DT-Web

DB01320 - Fosphenytoin


Identification
Name Fosphenytoin
Accession Number DB01320
Type small molecule
Description Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 362.2739
Groups approved
Monoisotopic Weight 362.066772734
Pharmacology
Indication For the control of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. It can also be substituted, short-term, for oral phenytoin.
Mechanism of action Fosphenytoin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.
Absorption Fosphenytoin is completely bioavailable following lM administration.
Protein binding Extensively bound (95% to 99%) to human plasma proteins, primarily albumin.
Biotransformation Hepatic.
Route of elimination Phenytoin derived from administration of Cerebyx is extensively metabolized in the liver and excreted in urine primarily as 5-(p-hydroxyphenyl)-5-phenylhydantoin and its glucuronide; little unchanged phenytoin (1%-5% of the Cerebyx dose) is recovered in urine.
Toxicity Nausea, vomiting, lethargy, tachycardia, bradycardia, asystole, cardiac arrest, hypotension, syncope, hypocalcemia, metabolic acidosis, and death have been reported in cases of overdosage with fosphenytoin. The median lethal dose of fosphenytoin given intravenously in mice and rats was 156 mg PE/kg and approximately 250 mg PE/kg, or about 0.6 and 2 times, respectively, the maximum human loading dose on a mg/m2 basis. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, and hypoactivity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Increased hydantoin levels and risk of bleeding
Alprazolam Fosphenytoin may increase the metabolism of alprazolam via CYP3A4.
Aminophylline Decreased effect of both products
Amiodarone Amiodarone may increase the effect of fosphenytoin.
Anisindione Increased hydantoin levels and risk of bleeding
Aprepitant The CYP3A4 inducer, fosphenytoin, may decrease the effect of aprepitant.
Atracurium Phenytoin decreases the effect of muscle relaxant
Betamethasone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, betamethasone.
Bleomycin The antineoplasic agent decreases the effect of hydantoin
Boceprevir Strong CYP3A4 inducers will decrease levels of boceprevir. Concomitant therapy is contraindicated.
Capecitabine Capecitabine increases the effect of hydantoin
Carboplatin The antineoplasic agent decreases the effect of hydantoin
Carmustine The antineoplasic agent decreases the effect of hydantoin
Chloramphenicol Increases phenytoin, modifies chloramphenicol
Chlordiazepoxide Fosphenytoin may increase the metabolism of chlordiazepoxide via CYP3A4.
Chlorotrianisene The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, chlorotrianisene.
Chlorpheniramine The antihistamine increases the effect of hydantoin
Cimetidine Cimetidine may increase the serum concentration of fosphenytoin by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of fosphenytoin if cimetidine is initiated, discontinued or dose changed.
Cisplatin The antineoplasic agent decreases the effect of hydantoin
Clarithromycin Clarithromycin may increase the therapeutic and adverse effects of fosphenytoin.
Clomifene The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, clomifene.
Clorazepate Fosphenytoin may increase the metabolism of clorazepate via CYP3A4.
Clozapine Hydantoin decreases the effect of clozapine
Conjugated Estrogens The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Cortisone acetate The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, cortisone acetate.
Cyclosporine The hydantoin decreases the effect of cyclosporine
Delavirdine The anticonvulsant, fosphenytoin, decreases the effect of delavirdine.
Dexamethasone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Diazepam Fosphenytoin may increase the metabolism of diazepam via CYP3A4.
Diazoxide Diazoxide decreases the hydantoin effect
Dicumarol Increased hydantoin levels and risk of bleeding
Diethylstilbestrol The enzyme inducer, fosphenytoin, may decrease the therapeutic effect of diethylstilbestrol.
Disopyramide The hydantoin decreases the effect of disopyramide
Disulfiram Disulfiram may increase the effect of fosphenytoin.
Dopamine Risk of severe hypotension
Doxacurium chloride Phenytoin decreases the effect of muscle relaxant
Doxycycline The anticonvulsant, fosphenytoin, decreases the effect of doxycycline.
Dyphylline Decreased effect of both products
Estradiol The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estradiol.
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Estriol The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estriol.
Estrone The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estrone.
Estropipate The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estropipate.
Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
Etravirine Etravirine, when administered concomitantly with fosphenytoin, may experience a decrease in serum concentration. It is recommended to avoid this combination.
Felbamate Increased phenytoin levels and decreased felbamate levels
Felodipine The hydantoin decreases the effect of felodipine
Fluconazole Fluconazole may increase the effect of hydantoin.
Fludrocortisone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Fluorouracil Fluorouracil increases the effect of hydantoin
Fluoxetine Fluoxetine increases the effect of phenytoin
Flurazepam Fosphenytoin may increase the metabolism of flurazepam via CYP3A4.
Fluvoxamine Fluvoxamine may increase the therapeutic and adverse effects of fosphenytoin.
Folic Acid Folic acid decreases the levels of hydantoin
Furosemide The hydantoin decreases the effect of furosemide
Gabapentin Gabapentin may increase the effect of fosphenytoin.
Gefitinib The CYP3A4 inducer, fosphenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Hydrocortisone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Imatinib The hydantoin decreases the levels of imatinib
Irinotecan The hydantoin decreases the effect of irinotecan
Isoniazid Isoniazid may increase the effect of phenytoin in 20% of patients.
Itraconazole Phenytoin decreases the effect of itraconazole
Lamotrigine Phenytoin may reduce levels of lamotrigine
Levodopa The hydantoin decreases the effect of levodopa
Levonorgestrel Phenytoin decreases the contraceptive effect
Lopinavir Levels of both drugs are affected
Lurasidone Concomitant therapy with a CYP3A4 inducer will decrease levels of lurasidone. Coadministration with lurasidone is contraindicated.
Mebendazole The hydantoin decreases the efficiency of mebendazole
Medroxyprogesterone The enzyme inducer, fosphenytoin, may decrease the effect of the hormone, medroxyprogesterone.
Megestrol The enzyme inducer, fosphenytoin, may decrease the effect of the hormone, megestrol.
Mestranol This product may cause a slight decrease of contraceptive effect
Methadone The hydantoin decreases the effect of methadone
Methotrexate The antineoplasic agent decreases the effect of hydantoin
Methoxsalen The hydantoin decreases the effect of psoralene
Methylprednisolone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, methylprednisolone.
Metocurine Phenytoin decreases the effect of muscle relaxant
Metyrapone The combination renders the test invalid
Mexiletine The hydantoin decreases the effect of mexiletine
Midazolam Fosphenytoin may increase the metabolism of midazolam via CYP3A4.
Mirtazapine The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Mivacurium Phenytoin decreases the effect of muscle relaxant
Nisoldipine Phenytoin decreases the efficiency of nisoldipine
Norethindrone This product may cause a slight decrease of contraceptive effect
Omeprazole Omeprazole increases the effect of hydantoin
Oxcarbazepine Oxcarbazepine increases the effect of hydantoin
Oxtriphylline Decreased effect of both products
Oxyphenbutazone The NSAID, oxphenbutazone, may increase the hydantoin effect of fosphenytoin.
Pancuronium Phenytoin decreases the effect of muscle relaxant
Paramethasone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, paramethasone.
Phenylbutazone The NSAID, phenylbutazone, may increase the hydantoin effect of fosphenytoin.
Posaconazole Modifications of drug levels for both agents
Prednisolone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, prednisolone.
Prednisone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, prednisone.
Quetiapine Phenytoin decreases the effect of quetiapine
Quinestrol The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, quinestrol.
Quinidine The anticonvulsant, fosphenytoin, decreases the effect of quinidine.
Quinupristin This combination presents an increased risk of toxicity
Rifampin Rifampin may decrease the effect of fosphenytoin.
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Sertraline Sertraline increases the effect of hydantoin
Sirolimus The hydantoin decreases sirolimus levels
Sucralfate Sucralfate decreases the effect of hydantoin
Sulfadiazine The sulfonamide increases the effect of hydantoin
Sulfamethizole The sulfonamide increases the effect of hydantoin
Tacrolimus The hydantoin decreases the effect of tacrolimus
Telithromycin Fosphenytoin may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus Fosphenytoin may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Theophylline Decreased effect of both products
Thiotepa Possible increase in thiotepa levels
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Fosphenytoin. Consider alternate therapy or monitor for adverse/toxic effects of Fosphenytoin if Ticlopidine is initiated, discontinued or dose changed.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Fosphenytoin. Consider alternate therapy or monitor for changes in Fosphenytoin therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Topiramate Increased phenytoin/decreased topiramate
Tramadol Fosphenytoin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inducer, Fosphenytoin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Fosphenytoin is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inducer, Fosphenytoin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Fosphenytoin is initiated, discontinued or dose changed.
Triamcinolone The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, triamcinolone.
Triazolam Fosphenytoin may increase the metabolism of triazolam via CYP3A4.
Trimethoprim Trimethoprim increases the effect of hydantoin
Trioxsalen The hydantoin decreases the effect of psoralene
Triprolidine The CNS depressants, Triprolidine and Fosphenytoin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Tubocurarine Phenytoin decreases the effect of muscle relaxant
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vecuronium Phenytoin decreases the effect of muscle relaxant
Vigabatrin Vigabatrin decreases the effect of hydantoin
Vinblastine The antineoplasic agent decreases the effect of hydantoin
Voriconazole The hydantoin decreases the effect of voriconazole
Warfarin Increased hydantoin levels and risk of bleeding
Food Interactions
  • Take with food.
  • Avoid alcohol.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M: A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004 Mar;11(3):244-52. - Pubmed
  • Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M: Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol. 2010 Apr;9(4):413-24. - Pubmed
  • Lenkowski PW, Ko SH, Anderson JD, Brown ML, Patel MK: Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin. Eur J Pharm Sci. 2004 Apr;21(5):635-44. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.49

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inducer
References
  • -
  • Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL: Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Goldstein JA: Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol. 2001 Oct;52(4):349-55. - Pubmed
  • Klotz U: The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications. Clin Pharmacokinet. 2007;46(4):271-9. - Pubmed
DTHybrid score 0.4977
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inducer
References
  • -
  • Kim KA, Park JY: Inhibitory effect of glyburide on human cytochrome p450 isoforms in human liver microsomes. Drug Metab Dispos. 2003 Sep;31(9):1090-2. - Pubmed
DTHybrid score 0.3561
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inducer
References
  • -
  • Anderson GD: Pharmacokinetic, pharmacodynamic, and pharmacogenetic targeted therapy of antiepileptic drugs. Ther Drug Monit. 2008 Apr;30(2):173-80. - Pubmed
  • Hennessy S, Leonard CE, Freeman CP, Metlay JP, Chu X, Strom BL, Bilker WB: CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity. J Clin Pharmacol. 2009 Dec;49(12):1483-7. Epub 2009 Jul 17. - Pubmed
  • Klotz U: The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications. Clin Pharmacokinet. 2007;46(4):271-9. - Pubmed
DTHybrid score 0.423
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • -
  • Zhou SF: Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab. 2008 May;9(4):310-22. - Pubmed
DTHybrid score 0.581
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • -
  • Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E: Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. Epub 2004 Apr 28. - Pubmed
  • Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL: Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58. - Pubmed
DTHybrid score 0.3197

Carriers


Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.318
4200 Cytochrome P450 1A2 CYP1A2 0.2518
1588 Multidrug resistance protein 1 ABCB1 0.2177
4118 Cytochrome P450 3A5 CYP3A5 0.1912
6013 Cytochrome P450 2E1 CYP2E1 0.1434
6107 Cytochrome P450 3A7 CYP3A7 0.1329
20 Prostaglandin G/H synthase 1 PTGS1 0.1085
5718 Cytochrome P450 2A6 CYP2A6 0.0985
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0937
6024 Cytochrome P450 1A1 CYP1A1 0.0903
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0824
6106 Cytochrome P450 2C18 CYP2C18 0.072
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0645
290 Prostaglandin G/H synthase 2 PTGS2 0.0613
1729 Solute carrier family 22 member 6 SLC22A6 0.0604
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0593
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0569
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0537
492 Histamine H1 receptor HRH1 0.0481
824 Sodium-dependent serotonin transporter SLC6A4 0.0465
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0453
862 Multidrug resistance-associated protein 1 ABCC1 0.0446
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0438
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0427
3811 Cytochrome P450 19A1 CYP19A1 0.0423
6145 Solute carrier family 22 member 1 SLC22A1 0.042
891 Dihydropteroate synthase folP 0.0395
5359 Dihydropteroate synthase folP 0.0395
7175 Dihydropteroate synthase sulI 0.0395
6142 Solute carrier family 22 member 8 SLC22A8 0.0392
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0391
465 Calmodulin CALM1 0.0384
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0375
6144 Solute carrier family 22 member 2 SLC22A2 0.0366
502 5-hydroxytryptamine 2A receptor HTR2A 0.035
136 Estrogen receptor ESR1 0.0337
2164 Multidrug resistance-associated protein 4 ABCC4 0.0327
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0321
1898 Cytochrome P450 1B1 CYP1B1 0.0317
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0312
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0305
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0305
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.03
831 D(2) dopamine receptor DRD2 0.0293
731 HIV-1 protease HIV-1 protease 0.0291
118 Organic cation/carnitine transporter 2 SLC22A5 0.0288
776 Bile salt export pump ABCB11 0.0287
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0285
556 Alpha-1A adrenergic receptor ADRA1A 0.0283
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0276
6143 Solute carrier family 22 member 7 SLC22A7 0.0272
617 Muscarinic acetylcholine receptor M2 CHRM2 0.027
260 Cytochrome P450 51 ERG11 0.0265
761 Cytochrome P450 51 ERG11 0.0265
3163 Cytochrome P450 51 cyp51 0.0265
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0264
713 Sodium-dependent dopamine transporter SLC6A3 0.0264
3923 Cholinesterase BCHE 0.0259
122 P2Y purinoceptor 12 P2RY12 0.0258
1024 Solute carrier family 22 member 11 SLC22A11 0.0256
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0254
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0248
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0248
871 Glucocorticoid receptor NR3C1 0.0247
847 Mu-type opioid receptor OPRM1 0.0246
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0239
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0232
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0232
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0226
468 Cytochrome P450 4A11 CYP4A11 0.0222
696 Kappa-type opioid receptor OPRK1 0.0216
467 Delta-type opioid receptor OPRD1 0.0213
146 Androgen receptor AR 0.0211
23 D(1A) dopamine receptor DRD1 0.0211
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0204
632 Alpha-1B adrenergic receptor ADRA1B 0.0203
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.02
274 Muscarinic acetylcholine receptor M5 CHRM5 0.02
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.02
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.02
158 Sodium channel protein type 1 subunit alpha SCN1A 0.02
318 Alpha-2A adrenergic receptor ADRA2A 0.0198
3941 Amine oxidase [flavin-containing] A MAOA 0.0195
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0195
320 5-hydroxytryptamine 1A receptor HTR1A 0.0195
6147 Solute carrier family 22 member 3 SLC22A3 0.0194
590 5-hydroxytryptamine 2C receptor HTR2C 0.0194
341 5-hydroxytryptamine 3 receptor HTR3A 0.0187
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0185
70 Type-1 angiotensin II receptor AGTR1 0.0184
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0183
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0183
6220 Aryl hydrocarbon receptor AHR 0.0182
833 Organic cation/carnitine transporter 1 SLC22A4 0.0182
6031 Cytochrome P450 3A43 CYP3A43 0.0179
844 Epidermal growth factor receptor EGFR 0.0175
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0173
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.017
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0169
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
172 Potassium channel subfamily K member 1 KCNK1 0.0168
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0166
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0164
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0163
756 Sex hormone-binding globulin SHBG 0.016
766 Beta-2 adrenergic receptor ADRB2 0.0159
811 Translocator protein TSPO 0.0156
3939 Amine oxidase [flavin-containing] B MAOB 0.0155
921 Glutamate receptor 2 GRIA2 0.0154
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0154
482 Glycine receptor subunit alpha-1 GLRA1 0.0154
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0151
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0151
6182 Cytochrome P450 2J2 CYP2J2 0.015
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0146
4604 Liver carboxylesterase 1 CES1 0.0145
6541 Peptostreptococcal albumin-binding protein pab 0.0142
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0142
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0141
6136 Multidrug resistance-associated protein 5 ABCC5 0.014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0138
6141 Sodium/bile acid cotransporter SLC10A1 0.0137
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0133
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0133
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0133
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0133
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0133
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0132
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0131
705 Glutamate receptor 1 GRIA1 0.0131
6085 Fatty acid-binding protein, intestinal FABP2 0.013
789 Alpha-1D adrenergic receptor ADRA1D 0.013
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0129
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0127
537 ATP synthase delta chain, mitochondrial ATP5D 0.0126
614 Progesterone receptor PGR 0.0125
4120 NADPH--cytochrome P450 reductase POR 0.0124
6102 Arylamine N-acetyltransferase 2 NAT2 0.0123
33 Cystine/glutamate transporter SLC7A11 0.0123
504 Mast/stem cell growth factor receptor KIT 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0121
6137 Multidrug resistance-associated protein 6 ABCC6 0.012
2183 Fatty acid-binding protein, adipocyte FABP4 0.0119
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0118
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0117
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0117
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0117
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0117
869 Estrogen receptor beta ESR2 0.0116
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0115
373 Transthyretin TTR 0.0115
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0109
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0109
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0109
183 Vascular endothelial growth factor A VEGFA 0.0108
380 Cytochrome P450 17A1 CYP17A1 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0107
6148 Multidrug resistance-associated protein 7 ABCC10 0.0105
818 50S ribosomal protein L10 rplJ 0.0104
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0103
592 Carbonic anhydrase 4 CA4 0.0103
1656 CYP2B protein CYP2B 0.0102
817 DNA topoisomerase 2-alpha TOP2A 0.0101
638 D(3) dopamine receptor DRD3 0.01
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.01
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0099
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0099
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0099
193 Beta-1 adrenergic receptor ADRB1 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
295 Carbonic anhydrase 1 CA1 0.0096
885 5-hydroxytryptamine 1B receptor HTR1B 0.0096
174 Sigma 1-type opioid receptor SIGMAR1 0.0096
29 Tubulin beta-1 chain TUBB1 0.0096
49 Endothelin B receptor EDNRB 0.0096
407 Vascular endothelial growth factor receptor 2 KDR 0.0095
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0095
427 Substance-P receptor TACR1 0.0095
558 Solute carrier family 12 member 1 SLC12A1 0.0094
566 Serotransferrin TF 0.0094
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0094
738 Monocarboxylate transporter 1 SLC16A1 0.0093
1010 Cytochrome P450 51A1 CYP51A1 0.0092
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0092
365 Dihydrofolate reductase DHFR 0.0091
2381 Dihydrofolate reductase DFR1 0.0091
2833 Dihydrofolate reductase Not Available 0.0091
2931 Dihydrofolate reductase folA 0.0091
3544 Dihydrofolate reductase folA 0.0091
3682 Dihydrofolate reductase folA 0.0091
6642 Dihydrofolate reductase folA 0.0091
6756 Dihydrofolate reductase dfrA 0.0091
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.009
578 Endothelin-1 receptor EDNRA 0.009
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.009
124 Histamine H2 receptor HRH2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6020 Aldehyde oxidase AOX1 0.0088
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0088
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0088
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0087
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0087
161 Tubulin beta chain TUBB 0.0086
312 Tubulin beta chain TUB2 0.0086
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0086
1757 Myeloperoxidase MPO 0.0086
357 Carbonic anhydrase 2 CA2 0.0086
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0086
6014 Cytochrome P450 2A13 CYP2A13 0.0085
629 Alpha-2B adrenergic receptor ADRA2B 0.0084
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0084
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0084
725 5-hydroxytryptamine 1D receptor HTR1D 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
26 Vascular endothelial growth factor receptor 3 FLT4 0.0083
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0082
777 Tumor necrosis factor TNF 0.0082
3932 Glutathione S-transferase A2 GSTA2 0.008
232 Corticosteroid-binding globulin SERPINA6 0.008
88 Retinoic acid receptor RXR-beta RXRB 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
228 Beta platelet-derived growth factor receptor PDGFRB 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
436 5-hydroxytryptamine 2B receptor HTR2B 0.0076
952 Dipeptidyl peptidase 4 DPP4 0.0075
1541 Metalloproteinase mmp20 0.0074
275 Arachidonate 5-lipoxygenase ALOX5 0.0074
716 5-hydroxytryptamine 7 receptor HTR7 0.0074
94 5-hydroxytryptamine 4 receptor HTR4 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.007
378 Alpha-2C adrenergic receptor ADRA2C 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
1618 High affinity nerve growth factor receptor NTRK1 0.0068
6126 Carbonic anhydrase 7 CA7 0.0067
24 Thymidylate synthase TMP1 0.0066
359 Thymidylate synthase TYMS 0.0066
2626 Thymidylate synthase thyA 0.0066
2729 Thymidylate synthase thyA 0.0066
5352 Thymidylate synthase THYA 0.0066
36 Insulin receptor INSR 0.0066
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0066
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0066
856 Vitamin D3 receptor VDR 0.0066
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
1992 Vitamin D-binding protein GC 0.0065
1050 Bile salt sulfotransferase SULT2A1 0.0064
780 Retinoic acid receptor RXR-gamma RXRG 0.0064
432 D(4) dopamine receptor DRD4 0.0063
6043 Putative G-protein coupled receptor 44 GPR44 0.0063
3810 Catechol O-methyltransferase COMT 0.0063
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0063
133 Dihydropterate synthase sulI 0.0063
459 Retinoic acid receptor RXR-alpha RXRA 0.0062
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0062
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0061
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0061
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.006
6103 Arylamine N-acetyltransferase 1 NAT1 0.0059
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
737 Mineralocorticoid receptor NR3C2 0.0059
6138 Multidrug resistance protein 3 ABCB4 0.0058
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
581 Cytochrome P450 2R1 CYP2R1 0.0058
5787 Angiopoietin-1 receptor TEK 0.0058
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0058
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0056
162 Retinoic acid receptor gamma-1 RARG 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0054
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0053
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0053
594 Thyroxine-binding globulin SERPINA7 0.0053
823 Fibroblast growth factor receptor 2 FGFR2 0.0053
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0052
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0052
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0052
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0052
518 Peroxidase/catalase T katG 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.005
751 Potassium channel subfamily K member 6 KCNK6 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0049
84 Nuclear receptor 0B1 NR0B1 0.0049
6432 Transporter snf 0.0049
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
814 Ryanodine receptor 1 RYR1 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0048
563 Thyroid peroxidase TPO 0.0047
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0047
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0047
528 5-hydroxytryptamine 1E receptor HTR1E 0.0046
6149 Solute carrier family 22 member 10 SLC22A10 0.0046
1648 Elastin ELN 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
5934 Cytochrome P450 26A1 CYP26A1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
1275 Estrogen sulfotransferase SULT1E1 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0045
768 FK506-binding protein 1A FKBP1A 0.0045
474 Acetylcholinesterase ACHE 0.0045
6174 50S ribosomal protein L32 rpmF 0.0045
319 Opioid receptor, sigma 1 OPRS1 0.0044
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
6033 High affinity interleukin-8 receptor A CXCR1 0.0044
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0043
1483 Membrane copper amine oxidase AOC3 0.0043
3809 Estrogen-related receptor gamma ESRRG 0.0043
4122 Histone deacetylase 2 HDAC2 0.0042
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0042
1630 Integrin beta-2 ITGB2 0.0042
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0042
3947 Xanthine dehydrogenase/oxidase XDH 0.0042
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0042
904 Glutathione S-transferase P GSTP1 0.0041
6677 Myelin P2 protein PMP2 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1629 Transcription factor AP-1 JUN 0.004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
634 Squalene monooxygenase SQLE 0.004
7196 Squalene monooxygenase ERG1 0.004
163 D(1B) dopamine receptor DRD5 0.004
730 Retinoic acid receptor alpha RARA 0.004
4217 Telomerase reverse transcriptase TERT 0.004
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.004
4210 Toll-like receptor 4 TLR4 0.0039
1192 Sulfotransferase 1A1 SULT1A1 0.0039
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0038
469 Annexin A1 ANXA1 0.0038
6146 High affinity copper uptake protein 1 SLC31A1 0.0038
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
165 FL cytokine receptor FLT3 0.0038
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0038
273 Apoptosis regulator Bcl-2 BCL2 0.0038
85 Growth hormone receptor GHR 0.0038
3937 Fatty-acid amide hydrolase FAAH 0.0037
1256 5-hydroxytryptamine 6 receptor HTR6 0.0037
3426 Glutamine synthetase glnA 0.0037
3987 Glutamine synthetase GLUL 0.0037
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0037
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0037
54 Prothrombin F2 0.0037
1291 cAMP response element-binding protein CREB1 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0036
4311 tRNA TRDMT1 0.0036
4325 tRNA trmD 0.0036
4328 tRNA trmD 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
16 Adenosine A1 receptor ADORA1 0.0036
7 Nitric oxide synthase, inducible NOS2 0.0036
1262 Corticotropin-lipotropin POMC 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
3808 Dihydropteroate synthase 2 folP2 0.0035
3601 Dihydropteroate synthase 1 folP1 0.0035
3807 Dihydropteroate synthase 1 folP1 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
1178 Adenosine A2a receptor ADORA2A 0.0035
2207 Rhodopsin RHO 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
153 Dopamine beta-hydroxylase DBH 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
239 Coagulation factor X F10 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0034
3639 Thymidine phosphorylase deoA 0.0034
3936 Thymidine phosphorylase TYMP 0.0034
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
5880 Thrombopoietin receptor MPL 0.0033
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0033
1353 DNA topoisomerase 1 TOP1 0.0032
3552 DNA topoisomerase 1 topA 0.0032
65 Matrix metalloproteinase-9 Not Available 0.0032
6131 Carbonic anhydrase 14 CA14 0.0032
1867 Major prion protein PRNP 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
2320 Thymidine kinase, cytosolic TK1 0.0031
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
6134 Sodium channel subunit beta-3 SCN3B 0.0031
6135 Sodium channel subunit beta-4 SCN4B 0.003
6132 Sodium channel subunit beta-1 SCN1B 0.003
6133 Sodium channel subunit beta-2 SCN2B 0.003
6127 Carbonic anhydrase-related protein CA8 0.003
6129 Carbonic anhydrase-related protein 11 CA11 0.003
6128 Carbonic anhydrase-related protein 10 CA10 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.003
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.003
6122 Carbonic anhydrase 3 CA3 0.003
2021 Thrombomodulin THBD 0.003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.003
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
976 Platelet glycoprotein IX GP9 0.0029
251 Alcohol dehydrogenase 1A ADH1A 0.0029
4103 Proteasome subunit beta type 2 PSMB2 0.0029
4102 Proteasome subunit beta type 5 PSMB5 0.0029
4101 Proteasome subunit beta type 1 PSMB1 0.0029
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
233 Potassium channel subfamily K member 2 KCNK2 0.0028
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
936 Ephrin type-A receptor 2 EPHA2 0.0028
131 Synaptic vesicular amine transporter SLC18A2 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
4226 Uridine phosphorylase 2 UPP2 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
6218 Pannexin-1 PANX1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
1039 Histone deacetylase 9 HDAC9 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0027
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0027
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0027
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6130 Carbonic anhydrase 13 CA13 0.0026
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
4225 Uridine phosphorylase 1 UPP1 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0025
164 Histamine H4 receptor HRH4 0.0025
1268 Neuropeptide S receptor NPSR1 0.0025
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0025
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0025
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0025
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
413 Amidophosphoribosyltransferase PPAT 0.0024
2515 Amidophosphoribosyltransferase purF 0.0024
3714 Amidophosphoribosyltransferase purF 0.0024
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
6044 Serum paraoxonase/lactonase 3 PON3 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
489 Monocarboxylate transporter 2 SLC16A7 0.0023
1864 RET proto-oncogene RET 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0023
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6459 Glycodelin PAEP 0.0022
572 Integrin alpha-L ITGAL 0.0022
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0022
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
3007 Carbonic anhydrase 12 CA12 0.0022
4205 Carbonic anhydrase 9 CA9 0.0022
2232 Interleukin-5 IL5 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
3904 Alanine aminotransferase 2 GPT2 0.0021
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0021
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
244 Angiotensin-converting enzyme ACE 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1792 Tissue-type plasminogen activator PLAT 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
291 Nitric-oxide synthase, endothelial NOS3 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.002
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
1253 Interferon gamma IFNG 0.0018
6151 Monocarboxylate transporter 10 SLC16A10 0.0018
511 5-hydroxytryptamine 1F receptor HTR1F 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
683 Potassium transporter GK0582 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4773 Deoxycytidine kinase DCK 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
6042 Prostaglandin reductase 2 PTGR2 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
3233 Bile acid receptor NR1H4 0.0015
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
1341 Histamine H3 receptor HRH3 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
1313 Lactoylglutathione lyase GLO1 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4192 DNA topoisomerase 2-beta TOP2B 0.0012
822 Aldose reductase AKR1B1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
3957 Adenosine deaminase ADA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
4954 Soluble cytochrome b558 Not Available 0.0011
4916 Cyanoglobin glbN 0.0011
4943 Cytochrome c6 petJ 0.0011
4925 Cytochrome c-type protein SHP shp 0.0011
4947 Bacterial hemoglobin vhb 0.0011
4915 Cytochrome c-550 psbV 0.0011
4959 Cytochrome c-550 psbV 0.0011
5216 Cytochrome c-550 psbV 0.0011
4994 Hemoglobin-like protein HbO glbO 0.0011
4975 Cytochrome c-556 RPA3973 0.0011
4934 Cytochrome c-551 nirM 0.0011
5218 Cytochrome c-551 nirM 0.0011
4984 Neuroglobin NGB 0.0011
5000 HemO hemO 0.0011
4936 Cytochrome c2 iso-2 Not Available 0.0011
4905 Cytochrome c2 Not Available 0.0011
4939 Cytochrome c2 cycA 0.0011
4964 Cytochrome c2 cycA 0.0011
4979 Cytochrome c2 cycA 0.0011
6673 Cytochrome c2 cycA 0.0011
4981 Iron-starvation protein PigA pigA 0.0011
4942 Diheme cytochrome c napB napB 0.0011
3116 Bacterioferritin bfr 0.0011
4906 Bacterioferritin bfr 0.0011
4965 Bacterioferritin bfr 0.0011
4998 Hemoglobin-like protein yjbI yjbI 0.0011
4910 Cytoglobin CYGB 0.0011
4909 CooA protein cooA 0.0011
4935 Cytochrome c-554 cycA1 0.0011
4961 Hemophore HasA hasA 0.0011
644 Heme oxygenase 2 HMOX2 0.0011
4982 Heme oxygenase 2 pbsA2 0.0011
4907 Cytochrome c-L moxG 0.0011
6865 Cytochrome c-L moxG 0.0011
4971 Nonaheme cytochrome c hmcA 0.0011
4904 Cytochrome c family protein GSU1996 0.0011
4976 Apocytochrome f petA 0.0011
6407 Apocytochrome f petA 0.0011
4931 Cytochrome P450 167A1 CYP167A1 0.0011
4937 Cytochrome oxidase subunit II rcoxA 0.0011
4989 Cytochrome c551 peroxidase ccp 0.0011
5222 Cytochrome c551 peroxidase ccpA 0.0011
4764 Cytochrome P450 165C4 CYP165C4 0.0011
4999 Cytochrome P450 165B3 CYP165B3 0.0011
4903 Methyl-accepting chemotaxis protein Tar4 0.0011
4960 Putative cytochrome P450-family protein SCO7417 0.0011
4972 P450cin cinA 0.0011
4926 Heme-based aerotactic transducer hemAT hemAT 0.0011
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0011
4922 Cytochrome c, putative SO_4144 0.0011
4993 Hydroxylamine oxidoreductase hao1 0.0011
4952 Catalase/peroxidase katA 0.0011
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0011
3093 Catalase HPII katE 0.0011
3221 Cytochrome c4 cc4 0.0011
2298 Cytochrome P450-cam camC 0.0011
1374 Natriuretic peptides B NPPB 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
1827 Gap junction alpha-1 protein GJA1 0.0011
1908 Vascular cell adhesion protein 1 VCAM1 0.0011
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
76 Nitric-oxide synthase, brain NOS1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
760 Fibroblast growth factor 1 FGF1 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1507 Cytochrome c CYCS 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4920 Peroxidase/catalase katG 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4990 PpcA ppcA 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
358 Cystathionine beta-synthase CBS 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
693 Hemoglobin subunit beta HBB 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
5961 Insulin INS 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
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