DT-Web

DB00977 - Ethinyl Estradiol


Identification
Name Ethinyl Estradiol
Accession Number DB00977 (APRD00691)
Type small molecule
Description A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives [PubChem]. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 296.4034
Groups approved
Monoisotopic Weight 296.177630012
Pharmacology
Indication For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Mechanism of action Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Absorption Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).
Protein binding 97%
Biotransformation Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.
Route of elimination Not Available
Toxicity Oral, mouse LD50: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Increased thrombotic risk due to estrogen
Aminophylline The contraceptive increases the effect and toxicity of theophylline
Amobarbital This product may cause a slight decrease of contraceptive effect
Amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive
Ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive
Amprenavir Ritonavir could decrease the contraceptive efficacy
Anisindione Increased thrombotic risk due to estrogen
Aprepitant Aprepitant could decrease the effect of the oral contraceptive
Aprobarbital This product may cause a slight decrease of contraceptive effect
Artemether Artemether may decrease the effectiveness of ethinyl estradiol by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Azlocillin This anti-infectious agent could decrease the effect of the oral contraceptive
Aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive
Bacampicillin This anti-infectious agent could decrease the effect of the oral contraceptive
Bendamustine Increases levels of bendamustine by decreasing metabolism. Ethinyl Estradiol is a CYP1A2 inhibitor and concurrent administration may result in elevated plasma concentrations of bendamustine.
Bosentan Bosentan may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be relied on alone during concomitant therapy with bosentan.
Butabarbital This product may cause a slight decrease of contraceptive effect
Butalbital This product may cause a slight decrease of contraceptive effect
Butethal This product may cause a slight decrease of contraceptive effect
Carbamazepine Carbamazepine may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be relied on alone during concomitant therapy with carbamazepine.
Clavulanate This anti-infectious agent could decrease the effect of the oral contraceptive
Cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Colesevelam Bile Acid Sequestrants may decrease the serum concentration of Contraceptives (Estrogens). Administer estrogen-based oral contraceptives at least 1-4 hours prior to or 4-6 hours after administration of a bile acid sequestrant. Consider alternatives in order to avoid this combination when possible, due to the risk for impaired contraceptive effectiveness. Ethinyl estradiol patches and vaginal rings may also be somewhat impacted by this interaction, though the extent and significance of such an interaction is uncertain.
Cyclacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Cyclosporine The contraceptive increases the effect and toxicity of cyclosporine
Demeclocycline This anti-infectious agent could decrease the effect of the oral contraceptive
Dicloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Dicumarol Increased thrombotic risk due to estrogen
Doxycycline Doxycycline may decrease the contraceptive effect of ethinyl estradiol.
Dyphylline The contraceptive increases the effect and toxicity of theophylline
Eltrombopag Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Ethotoin This product may cause a slight decrease of contraceptive effect
Etoricoxib Etoricoxib may increase the levels of ethinyl estradiol.
Flucloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Fosphenytoin This product may cause a slight decrease of contraceptive effect
Griseofulvin This product may cause a slight decrease of contraceptive effect
Heptabarbital This product may cause a slight decrease of contraceptive effect
Hetacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Hexobarbital This product may cause a slight decrease of contraceptive effect
Ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive
Lamotrigine The oral contraceptive decreases the effect of lamotrigine
Mephenytoin This product may cause a slight decrease of contraceptive effect
Methacycline This anti-infectious agent could decrease the effect of the oral contraceptive
Methohexital This product may cause a slight decrease of contraceptive effect
Methylphenobarbital This product may cause a slight decrease of contraceptive effect
Meticillin This anti-infectious agent could decrease the effect of the oral contraceptive
Mezlocillin This anti-infectious agent could decrease the effect of the oral contraceptive
Minocycline This anti-infectious agent could decrease the effect of the oral contraceptive
Modafinil Modafinil may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be solely relied on during concomitant therapy with modafinil.
Nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive
Nelfinavir Ritonavir could decrease the contraceptive efficacy
Oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Oxcarbazepine Oxcarbazepine may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be solely relied upon during concomitant therapy with oxcarbazepine.
Oxtriphylline The contraceptive increases the effect and toxicity of theophylline
Oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive
Pentobarbital This product may cause a slight decrease of contraceptive effect
Phenobarbital This product may cause a slight decrease of contraceptive effect
Phenytoin This product may cause a slight decrease of contraceptive effect
Piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive
Pivampicillin This anti-infectious agent could decrease the effect of the oral contraceptive
Prednisolone The estrogenic agent, ethinyl estradiol, may increase the effect of the corticosteroid, prednisolone.
Prednisone The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisone.
Primidone This product may cause a slight decrease of contraceptive effect
Raloxifene Association not recommended
Rifabutin Rifabutin may decrease the contraceptive effect of ethinyl estradiol. Hormonal contraception should not be solely relied on alone during concomitant therapy with rifabutin.
Rifampin This product may cause a slight decrease of contraceptive effect
Rifapentine This product may cause a slight decrease of contraceptive effect
Ritonavir Ritonavir could decrease the contraceptive efficacy
Rolitetracycline This anti-infectious agent could decrease the effect of the oral contraceptive
Rufinamide Rufinamide decreases plasma concentrations of ethinyl estradiol, thus consider therapy modification
Secobarbital This product may cause a slight decrease of contraceptive effect
St. John's Wort St. John's Wort could reduce the contraceptive effect
Tacrolimus Ethinyl estradiol may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Ethinyl estradiol therapy is initiated, discontinued or altered.
Talbutal This product may cause a slight decrease of contraceptive effect
Tazobactam This anti-infectious agent could decrease the effect of the oral contraceptive
Tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive
Theophylline The contraceptive increases the effect and toxicity of theophylline
Thiopental Thiopental may decrease the effect of Ethinyl estradiol. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive
Tipranavir Tipranavir, co-administered with Ritonavir, decreases Ethinyl estradiol concentrations. Ethinyl estradiol may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Use an alternate form of contraception or monitor for estrogen deficiency if Ethinyl estradiol is used for hormone replacement therapy.
Tizanidine Ethinyl estradiol may increase the serum concentration of tizanidine. Monitor for changes in the therapeutic and adverse effects of tizanidine if ethinyl estradiol is initiated, discontinued or dose changed.
Topiramate Topiramate may decrease the effect of the oral contraceptive, Ethinyl estradiol. An alternate form of contraception should be used during concomitant therapy.
Tretinoin Oral Tretinoin may decrease the effect of the oral contraceptive, Ethinyl Estradiol. An alternate form of contraception should be used during concomitant therapy.
Troglitazone Possible loss of contracepitve effect
Ursodeoxycholic acid Estrogens decreases the effect of ursodiol
Warfarin Ethinyl estradiol may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if ethinyl estradiol is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Micevych PE, Chaban V, Ogi J, Dewing P, Lu JK, Sinchak K: Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures. Endocrinology. 2007 Feb;148(2):782-9. Epub 2006 Nov 9. - Pubmed
  • Garcia-Segura LM, Sanz A, Mendez P: Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection. Neuroendocrinology. 2006;84(4):275-9. Epub 2006 Nov 23. - Pubmed
  • Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G, Mariani S, Cherubini S, d'Abusco AS, Scandurra R, Migliaccio S: Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):102-8. Epub 2006 Nov 27. - Pubmed
  • Lehnes K, Winder AD, Alfonso C, Kasid N, Simoneaux M, Summe H, Morgan E, Iann MC, Duncan J, Eagan M, Tavaluc R, Evans CH Jr, Russell R, Wang A, Hu F, Stoica A: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway. Endocrinology. 2007 Mar;148(3):1171-80. Epub 2006 Nov 30. - Pubmed
  • Mukai H, Tsurugizawa T, Ogiue-Ikeda M, Murakami G, Hojo Y, Ishii H, Kimoto T, Kawato S: Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory. Neuroendocrinology. 2006;84(4):255-63. Epub 2006 Dec 1. - Pubmed
  • Notch EG, Mayer GD: 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8. Epub 2009 Jan 23. - Pubmed
  • Bennink HJ: Reprint of Are all estrogens the same? Maturitas. 2008 Sep-Oct;61(1-2):195-201. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7461
Nuclear receptor subfamily 1 group I member 2
Name Nuclear receptor subfamily 1 group I member 2
Gene Name NR1I2
Pharmacological action unknown
Actions agonist
References
  • Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol. 2007 May;21(5):1028-38. Epub 2007 Feb 27. - Pubmed
DTHybrid score 0.3394

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Wang B, Sanchez RI, Franklin RB, Evans DC, Huskey SE: The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12. Epub 2004 Aug 10. - Pubmed
DTHybrid score 0.5189
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
DTHybrid score 0.2848

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor,inducer
References
  • Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan;118(1):163-72. - Pubmed
  • Huang L, Smit JW, Meijer DK, Vore M: Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. Hepatology. 2000 Jul;32(1):66-72. - Pubmed
DTHybrid score 0.2375
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions inducer
References
  • Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan;118(1):163-72. - Pubmed
DTHybrid score 0.1912
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Kauffmann HM, Schrenk D: Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun. 1998 Apr 17;245(2):325-31. - Pubmed
  • Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL: The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 1997 Jul;113(1):255-64. - Pubmed
DTHybrid score 0.2846
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. - Pubmed
DTHybrid score 0.4292

Predictions


Id Partner name Gene Name Score
6241 Nuclear receptor coactivator 2 NCOA2 0.2483
4757 Cytochrome P450 2C9 CYP2C9 0.2254
4118 Cytochrome P450 3A5 CYP3A5 0.1763
4119 Cytochrome P450 2D6 CYP2D6 0.1667
6016 Cytochrome P450 2C19 CYP2C19 0.1667
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1562
4200 Cytochrome P450 1A2 CYP1A2 0.151
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1409
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1273
6107 Cytochrome P450 3A7 CYP3A7 0.1247
6030 Cytochrome P450 2B6 CYP2B6 0.115
862 Multidrug resistance-associated protein 1 ABCC1 0.1086
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0971
869 Estrogen receptor beta ESR2 0.0949
6013 Cytochrome P450 2E1 CYP2E1 0.0905
587 Serum albumin ALB 0.0901
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0893
6024 Cytochrome P450 1A1 CYP1A1 0.0873
614 Progesterone receptor PGR 0.0866
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.069
3811 Cytochrome P450 19A1 CYP19A1 0.0655
1729 Solute carrier family 22 member 6 SLC22A6 0.0643
6142 Solute carrier family 22 member 8 SLC22A8 0.0629
2164 Multidrug resistance-associated protein 4 ABCC4 0.0625
1898 Cytochrome P450 1B1 CYP1B1 0.0621
5718 Cytochrome P450 2A6 CYP2A6 0.0599
20 Prostaglandin G/H synthase 1 PTGS1 0.0574
284 DNA-directed RNA polymerase beta chain rpoB 0.056
5773 DNA-directed RNA polymerase beta chain rpoB 0.056
6145 Solute carrier family 22 member 1 SLC22A1 0.0534
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0527
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0489
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0475
6148 Multidrug resistance-associated protein 7 ABCC10 0.0473
6144 Solute carrier family 22 member 2 SLC22A2 0.0466
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0433
6143 Solute carrier family 22 member 7 SLC22A7 0.0427
1024 Solute carrier family 22 member 11 SLC22A11 0.0394
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0378
871 Glucocorticoid receptor NR3C1 0.0371
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0358
275 Arachidonate 5-lipoxygenase ALOX5 0.0346
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0322
6106 Cytochrome P450 2C18 CYP2C18 0.0312
290 Prostaglandin G/H synthase 2 PTGS2 0.0305
6228 Nuclear receptor coactivator 1 NCOA1 0.0301
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.03
118 Organic cation/carnitine transporter 2 SLC22A5 0.0298
6137 Multidrug resistance-associated protein 6 ABCC6 0.0293
6147 Solute carrier family 22 member 3 SLC22A3 0.0283
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0282
756 Sex hormone-binding globulin SHBG 0.0281
817 DNA topoisomerase 2-alpha TOP2A 0.0269
492 Histamine H1 receptor HRH1 0.0268
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0263
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0263
146 Androgen receptor AR 0.026
70 Type-1 angiotensin II receptor AGTR1 0.0246
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
6283 Oxysterols receptor LXR-alpha NR1H3 0.0242
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0241
824 Sodium-dependent serotonin transporter SLC6A4 0.0232
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0231
556 Alpha-1A adrenergic receptor ADRA1A 0.0229
1852 Microtubule-associated protein 2 MAP2 0.0226
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0225
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0222
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0222
88 Retinoic acid receptor RXR-beta RXRB 0.0222
468 Cytochrome P450 4A11 CYP4A11 0.022
4604 Liver carboxylesterase 1 CES1 0.0218
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0213
6031 Cytochrome P450 3A43 CYP3A43 0.0211
831 D(2) dopamine receptor DRD2 0.021
683 Potassium transporter GK0582 0.0203
29 Tubulin beta-1 chain TUBB1 0.0202
502 5-hydroxytryptamine 2A receptor HTR2A 0.0201
731 HIV-1 protease HIV-1 protease 0.02
220 Sodium channel protein type 5 subunit alpha SCN5A 0.02
6136 Multidrug resistance-associated protein 5 ABCC5 0.0197
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0194
847 Mu-type opioid receptor OPRM1 0.0194
2808 Chloramphenicol acetyltransferase 3 cat3 0.0192
844 Epidermal growth factor receptor EGFR 0.0191
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0184
161 Tubulin beta chain TUBB 0.0182
312 Tubulin beta chain TUB2 0.0182
833 Organic cation/carnitine transporter 1 SLC22A4 0.0182
3270 Elongation factor G fusA 0.0181
467 Delta-type opioid receptor OPRD1 0.0181
738 Monocarboxylate transporter 1 SLC16A1 0.018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.018
373 Transthyretin TTR 0.0179
6167 Organic solute transporter subunit beta OSTB 0.0179
6166 Organic solute transporter subunit alpha OSTA 0.0179
380 Cytochrome P450 17A1 CYP17A1 0.0177
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0174
737 Mineralocorticoid receptor NR3C2 0.0171
3923 Cholinesterase BCHE 0.0171
477 DNA topoisomerase 4 subunit A parC 0.0167
886 DNA topoisomerase 4 subunit A parC 0.0167
6226 DNA topoisomerase 4 subunit A parC 0.0167
260 Cytochrome P450 51 ERG11 0.0165
761 Cytochrome P450 51 ERG11 0.0165
3163 Cytochrome P450 51 cyp51 0.0165
696 Kappa-type opioid receptor OPRK1 0.0165
404 DNA gyrase subunit A gyrA 0.0165
6224 DNA gyrase subunit A gyrA 0.0165
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0157
594 Thyroxine-binding globulin SERPINA7 0.0156
5923 Microtubule-associated protein tau MAPT 0.0156
5924 Microtubule-associated protein 4 MAP4 0.0156
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
320 5-hydroxytryptamine 1A receptor HTR1A 0.0149
632 Alpha-1B adrenergic receptor ADRA1B 0.0146
273 Apoptosis regulator Bcl-2 BCL2 0.0146
758 Thyroid hormone receptor alpha THRA 0.0145
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0144
3587 Gastrotropin FABP6 0.0142
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0142
4120 NADPH--cytochrome P450 reductase POR 0.0141
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0139
49 Endothelin B receptor EDNRB 0.0139
23 D(1A) dopamine receptor DRD1 0.0138
504 Mast/stem cell growth factor receptor KIT 0.0138
318 Alpha-2A adrenergic receptor ADRA2A 0.0137
6182 Cytochrome P450 2J2 CYP2J2 0.0136
766 Beta-2 adrenergic receptor ADRB2 0.0135
6149 Solute carrier family 22 member 10 SLC22A10 0.0135
193 Beta-1 adrenergic receptor ADRB1 0.0133
346 Thyroid hormone receptor beta-1 THRB 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
578 Endothelin-1 receptor EDNRA 0.0131
904 Glutathione S-transferase P GSTP1 0.0129
322 Vasopressin V2 receptor AVPR2 0.0128
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0125
6085 Fatty acid-binding protein, intestinal FABP2 0.0125
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0123
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0123
3809 Estrogen-related receptor gamma ESRRG 0.0123
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0122
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0122
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0122
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0122
1629 Transcription factor AP-1 JUN 0.012
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.012
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
465 Calmodulin CALM1 0.0118
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
1192 Sulfotransferase 1A1 SULT1A1 0.0118
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0116
3947 Xanthine dehydrogenase/oxidase XDH 0.0116
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0116
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
407 Vascular endothelial growth factor receptor 2 KDR 0.0114
33 Cystine/glutamate transporter SLC7A11 0.0113
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0113
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0112
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
3868 Calcineurin subunit B isoform 2 PPP3R2 0.011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.011
450 Muscarinic acetylcholine receptor M4 CHRM4 0.011
952 Dipeptidyl peptidase 4 DPP4 0.0109
2443 Azurin azu 0.0108
2539 Tubulin alpha-1 chain TUBA4A 0.0108
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0107
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0106
2449 Tubulin alpha-3 chain TUBA1A 0.0106
2107 Microtubule-associated protein 1A MAP1A 0.0106
3941 Amine oxidase [flavin-containing] A MAOA 0.0105
131 Synaptic vesicular amine transporter SLC18A2 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0105
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0104
789 Alpha-1D adrenergic receptor ADRA1D 0.0104
24 Thymidylate synthase TMP1 0.0104
359 Thymidylate synthase TYMS 0.0104
2626 Thymidylate synthase thyA 0.0104
2729 Thymidylate synthase thyA 0.0104
5352 Thymidylate synthase THYA 0.0104
558 Solute carrier family 12 member 1 SLC12A1 0.0101
3932 Glutathione S-transferase A2 GSTA2 0.0101
590 5-hydroxytryptamine 2C receptor HTR2C 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0099
283 SEC14-like protein 2 SEC14L2 0.0098
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0097
26 Vascular endothelial growth factor receptor 3 FLT4 0.0097
122 P2Y purinoceptor 12 P2RY12 0.0095
381 Prolactin receptor PRLR 0.0093
777 Tumor necrosis factor TNF 0.0093
32 Vascular endothelial growth factor receptor 1 FLT1 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0093
6020 Aldehyde oxidase AOX1 0.0092
885 5-hydroxytryptamine 1B receptor HTR1B 0.0092
232 Corticosteroid-binding globulin SERPINA6 0.0091
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.009
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.009
165 FL cytokine receptor FLT3 0.009
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.009
725 5-hydroxytryptamine 1D receptor HTR1D 0.0089
3810 Catechol O-methyltransferase COMT 0.0089
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0089
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0087
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
86 SEC14-like protein 4 SEC14L4 0.0087
375 SEC14-like protein 3 SEC14L3 0.0087
4076 Diacylglycerol kinase alpha DGKA 0.0087
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0087
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0087
228 Beta platelet-derived growth factor receptor PDGFRB 0.0087
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0086
6151 Monocarboxylate transporter 10 SLC16A10 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0084
663 Solute carrier family 12 member 4 SLC12A4 0.0084
53 Solute carrier family 12 member 5 SLC12A5 0.0084
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0083
6211 Tubulin epsilon chain TUBE1 0.0083
6210 Tubulin delta chain TUBD1 0.0083
6212 Tubulin gamma-1 chain TUBG1 0.0083
638 D(3) dopamine receptor DRD3 0.0083
713 Sodium-dependent dopamine transporter SLC6A3 0.0082
708 Alpha-tocopherol transfer protein TTPA 0.0082
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0082
124 Histamine H2 receptor HRH2 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
6043 Putative G-protein coupled receptor 44 GPR44 0.008
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.008
899 Glutathione S-transferase Mu 3 GSTM3 0.0079
905 Glutathione transferase omega-1 GSTO1 0.0079
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0079
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0078
811 Translocator protein TSPO 0.0078
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0078
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0077
310 Solute carrier family 12 member 2 SLC12A2 0.0077
2391 Ferrochelatase hemH 0.0077
6502 Ferrochelatase DKFZp686P18130 0.0077
1591 Ferrochelatase, mitochondrial FECH 0.0077
436 5-hydroxytryptamine 2B receptor HTR2B 0.0077
4192 DNA topoisomerase 2-beta TOP2B 0.0077
1353 DNA topoisomerase 1 TOP1 0.0077
3552 DNA topoisomerase 1 topA 0.0077
997 Protein kinase C beta type PRKCB 0.0077
341 5-hydroxytryptamine 3 receptor HTR3A 0.0076
629 Alpha-2B adrenergic receptor ADRA2B 0.0076
908 Glutathione S-transferase theta-1 GSTT1 0.0076
199 Monocarboxylate transporter 8 SLC16A2 0.0076
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0075
474 Acetylcholinesterase ACHE 0.0073
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0073
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0072
1757 Myeloperoxidase MPO 0.0071
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
6218 Pannexin-1 PANX1 0.0071
6014 Cytochrome P450 2A13 CYP2A13 0.007
1010 Cytochrome P450 51A1 CYP51A1 0.007
1970 Protein kinase C alpha type PRKCA 0.007
489 Monocarboxylate transporter 2 SLC16A7 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
3856 Fibroblast growth factor receptor 3 FGFR3 0.0068
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0067
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0066
6493 Cytochrome c oxidase subunit 6C COX6C 0.0066
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0066
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0066
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0066
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0066
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0066
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0066
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0066
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0066
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0066
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0066
6559 Cytochrome c oxidase subunit 2 ctaC 0.0066
6669 Cytochrome c oxidase subunit 2 ctaC 0.0066
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0066
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0066
6558 Cytochrome c oxidase subunit 1 ctaD 0.0066
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0065
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0065
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0065
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0065
378 Alpha-2C adrenergic receptor ADRA2C 0.0065
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0065
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0065
810 Heme oxygenase 1 HMOX1 0.0064
3391 Heme oxygenase 1 pbsA1 0.0064
469 Annexin A1 ANXA1 0.0064
365 Dihydrofolate reductase DHFR 0.0064
2381 Dihydrofolate reductase DFR1 0.0064
2833 Dihydrofolate reductase Not Available 0.0064
2931 Dihydrofolate reductase folA 0.0064
3544 Dihydrofolate reductase folA 0.0064
3682 Dihydrofolate reductase folA 0.0064
6642 Dihydrofolate reductase folA 0.0064
6756 Dihydrofolate reductase dfrA 0.0064
3939 Amine oxidase [flavin-containing] B MAOB 0.0064
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4210 Toll-like receptor 4 TLR4 0.0063
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
1291 cAMP response element-binding protein CREB1 0.0061
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0061
2540 Choloylglycine hydrolase cbh 0.0061
6102 Arylamine N-acetyltransferase 2 NAT2 0.0061
6146 High affinity copper uptake protein 1 SLC31A1 0.006
6824 Tyrosine-protein kinase Lyn LYN 0.0059
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0059
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0058
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0057
6042 Prostaglandin reductase 2 PTGR2 0.0056
6501 Fatty acid-binding protein, liver FABP1 0.0056
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0056
5787 Angiopoietin-1 receptor TEK 0.0056
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0056
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0055
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0055
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0055
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0055
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0055
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0055
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0055
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0055
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0055
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0054
461 Glycine receptor subunit alpha-3 GLRA3 0.0054
2216 Fibroblast growth factor receptor 4 FGFR4 0.0054
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0054
84 Nuclear receptor 0B1 NR0B1 0.0054
716 5-hydroxytryptamine 7 receptor HTR7 0.0054
5626 Nucleoside diphosphate kinase B NME2 0.0054
1649 Small inducible cytokine A2 CCL2 0.0054
7 Nitric oxide synthase, inducible NOS2 0.0054
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0053
896 Glutathione S-transferase Mu 1 GSTM1 0.0052
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0052
2499 Tubulin beta-2C chain TUBB2C 0.0051
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
6163 Copper-transporting ATPase 2 ATP7B 0.005
6165 Copper-transporting ATPase 1 ATP7A 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
6599 HTH-type transcriptional regulator ttgR ttgR 0.0049
2981 Phospholipase A2, membrane associated PLA2G2A 0.0049
1541 Metalloproteinase mmp20 0.0049
823 Fibroblast growth factor receptor 2 FGFR2 0.0049
1313 Lactoylglutathione lyase GLO1 0.0049
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0049
751 Potassium channel subfamily K member 6 KCNK6 0.0048
814 Ryanodine receptor 1 RYR1 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0047
226 Gonadotropin-releasing hormone receptor GNRHR 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6500 Phospholipase A2 PLA2G1B 0.0047
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0046
2232 Interleukin-5 IL5 0.0045
68 Cannabinoid receptor 1 CNR1 0.0045
1593 Mucin-2 MUC2 0.0045
432 D(4) dopamine receptor DRD4 0.0045
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0045
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0045
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0045
172 Potassium channel subfamily K member 1 KCNK1 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0044
5294 Nucleoside diphosphate kinase A NME1 0.0044
517 Alcohol dehydrogenase 1C ADH1C 0.0044
1050 Bile salt sulfotransferase SULT2A1 0.0044
921 Glutamate receptor 2 GRIA2 0.0044
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0043
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0043
856 Vitamin D3 receptor VDR 0.0043
891 Dihydropteroate synthase folP 0.0043
5359 Dihydropteroate synthase folP 0.0043
7175 Dihydropteroate synthase sulI 0.0043
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0043
6220 Aryl hydrocarbon receptor AHR 0.0043
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0043
992 Protein tyrosine kinase 2 beta PTK2B 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
427 Substance-P receptor TACR1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0041
1656 CYP2B protein CYP2B 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.004
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.004
4203 Histamine N-methyltransferase HNMT 0.004
1630 Integrin beta-2 ITGB2 0.004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.004
1178 Adenosine A2a receptor ADORA2A 0.0039
1760 Aminopeptidase N ANPEP 0.0039
6843 Aminopeptidase N pepN 0.0039
239 Coagulation factor X F10 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
319 Opioid receptor, sigma 1 OPRS1 0.0039
357 Carbonic anhydrase 2 CA2 0.0038
117 Sterol O-acyltransferase 1 SOAT1 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
5934 Cytochrome P450 26A1 CYP26A1 0.0037
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0037
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0037
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0037
267 Plasminogen activator inhibitor 1 SERPINE1 0.0037
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
162 Retinoic acid receptor gamma-1 RARG 0.0036
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0036
6837 Serine/threonine-protein kinase 17B STK17B 0.0036
1650 Heme carrier protein 1 SLC46A1 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
4773 Deoxycytidine kinase DCK 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
295 Carbonic anhydrase 1 CA1 0.0034
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0034
484 Tyrosine-protein kinase ABL2 ABL2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0034
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
6221 Steroid hormone receptor ERR1 ESRRA 0.0033
5880 Thrombopoietin receptor MPL 0.0033
571 Melatonin receptor type 1A MTNR1A 0.0033
362 Melatonin receptor type 1B MTNR1B 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
229 Retinoic acid receptor beta RARB 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
702 UMP-CMP kinase CMPK1 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1648 Elastin ELN 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
572 Integrin alpha-L ITGAL 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
94 5-hydroxytryptamine 4 receptor HTR4 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.003
208 DNA-directed RNA polymerase beta' chain rpoC 0.003
5774 DNA-directed RNA polymerase beta' chain rpoC 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0029
292 Activin receptor type-1 ACVR1 0.0029
849 Activated CDC42 kinase 1 TNK2 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
1618 High affinity nerve growth factor receptor NTRK1 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
528 5-hydroxytryptamine 1E receptor HTR1E 0.0027
3917 Methylenetetrahydrofolate reductase MTHFR 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
1256 5-hydroxytryptamine 6 receptor HTR6 0.0027
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
780 Retinoic acid receptor RXR-gamma RXRG 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
76 Nitric-oxide synthase, brain NOS1 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0026
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3830 Calreticulin CALR 0.0025
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6035 Nuclear receptor ROR-beta RORB 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0024
6036 Eosinophil peroxidase EPX 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
518 Peroxidase/catalase T katG 0.0023
740 Argininosuccinate synthase ASS1 0.0023
865 Argininosuccinate synthase ASS1 0.0023
2680 Argininosuccinate synthase argG 0.0023
3194 Argininosuccinate synthase argG 0.0023
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0023
6021 Adenosine kinase ADK 0.0023
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0021
6432 Transporter snf 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
976 Platelet glycoprotein IX GP9 0.002
6459 Glycodelin PAEP 0.002
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
4217 Telomerase reverse transcriptase TERT 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
511 5-hydroxytryptamine 1F receptor HTR1F 0.0019
54 Prothrombin F2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
174 Sigma 1-type opioid receptor SIGMAR1 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
3957 Adenosine deaminase ADA 0.0017
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
2810 Dr hemagglutinin structural subunit draA 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6755 Poliovirus receptor PVR 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
5818 Folate receptor alpha FOLR1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1992 Vitamin D-binding protein GC 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
2207 Rhodopsin RHO 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
183 Vascular endothelial growth factor A VEGFA 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
293 Gamma-glutamyl hydrolase GGH 0.0013
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0013
164 Histamine H4 receptor HRH4 0.0013
2021 Thrombomodulin THBD 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
6859 Protein S100-A4 S100A4 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1864 RET proto-oncogene RET 0.0008
2298 Cytochrome P450-cam camC 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
1830 5'-nucleotidase NT5E 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
125 DNA polymerase beta POLB 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
3221 Cytochrome c4 cc4 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
563 Thyroid peroxidase TPO 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
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