DT-Web

DB01097 - Leflunomide


Identification
Name Leflunomide
Accession Number DB01097 (APRD00205)
Type small molecule
Description Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 270.2073
Groups approved
Monoisotopic Weight 270.061612157
Pharmacology
Indication For the management of the signs and symptoms of active rheumatoid arthritis (RA) to improve physical function and to slow the progression of structural damage associated with the disease. Has also been used for the prevention of acute and chronic rejection in recipients of solid organ trasnplants and is designated by the FDA as an orphan drug for this use.
Mechanism of action Leflunomide is a prodrug that is rapidly and almost completely metabolized following oral administration to its pharmacologically active metabolite, A77 1726. This metabolite is responsible for essentially all of the drug's activity in-vivo. The mechanism of action of leflunomide has not been fully determined, but appears to primarily involve regulation of autoimmune lymphocytes. It has been suggested that leflunomide exerts its immunomodulating effects by preventing the expansion of activated autoimmune lymphocytes via interferences with cell cycle progression. In-vitro data indicates that leflunomide interferes with cell cycle progression by inhibiting dihydroorotate dehydrogenase (a mitochondrial enzyme involved in de novo pyrimidine ribonucleotide uridine monophosphate (rUMP)synthesis) and has antiproliferative activity. Human dihydroorotate dehydrogenase consists of 2 domains: an ?/?-barrel domain containing the active site and an ?-helical domain that forms a tunnel leading to the active site. A77 1726 binds to the hydrophobic tunnel at a site near the flavin mononucleotide. Inhibition of dihydroorotate dehydrogenase by A77 1726 prevents production of rUMP by the de novo pathway; such inhibition leads to decreased rUMP levels, decreased DNA and RNA synthesis, inhibition of cell proliferation, and G1 cell cycle arrest. It is through this action that leflunomide inhibits autoimmune T-cell proliferation and production of autoantibodies by B cells. Since salvage pathways are expected to sustain cells arrested in the G1 phase, the activity of leflunomide is cytostatic rather than cytotoxic. Other effects that result from reduced rUMP levels include interference with adhesion of activated lymphocytes to the synovial vascular endothelial cells, and increased synthesis of immunosuppressive cytokines such as transforming growth factor-? (TGF-?). Leflunomide is also a tyrosine kinase inhibitor. Tyrosine kinases activate signalling pathways leading to DNA repair, apoptosis and cell proliferation. Inhibition of tyrosine kinases can help to treating cancer by preventing repair of tumor cells.
Absorption Well absorbed, peak plasma concentrations appear 6-12 hours after dosing
Protein binding >99.3%
Biotransformation Primarily hepatic. Leflunomide is converted to its active form following oral intake.
Route of elimination The active metabolite is eliminated by further metabolism and subsequent renal excretion as well as by direct biliary excretion. In a 28 day study of drug elimination (n=3) using a single dose of radiolabeled compound, approximately 43% of the total radioactivity was eliminated in the urine and 48% was eliminated in the feces. It is not known whether leflunomide is excreted in human milk. Many drugs are excreted in human milk, and there is a potential for serious adverse reactions in nursing infants from leflunomide.
Toxicity LD50=100-250 mg/kg (acute oral toxicity)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Leflunomide may increase the anticoagulant effect of acenocoumarol.
Anisindione Leflunomide may increase the anticoagulant effect of anisindione.
Bleomycin Immunosuppressants like bleomycin may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity.
Carboplatin Immunosuppressants such as carboplatin may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Carmustine Immunosuppressants such as carmustine may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Chlorambucil Immunosuppressants such as chlorambucil may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Cisplatin Immunosuppressants such as cisplatin may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Cladribine Immunosuppressants such as cladribine may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Clofarabine Immunosuppressants such as clofarabine may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Colesevelam Bile Acid Sequestrants may decrease serum concentrations of the active metabolite(s) of Leflunomide. Unless using cholestyramine (or another bile acid sequestrant) together with leflunomide to intentionally enhance the removal/elimination of leflunomide, consider using an alternative to the bile acid sequestrants whenever possible. Separating the administration of these agents is unlikely to be an effective means of avoiding the interaction.
Corticotropin Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Dicumarol Leflunomide may increase the anticoagulant effect of dicumarol.
Eltrombopag Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Rifampin Rifampin increases the effect of leflunomide
Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Teriflunomide Avoid combination due to increased adverse effects of teriflunomide.
Tofacitinib Leflunomide may experience an increase in toxicity and adverse effects (ie. pancytopenia, agranulocytosis, thrombocytopenia). It is recommended to adjust therapy by forgoing a leflunomide loading dose, and to monitor for bone marrow suppression monthly.
Vinblastine Vinblastine may increase the adverse/toxic effects of Leflunomide. This may increase the risk of hematologic toxicities such as pancytopenia, agranulocytosis and thrombocytopenia. In patients receiving Vinblastine, consider eliminating the loading dose of Leflunomide. Monitor for bone marrow suppression at least monthly during concomitant therapy.
Vincristine Vincristine may increase the adverse/toxic effects of Leflunomide. This may increase the risk of hematologic toxicities such as pancytopenia, agranulocytosis and thrombocytopenia. In patients receiving Vincristine, consider eliminating the loading dose of Leflunomide. Monitor for bone marrow suppression at least monthly during concomitant therapy.
Vinorelbine Vinorelbine may increase the adverse/toxic effects of Leflunomide. This may increase the risk of hematologic toxicities such as pancytopenia, agranulocytosis and thrombocytopenia. In patients receiving Vinorelbine, consider eliminating the loading dose of Leflunomide. Monitor for bone marrow suppression at least monthly during concomitant therapy.
Warfarin Leflunomide may increase the anticoagulant effect of warfarin.
Food Interactions
  • Take without regard to meals.

Targets


Dihydroorotate dehydrogenase, mitochondrial
Name Dihydroorotate dehydrogenase, mitochondrial
Gene Name DHODH
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Goldenberg MM: Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis. Clin Ther. 1999 Nov;21(11):1837-52; discussion 1821. - Pubmed
  • Prakash A, Jarvis B: Leflunomide: a review of its use in active rheumatoid arthritis. Drugs. 1999 Dec;58(6):1137-64. - Pubmed
  • Li EK, Tam LS, Tomlinson B: Leflunomide in the treatment of rheumatoid arthritis. Clin Ther. 2004 Apr;26(4):447-59. - Pubmed
  • Wozel G, Pfeiffer C: [Leflunomide--a new drug for pharmacological immunomodulation] Hautarzt. 2002 May;53(5):309-15. - Pubmed
  • Sanders S, Harisdangkul V: Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. Am J Med Sci. 2002 Apr;323(4):190-3. - Pubmed
  • Breedveld FC, Dayer JM: Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000 Nov;59(11):841-9. - Pubmed
  • Reitzik M, Lownie JF: Familial polyostotic fibrous dysplasia. Oral Surg Oral Med Oral Pathol. 1975 Dec;40(6):769-74. - Pubmed
  • Herrmann ML, Schleyerbach R, Kirschbaum BJ: Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology. 2000 May;47(2-3):273-89. - Pubmed
  • Schattenkirchner M: The use of leflunomide in the treatment of rheumatoid arthritis: an experimental and clinical review. Immunopharmacology. 2000 May;47(2-3):291-8. - Pubmed
  • Fox RI: Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol Suppl. 1998 Jul;53:20-6. - Pubmed
  • Fukushima R, Kanamori S, Hirashiba M, Hishikawa A, Muranaka RI, Kaneto M, Nakamura K, Kato I: Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice. Reprod Toxicol. 2007 Nov-Dec;24(3-4):310-6. Epub 2007 May 18. - Pubmed
DTHybrid score 1.4669
Aryl hydrocarbon receptor
Name Aryl hydrocarbon receptor
Gene Name AHR
Pharmacological action unknown
Actions agonist
References
  • O'Donnell EF, Saili KS, Koch DC, Kopparapu PR, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvliet NI, Tanguay RL, Kolluri SK: The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One. 2010 Oct 1;5(10). pii: e13128. - Pubmed
  • Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. - Pubmed
DTHybrid score 0.3316
Protein tyrosine kinase 2 beta
Name Protein tyrosine kinase 2 beta
Gene Name PTK2B
Pharmacological action unknown
Actions antagonist
References
  • Pytel D, Sliwinski T, Poplawski T, Ferriola D, Majsterek I: Tyrosine kinase blockers: new hope for successful cancer therapy. Anticancer Agents Med Chem. 2009 Jan;9(1):66-76. - Pubmed
  • Fukushima R, Kanamori S, Hirashiba M, Hishikawa A, Muranaka RI, Kaneto M, Nakamura K, Kato I: Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice. Reprod Toxicol. 2007 Nov-Dec;24(3-4):310-6. Epub 2007 May 18. - Pubmed
  • Steeghs N, Nortier JW, Gelderblom H: Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann Surg Oncol. 2007 Feb;14(2):942-53. Epub 2006 Nov 14. - Pubmed
DTHybrid score 0.7358

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sevilla-Mantilla C, Ortega L, Agundez JA, Fernandez-Gutierrez B, Ladero JM, Diaz-Rubio M: Leflunomide-induced acute hepatitis. Dig Liver Dis. 2004 Jan;36(1):82-4. - Pubmed
DTHybrid score 0.317
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3617

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Kis E, Nagy T, Jani M, Molnar E, Janossy J, Ujhellyi O, Nemet K, Heredi-Szabo K, Krajcsi P: Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance. Ann Rheum Dis. 2009 Jul;68(7):1201-7. doi: 10.1136/ard.2007.086264. Epub 2008 Apr 8. - Pubmed
DTHybrid score 0.2754

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2024
6016 Cytochrome P450 2C19 CYP2C19 0.1553
1159 Interleukin-6 IL6 0.1354
1588 Multidrug resistance protein 1 ABCB1 0.1352
4119 Cytochrome P450 2D6 CYP2D6 0.1319
4924 Cytochrome P450 2C8 CYP2C8 0.1157
4118 Cytochrome P450 3A5 CYP3A5 0.1001
6030 Cytochrome P450 2B6 CYP2B6 0.0884
6024 Cytochrome P450 1A1 CYP1A1 0.0821
6013 Cytochrome P450 2E1 CYP2E1 0.0802
290 Prostaglandin G/H synthase 2 PTGS2 0.0721
862 Multidrug resistance-associated protein 1 ABCC1 0.0651
6107 Cytochrome P450 3A7 CYP3A7 0.0544
20 Prostaglandin G/H synthase 1 PTGS1 0.0502
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0469
587 Serum albumin ALB 0.0467
1898 Cytochrome P450 1B1 CYP1B1 0.0466
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.044
817 DNA topoisomerase 2-alpha TOP2A 0.0434
5718 Cytochrome P450 2A6 CYP2A6 0.043
6532 Light-harvesting protein B-800/850 beta 1 chain B1 0.0419
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0392
136 Estrogen receptor ESR1 0.0373
869 Estrogen receptor beta ESR2 0.0325
6765 3-ketoacyl-CoA thiolase fadA 0.0314
6530 Pancreatic lipase-related protein 2 PNLIPRP2 0.0313
6764 Fatty acid oxidation complex subunit alpha fadB 0.0313
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0297
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0295
6228 Nuclear receptor coactivator 1 NCOA1 0.0293
6241 Nuclear receptor coactivator 2 NCOA2 0.029
373 Transthyretin TTR 0.0278
2387 Ferripyoverdine receptor fpvA 0.0273
1729 Solute carrier family 22 member 6 SLC22A6 0.0269
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0261
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0261
36 Insulin receptor INSR 0.0258
2164 Multidrug resistance-associated protein 4 ABCC4 0.0245
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0245
1227 Cytochrome b MT-CYB 0.0244
6386 Cytochrome b petB 0.0244
6937 Cytochrome b MT-CYB 0.0244
3680 Dihydroorotate dehydrogenase A pyrDA 0.024
3259 Autolysin lytA 0.0238
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0235
6106 Cytochrome P450 2C18 CYP2C18 0.023
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0224
2775 Dihydroorotate dehydrogenase pyrD 0.0221
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.022
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.022
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0217
146 Androgen receptor AR 0.0215
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0213
6145 Solute carrier family 22 member 1 SLC22A1 0.0213
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0202
492 Histamine H1 receptor HRH1 0.0202
776 Bile salt export pump ABCB11 0.02
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.02
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.02
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0199
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0197
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0194
2646 Dihydroorotase pyrC 0.019
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0181
3811 Cytochrome P450 19A1 CYP19A1 0.018
2794 Orotate phosphoribosyltransferase pyrE 0.0178
6144 Solute carrier family 22 member 2 SLC22A2 0.0176
2427 Ferrichrome-iron receptor fhuA 0.0176
824 Sodium-dependent serotonin transporter SLC6A4 0.0171
3941 Amine oxidase [flavin-containing] A MAOA 0.0169
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0165
6142 Solute carrier family 22 member 8 SLC22A8 0.0165
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0165
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0165
502 5-hydroxytryptamine 2A receptor HTR2A 0.0163
844 Epidermal growth factor receptor EGFR 0.016
737 Mineralocorticoid receptor NR3C2 0.0153
318 Alpha-2A adrenergic receptor ADRA2A 0.0146
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0145
6143 Solute carrier family 22 member 7 SLC22A7 0.0142
831 D(2) dopamine receptor DRD2 0.014
6137 Multidrug resistance-associated protein 6 ABCC6 0.0138
6136 Multidrug resistance-associated protein 5 ABCC5 0.0138
118 Organic cation/carnitine transporter 2 SLC22A5 0.0136
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
504 Mast/stem cell growth factor receptor KIT 0.0134
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0133
556 Alpha-1A adrenergic receptor ADRA1A 0.0132
6148 Multidrug resistance-associated protein 7 ABCC10 0.0131
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
6147 Solute carrier family 22 member 3 SLC22A3 0.0122
885 5-hydroxytryptamine 1B receptor HTR1B 0.0121
117 Sterol O-acyltransferase 1 SOAT1 0.012
590 5-hydroxytryptamine 2C receptor HTR2C 0.012
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0119
3939 Amine oxidase [flavin-containing] B MAOB 0.0118
341 5-hydroxytryptamine 3 receptor HTR3A 0.0118
23 D(1A) dopamine receptor DRD1 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0114
70 Type-1 angiotensin II receptor AGTR1 0.0113
713 Sodium-dependent dopamine transporter SLC6A3 0.0111
731 HIV-1 protease HIV-1 protease 0.011
33 Cystine/glutamate transporter SLC7A11 0.0108
468 Cytochrome P450 4A11 CYP4A11 0.0107
632 Alpha-1B adrenergic receptor ADRA1B 0.0104
725 5-hydroxytryptamine 1D receptor HTR1D 0.0104
891 Dihydropteroate synthase folP 0.0103
5359 Dihydropteroate synthase folP 0.0103
7175 Dihydropteroate synthase sulI 0.0103
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0102
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0102
320 5-hydroxytryptamine 1A receptor HTR1A 0.0102
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0101
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1757 Myeloperoxidase MPO 0.0094
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0093
122 P2Y purinoceptor 12 P2RY12 0.0093
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.009
407 Vascular endothelial growth factor receptor 2 KDR 0.0089
4120 NADPH--cytochrome P450 reductase POR 0.0089
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0087
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0086
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0086
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0085
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0083
26 Vascular endothelial growth factor receptor 3 FLT4 0.0083
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0082
4773 Deoxycytidine kinase DCK 0.0082
789 Alpha-1D adrenergic receptor ADRA1D 0.0082
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0082
450 Muscarinic acetylcholine receptor M4 CHRM4 0.008
32 Vascular endothelial growth factor receptor 1 FLT1 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0078
571 Melatonin receptor type 1A MTNR1A 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
766 Beta-2 adrenergic receptor ADRB2 0.0077
3947 Xanthine dehydrogenase/oxidase XDH 0.0077
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0077
629 Alpha-2B adrenergic receptor ADRA2B 0.0076
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
16 Adenosine A1 receptor ADORA1 0.0075
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0075
465 Calmodulin CALM1 0.0075
193 Beta-1 adrenergic receptor ADRB1 0.0075
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0075
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0075
3810 Catechol O-methyltransferase COMT 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0074
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0074
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0074
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
198 Sodium channel protein type 10 subunit alpha SCN10A 0.007
273 Apoptosis regulator Bcl-2 BCL2 0.0069
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0069
6141 Sodium/bile acid cotransporter SLC10A1 0.0069
511 5-hydroxytryptamine 1F receptor HTR1F 0.0068
3923 Cholinesterase BCHE 0.0065
833 Organic cation/carnitine transporter 1 SLC22A4 0.0064
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0064
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0064
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0064
638 D(3) dopamine receptor DRD3 0.0063
908 Glutathione S-transferase theta-1 GSTT1 0.0063
133 Dihydropterate synthase sulI 0.0063
1178 Adenosine A2a receptor ADORA2A 0.0062
6031 Cytochrome P450 3A43 CYP3A43 0.0062
777 Tumor necrosis factor TNF 0.0062
6146 High affinity copper uptake protein 1 SLC31A1 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0061
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0061
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0061
4604 Liver carboxylesterase 1 CES1 0.006
29 Tubulin beta-1 chain TUBB1 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
275 Arachidonate 5-lipoxygenase ALOX5 0.0059
952 Dipeptidyl peptidase 4 DPP4 0.0059
6014 Cytochrome P450 2A13 CYP2A13 0.0059
260 Cytochrome P450 51 ERG11 0.0058
761 Cytochrome P450 51 ERG11 0.0058
3163 Cytochrome P450 51 cyp51 0.0058
904 Glutathione S-transferase P GSTP1 0.0057
756 Sex hormone-binding globulin SHBG 0.0057
847 Mu-type opioid receptor OPRM1 0.0056
378 Alpha-2C adrenergic receptor ADRA2C 0.0056
696 Kappa-type opioid receptor OPRK1 0.0055
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0055
183 Vascular endothelial growth factor A VEGFA 0.0055
6182 Cytochrome P450 2J2 CYP2J2 0.0054
5787 Angiopoietin-1 receptor TEK 0.0053
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0053
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0053
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0052
467 Delta-type opioid receptor OPRD1 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
6163 Copper-transporting ATPase 2 ATP7B 0.0051
6165 Copper-transporting ATPase 1 ATP7A 0.0051
432 D(4) dopamine receptor DRD4 0.0051
738 Monocarboxylate transporter 1 SLC16A1 0.005
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.005
1650 Heme carrier protein 1 SLC46A1 0.005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0049
94 5-hydroxytryptamine 4 receptor HTR4 0.0048
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0048
165 FL cytokine receptor FLT3 0.0048
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0048
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0048
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0048
3917 Methylenetetrahydrofolate reductase MTHFR 0.0047
24 Thymidylate synthase TMP1 0.0047
359 Thymidylate synthase TYMS 0.0047
2626 Thymidylate synthase thyA 0.0047
2729 Thymidylate synthase thyA 0.0047
5352 Thymidylate synthase THYA 0.0047
365 Dihydrofolate reductase DHFR 0.0047
2381 Dihydrofolate reductase DFR1 0.0047
2833 Dihydrofolate reductase Not Available 0.0047
2931 Dihydrofolate reductase folA 0.0047
3544 Dihydrofolate reductase folA 0.0047
3682 Dihydrofolate reductase folA 0.0047
6642 Dihydrofolate reductase folA 0.0047
6756 Dihydrofolate reductase dfrA 0.0047
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0046
527 Prostacyclin receptor PTGIR 0.0045
2539 Tubulin alpha-1 chain TUBA4A 0.0045
823 Fibroblast growth factor receptor 2 FGFR2 0.0045
49 Endothelin B receptor EDNRB 0.0044
4122 Histone deacetylase 2 HDAC2 0.0043
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0042
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0042
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
6102 Arylamine N-acetyltransferase 2 NAT2 0.0041
427 Substance-P receptor TACR1 0.0041
3856 Fibroblast growth factor receptor 3 FGFR3 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
1275 Estrogen sulfotransferase SULT1E1 0.0041
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.004
871 Glucocorticoid receptor NR3C1 0.004
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.004
1618 High affinity nerve growth factor receptor NTRK1 0.004
295 Carbonic anhydrase 1 CA1 0.004
811 Translocator protein TSPO 0.0039
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
106 Cannabinoid receptor 2 CNR2 0.0038
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0037
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0037
6085 Fatty acid-binding protein, intestinal FABP2 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
130 Prostacyclin synthase PTGIS 0.0037
68 Cannabinoid receptor 1 CNR1 0.0036
3639 Thymidine phosphorylase deoA 0.0036
3936 Thymidine phosphorylase TYMP 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
936 Ephrin type-A receptor 2 EPHA2 0.0036
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0035
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0035
5923 Microtubule-associated protein tau MAPT 0.0035
5924 Microtubule-associated protein 4 MAP4 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0034
239 Coagulation factor X F10 0.0034
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
469 Annexin A1 ANXA1 0.0033
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
1852 Microtubule-associated protein 2 MAP2 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
1648 Elastin ELN 0.0032
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0032
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0032
1656 CYP2B protein CYP2B 0.0032
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
293 Gamma-glutamyl hydrolase GGH 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0031
124 Histamine H2 receptor HRH2 0.0031
4226 Uridine phosphorylase 2 UPP2 0.0031
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0031
1010 Cytochrome P450 51A1 CYP51A1 0.003
818 50S ribosomal protein L10 rplJ 0.003
780 Retinoic acid receptor RXR-gamma RXRG 0.003
173 Toll-like receptor 7 TLR7 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
921 Glutamate receptor 2 GRIA2 0.0029
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0029
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
54 Prothrombin F2 0.0029
1192 Sulfotransferase 1A1 SULT1A1 0.0029
716 5-hydroxytryptamine 7 receptor HTR7 0.0029
4225 Uridine phosphorylase 1 UPP1 0.0029
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0028
3809 Estrogen-related receptor gamma ESRRG 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
88 Retinoic acid receptor RXR-beta RXRB 0.0027
5626 Nucleoside diphosphate kinase B NME2 0.0027
474 Acetylcholinesterase ACHE 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3957 Adenosine deaminase ADA 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
413 Amidophosphoribosyltransferase PPAT 0.0026
2515 Amidophosphoribosyltransferase purF 0.0026
3714 Amidophosphoribosyltransferase purF 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6689 TraN protein traN 0.0026
6671 Ig heavy chain V-III region VH26 Not Available 0.0026
6680 Cofilin-1 CFL1 0.0026
6404 Rhomboid protease glpG glpG 0.0026
6797 Rhomboid protease glpG glpG 0.0026
6670 Ig kappa chain V-I region Bi Not Available 0.0026
6690 BenF-like porin PFL_1329 0.0026
3710 Acyl-CoA thioesterase 2 tesB 0.0026
6672 Destrin DSTN 0.0026
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0026
6559 Cytochrome c oxidase subunit 2 ctaC 0.0026
6669 Cytochrome c oxidase subunit 2 ctaC 0.0026
6688 TraF protein traF 0.0026
6679 Colicin-Ia cia 0.0026
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0026
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0026
6687 TraO protein traO 0.0026
6685 Outer membrane protein II porB 0.0026
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0026
6676 Fe(3+)-pyochelin receptor fptA 0.0026
115 Penicillin-binding protein 2 mrdA 0.0026
6069 Penicillin-binding protein 2 mrdA 0.0026
6118 Penicillin-binding protein 2 penA 0.0026
6187 Penicillin-binding protein 2 pbpA 0.0026
6686 Penicillin-binding protein 2 pbp2 0.0026
6939 Penicillin-binding protein 2 mrdA 0.0026
7163 Penicillin-binding protein 2 pbpA 0.0026
6020 Aldehyde oxidase AOX1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
153 Dopamine beta-hydroxylase DBH 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
1541 Metalloproteinase mmp20 0.0025
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0024
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0024
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0024
5198 Flavodoxin-1 fldA 0.0024
5175 Hypothetical protein SMU.260 SMU_260 0.0024
4405 Nitric oxide reductase fprA 0.0024
6070 Nischarin NISCH 0.0024
5179 Probable aromatic acid decarboxylase pad1 0.0024
5202 Nitroreductase family protein BC_1844 0.0024
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0024
5200 NADH dehydrogenase nox 0.0024
5201 FMN-binding protein DvMF_2023 0.0024
5193 Phenazine biosynthesis protein phzG phzG 0.0024
5178 Protein nrdI nrdI 0.0024
3293 Flavodoxin Not Available 0.0024
4614 Flavodoxin DVU_2680 0.0024
5172 Flavodoxin isiB 0.0024
5173 Flavodoxin isiB 0.0024
5182 Flavodoxin fldA 0.0024
5131 PhzG phzG 0.0024
5181 Hypothetical protein yhdA azr 0.0024
5170 Epidermin decarboxylase epiD 0.0024
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0024
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5191 Morphinone reductase morB 0.0024
5190 Rubredoxin-oxygen oxidoreductase roo 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
1864 RET proto-oncogene RET 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
518 Peroxidase/catalase T katG 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
4760 Mll3241 protein mll3241 0.0023
3578 Protein crcA crcA 0.0023
6438 Outer membrane protein G ompG 0.0023
6474 Outer membrane protein W ompW 0.0023
2447 Ammonia channel amtB 0.0023
6675 Colicin-E3 ceaC 0.0023
2925 Long-chain fatty acid transport protein fadL 0.0023
6385 H subunit of photosynthetic reaction center complex puhA 0.0023
6480 Outer membrane usher protein papC papC 0.0023
3395 Iron(III) dicitrate transport protein fecA fecA 0.0023
6678 Colicin I receptor cirA 0.0023
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1629 Transcription factor AP-1 JUN 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0022
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0021
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
563 Thyroid peroxidase TPO 0.0021
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0021
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0021
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6524 Protein tonB tonB 0.0021
4503 NADPH-flavin oxidoreductase frp 0.0021
2679 Vitamin B12 transporter btuB btuB 0.0021
5189 Trimethylamine dehydrogenase tmd 0.0021
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0021
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0021
4407 FMN-dependent NADH-azoreductase azoR 0.0021
5169 FMN-dependent NADH-azoreductase azoR 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0021
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0021
3507 Chorismate synthase aroC 0.0021
5171 Chorismate synthase aroC 0.0021
5176 YtnJ moxC 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
7 Nitric oxide synthase, inducible NOS2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
484 Tyrosine-protein kinase ABL2 ABL2 0.002
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1820 Beta-nerve growth factor NGF 0.002
6677 Myelin P2 protein PMP2 0.002
2981 Phospholipase A2, membrane associated PLA2G2A 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.002
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.002
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.002
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.002
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
76 Nitric-oxide synthase, brain NOS1 0.0019
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0019
528 5-hydroxytryptamine 1E receptor HTR1E 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0019
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0018
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0018
5180 L(+)-mandelate dehydrogenase mdlB 0.0018
2207 Rhodopsin RHO 0.0018
760 Fibroblast growth factor 1 FGF1 0.0018
614 Progesterone receptor PGR 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
6354 Reaction center protein M chain pufM 0.0017
6455 Reaction center protein M chain pufM 0.0017
6684 Reaction center protein M chain pufM 0.0017
6352 Reaction center protein H chain puhA 0.0017
6456 Reaction center protein H chain puhA 0.0017
6682 Reaction center protein H chain puhA 0.0017
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0017
6353 Reaction center protein L chain pufL 0.0017
6454 Reaction center protein L chain pufL 0.0017
6683 Reaction center protein L chain pufL 0.0017
408 Riboflavin kinase RFK 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0016
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0016
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
2828 Squalene--hopene cyclase shc 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0016
4284 Pentaerythritol tetranitrate reductase onr 0.0016
1243 Cathepsin D CTSD 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
6268 Hydroxyacid oxidase 1 HAO1 0.0016
3830 Calreticulin CALR 0.0016
2853 14 kDa fatty acid-binding protein Not Available 0.0015
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0015
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
976 Platelet glycoprotein IX GP9 0.0015
654 Flavin reductase BLVRB 0.0015
6432 Transporter snf 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
164 Histamine H4 receptor HRH4 0.0014
1374 Natriuretic peptides B NPPB 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
814 Ryanodine receptor 1 RYR1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
251 Alcohol dehydrogenase 1A ADH1A 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
705 Glutamate receptor 1 GRIA1 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
820 Glycine receptor subunit alpha-2 GLRA2 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
162 Retinoic acid receptor gamma-1 RARG 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
444 Alcohol dehydrogenase 1B ADH1B 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
3587 Gastrotropin FABP6 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
4237 50S ribosomal protein L22 rplV 0.001
5818 Folate receptor alpha FOLR1 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.001
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
5934 Cytochrome P450 26A1 CYP26A1 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
751 Potassium channel subfamily K member 6 KCNK6 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
229 Retinoic acid receptor beta RARB 0.0009
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
3937 Fatty-acid amide hydrolase FAAH 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
172 Potassium channel subfamily K member 1 KCNK1 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0008
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0008
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
1992 Vitamin D-binding protein GC 0.0007
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
822 Aldose reductase AKR1B1 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
1630 Integrin beta-2 ITGB2 0.0007
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
3221 Cytochrome c4 cc4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0005
856 Vitamin D3 receptor VDR 0.0005
572 Integrin alpha-L ITGAL 0.0005
798 Osteocalcin BGLAP 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
1507 Cytochrome c CYCS 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6218 Pannexin-1 PANX1 0.0005
369 Coagulation factor VII F7 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
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