DT-Web: DB00570

Identification

Name

Vinblastine

Accession Number

DB00570 (APRD00708)

Type

small molecule

Description

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

810.9741

Groups

approved

Monoisotopic Weight

810.420379474

Pharmacology

Indication

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Mechanism of action

The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.

Absorption

Not Available

Protein binding

98-99%

Biotransformation

Hepatic. Metabolism of vinblastine has been shown to be mediated by hepatic cytochrome P450 3A isoenzymes.

Route of elimination

The major route of excretion may be through the biliary system.

Toxicity

Oral, mouse: LD₅₀ = 423 mg/kg; Oral, rat: LD₅₀ = 305 mg/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	Amprenavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Amprenavir is initiated, discontinued or dose changed.
Aprepitant	Aprepitant may change levels of the chemotherapy agent, vinblastine.
Atazanavir	Atazanavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Atazanavir is initiated, discontinued or dose changed.
Clarithromycin	Clarithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Clarithromycin is initiated, discontinued or dose changed.
Conivaptan	Conivaptan, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Conivaptan is initiated, discontinued or dose changed.
Dabigatran etexilate	P-Glycoprotein inducers such as vinblastine may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Darunavir	Darunavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Darunavir is initiated, discontinued or dose changed.
Delavirdine	Delavirdine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Delavirdine is initiated, discontinued or dose changed.
Dirithromycin	Dirithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Dirithromycin is initiated, discontinued or dose changed.
Erythromycin	Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of vinblastine if erythromycin is initiated, discontinued or dose changed.
Fluconazole	Increases the effect and toxicity of anticancer agent
Fosamprenavir	Fosamprenavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Fosamprenavir is initiated, discontinued or dose changed.
Fosphenytoin	The antineoplasic agent decreases the effect of hydantoin
Imatinib	Imatinib, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Imatinib is initiated, discontinued or dose changed.
Indinavir	Indinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Indinavir is initiated, discontinued or dose changed.
Isoniazid	Isoniazid, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Isoniazid is initiated, discontinued or dose changed.
Itraconazole	Itraconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Itraconazole is initiated, discontinued or dose changed.
Ketoconazole	Ketoconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Ketoconazole is initiated, discontinued or dose changed.
Leflunomide	Vinblastine may increase the adverse/toxic effects of Leflunomide. This may increase the risk of hematologic toxicities such as pancytopenia, agranulocytosis and thrombocytopenia. In patients receiving Vinblastine, consider eliminating the loading dose of Leflunomide. Monitor for bone marrow suppression at least monthly during concomitant therapy.
Lopinavir	Lopinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Lopinavir is initiated, discontinued or dose changed.
Miconazole	Miconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Miconazole is initiated, discontinued or dose changed.
Mitomycin	Potentially severe lung toxicity
Natalizumab	Concomitant Vinblastine and Natalizumab therapy may increase the risk of infection. Concurrent therapy should be avoided.
Nefazodone	Nefazodone, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nefazodone is initiated, discontinued or dose changed.
Nelfinavir	Nelfinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nelfinavir is initiated, discontinued or dose changed.
Nicardipine	Nicardipine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nicardipine is initiated, discontinued or dose changed.
Phenytoin	The antineoplasic agent decreases the effect of hydantoin
Posaconazole	Posaconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Posaconazole is initiated, discontinued or dose changed.
Quinidine	Quinidine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Quinidine is initiated, discontinued or dose changed.
Quinupristin	This combination presents an increased risk of toxicity
Ritonavir	Ritonavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Ritonavir is initiated, discontinued or dose changed.
Saquinavir	Saquinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Saquinavir is initiated, discontinued or dose changed.
Spiramycin	Spiramycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Spiramycin is initiated, discontinued or dose changed.
Telithromycin	Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed.
Tolterodine	Vinblastine, a CYP3A4 inhibitor, may increase the serum concentration of Tolterodine by decreasing its metabolism. Poor CYP2D6 metabolizers metabolize Tolterodine via CYP3A4. A dose adjustment of Tolterodine may be required. Monitor for changes in the therapeutic/adverse effects of Tolterodine if Vinblastine is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Voriconazole is initiated, discontinued or dose changed.

Food Interactions

Not Available

Tubulin alpha-3 chain
Name	Tubulin alpha-3 chain
Gene Name	TUBA1A
Pharmacological action	yes
Actions	adduct
References	Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets. 2007 Dec;7(8):730-42. - Pubmed Correia JJ: Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther. 1991 Nov;52(2):127-47. - Pubmed Jordan A, Hadfield JA, Lawrence NJ, McGown AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998 Jul;18(4):259-96. - Pubmed Islam MN, Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 2004 Dec;4(10):1077-104. - Pubmed Gupta S, Bhattacharyya B: Antimicrotubular drugs binding to vinca domain of tubulin. Mol Cell Biochem. 2003 Nov;253(1-2):41-7. - Pubmed
DTHybrid score	0.471
Tubulin beta chain
Name	Tubulin beta chain
Gene Name	TUBB
Pharmacological action	yes
Actions	adduct
References	Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets. 2007 Dec;7(8):730-42. - Pubmed Correia JJ: Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther. 1991 Nov;52(2):127-47. - Pubmed Jordan A, Hadfield JA, Lawrence NJ, McGown AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998 Jul;18(4):259-96. - Pubmed Islam MN, Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 2004 Dec;4(10):1077-104. - Pubmed Gupta S, Bhattacharyya B: Antimicrotubular drugs binding to vinca domain of tubulin. Mol Cell Biochem. 2003 Nov;253(1-2):41-7. - Pubmed
DTHybrid score	0.4875
Tubulin delta chain
Name	Tubulin delta chain
Gene Name	TUBD1
Pharmacological action	yes
Actions	adduct
References	Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets. 2007 Dec;7(8):730-42. - Pubmed Correia JJ: Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther. 1991 Nov;52(2):127-47. - Pubmed Jordan A, Hadfield JA, Lawrence NJ, McGown AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998 Jul;18(4):259-96. - Pubmed Islam MN, Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 2004 Dec;4(10):1077-104. - Pubmed Gupta S, Bhattacharyya B: Antimicrotubular drugs binding to vinca domain of tubulin. Mol Cell Biochem. 2003 Nov;253(1-2):41-7. - Pubmed
DTHybrid score	0.4918
Tubulin gamma-1 chain
Name	Tubulin gamma-1 chain
Gene Name	TUBG1
Pharmacological action	yes
Actions	adduct
References	Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets. 2007 Dec;7(8):730-42. - Pubmed Correia JJ: Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther. 1991 Nov;52(2):127-47. - Pubmed Jordan A, Hadfield JA, Lawrence NJ, McGown AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998 Jul;18(4):259-96. - Pubmed Islam MN, Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 2004 Dec;4(10):1077-104. - Pubmed Gupta S, Bhattacharyya B: Antimicrotubular drugs binding to vinca domain of tubulin. Mol Cell Biochem. 2003 Nov;253(1-2):41-7. - Pubmed
DTHybrid score	0.4916
Tubulin epsilon chain
Name	Tubulin epsilon chain
Gene Name	TUBE1
Pharmacological action	yes
Actions	adduct
References	Jordan MA, Kamath K: How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets. 2007 Dec;7(8):730-42. - Pubmed Correia JJ: Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther. 1991 Nov;52(2):127-47. - Pubmed Jordan A, Hadfield JA, Lawrence NJ, McGown AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998 Jul;18(4):259-96. - Pubmed Islam MN, Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 2004 Dec;4(10):1077-104. - Pubmed Gupta S, Bhattacharyya B: Antimicrotubular drugs binding to vinca domain of tubulin. Mol Cell Biochem. 2003 Nov;253(1-2):41-7. - Pubmed
DTHybrid score	0.4916
Transcription factor AP-1
Name	Transcription factor AP-1
Gene Name	JUN
Pharmacological action	no
Actions	other/unknown
References	Brantley-Finley C, Lyle CS, Du L, Goodwin ME, Hall T, Szwedo D, Kaushal GP, Chambers TC: The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochem Pharmacol. 2003 Aug 1;66(3):459-69. - Pubmed Bene A, Kurten RC, Chambers TC: Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic Acids Res. 2004 Oct 21;32(19):e142. - Pubmed Obey TB, Lyle CS, Chambers TC: Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine. Biochem Biophys Res Commun. 2005 Oct 7;335(4):1179-84. - Pubmed Martinez-Campa C, Casado P, Rodriguez R, Zuazua P, Garcia-Pedrero JM, Lazo PS, Ramos S: Effect of vinca alkaloids on ERalpha levels and estradiol-induced responses in MCF-7 cells. Breast Cancer Res Treat. 2006 Jul;98(1):81-9. Epub 2006 Mar 23. - Pubmed Duan L, Sterba K, Kolomeichuk S, Kim H, Brown PH, Chambers TC: Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol. 2007 Feb 15;73(4):481-90. Epub 2006 Oct 29. - Pubmed
DTHybrid score	0.4075

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	0.7022
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5038

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Arora A, Shukla Y: Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. Cancer Lett. 2003 Jan 28;189(2):167-73. - Pubmed Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R: Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther. 1992 Nov;263(2):840-5. - Pubmed Tiberghien F, Loor F: Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs. 1996 Jul;7(5):568-78. - Pubmed Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E: Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol. 1997 Jan 10;53(1):17-25. - Pubmed Smit JW, Weert B, Schinkel AH, Meijer DK: Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. J Pharmacol Exp Ther. 1998 Jul;286(1):321-7. - Pubmed Shepard RL, Winter MA, Hsaio SC, Pearce HL, Beck WT, Dantzig AH: Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein. Biochem Pharmacol. 1998 Sep 15;56(6):719-27. - Pubmed Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R: P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999 Apr;437(5):652-60. - Pubmed Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA: Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22. - Pubmed Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA: Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. - Pubmed Atkinson DE, Greenwood SL, Sibley CP, Glazier JD, Fairbairn LJ: Role of MDR1 and MRP1 in trophoblast cells, elucidated using retroviral gene transfer. Am J Physiol Cell Physiol. 2003 Sep;285(3):C584-91. Epub 2003 Apr 30. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Dagenais C, Graff CL, Pollack GM: Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol. 2004 Jan 15;67(2):269-76. - Pubmed Taipalensuu J, Tavelin S, Lazorova L, Svensson AC, Artursson P: Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity. Eur J Pharm Sci. 2004 Jan;21(1):69-75. - Pubmed Hunter J, Hirst BH, Simmons NL: Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm Res. 1993 May;10(5):743-9. - Pubmed Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. - Pubmed Dantzig AH, Shepard RL, Law KL, Tabas L, Pratt S, Gillespie JS, Binkley SN, Kuhfeld MT, Starling JJ, Wrighton SA: Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed Fedoruk MN, Gimenez-Bonafe P, Guns ES, Mayer LD, Nelson CC: P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate. 2004 Apr 1;59(1):77-90. - Pubmed Takara K, Sakaeda T, Kakumoto M, Tanigawara Y, Kobayashi H, Okumura K, Ohnishi N, Yokoyama T: Effects of alpha-adrenoceptor antagonist doxazosin on MDR1-mediated multidrug resistance and transcellular transport. Oncol Res. 2009;17(11-12):527-33. - Pubmed Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. Epub 2009 Jul 21. - Pubmed Kugawa F, Suzuki T, Miyata M, Tomono K, Tamanoi F: Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Pharmazie. 2009 May;64(5):296-300. - Pubmed Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ: MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4. - Pubmed Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol Pharmacol. 2002 May;61(5):974-81. - Pubmed Takara K, Sakaeda T, Yagami T, Kobayashi H, Ohmoto N, Horinouchi M, Nishiguchi K, Okumura K: Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines. Biol Pharm Bull. 2002 Jun;25(6):771-8. - Pubmed Henning U, Loffler S, Krieger K, Klimke A: Uptake of clozapine into HL-60 promyelocytic leukaemia cells. Pharmacopsychiatry. 2002 May;35(3):90-5. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
DTHybrid score	0.6304
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor,inducer
References	Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed Loe DW, Almquist KC, Cole SP, Deeley RG: ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem. 1996 Apr 19;271(16):9683-9. - Pubmed Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002;64(3):126-34. - Pubmed Yildiz M, Celik-Ozenci C, Akan S, Akan I, Sati L, Demir R, Savas B, Ozben T, Samur M, Ozdogan M, Artac M, Bozcuk H: Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: an in vitro study. Cell Biol Int. 2006 Mar;30(3):278-82. Epub 2006 Feb 2. - Pubmed
DTHybrid score	0.4294
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor,inducer
References	Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA: Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22. - Pubmed Ishikawa T, Muller M, Klunemann C, Schaub T, Keppler D: ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem. 1990 Nov 5;265(31):19279-86. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed
DTHybrid score	0.4356
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions	inhibitor
References	Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P: Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 2002 Jun 25;41(25):8058-67. - Pubmed
DTHybrid score	0.3482
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate,inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.36
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate
References	Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA: A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb;47(2):181-6. - Pubmed
DTHybrid score	0.3383

Id	Partner name	Gene Name	Score
312	Tubulin beta chain	TUB2	0.4875
4757	Cytochrome P450 2C9	CYP2C9	0.2313
4118	Cytochrome P450 3A5	CYP3A5	0.2102
4200	Cytochrome P450 1A2	CYP1A2	0.199
6016	Cytochrome P450 2C19	CYP2C19	0.1964
4924	Cytochrome P450 2C8	CYP2C8	0.187
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1866
2499	Tubulin beta-2C chain	TUBB2C	0.1629
2342	Tubulin alpha-ubiquitous chain	TUBA1B	0.1535
2536	Tubulin alpha-6 chain	TUBA1C	0.1528
6107	Cytochrome P450 3A7	CYP3A7	0.1412
2539	Tubulin alpha-1 chain	TUBA4A	0.1404
6024	Cytochrome P450 1A1	CYP1A1	0.1395
6030	Cytochrome P450 2B6	CYP2B6	0.1294
6145	Solute carrier family 22 member 1	SLC22A1	0.1265
817	DNA topoisomerase 2-alpha	TOP2A	0.1068
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1064
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1031
6013	Cytochrome P450 2E1	CYP2E1	0.1025
29	Tubulin beta-1 chain	TUBB1	0.0991
2601	Tubulin alpha-2 chain	TUBA3C	0.0949
2565	Tubulin beta-4 chain	TUBB4	0.0936
2480	Tubulin alpha-8 chain	TUBA8	0.093
2444	Tubulin beta-4q chain	TUBB4Q	0.0911
118	Organic cation/carnitine transporter 2	SLC22A5	0.0899
2578	Tubulin beta-3 chain	TUBB3	0.0885
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.085
6147	Solute carrier family 22 member 3	SLC22A3	0.0793
1898	Cytochrome P450 1B1	CYP1B1	0.0774
1729	Solute carrier family 22 member 6	SLC22A6	0.0767
587	Serum albumin	ALB	0.0754
6148	Multidrug resistance-associated protein 7	ABCC10	0.0747
2164	Multidrug resistance-associated protein 4	ABCC4	0.0684
5812	Tubulin beta-2B chain	TUBB2B	0.0665
6141	Sodium/bile acid cotransporter	SLC10A1	0.0657
6142	Solute carrier family 22 member 8	SLC22A8	0.0638
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0602
20	Prostaglandin G/H synthase 1	PTGS1	0.0599
5718	Cytochrome P450 2A6	CYP2A6	0.0576
6506	Stathmin-4	STMN4	0.0562
492	Histamine H1 receptor	HRH1	0.0545
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0536
70	Type-1 angiotensin II receptor	AGTR1	0.0535
824	Sodium-dependent serotonin transporter	SLC6A4	0.0475
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0474
1569	G1/S-specific cyclin-D1	CCND1	0.0469
6143	Solute carrier family 22 member 7	SLC22A7	0.0463
556	Alpha-1A adrenergic receptor	ADRA1A	0.0455
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0454
766	Beta-2 adrenergic receptor	ADRB2	0.0453
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.045
833	Organic cation/carnitine transporter 1	SLC22A4	0.0437
193	Beta-1 adrenergic receptor	ADRB1	0.0432
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.042
831	D(2) dopamine receptor	DRD2	0.0414
1024	Solute carrier family 22 member 11	SLC22A11	0.0405
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0402
605	Fumarate reductase flavoprotein subunit	frdA	0.039
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.039
3673	Fumarate reductase flavoprotein subunit	fccA	0.039
4912	Fumarate reductase flavoprotein subunit	ifcA	0.039
6549	Fumarate reductase flavoprotein subunit	frdA	0.039
136	Estrogen receptor	ESR1	0.0376
6136	Multidrug resistance-associated protein 5	ABCC5	0.0375
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0367
731	HIV-1 protease	HIV-1 protease	0.0366
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0363
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0344
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0343
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0341
3923	Cholinesterase	BCHE	0.0327
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0326
871	Glucocorticoid receptor	NR3C1	0.0325
1714	Mitogen-activated protein kinase 3	MAPK3	0.0319
3811	Cytochrome P450 19A1	CYP19A1	0.0316
3947	Xanthine dehydrogenase/oxidase	XDH	0.0307
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0299
290	Prostaglandin G/H synthase 2	PTGS2	0.0297
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0293
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0289
6106	Cytochrome P450 2C18	CYP2C18	0.0287
318	Alpha-2A adrenergic receptor	ADRA2A	0.0285
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0283
6138	Multidrug resistance protein 3	ABCB4	0.0283
477	DNA topoisomerase 4 subunit A	parC	0.0281
886	DNA topoisomerase 4 subunit A	parC	0.0281
6226	DNA topoisomerase 4 subunit A	parC	0.0281
4120	NADPH--cytochrome P450 reductase	POR	0.0278
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0278
404	DNA gyrase subunit A	gyrA	0.0276
6224	DNA gyrase subunit A	gyrA	0.0276
632	Alpha-1B adrenergic receptor	ADRA1B	0.027
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0267
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0266
4192	DNA topoisomerase 2-beta	TOP2B	0.0266
713	Sodium-dependent dopamine transporter	SLC6A3	0.0257
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0255
23	D(1A) dopamine receptor	DRD1	0.0247
614	Progesterone receptor	PGR	0.0246
847	Mu-type opioid receptor	OPRM1	0.0245
1176	Mitogen-activated protein kinase 1	MAPK1	0.0245
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0244
908	Glutathione S-transferase theta-1	GSTT1	0.0241
738	Monocarboxylate transporter 1	SLC16A1	0.0239
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0234
468	Cytochrome P450 4A11	CYP4A11	0.0223
4604	Liver carboxylesterase 1	CES1	0.0223
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0219
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0219
341	5-hydroxytryptamine 3 receptor	HTR3A	0.021
904	Glutathione S-transferase P	GSTP1	0.0208
124	Histamine H2 receptor	HRH2	0.0205
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0205
7	Nitric oxide synthase, inducible	NOS2	0.0204
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0204
683	Potassium transporter	GK0582	0.0203
467	Delta-type opioid receptor	OPRD1	0.02
131	Synaptic vesicular amine transporter	SLC18A2	0.0198
789	Alpha-1D adrenergic receptor	ADRA1D	0.0197
629	Alpha-2B adrenergic receptor	ADRA2B	0.0197
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0196
378	Alpha-2C adrenergic receptor	ADRA2C	0.0193
6085	Fatty acid-binding protein, intestinal	FABP2	0.0193
380	Cytochrome P450 17A1	CYP17A1	0.0187
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0186
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0182
3270	Elongation factor G	fusA	0.0181
2808	Chloramphenicol acetyltransferase 3	cat3	0.0179
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0178
696	Kappa-type opioid receptor	OPRK1	0.0178
638	D(3) dopamine receptor	DRD3	0.0176
474	Acetylcholinesterase	ACHE	0.0175
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0173
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0171
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.017
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0168
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0167
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0167
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0167
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0164
465	Calmodulin	CALM1	0.0163
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0159
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
260	Cytochrome P450 51	ERG11	0.0152
761	Cytochrome P450 51	ERG11	0.0152
3163	Cytochrome P450 51	cyp51	0.0152
952	Dipeptidyl peptidase 4	DPP4	0.0152
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0144
6146	High affinity copper uptake protein 1	SLC31A1	0.0143
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0143
3939	Amine oxidase [flavin-containing] B	MAOB	0.0142
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0142
6031	Cytochrome P450 3A43	CYP3A43	0.0141
6163	Copper-transporting ATPase 2	ATP7B	0.014
6165	Copper-transporting ATPase 1	ATP7A	0.014
3941	Amine oxidase [flavin-containing] A	MAOA	0.014
49	Endothelin B receptor	EDNRB	0.0139
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0139
504	Mast/stem cell growth factor receptor	KIT	0.0138
1852	Microtubule-associated protein 2	MAP2	0.0137
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0137
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0137
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0135
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0134
6149	Solute carrier family 22 member 10	SLC22A10	0.0133
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0133
723	Cytosolic phospholipase A2	PLA2G4A	0.0133
185	Vasopressin V1a receptor	AVPR1A	0.0131
578	Endothelin-1 receptor	EDNRA	0.0131
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.013
6167	Organic solute transporter subunit beta	OSTB	0.013
432	D(4) dopamine receptor	DRD4	0.013
6166	Organic solute transporter subunit alpha	OSTA	0.013
3307	Acriflavine resistance protein B	acrB	0.013
896	Glutathione S-transferase Mu 1	GSTM1	0.0129
737	Mineralocorticoid receptor	NR3C2	0.0129
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
4773	Deoxycytidine kinase	DCK	0.0126
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0126
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0125
273	Apoptosis regulator Bcl-2	BCL2	0.0124
844	Epidermal growth factor receptor	EGFR	0.0123
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0122
5923	Microtubule-associated protein tau	MAPT	0.0121
5924	Microtubule-associated protein 4	MAP4	0.0121
6182	Cytochrome P450 2J2	CYP2J2	0.0121
5251	Carbonyl reductase [NADPH] 1	CBR1	0.012
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0119
6218	Pannexin-1	PANX1	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
869	Estrogen receptor beta	ESR2	0.0118
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0117
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0115
1757	Myeloperoxidase	MPO	0.0114
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0113
33	Cystine/glutamate transporter	SLC7A11	0.0113
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0112
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0112
6168	Solute carrier family 22 member 16	SLC22A16	0.0111
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0109
6043	Putative G-protein coupled receptor 44	GPR44	0.0109
2443	Azurin	azu	0.0108
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0107
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0106
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0106
887	DNA gyrase subunit B	gyrB	0.0105
4150	DNA gyrase subunit B	gyrB	0.0105
6225	DNA gyrase subunit B	gyrB	0.0105
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0105
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0104
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0104
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0104
407	Vascular endothelial growth factor receptor 2	KDR	0.0104
163	D(1B) dopamine receptor	DRD5	0.0103
489	Monocarboxylate transporter 2	SLC16A7	0.0103
232	Corticosteroid-binding globulin	SERPINA6	0.0103
4203	Histamine N-methyltransferase	HNMT	0.0102
461	Glycine receptor subunit alpha-3	GLRA3	0.01
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.01
1192	Sulfotransferase 1A1	SULT1A1	0.0099
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0097
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
4237	50S ribosomal protein L22	rplV	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
146	Androgen receptor	AR	0.0096
1353	DNA topoisomerase 1	TOP1	0.0096
3552	DNA topoisomerase 1	topA	0.0096
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0096
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0095
5626	Nucleoside diphosphate kinase B	NME2	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0095
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0094
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
3587	Gastrotropin	FABP6	0.0091
24	Thymidylate synthase	TMP1	0.009
359	Thymidylate synthase	TYMS	0.009
2626	Thymidylate synthase	thyA	0.009
2729	Thymidylate synthase	thyA	0.009
5352	Thymidylate synthase	THYA	0.009
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0088
777	Tumor necrosis factor	TNF	0.0088
275	Arachidonate 5-lipoxygenase	ALOX5	0.0088
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0088
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0088
6010	Thiamine transporter 1	SLC19A2	0.0086
26	Vascular endothelial growth factor receptor 3	FLT4	0.0086
165	FL cytokine receptor	FLT3	0.0085
6042	Prostaglandin reductase 2	PTGR2	0.0085
5787	Angiopoietin-1 receptor	TEK	0.0085
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0085
373	Transthyretin	TTR	0.0085
4238	50S ribosomal protein L4	rplD	0.0085
5578	50S ribosomal protein L4	rplD	0.0085
6173	50S ribosomal protein L4	rplD	0.0085
6219	50S ribosomal protein L4	rplD	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0083
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0083
32	Vascular endothelial growth factor receptor 1	FLT1	0.0083
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0082
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
132	ATP-binding cassette sub-family A member 1	ABCA1	0.008
716	5-hydroxytryptamine 7 receptor	HTR7	0.008
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.008
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0079
122	P2Y purinoceptor 12	P2RY12	0.0079
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0079
1770	Phospholipase C	PLCL1	0.0079
2841	Phospholipase C	plc	0.0079
5294	Nucleoside diphosphate kinase A	NME1	0.0077
1050	Bile salt sulfotransferase	SULT2A1	0.0077
175	Thiamin pyrophosphokinase 1	TPK1	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
1313	Lactoylglutathione lyase	GLO1	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0076
1517	Beta-3 adrenergic receptor	ADRB3	0.0076
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0075
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0074
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0074
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0074
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0074
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0073
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0073
284	DNA-directed RNA polymerase beta chain	rpoB	0.0073
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0073
702	UMP-CMP kinase	CMPK1	0.0072
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0072
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0072
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0072
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0072
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0071
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.007
76	Nitric-oxide synthase, brain	NOS1	0.007
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.007
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0069
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0068
756	Sex hormone-binding globulin	SHBG	0.0068
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0068
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0068
6220	Aryl hydrocarbon receptor	AHR	0.0068
291	Nitric-oxide synthase, endothelial	NOS3	0.0068
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0068
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0068
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0068
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0067
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0067
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0067
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0066
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0065
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0065
3809	Estrogen-related receptor gamma	ESRRG	0.0064
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0064
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0063
751	Potassium channel subfamily K member 6	KCNK6	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
1010	Cytochrome P450 51A1	CYP51A1	0.0062
3856	Fibroblast growth factor receptor 3	FGFR3	0.0062
1656	CYP2B protein	CYP2B	0.0061
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.006
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.006
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.006
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.006
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0059
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0059
694	Matrix protein 2	M	0.0059
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0058
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0058
365	Dihydrofolate reductase	DHFR	0.0058
2381	Dihydrofolate reductase	DFR1	0.0058
2833	Dihydrofolate reductase	Not Available	0.0058
2931	Dihydrofolate reductase	folA	0.0058
3544	Dihydrofolate reductase	folA	0.0058
3682	Dihydrofolate reductase	folA	0.0058
6642	Dihydrofolate reductase	folA	0.0058
6756	Dihydrofolate reductase	dfrA	0.0058
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0058
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0058
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0058
172	Potassium channel subfamily K member 1	KCNK1	0.0057
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0057
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0057
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0057
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0057
6824	Tyrosine-protein kinase Lyn	LYN	0.0057
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0057
2599	Tyrosine-protein kinase HCK	HCK	0.0057
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0056
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0056
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0055
6432	Transporter	snf	0.0055
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0055
183	Vascular endothelial growth factor A	VEGFA	0.0054
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0052
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0052
6837	Serine/threonine-protein kinase 17B	STK17B	0.0052
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0052
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0051
469	Annexin A1	ANXA1	0.0051
6020	Aldehyde oxidase	AOX1	0.0051
164	Histamine H4 receptor	HRH4	0.0051
2216	Fibroblast growth factor receptor 4	FGFR4	0.0051
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
1256	5-hydroxytryptamine 6 receptor	HTR6	0.005
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.005
3611	Cytidine deaminase	cdd	0.005
3707	Cytidine deaminase	cdd	0.005
4211	Cytidine deaminase	CDA	0.005
6164	POU domain, class 5, transcription factor 1	POU5F1	0.005
2391	Ferrochelatase	hemH	0.0049
6502	Ferrochelatase	DKFZp686P18130	0.0049
1591	Ferrochelatase, mitochondrial	FECH	0.0049
173	Toll-like receptor 7	TLR7	0.0049
1830	5'-nucleotidase	NT5E	0.0049
3810	Catechol O-methyltransferase	COMT	0.0049
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0048
3932	Glutathione S-transferase A2	GSTA2	0.0048
6070	Nischarin	NISCH	0.0048
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0047
1650	Heme carrier protein 1	SLC46A1	0.0047
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
125	DNA polymerase beta	POLB	0.0047
6014	Cytochrome P450 2A13	CYP2A13	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1341	Histamine H3 receptor	HRH3	0.0046
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
2232	Interleukin-5	IL5	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
1593	Mucin-2	MUC2	0.0045
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0045
814	Ryanodine receptor 1	RYR1	0.0045
84	Nuclear receptor 0B1	NR0B1	0.0045
811	Translocator protein	TSPO	0.0044
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0044
1178	Adenosine A2a receptor	ADORA2A	0.0044
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0044
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0043
2472	Voltage-gated potassium channel	kcsA	0.0043
6366	Voltage-gated potassium channel	kcsA	0.0043
357	Carbonic anhydrase 2	CA2	0.0043
992	Protein tyrosine kinase 2 beta	PTK2B	0.0042
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0042
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0042
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0042
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0042
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0042
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0042
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0042
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0042
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0042
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0042
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0042
6559	Cytochrome c oxidase subunit 2	ctaC	0.0042
6669	Cytochrome c oxidase subunit 2	ctaC	0.0042
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0042
6558	Cytochrome c oxidase subunit 1	ctaD	0.0042
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0042
976	Platelet glycoprotein IX	GP9	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
823	Fibroblast growth factor receptor 2	FGFR2	0.0042
94	5-hydroxytryptamine 4 receptor	HTR4	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0041
2300	Lysozyme	E	0.0041
3633	Lysozyme	R	0.0041
5597	Lysozyme	17	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0041
856	Vitamin D3 receptor	VDR	0.004
4122	Histone deacetylase 2	HDAC2	0.004
828	Phenylalanine-4-hydroxylase	PAH	0.004
3109	Phenylalanine-4-hydroxylase	phhA	0.004
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0039
1760	Aminopeptidase N	ANPEP	0.0039
6843	Aminopeptidase N	pepN	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
295	Carbonic anhydrase 1	CA1	0.0039
2540	Choloylglycine hydrolase	cbh	0.0039
1618	High affinity nerve growth factor receptor	NTRK1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0039
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0038
117	Sterol O-acyltransferase 1	SOAT1	0.0038
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0038
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0037
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0037
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0037
1630	Integrin beta-2	ITGB2	0.0037
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0037
921	Glutamate receptor 2	GRIA2	0.0036
527	Prostacyclin receptor	PTGIR	0.0036
6501	Fatty acid-binding protein, liver	FABP1	0.0036
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0036
340	Apoptotic protease-activating factor 1	APAF1	0.0035
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0035
672	Prostaglandin F2-alpha receptor	PTGFR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
5126	Arginase	rocF	0.0035
319	Opioid receptor, sigma 1	OPRS1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
5934	Cytochrome P450 26A1	CYP26A1	0.0035
4217	Telomerase reverse transcriptase	TERT	0.0035
484	Tyrosine-protein kinase ABL2	ABL2	0.0034
6102	Arylamine N-acetyltransferase 2	NAT2	0.0034
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0034
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0034
4103	Proteasome subunit beta type 2	PSMB2	0.0034
4102	Proteasome subunit beta type 5	PSMB5	0.0034
4101	Proteasome subunit beta type 1	PSMB1	0.0034
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0034
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0033
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0033
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0033
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0032
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0031
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0031
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0031
6111	DNA polymerase epsilon subunit 4	POLE4	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
6112	DNA polymerase epsilon subunit 3	POLE3	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0031
6110	DNA polymerase epsilon subunit 2	POLE2	0.0031
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0031
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0031
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
1864	RET proto-oncogene	RET	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
3917	Methylenetetrahydrofolate reductase	MTHFR	0.003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.003
6500	Phospholipase A2	PLA2G1B	0.003
6228	Nuclear receptor coactivator 1	NCOA1	0.003
153	Dopamine beta-hydroxylase	DBH	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
239	Coagulation factor X	F10	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
5818	Folate receptor alpha	FOLR1	0.003
705	Glutamate receptor 1	GRIA1	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
6044	Serum paraoxonase/lactonase 3	PON3	0.003
6171	Solute carrier family 28 member 3	SLC28A3	0.003
267	Plasminogen activator inhibitor 1	SERPINE1	0.003
517	Alcohol dehydrogenase 1C	ADH1C	0.0029
174	Sigma 1-type opioid receptor	SIGMAR1	0.0029
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0029
292	Activin receptor type-1	ACVR1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
849	Activated CDC42 kinase 1	TNK2	0.0028
572	Integrin alpha-L	ITGAL	0.0028
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0028
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
624	Guanidinoacetate N-methyltransferase	GAMT	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
6221	Steroid hormone receptor ERR1	ESRRA	0.0027
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
2320	Thymidine kinase, cytosolic	TK1	0.0026
16	Adenosine A1 receptor	ADORA1	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
427	Substance-P receptor	TACR1	0.0026
2021	Thrombomodulin	THBD	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0025
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0025
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0025
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0025
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
603	DNA polymerase alpha catalytic subunit	POLA1	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
6021	Adenosine kinase	ADK	0.0023
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0022
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
298	Renin	REN	0.0021
4311	tRNA	TRDMT1	0.0021
4325	tRNA	trmD	0.0021
4328	tRNA	trmD	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.002
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
6126	Carbonic anhydrase 7	CA7	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
482	Glycine receptor subunit alpha-1	GLRA1	0.002
4031	Glutathione S-transferase A1	GSTA1	0.0019
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0019
3926	Choline transporter-like protein 2	SLC44A2	0.0019
3925	Choline transporter-like protein 4	SLC44A4	0.0019
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0019
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0019
3927	Choline transporter-like protein 3	SLC44A3	0.0019
1686	Choline transporter-like protein 1	SLC44A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
861	Choline kinase alpha	CHKA	0.0019
769	High-affinity choline transporter 1	SLC5A7	0.0019
700	Choline dehydrogenase, mitochondrial	CHDH	0.0019
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0019
576	Choline O-acetyltransferase	CHAT	0.0019
3922	Phospholipase D2	PLD2	0.0019
3924	Phospholipase D1	PLD1	0.0019
5682	Ribonuclease pancreatic	RNASE1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
54	Prothrombin	F2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
1074	Urokinase-type plasminogen activator	PLAU	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
277	Purine nucleoside phosphorylase	PNP	0.0018
2870	Purine nucleoside phosphorylase	punA	0.0018
2945	Purine nucleoside phosphorylase	punA	0.0018
4659	Purine nucleoside phosphorylase	TM_1596	0.0018
4825	Purine nucleoside phosphorylase	TTHA1435	0.0018
1792	Tissue-type plasminogen activator	PLAT	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
518	Peroxidase/catalase T	katG	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0016
898	Glutathione S-transferase A3	GSTA3	0.0016
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6755	Poliovirus receptor	PVR	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
3957	Adenosine deaminase	ADA	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
563	Thyroid peroxidase	TPO	0.0015
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
899	Glutathione S-transferase Mu 3	GSTM3	0.0015
905	Glutathione transferase omega-1	GSTO1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1541	Metalloproteinase	mmp20	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
207	Glutathione synthetase	GSS	0.0013
5269	Glutathione synthetase	gshB	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1275	Estrogen sulfotransferase	SULT1E1	0.0012
1295	Fatty acid synthase	FASN	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6459	Glycodelin	PAEP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2207	Rhodopsin	RHO	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
162	Retinoic acid receptor gamma-1	RARG	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4692	A/G-specific adenine glycosylase	mutY	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00570 - Vinblastine

Targets

Enzymes

Transporters

Predictions