DT-Web

DB08172 - (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide


Identification
Name (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
Accession Number DB08172
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 342.776
Groups experimental
Monoisotopic Weight 342.077120063
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydroorotate dehydrogenase, mitochondrial
Name Dihydroorotate dehydrogenase, mitochondrial
Gene Name DHODH
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3767

Predictions


Id Partner name Gene Name Score
6532 Light-harvesting protein B-800/850 beta 1 chain B1 0.0419
6765 3-ketoacyl-CoA thiolase fadA 0.0314
6530 Pancreatic lipase-related protein 2 PNLIPRP2 0.0313
6764 Fatty acid oxidation complex subunit alpha fadB 0.0313
2387 Ferripyoverdine receptor fpvA 0.0273
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0256
3680 Dihydroorotate dehydrogenase A pyrDA 0.024
3259 Autolysin lytA 0.0238
2775 Dihydroorotate dehydrogenase pyrD 0.0221
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0214
1227 Cytochrome b MT-CYB 0.0214
6386 Cytochrome b petB 0.0214
6937 Cytochrome b MT-CYB 0.0214
2646 Dihydroorotase pyrC 0.019
2794 Orotate phosphoribosyltransferase pyrE 0.0178
2427 Ferrichrome-iron receptor fhuA 0.0176
992 Protein tyrosine kinase 2 beta PTK2B 0.0135
4757 Cytochrome P450 2C9 CYP2C9 0.0121
6220 Aryl hydrocarbon receptor AHR 0.0109
4200 Cytochrome P450 1A2 CYP1A2 0.005
6689 TraN protein traN 0.0026
6671 Ig heavy chain V-III region VH26 Not Available 0.0026
6680 Cofilin-1 CFL1 0.0026
6404 Rhomboid protease glpG glpG 0.0026
6797 Rhomboid protease glpG glpG 0.0026
6670 Ig kappa chain V-I region Bi Not Available 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
6690 BenF-like porin PFL_1329 0.0026
3710 Acyl-CoA thioesterase 2 tesB 0.0026
6672 Destrin DSTN 0.0026
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0026
6559 Cytochrome c oxidase subunit 2 ctaC 0.0026
6669 Cytochrome c oxidase subunit 2 ctaC 0.0026
6688 TraF protein traF 0.0026
6679 Colicin-Ia cia 0.0026
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0026
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0026
6687 TraO protein traO 0.0026
6685 Outer membrane protein II porB 0.0026
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0026
6676 Fe(3+)-pyochelin receptor fptA 0.0026
115 Penicillin-binding protein 2 mrdA 0.0026
6069 Penicillin-binding protein 2 mrdA 0.0026
6118 Penicillin-binding protein 2 penA 0.0026
6187 Penicillin-binding protein 2 pbpA 0.0026
6686 Penicillin-binding protein 2 pbp2 0.0026
6939 Penicillin-binding protein 2 mrdA 0.0026
7163 Penicillin-binding protein 2 pbpA 0.0026
5198 Flavodoxin-1 fldA 0.0024
5175 Hypothetical protein SMU.260 SMU_260 0.0024
4405 Nitric oxide reductase fprA 0.0024
5179 Probable aromatic acid decarboxylase pad1 0.0024
5202 Nitroreductase family protein BC_1844 0.0024
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0024
5200 NADH dehydrogenase nox 0.0024
5201 FMN-binding protein DvMF_2023 0.0024
5193 Phenazine biosynthesis protein phzG phzG 0.0024
5178 Protein nrdI nrdI 0.0024
3293 Flavodoxin Not Available 0.0024
4614 Flavodoxin DVU_2680 0.0024
5172 Flavodoxin isiB 0.0024
5173 Flavodoxin isiB 0.0024
5182 Flavodoxin fldA 0.0024
5131 PhzG phzG 0.0024
4037 Hypothetical protein GPX1 0.0024
4297 Hypothetical protein SP_1951 0.0024
4521 Hypothetical protein BC_2969 0.0024
4540 Hypothetical protein TM_1070 0.0024
4555 Hypothetical protein MT1739 0.0024
4569 Hypothetical protein mshD 0.0024
4578 Hypothetical protein PA3270 0.0024
4747 Hypothetical protein PA3967 0.0024
5177 Hypothetical protein TM_0096 0.0024
5194 Hypothetical protein PA1204 0.0024
5240 Hypothetical protein Rv2991 0.0024
5370 Hypothetical protein TM_1158 0.0024
5710 Hypothetical protein Tb927.5.1360 0.0024
5181 Hypothetical protein yhdA azr 0.0024
5170 Epidermin decarboxylase epiD 0.0024
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0024
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5191 Morphinone reductase morB 0.0024
5190 Rubredoxin-oxygen oxidoreductase roo 0.0024
4760 Mll3241 protein mll3241 0.0023
3578 Protein crcA crcA 0.0023
6438 Outer membrane protein G ompG 0.0023
6474 Outer membrane protein W ompW 0.0023
2447 Ammonia channel amtB 0.0023
6675 Colicin-E3 ceaC 0.0023
2925 Long-chain fatty acid transport protein fadL 0.0023
6385 H subunit of photosynthetic reaction center complex puhA 0.0023
6480 Outer membrane usher protein papC papC 0.0023
3395 Iron(III) dicitrate transport protein fecA fecA 0.0023
6678 Colicin I receptor cirA 0.0023
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0021
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0021
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0021
6524 Protein tonB tonB 0.0021
4503 NADPH-flavin oxidoreductase frp 0.0021
2679 Vitamin B12 transporter btuB btuB 0.0021
5189 Trimethylamine dehydrogenase tmd 0.0021
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0021
4407 FMN-dependent NADH-azoreductase azoR 0.0021
5169 FMN-dependent NADH-azoreductase azoR 0.0021
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0021
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0021
3507 Chorismate synthase aroC 0.0021
5171 Chorismate synthase aroC 0.0021
5176 YtnJ moxC 0.0021
6677 Myelin P2 protein PMP2 0.002
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0019
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0018
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0018
5180 L(+)-mandelate dehydrogenase mdlB 0.0018
6354 Reaction center protein M chain pufM 0.0017
6455 Reaction center protein M chain pufM 0.0017
6684 Reaction center protein M chain pufM 0.0017
6352 Reaction center protein H chain puhA 0.0017
6456 Reaction center protein H chain puhA 0.0017
6682 Reaction center protein H chain puhA 0.0017
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0017
6353 Reaction center protein L chain pufL 0.0017
6454 Reaction center protein L chain pufL 0.0017
6683 Reaction center protein L chain pufL 0.0017
408 Riboflavin kinase RFK 0.0017
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0017
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0017
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0017
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0016
2828 Squalene--hopene cyclase shc 0.0016
4284 Pentaerythritol tetranitrate reductase onr 0.0016
6268 Hydroxyacid oxidase 1 HAO1 0.0015
2207 Rhodopsin RHO 0.0015
654 Flavin reductase BLVRB 0.0015
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0012
4120 NADPH--cytochrome P450 reductase POR 0.0011
3939 Amine oxidase [flavin-containing] B MAOB 0.0011
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