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Orotate phosphoribosyltransferase


Partner ID 2794
Name Orotate phosphoribosyltransferase
Synonyms 4769
Gene name pyrE
General function Nucleotide transport and metabolism
Specific function Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Gene sequence + ...

ATGAAACCGTATCAGCGCCAGTTTATTGAGTTTGCGCTTAACAAGCAGGTACTAAAGTTTGGCGAGTTTACGCTGAAATCCGGGCGCAAAAGCCCCTATTTCTTCAACGCCGGGCTGTTTAATACCGGGCGCGACCTGGCGTTGTTAGGCCGTTTTTATGCCGAAGCGCTGGTGGATTCCGGTATTGAATTTGATCTGCTGTTTGGCCCCGCGTACAAAGGTATTCCGATCGCGACGACGACGGCGGTTGCGCTGGCGGAACATCACGATAAAGACCTGCCGTACTGCTTTAACCGCAAAGAGGCAAAAGATCATGGTGAAGGCGGGAGCCTGGTGGGCAGCGCGCTACAGGGCCGCGTGATGCTGGTGGATGACGTGATTACCGCAGGTACGGCGATTCGCGAGTCAATGGAGATTATTCAGGCGCACGGGGCTACGCTGGCTGGCGTACTGATTTCGCTGGATCGTCAGGAACGTGGCCGCGGCGAGATTTCCGCGATTCAGGAAGTGGAGCGCGACTATGGTTGTAAGGTTATCTCCATCATTACGCTGAAAGACCTGATTGCCTATCTGGAAGAAAAACCTGATATGGCTGAGCATCTGGCGGCTGTGCGAGCATACCGGGAAGAATTTGGCGTGTAA
Protein sequence + ...

MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV
GO Classification
function
transferase activity, transferring pentosyl groups
orotate phosphoribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
process
pyrimidine nucleotide metabolism
pyrimidine nucleotide biosynthesis
nucleoside metabolism
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB02262 Orotic Acid

Associated as Prediction

Id Name
DB00131 Adenosine monophosphate
DB00173 Adenine
DB00352 Thioguanine
DB00993 Azathioprine
DB01033 Mercaptopurine
DB01097 Leflunomide
DB01117 Atovaquone
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01942 Formic Acid
DB02129 Dihydroorotic Acid
DB02212 Pyrophosphate 2-
DB02262 Orotic Acid
DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
DB02613 Decylamine-N,N-Dimethyl-N-Oxide
DB03153 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol
DB03247 Riboflavin Monophosphate
DB03480 Brequinar Analog
DB03506 9-Deazaadenine
DB03523 6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB03805 Antiproliferative Agent A771726
DB04147 Lauryl Dimethylamine-N-Oxide
DB04198 Formycin B
DB04252 N-Carbamoyl-L-Aspartate
DB04272 Citric Acid
DB04281 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone
DB04356 9-Deazaguanine
DB04566 Inosinic Acid
DB04583 5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACID
DB07443 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide
DB07559 (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07561 (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide
DB07646 UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE
DB07975 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID
DB07976 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID
DB07977 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID
DB07978 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID
DB08006 N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08008 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
DB08169 (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide
DB08172 (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
DB08249 3,6,9,12,15-PENTAOXATRICOSAN-1-OL
DB08880 Teriflunomide
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