fccA 0.0031
4912 Fumarate reductase flavoprotein subunit ifcA 0.0031
6549 Fumarate reductase flavoprotein subunit frdA 0.0031
758 Thyroid hormone receptor alpha THRA 0.0031
4608 Putative cytochrome P450 SCO1207 0.0031
4963 Putative cytochrome P450 SCO2884 0.0031
6254 Putative cytochrome P450 SCO6998 0.0031
2972 6-deoxyerythronolide B hydroxylase eryF 0.0031
518 Peroxidase/catalase T katG 0.0031
4225 Uridine phosphorylase 1 UPP1 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
654 Flavin reductase BLVRB 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
260 Cytochrome P450 51 ERG11 0.0029
761 Cytochrome P450 51 ERG11 0.0029
3163 Cytochrome P450 51 cyp51 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
3810 Catechol O-methyltransferase COMT 0.0029
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
693 Hemoglobin subunit beta HBB 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
6268 Hydroxyacid oxidase 1 HAO1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
358 Cystathionine beta-synthase CBS 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0026
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0026
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0026
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
2298 Cytochrome P450-cam camC 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
6501 Fatty acid-binding protein, liver FABP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
76 Nitric-oxide synthase, brain NOS1 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
7 Nitric oxide synthase, inducible NOS2 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
3957 Adenosine deaminase ADA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
6500 Phospholipase A2 PLA2G1B 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0017
5773 DNA-directed RNA polymerase beta chain rpoB 0.0017
869 Estrogen receptor beta ESR2 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
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